환자고유의 호흡 패턴을 적용한 호흡 연습장치 개발 및 유용성 평가

강성희,윤제웅,김태호,서태석,Kang, Seong-Hee,Yoon, Jai-Woong,Kim, Tae-Ho,Suh, Tae-Suk 한국의학물리학회 2012 의학물리 Vol.23 No.1

본 연구에서는 환자 고유의 호흡 패턴을 적용하여 호흡의 규칙성을 향상 시킬 수 있는 호흡 연습장치(respiratory training system)를 개발하여, 호흡에 의한 움직임이 고려된 4D-RT (4-dimension radiation therapy) 또는 4D-CT (4-dimension computed tomography) 수행 시 효율성과 정확성을 높이고자 했다. 개발한 호흡연습장치는 푸리에 급수(Fourier series)를 기반으로 환자 고유의 호흡패턴을 만들어 환자에게 편안한 호흡 유도를 제공한다. 호흡연습장치를 사용했을 때 호흡의 규칙성 향상 정도를 알아보기 위하여 5명의 지원자를 대상으로 실험을 진행하였다. 10개의 자유호흡신호를 획득하여 실험 대상자의 고유한 호흡패턴(guiding waveform)을 만들고, 자유호흡(free breathing)을 3분 동안 시행한 후, 고유한 호흡패턴을 이용하여 호흡을 유도하는 신호모니터-호흡(guide breathing)을 3분 동안 시행하여 데이터를 획득하였다. 획득된 자유호흡과 신호모니터-호흡의 데이터를 이용하여 호흡크기(displacement)와 호흡주기(period)의 변동성을 Root mean square error (RMSE)를 적용하여 정량적으로 비교 분석하였다. 호흡의 변동성을 분석한 결과 신호모니터-호흡은 자유호흡과 비교하여 호흡크기의 경우 최대 40%, 호흡주기의 경우 최대 76%까지 RMSE 값이 감소하였으며, 모든 지원자들의 데이터를 분석한 결과 평균적으로 호흡주기의 경우 RMSE 값이 55% 감소되었고, 호흡크기의 경우 33% 감소하였다. 본 연구에서 개발한 호흡연습장치는 실험대상자의 고유한 호흡패턴을 이용하여 규칙적인 호흡을 유도했기 때문에 피실험자는 큰 노력 없이도 신호모니터-호흡을 따라 할 수 있었다. 따라서 규칙적인 호흡을 오랜 시간 지속시킬 수 있다는 측면에서 장점을 가질 수 있으며, 4D RT, 4D CT를 시행 할 경우 규칙적인 호흡을 통해 효율성과 정확성을 향상 시킬 수 있다. The purpose of this study was to develop the respiratory training system using individual characteristic guiding waveform to reduce the impact of respiratory motion that causes artifact in radiotherapy. In order to evaluate the improvement of respiratory regularity, 5 volunteers were included and their respiratory signals were acquired using the in-house developed belt-type sensor. Respiratory training system needs 10 free breathing cycles of each volunteer to make individual characteristic guiding waveform based on Fourier series and it guides patient's next breathing. For each volunteer, free breathing and guided breathing which uses individual characteristic guiding waveform were performed to acquire the respiratory cycles for 3 min. The root mean square error (RMSE) was computed to analyze improvement of respiratory regularity in period and displacement. It was found that respiratory regularity was improved by using respiratory training system. RMSE of guided breathing decreased up to 40% in displacement and 76% in period compared with free breathing. In conclusion, since the guiding waveform was easy to follow for the volunteers, the respiratory regularity was significantly improved by using in-house developed respiratory training system. So it would be helpful to improve accuracy and efficiency during 4D-RT, 4D-CT.

