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Lee, M.,Bae, I.,Kwak, Y.,Moon, K. Elsevier 2012 CURRENT APPLIED PHYSICS Vol.12 No.suppl2
The surface morphology of Zn-Mg thin film prepared by vacuum evaporation PVD method has formed a structure of various shapes by diffusion of metal particles which is generated migration resulting from accelerated evaporation condition. The surface morphology became smaller as gas pressure increased. Consequently, the grain size decreased further on the low surface energy (101) plane than on the high surface energy (002) plane, which appeared in a vertical direction towards the metal surface due to the influence of residual gases in the vacuum chamber. Also, grain size became smaller with the increase of Mg contents by grain size miniature effect. The grain size of Zn-Mg thin films prepared by the PVD decreased as Mg content increased, and good corrosion resistance increased as well. Also, Zn-Mg thin films have been promoted not only film minuteness but also formation of passivation to corrosion course with the formative increase of intermetallic compound, i.e. MgZn<SUB>2</SUB>, Mg<SUB>2</SUB>Zn<SUB>11</SUB>.
The barycenter property for robust and generic diffeomorphisms
Springer Business + Business Media 2016 Acta mathematica Sinica. English series Vol.32 No.8
<P>Let f: M (d) -> M (d) (d a parts per thousand yen 2) be a diffeomorphism on a compact C (a) manifold on M. If a diffeomorphism f belongs to the C (1)-interior of the set of all diffeomorphisms having the barycenter property, then f is Omega-stable. Moreover, if a generic diffeomorphism f has the barycenter property, then f is Omega-stable. We also apply our results to volume preserving diffeomorphisms.</P>
Lee, M.,Kim, E.J.,Cho, Y.,Kim, S.,Chung, H.H.,Park, N.H.,Song, Y.S. Academic Press 2017 Gynecologic oncology Vol.145 No.2
<P>Conclusion. Proof-of-concept was provided for an electrically conductive and nanoroughened microfluidic platform-based chip designed to capture CTCs in patients with EOC. A larger patient sampling and longer duration of follow-up are needed to determine its suitability for clinical use. (C) 2017 The Authors. Published by Elsevier Inc.</P>
Lee, M.,Kim, S.H.,Lee, H.K.,Cho, Y.,Kang, J.,Sung, S.H. PHARMACEUTICAL SOCIETY OF JAPAN 2014 Biological & pharmaceutical bulletin Vol.37 No.1
The extract of Siegesbeckia pubescens herb and its chemical constituents were tested for the ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglia. The methanol extract and the 90% MeOH fraction of S. pubescens effectively attenuated lipopolysaccharide-induced nitric oxide production. Several steps of chromatography yielded eight ent-kaurane diterpenes (1-8) and one ent-pimarane diterpene (9) from the 90% MeOH fraction. Among these compounds, compounds 2-9 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Compounds 3 and 9 concentration-dependently decreased the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), supported by quantitative real time polymerase chain reaction (PCR) and Western blot analysis. These results suggest that ent-kaurane and ent-pimarane diterpenes isolated from S. pubescens are expected to be potential candidates against neuroinflammation-related disease.
Draft Genome Sequence of Pedobacter agri PB92T, Which Belongs to the Family Sphingobacteriaceae
Lee, M.,Roh, S. W.,Lee, H.-W.,Yim, K. J.,Kim, K.-N.,Bae, J.-W.,Choi, K.-S.,Jeon, Y.-J.,Jung, W.-K.,Kang, H.,Hyun, C.-G.,Kim, D. American Society for Microbiology 2012 Journal of Bacteriology Vol.194 No.14
General Expansiveness for Diffeomorphisms from the Robust and Generic Properties
Springer Science + Business Media 2016 Journal of dynamical and control systems Vol.22 No.3
<P>Let f:M -> M be a diffeomorphism on a closed smooth d(d a parts per thousand yen 2)-dimensional manifold. For each , if f belongs to C (1)-interior of the set of the n-expansive diffeomorphisms, then f satisfies quasi-Anosov. For C (1)-generic f, if f is n-expansive then f satisfies both Axiom A and the no-cycle condition.</P>
Lee, M.,Kim, Y.,Ryu, J.H.,Kim, K.,Han, Y.M.,Lee, H. Elsevier BV 2016 ACTA BIOMATERIALIA Vol.32 No.-
For practical applications of human embryonic stem cells (hESCs) in regenerative medicine, hESCs should be cultured on a large scale, and at the same time their properties have to be maintained in a controllable manner. Here, we report a chemically defined, scalable culture platform involving co-immobilization of heparin-catechol (HepC) and collagen type-1 (Col) for the long-term maintenance (>18 passages) of hESCs in a feeder-free condition. This platform utilizes a wet-adhesive, mussel-inspired heparin-catechol conjugate as a key component. We hypothesized that the heparin's affinity toward a wide range of proteins, might support undifferentiated in vitro growth of hESC. In fact, on the HepC-coated substrate, most hESC clumps were adhered (~78% at passage 2 (P2)) and expressed pluripotency markers (Fig. 2). Although HepC alone wasn't able to support long-term maintenance of hESCs in a feeder-free system due to decrease in the adhesion rate of hESCs on HepC coating (~ 44% at P4) during the repeated passaging processes, we found that when collagen type I was co-immobilized in the process of HepC coating, the long-term maintenance (passage 18 or more) of hESCs could be achieved with 100% adhesion efficiency (Fig. 4). One remarkable observation is that hESCs on collagen type-I underwent spontaneous differentiation after P6 (Fig. 3), which implied co-immobilized HepC played a role to suppress differentiation of hESCs. This study suggests that unlike the previous studies using proteins, peptides, or synthetic polymers, a polysaccharide, heparin, can be used as a cost-effective component for chemically defined, feeder-free culture of hESC. Statement of Significance: Towards practical applications of human embryonic stem cells (hESCs) in regenerative medicine, hESCs should be cultured on a large scale, and their pluripotent property has to be maintained in a controllable manner. To address these issues, studies that develop chemically defined culture substrates have been explored to replace the widely used, complex, and undefined culture materials represented by Matrigel. Most reports have focused on utilizing proteins, peptides and/or synthetic polymers. However, there have not yet been studies on using polysaccharides as two-dimensional coating materials to potentially replace Matrigel coating. Here, we report that heparin is an effective polysaccharide for the feeder-free, two dimensional culture of hESCs. Our study implies that use of polysaccharides or a polysaccharide/ECM combination can be a new, alternative design principle for hESC culture systems.