만성 알코올 유발 마우스 간손상 및 지방 축적에 대한 제주조릿대잎 에틸 아세테이트 분획물의 간 보호 효과

김아름,이영주,김효진,양지원,김주성,지영흔,Kim, Areum,Lee, Youngju,Herath, Kalahe Hewage Iresha Nadeeka Madushani,Kim, Hyo Jin,Yang, Jiwon,Kim, Ju-Sung,Jee, Youngheun 대한수의학회 2020 大韓獸醫學會誌 Vol.60 No.4

Sasa (S.) quelpaertensis Nakai (Korean name, Jeju-Joritdae), which has anti-oxidative and anti-inflammatory activities, is a type of bamboo grass distributed widely in Jeju Island, Korea. S. quelpaertensis leaves are used for therapeutic purposes in traditional Korean medicine. This study examined the hepatoprotective effects of the S. quelpaertensis ethyl acetate fraction (SQEA) in a mouse model to mimic alcoholic liver damage. The mice were administered orally with 30% alcohol (5 g/kg) once per day with or without SQEA treatments (100 and 200 mg/kg) for 14 days consecutively. Alcohol consumption increased the serum alcohol content and histopathological changes but reduced the liver weight. Moreover, the livers of the alcohol group exhibited the accumulation of malondialdehyde and cytochrome P450 2E1 (CYP2E1), and lipid droplet coating protein perilipin-2. On the other hand, SQEA dose-dependently attenuated the alcohol-induced serum ethanol content and liver histopathological changes but increased the liver weight. Moreover, SQEA attenuated the level of CYP2E1 and inhibited alcohol-induced lipogenesis in the liver via decreased perilipin-2 expression. These results suggest that SQEA can provide a potent way to reduce the liver damage caused by alcohol consumption.

The Correlation Between Deltamethrin Exposure and Urinary 3-PBA Concentrations in Rats

김아름누리 ( Areumnuri Kim ),박지현 ( Ji Hyun Park ),전경미 ( Kyongmi Chon ),박경훈 ( Kyung-hun Park ),문병철 ( Byeong-chul Moon ),백민경 ( Min Kyoung Paik ) 한국환경농학회 2016 한국환경농학회 학술대회집 Vol.2016 No.-

Pyrethroids (PYRs) are a widely used insecticide in agriculture and household area.PYRs caninduce neurotoxic effects in mammalsby disrupting voltage-sensitive sodium channelswhen exposed to overdose.In mammals, PYRs such as deltamethrinis metabolized to 3-phenoxybenzoic acid (3-PBA) in liver that is mainly excreted in urine.Urine is highly useful as a testing matrix because it is easily accessible and can be collected noninvasively. Little studies have reported on the PYRs-dosedependent effects on urinary 3-PBA.This study is designed to identify the correlation of deltamethrinamount exposured orally and dermally to rats and its metabolite(3-PBA) excreted in urine.This study is designed to exposure deltamethrin to rats in a dose-dependent manner and identify the correlation between deltamethrin exposure and its metabolite(3-PBA) in urine. Exposure levels consisted of three concentration of deltamethrin; control (0mg/kgbw), low (0.0705 mg/kgbw), medium (0.705 mg/kgbw) and high(7.05 mg/kgbw) dose. Low concentration of deltamethrin was calculated on the basis of Korea predictive operator exposure model (KoPOEM), indicating the field-realistic exposure to pesticides for farmer when mixing and applying pesticides. Single exposure of deltamethrin to Spraque-Dawley rats were conducted through oral and dermal pathway. Dermal exposure persisted for 6 h, and urine specimens were collected for 24h after exposure of both two pathway. The following procedures including hydrolysis, extraction and derivatization were conducted prior to the analysis of urinary 3-PBA. After acidic hydrolysis for the cleavage of conjugates, the analytes3-PBAwas extracted from urine matrix using n-hexane. Then, 3-PBA was derivatized to volatile estersusing N-tert.-butyldimethylsilyl-N-methyltrifluoroacetamid (MTBSTFA). Separation and detection was carried out using GC/MS. 2-Phenoxybenzoic acid served as internal standard for the quantification of 3-PBA. The limit of quantificationfor all analyteswas 0.98ng/ml urine.In the low-, medium- and high-dose oral deltamethrin groups, the concentrations of urinary 3-PBA were 44±2, 104±37, 943±65 ng/ml urine, respectively, showing good correlation between oral deltamethrin exposure and urinary 3-PBA in rats. This result was similar with those for dermal administration of deltamethrin. Based on these results, therefore, 3-PBA that is a main metabolite of PYRs may be suitable for urinary biomarker of exposure to PYRs.This study can be used as an index that can be predictedto exposuredosage of deltamethrinin the human from detection of urinary 3-PBA excretion.

