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High-quality SNP calling from olive flounder, Paralichthys olivaceus, in Jeju Island, South Korea
Sukkyoung Lee,Taehyug Jeong,W.K.M. Omeka,D.S. Liyanage,Chaehyeon Lim,Kishanthini Nadarajapillai,H.M.V. Udayantha,W.M. Gayashani Sandamalika,Seong-Rip Oh,David B. Jones,Dean R. Jerry,Jehee Lee 한국수산과학회 양식분과 2021 한국수산과학회 양식분과 학술대회 Vol.2021 No.4
Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes
Swietach, P.,Leem, C.H.,Spitzer, K.W.,Vaughan-Jones, R.D. Biophysical Society ; Published for the Biophysica 2005 Biophysical journal Vol.88 No.4
It is often assumed that pH<SUB>i</SUB> is spatially uniform within cells. A double-barreled microperfusion system was used to apply solutions of weak acid (acetic acid, CO<SUB>2</SUB>) or base (ammonia) to localized regions of an isolated ventricular myocyte (guinea pig). A stable, longitudinal pH<SUB>i</SUB> gradient (up to 1pH<SUB>i</SUB> unit) was observed (using confocal imaging of SNARF-1 fluorescence). Changing the fractional exposure of the cell to weak acid/base altered the gradient, as did changing the concentration and type of weak acid/base applied. A diffusion-reaction computational model accurately simulated this behavior of pH<SUB>i</SUB>. The model assumes that H<SUB>i</SUB><SUP>+</SUP> movement occurs via diffusive shuttling on mobile buffers, with little free H<SUP>+</SUP> diffusion. The average diffusion constant for mobile buffer was estimated as 33x10<SUP>-7</SUP>cm<SUP>2</SUP>/s, consistent with an apparent H<SUB>i</SUB><SUP>+</SUP> diffusion coefficient, D<SUB>H</SUB><SUP>app</SUP>, of 14.4x10<SUP>-7</SUP>cm<SUP>2</SUP>/s (at pH<SUB>i</SUB> 7.07), a value two orders of magnitude lower than for H<SUP>+</SUP> ions in water but similar to that estimated recently from local acid injection via a cell-attached glass micropipette. We conclude that, because H<SUB>i</SUB><SUP>+</SUP> mobility is so low, an extracellular concentration gradient of permeant weak acid readily induces pH<SUB>i</SUB> nonuniformity. Similar concentration gradients for weak acid (e.g., CO<SUB>2</SUB>) occur across border zones during regional myocardial ischemia, raising the possibility of steep pH<SUB>i</SUB> gradients within the heart under some pathophysiological conditions.
Super-Eddington Accretion in the <i>WISE</i>-selected Extremely Luminous Infrared Galaxy W2246−0526
Tsai, Chao-Wei,Eisenhardt, Peter R. M.,Jun, Hyunsung D.,Wu, Jingwen,Assef, Roberto J.,Blain, Andrew W.,Dí,az-Santos, Tanio,Jones, Suzy F.,Stern, Daniel,Wright, Edward L.,Yeh, Sherry C. C. American Astronomical Society 2018 The Astrophysical journal Vol.868 No.1
Coupled double-row formation in a quasi-1D wire
Smith, L.W.,Hew, W.K.,Thomas, K.J.,Pepper, M.,Farrer, I.,Anderson, D.,Jones, G.A.C.,Ritchie, D.A. North-Holland 2010 Physica E, Low-dimensional systems & nanostructure Vol.42 No.4
We investigate one-dimensional (1D) quantum wires in the weak confinement regime, where, at certain densities, the 1D system of electrons bifurcates into two rows. We show that the two rows are coupled, forming bonding and antibonding states, and that the coupling persists in magnetic fields from 0 to 16 T. In order for a double row to form, the Coulomb interactions in the channel must overcome the confining potential, which can be achieved by tuning the density and confinement. Using a split-gate device with a top gate and back gate, we observe a transition from single-row to double-row behaviour in the weak confinement regime. We further probe the characteristics of the coupled double row regime with dc source-drain bias measurements.
3D MHD interactions of jets with cluster media
O'Neill, S. M.,Jones, T. W.,Tregillis, I. L.,Ryu, D. WILEY-VCH Verlag 2006 Astronomische Nachrichten Vol.327 No.5
<P>As an initial step in a program to examine the interactions of AGN jets with magnetized cluster media, we have carried out high resolution, 3D MHD medium-to-high luminosity jet simulations in both uniform and stratified, cluster-like atmospheres extending over distances ∼ 200 kpc. The steady jets asymptotically deposit approximately 1/2 of their power into ambient thermal energy, almost independent of the jet Mach number or the external density gradient. Nearly 1/4 of the jet power goes directly into irreversible, dissipative heating of the ICM. The remaining energy is mostly stored in the jet backflow cocoon. Magnetic energy introduced by the jet is generally amplified, especially by sheared flows. We also examined the dynamical evolution of the jets and their cocoons, comparing them to simple analytic models. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)</P>
Lee, M.K.,Kim, J.Y.,Kim, D.I.,Kang, D.W.,Park, J.h.,Ahn, K.Y.,In Yang, H.,Lee, D.H.,Roh, Y.H.,Lee, J.W.,Chu, S.H.,Meyerhardt, J.A.,Jones, L.W.,Kim, N.K.,Jeon, J.Y. W.B.Saunders [etc.] 2017 clinical and experimental Vol.76 No.-
<P>Background and Aims. Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. Methods. One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n = 62) or standard care control group (n = 61) for 12 weeks. Home-based exercise consisted of aerobic and resistance training, with a goal of obtaining >= 18 metabolic equivalent task (MET)-h/wk. Participants in the exercise group were instructed to participate in > 18 MET-h/wk. of aerobic and resistance exercise while the participants in the control group were asked to maintain their usual daily activity. The primary outcome was fasting insulin levels. Secondary outcomes were adiponectin, TNT-alpha levels and 6 min walk distance from baseline to post-intervention. Results. After the 12-weeks, moderate-vigorous physical activity participation increased from 9.1 +/- 14.7 MET-h/wk. to 26.6 +/- 21.7 MET-h/wk. in the exercise group, with no change in the control group (p < 0.01 for group and time interaction). Circulating insulin level decreased by 1 mu U/ml (6.0 +/- 3.9 vs. 5.0 +/- 3.5, p = 0.009) in the exercise group with no change in the control group (p = 0.022 for group and time interaction). A similar trend was observed in TNF-alpha (p = 0.030 for group and time interaction). Six minute walk distance increased by 25.2 m in the exercise group with no change in the control group (p = 0.061 for group and time interaction). Conclusions. The 12 week home-based exercise program increased level of physical activity and decreased circulating insulin levels in CRC survivors. (C) 2017 Elsevier Inc. All rights reserved.</P>