The high thermal stability induced by a synergistic effect of ZrC nanoparticles and Re solution in W matrix in hot rolled tungsten alloy

Zhang T.,Du W.Y.,Zhan C.Y.,Wang M.M.,Deng H.W.,Xie Z.M.,Li H. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.8

The synergistic effect of ZrC nanoparticle pining and Re solution in W matrix on the thermal stability of tungsten was studied by investigating the evolution of the microstructure, hardness and tensile properties after annealing in a temperature range of 1000e1700 C. The results of metallography, electron backscatter diffraction pattern and Vickers micro-hardness indicate that the rolled W-1wt%Re-0.5 wt% ZrC alloy has a higher recrystallization temperature (1600 Ce1700 C) than that of the rolled pure W (1200 C), W-0.5 wt%ZrC (1300 C), W-0.5 wt%HfC (1400e1500 C) and WeK-3wt%Re alloy fabricated by the same technology. The molecular dynamics simulation results indicated that solution Re atoms in W matrix can slow down the self-diffusion of W atoms and form dragging effect to delay the growth of W grain, moreover, the diffusion coefficient decrease with increasing Re content. In addition, the ZrC nanoparticles can pin the grain boundaries and dislocations effectively, preventing the recrystallization. Therefore, synergistic effect of solid solution Re element and dispersed ZrC nanoparticles significantly increase recrystallization temperature

A Phase 3 Evaluation of Daclatasvir plus Asunaprevir in Treatment-Naive Patients with Chronic HCV Genotype 1b Infection

( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.

Anisotropic Electronic Transport of Graphene on a Nano-Patterned Substrate

H. M. W. Khalil(칼릴 하피츠),O. Kelekci(켈렉시 오즈구르),H. Noha(노화용),Y. H. Xie(시에 야홍) 한국진공학회(ASCT) 2012 Applied Science and Convergence Technology Vol.21 No.5

주기적인 나노트랜치 패턴이 있는 기판 위에 놓인 CVD 그래핀의 전도특성을 측정하였다. 나노트랜치에 대해 평행한 방향과 수직한 방향 사이에 전도특성의 큰 비등방성을 발견하였다. 전기 전도의 방향이 나노트랜치에 수직한 경우, 약한 한곳모임의 특성에 있어서도 큰 차이점이 발견되었는데, 이는 퍼텐셜 변조에 의해 생겨나는 전하밀도의 비균일성에 의해 생겨나는 것으로 해석된다. We report on the measurements of electronic transport properties of CVD graphene placed on a pre-patterned substrate with periodic nano trenches. A strong anisotropy has been observed between the transport parallel and perpendicular to the trenches. Characteristically different weak localization corrections have been also observed when the transport was perpendicular to the trench, which is interpreted as due to a density inhomogeneity generated by the potential modulations.

임상실습 간호대학생의 공감능력, 의사소통능력, 심리적 소진 간의 관계

고재원,김지은,박진영,서혜영,신유진,이동민,정다은,진서정,최서원,XIE WEI,YANG JING,배성희,손지희 이화여자대학교 간호학회 2018 이화간호학회지 Vol.- No.52

Purpose: The purpose of this study was to determine the relationship among empathy ability, communication ability, and psychological burnout in nursing students on clinical practice. Method: Data was collected using questionnaires between September 20th, 2017 to January 2th, 2018. Participants of this study were 159 of grade 3 and 4 nursing students who had completed at least one semester of clinical practice experience and currently attending universities located in Seoul. Data were analyzed using percentage, average, standard deviation, t-test, one-way ANOVA, Scheffe’s test and Pearson’s correlation coefficient using the SPSS WIN 24.0 program. Results: The empathy ability was positively correlated with communication ability(r=.437, p=.000). And the communication ability was negatively correlated with psychological burnout(r=-.390, p=.000). Also the empathy ability was negatively correlated with psychological burnout(r=-217, p=.006). Conclusion: These results suggest that psychological burnout is closely related to empathy ability and communication ability. Based on these results, empathy ability and communication ability need to be increased by efficient management and intervention to decrease the degree of psychological burnout in nursing students. Also, the findings should be considered when developing plans or education programs for nursing students’ major adjustment.