방사선으로 인한 산화적 손상에서 phloroglucinol의 모낭 보호 효과

김아름,빙소진,조진희,전유진,이병걸,박재우,지영흔,Kim, Areum,Bing, So Jin,Cho, Jinhee,Herath, KHINM,Jeon, You-Jin,Lee, Byung-Gul,Park, Jae-Woo,Jee, Youngheun 대한수의학회 2016 大韓獸醫學會誌 Vol.56 No.1

When exposed to gamma-rays, hair follicular cells immediately go through apoptosis, which hampers their rapid differentiation essential for the regeneration of hair. Phloroglucinol (PG) is a phenolic compound of Ecklonia cava, brown algae abundant in Jeju island, Korea. Containing plentiful polyphenols, PG is known for its instructive effects by inhibiting apoptosis, scavenging oxygen radicals, and protecting cells against oxidative stress. In this study, we demonstrate that PG rescues radiosensitive hair follicular cells from gamma radiation-induced apoptosis and DNA damage. To identify protective capacity of PG on hair follicles, we irradiated with 8.5 Gy (1.5 Gy/min) of gamma-rays to the whole body of C57BL/6 mice at day 6 after depilation with or without PG. In mice exposed to radiation, the expression of proapoptotic molecule p53 was downregulated in the skin of PG treated group. On immunohistochemical observation of the skin, PG inhibited the immunoreactivity of p53 and cleaved caspase-3. PG treatment protected hair follicular cells from cell death due to gamma-radiation. Our results suggest that PG presents radioprotective effects by inhibiting apoptosis of radiosensitive hair follicular cells and can protect hair follicular cells from gamma-ray induced damage.

뉴타운사업 내 재개발구역의 주체별 개발이익 비교 분석 - 길음 뉴타운 2, 4구역을 중심으로 -

김아름,구자훈,김현진,Kim, Ah-Leum,Koo, Ja-Hoon,Kim, Hyun-Jin 한국주거학회 2009 한국주거학회 논문집 Vol.20 No.5

This New-Town Project has been proposed to improve the environments of deprived residential areas. This paper investigates the distribution levels of the participating parties' monetary surpluses from New-Town Projects through a case study and tentatively suggests political issues and measures. The methodology followed includes a thorough survey of the precedent theories, including a literature review concerning issues and tasks that have been raised since the development was initiated. A general assessment of the complete project is also provided with a broad perspective of the background settings. Secondly, the case study of Gil-Eum will be the focus for identifying the mechanism for the project's profit distribution levels, then for constructing a set of measuring procedures according to the stages of the project and the participating parties. This set of procedures that has been drawn out from recognizing the system, is applied to the target project and measures the amount of profit gained from each stage of the development. This also aids in collating information about the procedural arguments concerning the financial gains of the operations that have been provided. This project falls under the 'Urban and Residential Environment Improvement Act', and based on the results of each stage, the measurement of the profits of the participating parties is analyzed.

A Study on the Condition Diagnosis for A Gas-insulated Transformer using Decomposition Gas Analysis

김아름,곽병섭,전태현,박현주,Ah-Reum, Kim,Byeong Sub, Kwak,Tae-Hyun, Jun,Hyun-joo, Park Korea Electric Power Corporation 2022 KEPCO Journal on electric power and energy Vol.8 No.2

A growing number of gas-insulated transformers in underground power substations in urban areas are approaching 20 years of operation, the time when failures begin to occur. It is thus essential to prevent failure through accurate condition diagnosis of the given facility. Various solid insulation materials exist inside of the transformers, and the generated decomposition gas may differ for each gas-insulated equipment. In this study, a simulation system was designed to analyze the deterioration characteristics of SF₆ decomposition gas and insulation materials under the conditions of partial discharge and thermal fault for diagnosis of gas-insulated transformers. Degradation characteristics of the insulation materials was determined using an automatic viscometer and FT-IR. The analysis results showed that the pattern of decomposition gas generation under partial discharge and thermal fault was different. In particular, acetaldehyde was detected under a thermal fault in all types of insulation, but not under partial discharge or an arc condition. In addition, in the case of insulation materials, deterioration of the insulation itself rapidly progressed as the experimental temperature increased. It was confirmed that it was possible to diagnose the internal discharge or thermal fault occurrence of the transformer through the ratio and type of decomposition gas generated in the gas-insulated transformer.