러시아어 충고 표현 구문에 대하여

강성희 ( Seong Hee Kang ) 한국러시아문학회 2007 러시아어문학 연구논집 Vol.24 No.-

17世紀 校生考講의 制度化와 그 運營

姜聲姬(Kang Seong-hee) 역사교육연구회 2000 歷史敎育 Vol.73 No.-

Gyosaeng Gogang(校生考講) has been performed with the purpose of rearranging the school system in the national reconstruction period(國家再建期). School rearrangement was pursued to bring back the order in society. Yangban literati(兩班 土族) sought reasons for the lost of morality from the failure of gyohwa(敎化). In this context Gyosaeng Gogang was systemized with the focus on hyanggyo(鄕校) and gyosaeng(校生). The discussion over Gyosaeng Gogang was proposed in 1625. continued through the 4th and 9th year of In-jo"s reign, and came to maturity on ‘Gakdogyosaenggogangsamok(各道校生考講事目)’ in the 22nd year of In-jo"s reign. Gyosaeng had to pass two subjects, choose one from Saseo(四書) and Sohak(小學), the other from jesajajip(諸史子集). As the most important emphasis was put on Sohak, it was considered the most important one in Gyosaeng Gogang. As the Chosun Dynasty was shaking from the base after the two wars, it tried to establish the firm social order based on inryun(人倫). Sohak matched this purpose most perfect. Gyosaeng Gogang was the test of provincial(外方民人)’s knowledge on Sohak. Gyosaeng Gogang was performed without the classification of aeknae(額內) and aekoi(額外): pass or fail would be the only standard. The failed were to be put at moohak(武學) and after three years of learning, an examination would be held. If failed again, he was to be gunbo(軍保) forever. Gyosaeng Gogang had the effect in forcing gyosaeng"s studying. However, gogang was put in hold in case of disasters and diseases, myungangchup(免講帖) which was issued to fill up the financial lack was abused by local administrators and the number of gyosaeng who took gogang decreased. Within this context, it was impossible to expect the full effect of Gyosaeng Gogang. In 1704, the proclamation of ‘Gyosaengnakgangjingpojulmok(校生落講徵布節目)’ was pointed at achieving the regulations of gogang(考講之規). It stipulated ? that gogang would be held once per year, ? that the subject would be only one from Gyungseo(經書) or Saseo(四書), ? that aeknae and aekoi should take gogang and that the failed would be recorded on the list and would be collected two pils(匹) of clothes(綿布). Yet, yangban literati couldn"t concede to this julmok in that there was no set clause for distiction between yangban and pyungmin. The movement back to the original principle which stipulated the failed to be put in military service was directed and Suk-jong(肅宗) agreed to it. In the 37th year in Suk-jong"s reign, Bibyunsa(備邊司) composed detailed principle on gogang. It is worth noticing that the standard distinguishing between aeknae and aekoi was ability not status, and that the empty spot in aeknae was to be supplied from aekoi. It was an enormous change compared to early Chosun. The government sticked to the original principle, putting the failed into military service(直定軍役), in order to control the irregular routes to hyanggyo and to rectify the social standing. However, it mitigated the principle to minimize pyungmin"s resistance. It was under this circumstances that the punishment for unqualified gyosaeng(不學無識者) was fortified and that those who made every endeavor in studying were granted chances to elevate social standing.