International Digital Design Invitation Exhibition

Boyang Feng,Chen Song,HanwenXU,He Gao,Kai Huo,Kuifang Li,Niu Wei,Shaopeng Han,Tingting Qu,Ting Li,Wang, di,Xu Yeni,Yanlin Xie,Bertrand Planes,Chi-Wook Nho,Jean-benoit Lallemant,Yeon Gyu-Seok,Bettina W 한국콘텐츠학회 2010 ICCC International Digital Design Invitation Exhib Vol.2010 No.12

Efficacy and Safety of Ombitasvir, Paritaprevir/Ritonavir, and Dasabuvir without Ribavirin in Patients with HCV Genotype 1b: Pooled Analysis

( Welzel Tm ),( Isakov V ),( Trinh R ),( Streinu-cercel A ),( Dufour J-f ),( Marinho Rt ),( Moreno C ),( Liu L ),( Xie W ),( Tatsch F ),( Shulman Ns ),( Craxi A ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Ombitasvir (OBV), paritaprevir with the pharmacokinetic enhancer ritonavir (PTV/r), and dasabuvir (DSV) without ribavirin (RBV) has demonstrated sustained virologic response at 12 weeks post-treatment (SVR12) rates of 99-100% in HCV GT1b-infected patients without cirrhosis. In GT1b-infected patients with cirrhosis, OBV/PTV/r + DSV with RBV for 12 weeks achieved an SVR12 rate of 98.5%. Regimens with RBV are associated with higher rates of adverse events (AEs), primarily anaemia, and a higher pill burden. This post hoc, pooled analysis from 5 Phase 3/3b trials investigated the efficacy and safety of the RBV-free, 12-week regimen of OBV/PTV/r + DSV among HCV GT1b-infected patients with or without compensated cirrhosis. Methods: Data for patients treated without RBV in 5 trials (GT1b-infected patients with cirrhosis: TURQUOISE-III; GT1b-infected patients without cirrhosis: PEARL-II, PEARL-III, TOPAZ-II, MALACHITE-I) were pooled and patients were characterised by the presence or absence of compensated cirrhosis at baseline. Treatment-naive and pegylated interferon/RBV-experienced patients were included in the analysis population. Efficacy and safety were assessed in all patients. Comparisons of safety outcomes between groups were analysed using Fisher’s exact test. Results: The pooled analysis included 60 patients with cirrhosis and 521 patients without cirrhosis: 62% and 48% were male, 87% and 91% were white, and 45% and 74% were treatment-naive, respectively. SVR12 with OBV/PTV/r + DSV for 12 weeks was 100% (60/60) and 99% (515/521) in patients with and without cirrhosis, respectively. Three patients without cirrhosis experienced virologic failure. Treatment-emergent AEs and laboratory abnormalities are provided in the following table. Conclusions: In HCV GT1b-infected patients, SVR12 rates with the RBV-free, 12-week regimen of OBV/PTV/r + DSV were very high in patients with and without compensated cirrhosis (100% and 99%). Treatment was well tolerated, with no discontinuations due to an AE, and there were low rates of serious AEs and grade 3/4 laboratory abnormalities.

Effect of Deoxidizer on Microstructure and Mechanical Properties of Micro-Slag Gas-Shielded Flux-Cored Wire