주민참여형 주거지 재생사업에 대한 고령거주자의 사업 만족도 결정요소 연구 - 연남동 사업지구를 대상으로 -

김아름,구자훈,Kim, Ah-Leum,Koo, Ja-Hoo 한국주거학회 2014 한국주거학회 논문집 Vol.25 No.5

The purpose of this study is to estimate the determinants of Elderly Residental Satisfaction on the residential environment improving projects and suggest the political implications. The survey include questionnaires about the satisfaction level on the project physical and non-physical maintenance factors. The results were statistically analyzed by Correlation Analysis and Regression Analysis. As the result of the study, firstly, it shows that 'traffic and improve pedestrian environment' and 'improved parking environment' factors that are important to the satisfaction of the elderly residents of a high impact on the business component a physical maintenance. Secondly, it shows that 'home improvement and management support' and 'economic foundation' factors that are important to the satisfaction of the elderly residents of a high impact on the business component a non-physical maintenance. The results of analysis on the determinants of Elderly Residental Satisfaction on the residential environment improving projects of Yonnam project may be important foundation for future strategies for improvement.

복원된 양재천에서 복원 효과 평가 및 평가 결과에 기초한 개선방안

김아름,김동욱,임봉순,설재원,이창석,Kim, A Reum,Kim, Dong Uk,Lim, Bong Soon,Seol, Jae Won,Lee, Chang Seok 한국하천호수학회 2020 생태와 환경 Vol.53 No.4

This study was carried out to evaluate the restoration effect in the restored Yangjae stream and to draw up an adaptive management plan based on the results. As the result of evaluation on the restoration effect, the restored Yangjae stream was evaluated with low naturalness in both terms of the morphology of the stream and the composition and spatial distribution of vegetation. The diverse functional groups were introduced in the vegetation restoration, but the flooding regime, which is significant in the spatial distribution of riparian vegetation, were not correctly reflected. Exotic species or species that were not ecologically suitable for the location were introduced on the embankment and thus a measure to improve those problems is required. As the ecological principle was not reflected in the restoration plan, the stream was constructed as the double terrace structure. Therefore, the width of the waterway was narrowed further, and the waterfront was not designed to accommodate changes from flooding disturbance, making the micro-topography of the stream simpler and the naturalness lower. The adaptive management plan was prepared to improve those problems, and a plan for creating an ecological network was recommended to enhance the restoration effect.

흰쥐의 뇨 중 3,5,6-Trichloro-2-Pyridinol 분석을 통한 Chloropyrifos 노출량 예측

김아름누리(Areumnuri Kim),백민경(Min-Kyoung Paik),이선영(Sun-Young Lee),홍수명(Su-Myeong Hong),정미혜(Mihye Jeong),오진아(Jin-A Oh) 한국농약과학회 2019 농약과학회지 Vol.23 No.4

교통소외지역 자율주행 모빌리티 서비스를 위한 도로 환경 분석 : 대구광역시와 세종특별자치시를 중심으로

김아름,우보람,탁세현,임서현,Kim, Ahreum,Woo, Boram,Tak, Sehyun,Lim, Seohyun 한국ITS학회 2022 한국ITS학회논문지 Vol.21 No.5

The introduction of Connected and Automated(CAD) technology has a growing interests especially in areas with low demand for transport, where often the local transport services do not connect to peripheral areas for more efficient and convenient mobility services. However, there are few researches on CAD-based mobility services in areas with low demand for transport. Because current researches are mainly focuses on introduction of CAD-based mobility services in area with high demand for transport such as urban and highway. These two areas have different road environments and these differences require different driving technology especially related to Operational Design Domain(ODD). ODD is important factors for introduction of CAD-based mobility services. Therefore, we compare the road environments of areas with low demand for transport and areas with high demand for transport in terms of ODD. In addition, this paper proposes suggest guidance for the introduction of CAD-based mobility services in areas with low demand for transport such as rural and suburban areas.

PVA 중합도가 고상-액상 혼합 방식에 의한 YAG:Ce³⁺ 형광체 분말 합성에 미치는 영향

김아름,이상진,Kim, A-Reum,Lee, Sang-Jin 한국세라믹학회 2014 한국세라믹학회지 Vol.51 No.5

YAG:$Ce^{3+}$ phosphor powders were synthesized using $Al(OH)_3$ seeds by means of a PVA-polymer-solution route. Various types of PVA with different molecular weights (different polymerization) were used. All dried precursor gels were calcined at $500^{\circ}C$ and then heated at $1500^{\circ}C$ in a mix of nitrogen and hydrogen gases. The final powders were characterized via XRD, SEM, PSA, PL, and PKG analyses. The phosphor properties and morphologies of the synthesized powders were dependent on the PVA type. As the molecular weight of the PVA was increased, the particle size gradually decreased with agglomeration, and the luminous intensity of the phosphor increased. However, the phosphor powder prepared from the PVA exhibiting very high molecular weight, showed a 531 nm (blue) shift from the 541 nm (yellow) wavelength of the YAG:$Ce^{3+}$ phosphor. Finally, the synthesized YAG:$Ce^{3+}$ phosphor powder prepared from the PVA with 89,000 - 98,000 molecular weight showed phosphor properties similar to those of a commercial phosphor powder, but without a post-treatment process.