뇌암 진단 및 치료 연구를 위한 교모세포종 동물모델 개발

강성희(Seong hee Kang),강보선(Bo sun Kang) 한국방사선학회 2014 한국방사선학회 논문지 Vol.8 No.7

본 연구는 교모세포종 (Glioblastoma multiform, GBM)에 대한 방사선 진단학적/치료학적 연구에 필수적으로 필요한 악성뇌종양 동물모델을 개발하기 위해 수행되었다. 악성뇌종양 동물모델 개발을 위해 뇌정위 기구(stereotactic instrument)를 이용하여 C6 세포(Glioblastoma cell line)를 SD rat의 우측 선조체 내에 동종이식하였다. 개발된 동물모델의 검증을 위해 MRI와 해부조직학적 검사방법을 이용하였다. 해부조직학적 검사방법으로는 H&E 염색법을 이용하였다. MRI를 이용한 종양 형성 검사에서 C6 세포 이식 7일 후 종양 형성이 확인되었고, 14일 후에는 이식한 우측뇌의 대부분이 종양으로 변화한 것을 확인하였다. 해부조직학적 검사에서는 과세포 발현 및 다형성 세포에 의해 형태학적 변화가 발생하는 것을 알 수 있었다. 본 연구에서 개발된 악성뇌종양 동물모델은 in vivo level에서 교모세포종에 대한 방사선 진단학적 기술 개발 및 새로운 치료법 개발을 위한 필수적인 도구로서 활용될 수 있을 것이다. The research was carried out to develop a animal model of malignant brain tumor for the researches in glioblastoma multiform (GBM) diagnosis and therapy. C6 cells were transplanted into the right striatum of SD rat using stereotactic instrument for the development. The developed animal model was verified by MRI and H&E stain assay of anatomicohistological examination. The MRI observations showed that the tumor developed at the injection site at the 7 days after glioblastoma inoculation. At 14 days post inoculation, the tumor grew to a large volume occupying almost a half of the right cerebral hemisphere. It was confirmed that the expression of excessive mitosis and pleomorphism in anatomicohistological examination. The developed animal model must be necessary and useful tool for the in vivo level research in the development of the new modality for the diagnosis and therapy of brain cancer.

스마트시티 유형분석을 위한 개념 및 서비스유형, 관련기술

강성희(Kang, Seong-Hee),정영수(Jung, Young-Soo) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.1

아동의 적응에 있어서 사회적 지지와 사회적 문제해결 기술의 스트레스 완충 효과에 대한 연구

강성희(Seong hee Kang),이재연(Jae Yeon Lee) 한국아동학회 1992 아동학회지 Vol.13 No.2

This study investigated the relation between stressful life events and adjustment in elementary school children, with particular emphasis on the potential main and stress-buffering effects of social support and social problem solving skills. 4-6 graders (N=170) completed the Social Support Appraisals Scale(SSAS) and social problem solving skills task. The SSAS is a 31-item measure that taps the child`s perceptions or appraisals of family, peer, and teacher support. Their parents provided ratings of stress in the child`s environment and ratings of the child`s behavioral adjustment. Teachers provided ratings of the child`s behavioral and academic adjustment. Hierarchical multiple regression analyses and graphic display were used to analyze the data. The major findings were that (1) The results for parent-rated problems supported a stress-buffering model for family support and problem solving. (2) The results for teacher-rated problems were consistent with the stress-buffering model of social support. (3) The results for grade-point average supported a main effect model for problem solving. peer support, and family support. In addition, teacher support had the strongest stress-buffering effect on grade-point average.

위장관 ; 과민성 장 증후군 환자를 대상으로 Fenoverine과 Trimebutine에 대한 유효성과 안전성을 평가하는 무작위배정, 이중맹검, 평행, 다기관 제4상 임상시험

강성희 ( Seong Hee Kang ),진윤태 ( Yoon Tae Jeen ),구자설 ( Ja Seol Koo ),구양서 ( Yang Seo Koo ),김경오 ( Kyoung Oh Kim ),김유선 ( You Sun Kim ),김승영 ( Seung Yeong Kim ),문정섭 ( Jeong Seop Moon ),박종재 ( Jong Jae Park ),백일 대한소화기학회 2013 대한소화기학회지 Vol.62 No.5