W. P. Xie,R. P. Liu,H. Wang,Y. H. Wei 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.5

With increasing requirements of continuous arc additive remanufacturing for robots in mold repair, the alloy and slag systemsin the traditional flux-cored wire have to be further improved. Especially in order to realize welding automation, the contentof slag must be cut down to decrease the time of removing the slag during the deposition. In this paper, Al–Mg and ferrotitaniumare used as deoxidizer to make up the side effect caused by lessening the slag. Six kinds of micro-slag gas-shieldedflux-cored wires with different content of deoxidizer based on the commercial cored wire RMD535 were developed. Theeffect of deoxidizer on microstructure and mechanical properties of micro-slag gas-shielded flux-cored wires were studied. The results demonstrated that the microstructure of deposited metal was mainly composed of acicular ferrite and proeutectoidferrite. With the increase of deoxidizer content, the toughness increases and then decrease, reaching the maximum of 33.45 Jand 35.02 J at Ag–Mg alloy and ferrotitanium content of 1.2% and 1.8%. The hardness is constantly increasing. Six kindsof welding wire had different properties, mainly because of the different characteristics of the inclusions in the depositedmetal. The spherical inclusion was the result of deoxidation by Al–Mg alloy or ferrotitanium and the diameter in range of0.4–0.8 μm were effective for acicular ferrite nucleation. However, inclusions predominantly TiOXwere more effective thanthat of Al2O3in the same size. The present work provided an effective way to improve the impact toughness of depositedmetal by the control of deoxidizer content.

Large-area aligned CuO nanowires arrays: Synthesis, anomalous ferromagnetic and CO gas sensing properties

C.W. Zou,J. Wang,F. Liang,W. Xie,L.X. Shao,D. J. Fu 한국물리학회 2012 Current Applied Physics Vol.12 No.5

Thermal evaporation was carried out in a horizontal quartz tube under an oxygen flow of about 50 ml/min and the influence of reaction time and temperature on the microstructure of the CuO nanowires (CNWs) is examined. The magnetic susceptibilities of the as-synthesized CNWs in the 5e300 K range were studied. It is interesting to note that the CNWs with a much larger diameter than 10 nm exhibit anomalous ferromagnetic behavior which has never been reported previously, demonstrating the effect of their peculiar morphology. The saturation magnetization (MS) and coercive field (Hc) of CNWs grown at 700 ℃ are 2.39 × 10-4 emu and 48 Oe, respectively. We fabricated gas sensors based on p-type single CNWs and demonstrate that CuO nanowires could be a promising candidate for a gas sensor with good performance. The reaction between the reducing gas and O leads to a decrease of the hole density in the surface charge layer and an increase of the CuO resistance.

Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing

Xie, T.,Cho, Y.B.,Wang, K.,Huang, D.,Hong, H.K.,Choi, Y.L.,Ko, Y.H.,Nam, D.H.,Jin, J.,Yang, H.,Fernandez, J.,Deng, S.,Rejto, P.A.,Lee, W.Y.,Mao, M. Academic Press 2014 Genomics Vol.104 No.4

Colorectal cancer (CRC) patients have poor prognosis after formation of distant metastasis. Understanding the molecular mechanisms by which genetic changes facilitate metastasis is critical for the development of targeted therapeutic strategies aimed at controlling disease progression while minimizing toxic side effects. A comprehensive portrait of somatic alterations in CRC and the changes between primary and metastatic tumors has yet to be developed. We performed whole genome sequencing of two primary CRC tumors and their matched liver metastases. By comparing to matched germline DNA, we catalogued somatic alterations at multiple scales, including single nucleotide variations, small insertions and deletions, copy number aberrations and structural variations in both the primary and matched metastasis. We found that the majority of these somatic alterations are present in both sites. Despite the overall similarity, several de novo alterations in the metastases were predicted to be deleterious, in genes including FBXW7, DCLK1 and FAT2, which might contribute to the initiation and progression of distant metastasis. Through careful examination of the mutation prevalence among tumor cells at each site, we also proposed distinct clonal evolution patterns between primary and metastatic tumors in the two cases. These results suggest that somatic alterations may play an important role in driving the development of colorectal cancer metastasis and present challenges and opportunities when considering the choice of treatment.

