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패혈증의 경과에 따른 혈중 스테로이드와 Nitric Oxide의 연관성
이규성 ( Keu Sung Lee ),김영선 ( Young Sun Kim ),이형노 ( Hyoung No Lee ),박주헌 ( Joo Hun Park ),오윤정 ( Yoon Jung Oh ),신승수 ( Seung Soo Sheen ),최영화 ( Young Hwa Choi ),박광주 ( Kwang Joo Park ),황성철 ( Sung Chul Hwang ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.4
연구배경: 패혈증에서 Nitric oxide 스테로이드 호르몬은 혈역학적 변화와 염증반응에 관여하는데 이 두 인자는 서로 상관성이 있는 것으로 알려지고 있다. 하지만 실제 환자에서 서로의 상관성이나 임상적 의의는 연구가 부족한 실정이다. 방법: 패혈증 환자 26예와 대조군 14예를 대상으로 혈중 총 NO와 혈중 코티졸 농도를 측정하였고 이어서 제 3, 5, 7병일에도 연속적으로 측정을 하였다. 결과: 패혈증 환자군에서 초기 혈중 코티졸 및 총 NO 농도는 대조군에 비하여 유의하게 증가하였고 경증 패혈증에 비하여 중증 패혈증 환자군에서 유의하게 높았다. 초기 혈중 총 NO의 농도는 APACHE II 점수, 정맥혈 lactate 농도와 상관성이 있었다. 패혈증의 시간의 경과에 따라 혈중 NO 농도는 제 1병일, 제 5병일, 제 7병일에 혈중 코티졸의 농도와 유의한 상관성이 있었다. 결론: 패혈증 환자들에서 혈중 NO와 코티졸 농도는 증가되어 있었으며, 경과에 따라 서로 유의한 상관성이 지속되었다. 상호작용기전에 대하여는 추가적인 연구가 필요할 것이다. Background: The nitric oxide (NO) released by inducible NO synthase (iNOS) plays an important role in the pathophysiology of sepsis. Corticosteroids also play a role in the hemodynamic and inflammatory reactions in sepsis. Both have been shown to have a relationship theoretically, but their correlation and clinical impacts have rarely been evaluated. Methods: 26 patients with sepsis and 14 healthy controls were enrolled in this study. The initial random plasma total NO and the serum cortisol levels were measured. The same measurements were serially carried out on the 3rd, 5th, and 7th days. Results: The initial total plasma levels of NO and cortisol were higher in the patients with sepsis than in the healthy controls. The total NO levels were higher in patients with severe sepsis than in the those with mild sepsis. There was a correlation between the total NO and cortisol level throughout the study. Conclusion: In patients with sepsis, the levels of plasma NO and cortisol were well correlated during the first week of sepsis, which suggests an interrelationship. However, the clinical and pathogenetic implications await further evaluation. (Tuberc Respir Dis 2007; 62: 308-313)
CFRP 복합적층판의 적층배향·계면수에 따른 저속충격특성
임광희,박노식,나승우,김영남,이현,심재기,양인영 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6
In this paper, this study aims at the evaluation on the characteristics of CFRP laminate plates using a falling weight impact tester. The experiment was conducted on several laminates of different orientation. A system was built for measuring the impact strength of CFRP laminates in consideration of stress wave propagation theory using a falling weight impact tester. Delamination areas of impacted specimens for the different ply orientation were measured with ultrasonic C-scanner to find correlation between impact energy and delamination area. Absorbed energy of quasi-isotropic specimen having four interfaces was higher than that of orthotropic laminates with two interfaces. The more interfaces, the greater the energy absorbed. The absorbed energy of a hybrid specimen containing a GFRP layer was higher than that of normal specimens.
地域綜合開發計劃의 樹立을 爲限 住民開發需要調査 分析 : 慶尙北道 永川郡事例를 中心으로 A case study of the Youngchen Gun , Kyngsang Buk Do
최외출,박노보,김문식,정하광,이정주 영남대학교 지역발전연구소 1995 새마을지역개발연구 Vol.17 No.-
The purpose of this study is to establish the integrated rural development plan based on the consciousness and development need of inhabitants in Youngchen Gun. Youngchen Gun is located near metropolitan Taegu city. It is a satellite town of Taegu. In the future it will become an industrial, educational center in a gardenlike environment. Youngchen Gun is an area having high level of the settlement consciousness in comparison with the other counties in Kyngsang Buk Do, but it has as ever the structural problem of rural. Obtained results of this study are as follows : 1. In a section of regional settlement consciousness, it is needed to establish the well organized settlement system. 2. In a section of zone of life, it is necessary to expand a marketing route for inhabitants. 3. In a section of agricultural industry, it is needed to expand the facilities for circulation, to improve an income crops and mechanize an agriculture. 4. In a section of residence, it is needed to expand the facilities of life benefit and enlarge housing lands. 5. In a section of transportation, it is needed to extend all sort of roads and traffic facilities. 6. In a section of education, it is necessary to elevate the qualities of education and modernize the education facilities. 7. In a section of medical service, it is needed to increase the medical specialist and expand medical facilities. 8. In a section of cultural service and welfare, it is necessary to establish and increase cultural and welfare facilities.
