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( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.
Novel magnetic nanostructures: Epitaxial cobalt films in transparent fluoride matrix
N. Yakovlev,A. Kaveev,N. Sokolov,B. Krichevtsov,A. Huan 한국물리학회 2006 Current Applied Physics Vol.6 No.3
Epitaxial magnetic layers in transparent matrix are novel nanostructures, which were proposed and made here. Cobalt and CaF2 weregrown on Si by molecular beam epitaxy. From reection high energy electron diraction images, it was found that epitaxial cobalt lmsgrow on CaF2 Kerr rotation and signicant increase of its value were observed depending on combination of cobalt and uoride layer thickness. In-plane magnetic anisotropy was demonstrated in the structures Co/CaF2/Si(001) with goered uoride layer. Combination of magneticand transparent materials in one structure allows us to control its magnetic and optical properties and observe a variety of magneto-opti-cal eects.
Catalytic combustion of sulfur-containing liquid fuels in the fluidized bed: Experiment and modeling
Yury V. Dubinin,Nikolay A. Yazykov,Sergei I. Reshetnikov,Vadim A. Yakovlev 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
Environmentally safe fuel combustion is an actual worldwide problem. The alternative technology ofcombustion influidized bed of catalyst was developed in the Boreskov Institute of Catalysis. Thetechnology allows one to conduct the process at 400–700 oC and significantly reduce outletconcentrations of toxic compounds. However, the use of sulfur oils as fuel demands solving a problemof the decreasing the outlet SO2 concentration because the oils contain small amount of ash to absorbSO2. The work is devoted to study features of sulfur light oil and high-sulfur heavy oil combustion in thefluidized bed of the Al–Cu–Cr-oxide catalyst. Reduction of SO2 emission at conserving oxidation degree ofoils within range of 99.5–99.8% might be reached by using a non-isothermal temperature profile in thereactor as well as a use of CaCO3 or CaO at Ca/S > 2 to absorb sulfur oxides. The non-isothermaltemperature profile in the reactor consisted of an oxidation zone with the temperature in thefluidizedbed of 700 oC and a catalytic oxidation of SO2 to SO3 zone with equilibrium shift to reducing SO2concentration because of the temperature change from 700 oC to 585 oC.
Pinchetti, Valerio,Shornikova, Elena V.,Qiang, Gang,Bae, Wan Ki,Meinardi, Francesco,Crooker, Scott A.,Yakovlev, Dmitri R.,Bayer, Manfred,Klimov, Victor I.,Brovelli, Sergio American Chemical Society 2019 NANO LETTERS Vol.19 No.12
<P>Colloidal CdSe nanocrystals (NCs) overcoated with an ultrathick CdS shell, also known as dot-in-bulk (DiB) structures, can support two types of excitons, one of which is core-localized and the other, shell-localized. In the case of weak “sub-single-exciton” pumping, emission alternates between the core- and shell-related channels, which leads to two-color light. This property makes these structures uniquely suited for a variety of photonic applications as well as ideal model systems for realizing complex excitonic quasi-particles that do not occur in conventional core/shell NCs. Here, we show that the DiB design can enable an unusual regime in which the same long-lived resident electron can endow trionlike characteristics to either of the two excitons of the DiB NC (core- or shell-based). These two spectrally distinct trion states are apparent in the measured photoluminescence (PL) and spin dynamics of core and shell excitons conducted over a wide range of temperatures and applied magnetic fields. Low-temperature PL measurements indicate that core- and shell-based trions are characterized by a nearly ideal (∼100%) emission quantum yield, suggesting the strong suppression of Auger recombination for both types of excitations. Polarization-resolved PL experiments in magnetic fields of up to 60 T reveal that the core- and the shell-localized trions exhibit remarkably similar spin dynamics, which in both cases are controlled by spin-flip processes involving a heavy hole.</P> [FIG OMISSION]</BR>