Gentiana straminea supplementation improves feed intake, nitrogen and energy utilization, and methane emission of Simmental calves in northwest China

Xie K. L.,Wang Z. F.,Guo Y. R.,Zhang C.,Zhu W. H.,Hou F. J. 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.6

Objective: Native plants can be used as additives to replace antibiotics to improve ruminant feed utilization and animal health. An experiment was conducted to evaluate the effects of Gentiana straminea (GS) on nutrient digestibility, methane emissions, and energy metabolism of Simmental calves. Methods: Thirty-two (5-week-old) male Simmental clves, with initial body weight (BW) of 155±12 kg were fed the same basal diet of concentrates (26%), alfalfa hay (37%), and oat hay (37%) and were randomly separated into four treatment groups according to the amount of GS that was added to their basal diet. The four different groups received different amounts of GS as a supplement to their basal diet during whole experiment: (0 GS) 0 mg/kg BW, the control; (100 GS) 100 mg/kg BW; (200 GS) 200 mg/kg BW; and (300 GS) 300 mg/kg BW. Results: For calves in the 200 GS and 300 GS treatment groups, there was a significant increase in dry matter (DM) intake (p<0.01), average daily gain (ADG) (p<0.05), organic matter intake (p<0.05), DM digestibility (p<0.05), neutral detergent fibre (NDF) digestibility (p<0.05), and acid detergent fibre (ADF) digestibility (p<0.05). Dietary GS supplementation result in quadratic increases of DM intake (p<0.01), ADG (p<0.05), NDF intake (p<0.05), and ADF intake (p<0.05). Supplementing the basal diet with GS significantly increased nitrogen (N) retention (p<0.001) and the ratio of retention N to N intake (p<0.001). Supplementing the basal diet with GS significantly decreased methane (CH4) emissions (p<0.01), CH4/BW0.75 (p<0.05) and CH4 energy (CH4-E) (p<0.05). Dietary GS supplementation result in quadratic increases of CH4 (p<0.01) and CH4/DM intake (p<0.01). Compared with 0 GS, GS-supplemented diets significantly improved their gross energy intake (p<0.05). The metabolizable energy and digestive energy intake were significantly greater for calves in the 100 GS and 200 GS calves than for 0 GS calves (p<0.05). Conclusion: From this study, we conclude that supplementing calf diets with GS could improve utilization of feed, energy, and N, and may reduce CH4 emissions without having any negative effects on animal health. Objective: Native plants can be used as additives to replace antibiotics to improve ruminant feed utilization and animal health. An experiment was conducted to evaluate the effects of Gentiana straminea (GS) on nutrient digestibility, methane emissions, and energy metabolism of Simmental calves.Methods: Thirty-two (5-week-old) male Simmental clves, with initial body weight (BW) of 155±12 kg were fed the same basal diet of concentrates (26%), alfalfa hay (37%), and oat hay (37%) and were randomly separated into four treatment groups according to the amount of GS that was added to their basal diet. The four different groups received different amounts of GS as a supplement to their basal diet during whole experiment: (0 GS) 0 mg/kg BW, the control; (100 GS) 100 mg/kg BW; (200 GS) 200 mg/kg BW; and (300 GS) 300 mg/kg BW.Results: For calves in the 200 GS and 300 GS treatment groups, there was a significant increase in dry matter (DM) intake (p<0.01), average daily gain (ADG) (p<0.05), organic matter intake (p<0.05), DM digestibility (p<0.05), neutral detergent fibre (NDF) digestibility (p<0.05), and acid detergent fibre (ADF) digestibility (p<0.05). Dietary GS supplementation result in quadratic increases of DM intake (p<0.01), ADG (p<0.05), NDF intake (p<0.05), and ADF intake (p<0.05). Supplementing the basal diet with GS significantly increased nitrogen (N) retention (p<0.001) and the ratio of retention N to N intake (p<0.001). Supplementing the basal diet with GS significantly decreased methane (CH4) emissions (p<0.01), CH4/BW0.75 (p<0.05) and CH4 energy (CH4-E) (p<0.05). Dietary GS supplementation result in quadratic increases of CH4 (p<0.01) and CH4/DM intake (p<0.01). Compared with 0 GS, GS-supplemented diets significantly improved their gross energy intake (p<0.05). The metabolizable energy and digestive energy intake were significantly greater for calves in the 100 GS and 200 GS calves than for 0 GS calves (p<0.05).Conclusion: From this study, we conclude that supplementing calf diets with GS could improve utilization of feed, energy, and N, and may reduce CH4 emissions without having any negative effects on animal health.