http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
가압추출공정을 이용한 해방풍 뿌리 유래 조다당류의 항산화 활성
김주현 ( Ju-hyeon Kim ),구율리 ( Yul-ri Gu ),홍주헌 ( Joo-heon Hong ) 한국키틴키토산학회 2018 한국키틴키토산학회지 Vol.23 No.1
본 연구에서는 다양한 생리활성이 있다고 알려져 있는 해방풍 뿌리를 기능성 소재로 활용하고자 가압추출하였고, 뿌리 유래 유용물질인 조다당류를 분리하여 항산화 활성을 조사하였다. 조다당류의 수율은 18.37~31.14%이었고, 총 당 및 총 단백질 함량은 가압추출 180분 처리구에서 각각 57.09 g/100 g 및 15.41 g/100 g으로 가장 높은 값을 나타내었고, 유리당 함량은 fructose 및 glucose가 가장 많이 함유되어 있었으며, 열수추출물보다 가압추출물에서 높은 함량을 나타내었다. 총 폴리페놀 및 총 플라보노이드 함량은 가압추출 60분 처리구에서 7.95 mg/g 및 6.49 mg/g으로 가장 높은 값을 나타내었다. DPPH 및 ABTS radical 소거활성은 가압추출 60분 처리구가 500~5,000 μg/mL 농도에서 18.07~45.31% 및 15.55~61.12%로 농도가 증가함에 따라 소거활성이 증가하였다. Superoxide radical 소거활성 및 FRAP 활성은 가압추출 60분 처리구가 500~5,000 μg/mL 농도에서 23.75~56.08% 및 112.19~421.22μM로 가장 우수한 활성을 나타내었다. 폐 정상세포인 L-132세포에 해방풍 뿌리 유래 조다당류를 처리하여 세포 사멸에 대한 보호효과를 측정한 결과, 열수추출물보다 가압추출물에서 높은 세포보호 효과를 나타내었으며, 특히 가압추출 60분 처리구에서 H2O2 처리구 대비 83.35%로 세포 활성이 증가하여 우수한 세포보호 효과를 확인하였다. This study was conducted to establish antioxidant activities of crude polysaccharides from Glehniae Radix root using pressurized extraction. The crude polysaccharides were isolated from Glehniae Radix roots by extracting at 150 kPa, 121oC for 30 min (PE30), 60 min (PE60), 120 min (PE120) and 180 min (PE180). The yield of crude polysaccharides (HE, PE30, PE60, PE120, PE180) were 24.60~31.14%. The total sugar and protein contents of PE180 were 57.09 g/100 g and 15.41 g/100 g, respectively. The main components in the free sugar of polysaccharide from Glehniae Radix root were fructose and glucose at 82.72~89.03 mg/100 g, 52.98~54.39 mg/100 g, respectively. The total polyphenol and flavonoid contents of PE60 were 7.95 g/100 g and 6.49 g/100 g, respectively. The DPPH and ABTS radical scavenging activities of PE60 at 5,000 μg/mL were 45.31% and 61.12%, respectively. The superoxide radical scavenging and FRAP activity of PE60 at 5,000 μg/mL were 56.08% and 421.22 μM, respectively. The PE60 extract was better than other extracts on protective effects against oxidative stress in L-132 cells (83.35%). In conclusion, we provided experimental evidence that crude polysaccharide from Glehniae Radix root have potential as functional food materials.
백서에서 흡인된 티타니아 나노입자의 생체 내 분포에 관한 연구
최세훈,박계현,전상훈,김주현,정진행,조소혜,박종구,김태헌,Choi, Se-Hoon,Park, Kay-Hyun,Jheon, San-Hhoon,Kim, Joo-Hyun,Chung, Jin-Haeng,Cho, So-Hye,Park, Jong-Ku,Kim, Tae-Heon 대한기관식도과학회 2010 大韓氣管食道科學會誌 Vol.16 No.1
Titania nanomaterials are widely used as cosmetics and dyes, however the impacts on human health are uncertain, We investigated the biodistribution of inhaled titania nanoparticles in rats, Methods Eight weeks-old SD rats were intubated and inhaled with 3 mg titania nanoparticles, twice a week, for 2 weeks, After inhalation, the rats were sacrificed and tissues or heart, lung. intestine, brain, and liver were obtained, We investigated the tissues with optical microscope (OM), transmission electron microscope (EM), scanning EM, And to analyze titania concentration of each tissue, we lysed the tissues with radioimmunoprecipitation assay (RlPA) lysis buffer or acid. Results Granulation tissues in lung were confirmed on the optical microscope, however the other organs had no abnormalities in OM images, In EM images, the rats which inhaled titania nanoparticles showed calcium deposition at heart, brain, and intestine, Titania concentration in lung was increased on the inhaled rat sacrificed I month after last exposure. Conclusion Inhaled titania nanoparticles is thought to be deposited and make inflammatory reaction in lung, and the deposition was not efficiently cleared over a month. However inhaled titania nanoparticles may rarely pass through the alveolus-blood barrier and distribute to other organs of the bod.
