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Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer
오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-
To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.
이상열 慶尙大學校 1989 論文集 Vol.28 No.2
The results of a retrospective clinical study on'71 cases of malignant skin tumor, which were managed in Gyeongsang National University Hospital and Seoul National University Hospital from 1984 to 1988 with histopathological confirmation, were presented. 1. of all cases, basal cell carcinoma was the most common type(49.3%) : squamous cell carcinoma(42.3%), melanoma(4.2%), Bowen's disease(4.2%). 2. The predilection sites of basal cell carcinoma were cheek, lower eyelid, nose and those of squamous cell carcinoma were scalp, extremity, lower lip. 3. Of all cases, face was the most commen site(66%) and 70% of the cases on the face revealed basal cell carcinoma. 4. In age and sex distribution, malignant skin tumors developed most commonly in 6th & 7th decade(51%), and in squamous cell carcinoma male was more frequently affected with male to female ratio of 2.3:1. 5. Of the reconstructive methods after tumor resection, local flaps were most commonly used, (53.5%) and primary repair was possible only in 11% of all cases. 6. 54% of all cases visited hospital and was treated after above 1 year from the onset of tumor.
이증훈,성열훈 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2
To determine the antibody titer for the diagnosis of tsutsugamushi disease by indirect immunof-luorescent test n Korea, the antibody titers of 6572 sera of the residents and 296 sera of the 109 patients confirmed as tsutsugamushi disease in the Cungcheung area were analyzed. At cut-off point of 1:40 specificity was 98% and sensitivity, positive predictive value and negative predictive value were 49%, 90%, 86% during the first week after onset, 85%, 94%, 95% during the second week, and 96%, 95%, 99% during the third week. At cut-off point of 1:80 specificity was 99% and sensitivity, positive predictive value and negative predictive value were 47%, 94%, 86% during the first week, 85%, 97%, 95% during the second week, and 96%, 97%, 99% during the third week. At cut-off point of 1:160 specificity was 100% and sensitivity, positive predictive value and negative predictive value were 31%, 995, 82% during the first week, 69%, 100%, 91% during the second week, and 89%, 100%, 97% during the third week.
치료 불응성 Still's병에서 자가 조혈모세포 채집시 사용된 G-CSF에 의한 급성 악화 1예
이재웅,박성현,왕준광,오호석,최정혜,배상철,이영열,김인순,최일영,안명주 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2
치료 불응성 자가면역질환에서 고용량 항암화학요법 및 자가 조혈모세포이식술이 시행되고 있으나 조혈모세포 가동화 및 이식술 시 사용되는 G-CSF에 의해 오히려 기존의 자가면역질환의 증세가 악화되었다는 보고가 있다. 저자들은 만성적으로 재발되는 Still's병 환자에서 조혈모세포 가동화를 위해 사용한 G-CSF에 의해 자가면역질환이 급성 악화된 1예를 경험하였기에 보고하는 바이다. High-dose immunosuppressive therapy with autologous stem cell transplantation is an increasingly used treatment for severe refractory autoimmune disorder including multiple sclerosis, rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus. Although the optimal method of collecting stem cell is not determined, G-CSF-based mobilization is generally considered safe. However, worsening of disease status was reported in autoimmune disease undergoing mobilization with G-CSF. We report a 24-year-old male with refractory Still's disease who developed acute disease flare after administration of G-CSF for stem cell mobilization.
이상열,임병훈,하충건 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1
The anterior interosseous nerve syndrome is a compressive neuropathy of a motor branch of the median nerve, caused by tendinous bands (deep head of pronator teres, arcade of flexor superficialis, thickened lacertus fibrosus etc, trauma, enlarged bursae, tumors, anomalous muscles such as Gantser's muscle or palmaris brevis. On clinical examination, there is weakness or paralysis of the flexor pollicis longus, flexor digitorum profundus of the index finger, and the pronator quadratus muscles with a history of pain in the proximal forearm. The patients will assume a weakness of pinch or an unusual posture of pinch without sensory deficit because of loss of function of these muscles, hyperextending the interphalangeal joint of the thumb and the distal interphalangeal joint of the index finger. We experienced two cases of anterior interosseous nerve syndrome with typical clinical manifestations, confirmed by electrodiagnostic studies. In both cases causative anatomical structures were released through surgical exploration. A case was caused by a sharp edge of the flexor superficialis arcade, another case by the tendinous portion of deep head of pronator teres muscle and a thickened lacertus fibrosus. Both cases revealed partial recoveries after postoperative 3 months.