목적: 진경제는 과민성 장 증후군의 치료제로 흔하게 사용하고 있다. 그러나, 과민성 장 증후군에 대한 이러한 진경제의 효과에 관해서는 여러 연구에서 다양한 결과를 보이고 있다. Fenoverine은 진경제의 하나로, 장관 내 평활근 세포막을 통한 칼슘 농도의 경사 조절을 통해 위장관 경축의 완화를 나타내는 약물이다. 이에 이번 연구는 과민성 장 증후군 환자에서 fenoverine과 trimebutine 약제의 효과를 비교하는 임상연구를 시행하였다. 대상 및 방법: 본 연구는 fenoverine과 trimebutine을 비교하기 위해 나이 및 성별에 따른 층화 무작위 배정, 이중 맹검, 약물 대조, 다기관, 제4상 임상시험으로 설계되었다. 피험자들은 8주간 임상 약물인 fenoverine (100 mg, 1일 3회) 혹은 trimebutine (150 mg, 1일 3회)을 투여받았다. 총 197명의 환자를 치료의도자(intention-to-treat, ITT) 통계 방법으로 분석하였다. 주 유효 변수는 투약 전에 장 증상 척도 중 하나인 복부 통증 혹은 불편감을 8주 후 다시 측정하여 30% 이상 개선된 피험자의 비율로 평가하였다. 이차 유효성 평가변수로 복부 통증 또는 복부 불편감, 복부 팽만감, 설사 정도, 그리고 설문 1주 전 전반적인 장 증후군 증상의 척도로 overall 장증후군 증상 척도(bowel symptom scale, BSS) 및 복부 통증 또는 복부 불편감, 복부 팽만감, 설사정도의 점수를 합친 total BSS 변화와 피험자의 치료 만족도를 통해 평가하였다. 결과: 8주 후 시험군(fenoverine)은 69.23% (54/78)에서 투약 전에 비해 30% 이상의 개선 효과를 보였으며, 대조군(trimebutine)은 67.47% (56/83)에서 30% 이상의 개선 효과를 나타내었다. 두 군 간의 평균 개선율의 차이인 1.76% (69.23%- 67.47%)에 대한 95% 양측 신뢰구간의 하한 -10.30%가 비열등성 한계인 20%보다 크므로, 시험군은 대조군에 비해 열등하지 않은 것으로 나타났다. 그 외 이차 유효성평가, 이상반응의 빈도와 중증도에 대해서도 두 군 간 차이는 없었다. 결론: 이번 연구는 과민성 장 증후군 환자의 치료에 있어서 fenoverine이 trimebutine에 비해 효과와 안전성 면에서 열등하지 않음을 보여주었다. Background/Aims: Antispasmodic agents have been used in the management of irritable bowel syndrome. However, systematic reviews have come to different conclusions about the efficacy in irritable bowel syndrome. Fenoverine acts as a synchronizer of smooth muscle in modulating the intracellular influx of calcium. We compared fenoverine with trimebutine for the treatment of patients with IBS. Methods: A multicenter, randomized, double-blind, non-inferiority clinical study was conducted to compared fenoverine with trimebutine. Subjects were randomized to receive either fenoverine (100 mg three times a day) or trimebutine (150 mg three times a day) for 8 weeks. A total of 197 patients were analyzed by the intention-to-treat approach. The primary endpoint was the proportion of patients who had 30% reduction in abdominal pain or discomfort measured by bowel symptom scale (BSS) score at week 8 compared to the baseline. The secondary endpoints were changes of abdominal bloating, diarrhea, constipation, overall and total scores of BSS, and overall satisfaction. Results: At week 8, fenoverine was shown to be non-inferior to trimebutine (treatment difference, 1.76%; 90% CI, -10.30-13.82; p=0.81); 69.23% (54 of 78 patients) of patients taking fenoverine and 67.47% (56 of 83 patients) of patients taking trimebutine showed 30% reduction in abdominal pain or discomfort compared to the baseline. There results of the secondary endpoints were also comparable between the fenoverine group and the trimebutine group. Conclusions: Fenoverine is non-inferior to trimebutine for treating IBS in terms of both efficacy and tolerability. (Korean J Gastroenterol 2013;62:278-287)

간질환 환자에서의 수술 위험도 평가 및 흔히 접하는 타과 협진 의뢰

강성희 ( Seong Hee Kang ) 대한간학회 2018 간질환 연수강좌 Vol.2018 No.1

우연히 발견된 간결절의 감별

강성희 ( Seong Hee Kang ) 대한간학회 2022 간질환 연수강좌 Vol.2022 No.1

비천공성 충수염 수술시 예방적 항균요법에 대한 연구

강성희(Seong-Hee Kang),김승욱(Sung-Wook Kim),조익행(Ik-Haeng Jo),황경선(Kyung-Sun Hwang),박숙제(Suk-Zae Park),김찬동(Chan-Dong Kim),김정수(Jung-Su Kim),민준홍(Jun-Hong Min),양대현(Dae-Hyun Yang),윤진(Jin Youn),박상수(Sang-Su Park),김 대한외과학회 2000 Annals of Surgical Treatment and Research Vol.58 No.6