세라믹 방열 복합체의 열전도도 분석 및 Wetting Process를 이용한 SiC/에폭시 복합체
황용선(Yong Seon Hwang),김주현(Joo Heon Kim),조원철(Won Chul Cho) 한국고분자학회 2014 폴리머 Vol.38 No.6
세라믹 방열 복합체의 특성 비교를 위해 casting method로 제작하였으며, 이들의 광학적 이미지와 단면 FESEM분석을 실시하였다. 각각의 복합체의 열전도성 특성을 비교 분석하였으며, silicon carbide(SiC)의 분산도 문제를 해결하기 위해 wetting process를 도입하여 SiC/epoxy 복합체를 제작하였다. 기존의 방법에서 발견된 복합체 내공극과 분산도 문제가 wetting process를 통해 향상되었으며, 충전제 함량에 따른 열전도성 특성을 분석하였다. SiC복합체의 함량에 따른 공극률 해석을 통해 70 wt% SiC 복합체에서 가장 높은 열전도도 값을 보였으며, 이들의 단면 FE-SEM 분석을 통해 복합체 내의 충전제 분산도를 확인하였다. Various kinds of thermal conductive ceramic/polymer composites (aluminum nitride, aluminum oxide, boronnitride, and silicon carbide/epoxy) were prepared by a casting method and their optical images were observed by FESEM. Among these, SiC/epoxy composite shows inhomogeneous dispersion features of SiC and air voids in the epoxymatrix layer, resulting in undesirable thermal conductive properties. To enhance the thermal conductivities of SiC/epoxycomposites, the epoxy wetting method which can directly infiltrate the epoxy droplet onto filtrated SiC cake wasemployed to fabricate the homogeneously dispersed SiC/epoxy composite for ideal thermal conductive behavior, withmaximum thermal conductivity of 3.85W/mK at 70 wt% of SiC filler contents.
유전자 6형 만성C형간염 환자의 유병률과 위험인자 그리고 임상적 특징: 단일기관 경험
신승각 ( Seung Kak Shin ),박수용 ( Soo Yong Park ),정영걸 ( Young Kul Jung ),김의주 ( Eui Joo Kim ),이헌남 ( Heon Nam Lee ),이종준 ( Jong Joon Lee ),권오상 ( Oh Sang Kwon ),최덕주 ( Duck Joo Choi ),김연수 ( Yun Soo Kim ),김주현 ( 대한소화기학회 2015 대한소화기학회지 Vol.65 No.2
Background/Aims: Hepatitis C genotypes 1 and 2 are widely distributed globally. In contrast, genotype 6 is found mainly in Southeast Asia, while genotype 6 is rare in Korea. This study aims to investigate the prevalence, risk factors and clinical characteristics of patients with genotype 6 chronic hepatitis C. Methods: We retrospectively identified 133 HCV-infected patients who underwent HCV genotype analysis between January 2012 and December 2012, and analyzed the prevalence, risk factors and clinical characteristics of patients diagnosed with genotype 6 chronic hepatitis C. Results: Among 133 patients, 53 patients (39.8%) were infected with genotype 1, 62 patients (46.6%) with genotype 2, 2 patients (1.5%) with genotype 3, 14 patients (10.5%) with genotype 6, and 2 patients (1.5%) with mixed genotypes (genotype 1 and 6). The risk factors associated with genotype 6 were acupuncture (n=4, 28.6%), intravenous drug use (n=3, 21.4%), tattoo (n=2, 14.3%), and transfusion (n=2, 14.3%). Of the 14 patients with genotype 6, 6 patients were treated with pegylated interferon and ribavirin. Five patients had reached the end of treatment. All patients reaching end of treatment for genotype 6 showed early virological response and sustained virological response. Conclusions: The prevalence of genotype 6 is 10.5% and mixed infections of genotype 1 and 6 are 1.5% in patients with chronic hepatitis C. A major potential risk factor is intravenous drug use and the treatment response rate to pegylated interferon plus ribavirin is high in patients with genotype 6 chronic hepatitis C. Large scale multicenter studies are needed.
김주현,심영수,김건열,김철우,한용철,조상헌,한성구 대한내과학회 1987 대한내과학회지 Vol.33 No.6
Lymphangiomas are benign, slow-growing tumors which are composed of lymphatic vessels and are classified into simple lymphangioma, cavernous lymphangioma, and cystic hygroma on the basis of the size of the cystic spaces. Pure mediastinal lymphangiomas are very rare in adults, whereas lymphangiomas of the neck, axilla, or mediastinum are not uncommon in children. As of 1976, about 50 cases of mediastinal lymphangiomas have been reported. Roentgenologically, they demonstrate well- circumscribed lesion with uniform density. Normal mediastinal structures are enveloped by the lesion rather than being markedly displaced or amputated. Lymphangiomas can be treated surgically by complete removal. We report a case of pure mediastinal lymphangioma in a 29-year-old man with the review of literature.