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강대환,양웅석,송근암,조몽,이재승,송철수,옥창민,이성훈,김형욱 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6
Background/Aims: The gastric cancer is highly prevalent in Korea, and it is the most common primary cancer metastatic to the ovary (Krukenberg tumor). We analyzed the clinical, endoscopic, and histologic features of the gastric cancer metastatic to the ovary. Methods: We retrospectively revie wed 11 patients with gastric cancer metastatic to the ovary. They were admitted in Pusan Nationa University Hospital from 1991 to 1997. Results: The mean age of the patients was 38.2 years. The primary gastric cancer was located on the body in 5 cases, both on body and cardia in 2 cases, both on body and antrum in 2 cases, and on antrum in 2 cases. In 5 cases, the gross appearance of th gastric cancer was Borrmann type 3 and that of the remaining 6 cases was Borrmann type 4. In 7 cases, the histologic features was poorly differentiated adenocarcinoma and in 4 cases, it was signe ring cell carcinoma. According to Lauren classification, 9 cases showed diffuse type and 2 cases were intestinal type. Conclusions: The primary gastric cancer metastatic to the ovary was characterized by young age, gastric body in location, and diffuse and poorly differentiated type in histology. Thus, i is important in younger patients with gastric cancer to examine ovary as a metastatic organ.
소화성 궤양 환자에서 cagA 양성 Helicobacter pylori의 유병율
강대환,박승근,양웅석,송근암,조몽,송철수 대한소화기학회 1998 대한소화기학회지 Vol.31 No.2
Background/Aims: Helicobacter pylori is an important factor in the significant gastrointestinal diseases. It has been suggested that the cytotoxin associated gene (cagA) is a marker of a more virulent strain of H. pylori. We tried to evaluate the prevalence of cagA-bearing H. pylori in patients with non-ulcer dyspepsia (NUD), duodenal ulcer (DU), and gastric ulcer (GU). Methods: Thirty eight NUD, 42 DU, 33 GU patients were included in this study. The rapid urease (CLO) test and PCR assay for the detection of H. pylori (ureA PCR) and cagA+ H. pylori (cagA PCR) were performed in the gastric mucosal biopsy specimen. Results: H. pylori were identified in 27/38 (71.1%) NUD, 38/42 (90.1%) DU, and 16/33 (48.5%) GU by rapid urease test. The ureA primer set amplified the 109bp of urease gene in 28/38 (73.7%) NUD, 34/42 (81.0%) DU, and 19/33 (57.6%) GU patients. The positivity of cagA+ strain in H. pylori were 18/28 (64.3%) NUD, 21/34 (61.8%) DU, and 11/19 (57.9%) GU patients when cagA PCR were performed in the H. pylori positive gastric mucosae. Although the prevalence of H. pylori in DU patients was higher than NUD patients, the prevalence of cagA+ strain of H. pylori did not differ in both groups. Conclusions: The prevalence of cagA+ strains in H. pylori positive gastric mucosae did not differ in the NUD, DU, and GU patients. There may be other important factors in the H. pylori associated pathogenesis of peptic ulcer diseases.
내시경적 점막절제술로 진단된 Proctitis Cystica Profunda 1예
강대환,박승근,양웅석,송근암,조몽,송철수,신호진 대한소화기학회 1998 대한소화기학회지 Vol.32 No.4
Proctitis cystica profunda is an uncommon benign rectal condition characterized by bloody stool and/or mucus, diarrhea, tenesmus, abdominal pain, or rectal pain. Since thickened muscularis mucosa and misplaced hyperplastic glands containing pools of mucin into the submucosa are pathologically typical features, it is easily diagnosed. Physical findings are varied, and include palpable mass, polyp, or irregular mucosal surface on digital rectal examination. On endoscopic examination, polyps, submucosal cysts, ulcerations, or irregular villous masses may be observed. Since it could be mistaken for malignant tumor both grossly and microscopically, it is important to differenciate proctitis cystica profunda from malignant tumor. We present an unusual case of proctitis cystica profunda diagnosed by endoscopic mucosal resection. It has been previously interpreted as adenomatous polyp by simple biopsy.