地域綜合開發計劃의 背景과 實際 : 경산지역을 중심으로 A Case of Kyongsan Region
최외출,박노보,김문식,정하광,이정주 영남대학교 지역발전연구소 1995 새마을지역개발연구 Vol.17 No.-
The purpose of this study is to examine background and characteristics of integrated rural development policy facing localization ages and to find out the effective ways for integrated rural development planning responding local settlement development and local autonomy. For this study, the case of Kyongsan region development planning was adopted. Policy issues were summarized as follows : 1. Endeavours for self-reliant regional development should be region-wide. Especially, residents, local government, local council, and local group concerned should be integrated through mutual cooperation. 2. Policy processes, including policy agend setting, policy making, policy implementation, policy evalution, should be opened to the public and should be institutionalized with the arrangement of participation of residents and experts. 3. Institutional arrangement should be made to compensate for scarce resources for regional development.
돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
생강나무(Lindera obtusiloba Blume) 잎 70% 에탄올 추출물의 단회와 14일 반복투여 독성시험의 안전성 평가
홍충의(Chung-Oui Hong),서문영(Young Seomun),구윤창(Yun-Chang Koo),남미현(Mi-Hyun Nam),이현아(Hyun Ah Lee),김지훈(Ji-Hoon Kim),왕증(Wang-Zeng),양성용(Sung Yong Yang),이성희(Sung-Hee Lee),노수환(Su Hwan No),이광원(Kwang-Won Lee) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.10
생강나무는 한국, 일본, 중국 등지에서 자생하며 열, 복통, 타박상, 출혈 등에 민간요법으로 사용되어온 식물이다. 이 논문의 목적은 오래전부터 민간요법으로 사용되어온 생강나무 잎의 안전성을 평가하고자 생강나무 잎 70% 에탄올 추출물을 암수 각 군당 5마리씩 5000(단회투여 독성시험), 0, 500, 1000, 2000(14일 반복투여 독성시험) ㎎/㎏의 용량으로 단회경구투여와 14일 반복경구투여를 실시하여 15일간의 사망률, 일반증상, 체중변화, 조직병리, 혈액학적 및 혈액 생화학적 검사를 실시하였다. 시험기간 중 사망동물은 암수 모든 시험군에서 관찰되지 않았으며, 일반증상, 체중변화, 조직병리, 혈액학적 및 혈액생화학적 검사에서 투여와 관련된 변화는 관찰되지 않았다. 이상의 결과로 보아 생강나무의 단회투여 독성은 5000 ㎎/㎏ 용량을 상회하며, 14일 반복투여의 최고용량인 2000 ㎎/㎏ 용량에서도 아무런 독성이 나타나지 않는 것으로 보아 최대무독성량은 이 농도를 상회하는 것으로 판단된다. 이로써 생강나무는 안전한 소재로서 식재료 또는 건강기능식품의 원료로서도 사용이 가능하다고 볼 수 있다. Lindera obtusiloba Blume (LO), which is widely distributed in Korea, Japan and China, has traditionally been used as a popular folk medicine for the treatment of fever, abdominal pain, bruise and extravation. The purpose of this study was to examine the toxicities of the single and 14-day repeated doses in Sprague-Dawley rats orally administrated with LO at doses of 0, 500, 1000, 2000 (14-day repeated toxicity test) and 5000 (single toxicity test) mg (dry weight)/㎏ of body weight/day. The results showed that there was no difference in body weight change, food intake, water consumption, or organ weight among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally administered LO and the control group, there was no statistical significance in hematological test or serum biochemical values. There were no evidences of histopathological alteration as well as abnormal gross finding mediated by single and 14 days treatments with LO. These results suggest that no observed adverse effect level (NOAEL) of the oral application of LO was considered to be more than 2000 mg/kg in rats under the conditions employed in this study.