위선암에서 장형화생의 변이형에 관한 연구

제갈승주,최영자,곽효일,노정섭,최찬 대한임상병리사협회 2001 대한임상병리사회지 Vol.21 No.1

위점막에서의 장형 화생 아형과 위암종과의 관계

조중현(Joong Hyeon Cho),이정희(Jung Hee Lee),고경혁(Gyung Hyuck Ko),이호용(Ho Yong Lee),김현주(Hyun Ju Kim) 대한소화기학회 1997 대한소화기학회지 Vol.30 No.1

N/A Background/Aims: Gastric carcinoma is the mnost common tumor in Korea and is known to be associated with intestinal metaplasia. By the way, the intestinal metaplasia is classified into subtypes in recent years. This study is to see the relationship between the subtypes of intestinal metaplasia and gastric carcinoma. Methods: This study involved 850 patients with various gastric disorders. After diagnosis with hematoxlin-eosin stain, alcian blue pH 2.5/Periodic acid-Schiff and high iron diamine/alcian blue pH2.5 stains were performed to classify the intestinal metaplasia. Results: The, intestinal metaplasia was found in 465 patients(54.7 %): the prevalence of type I, II, and III intestinal metaplasia were 88.2%, 66.2%, and 22.4%, respectively. There are no difference in the prevalence of type I and II intestinal metaplasia among the various gastric disorders(p 0.05). But, type III was strongly associated with intestinal-type gastric carcinoma as compared to either benign gastric disorders(p(0.01) or diffuse-type gastric carcinoma(p(0.01). Conclusions: This results suggest that the type III intestinal metaplasia may play a special role in the histogenesis of intestinal-type carcinoma. (Korean J Gastroenterol 1997; 30:1 - 8)

Genta 염색을 이용한 위점막 장형화생 부위의 Helicobacter pylori의 검출

이광주 ( Kwang Ju Lee ),황석연 ( Seock Yeon Hwang ),이명환 ( Myung Hwan Lee ),김성인 ( Sung In Kim ) 대한임상검사과학회 2000 대한임상검사과학회지(KJCLS) Vol.32 No.3

Infection with Helicobacter pylori is the most important cause of chronic active gastritis. One mean of evolution of chronic active gastritis is the development of atrophic gastritis, a condition almost universally associated with extensive intestinal metaplasia. The study was conducted on 69 gastric biopsy specimens with intestinal metaplasia. S1ide from each specimens were stained using the Genta stain to identify the detection of bacteria and types of intestinal metaplasia. In 56 (81 %) of 96 patients, incompletε intestinal metaplasia was found. In 9 (16 % ) of 56 patients with incomplete intestinal metaplasia.But in all of the intestinal metaplasia H. pylori was not detection in the area of intestinal metaplasia. The common subtype of intestinal metaplasia was incomplete metaplasia. Although in small case, H. pylori was detection only to the area of the incomplete type of intestinal metaplasia.

위의 장형화생과 위선암종과의 상관관계에 관한 연구

오화은,최종상,박미자 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.12

위 Helicobacter pylori 감염 및 중성구침윤과 장상피화생의 연관성

박강훈 ( Kang Hoon Park ) 대한임상검사과학회 2005 대한임상검사과학회지(KJCLS) Vol.37 No.3

Helicobacter pylori (H. pylori) infection is uncommon in developed countries, yet is common in underdeveloped and developing countries. Infection rate of H. pylori is minimally influenced by economic, environmental, and public health status and genetic factors. Korea is a developing country with a high incidence of H. pylori infection and gastric carcinoma, which is one of the leading causes of death. For this reason, accurate clinical and pathologic data on H. pylori-associated disease are very important. Intestinal metaplasia accompanies chronic gastritis and increases the risk of gastric carcinoma. For this reason, the relationship between H. pylori infection and intestinal metaplasia is very closely linked. Because of this, as the antecedent condition is guessed, it examines the relationship of the H. pylori and the intestinal metaplasia. Intestinal metaplasia is thought to be the basis in the development of intestinal type gastric carcinomas. Recent investigations showed that inflammatory reaction in the gastric fundus affect the development of gastric carcinogenesis. To verify neutrophilic activity in the gastric fundus and development of intestinal metaplasia in both gastric fundus and antral mucosa, their relationship was studied using 159 healthy patients who had undergone gastric endoscopic biopsies without any identifiable pathologic disesaes. When neutrophilic activity accompanied, incidence of intestinal metaplasia was significantly increased (p<0.05). H. pylori infection was statistically and significantly associated with the presence of intestinal metaplasia (p<0.05). These results suggest that H. pylori infection affected the development of intestinal metaplasia in the stomach. These results will help our understanding of H. pylori infection in the pathogenesis of intestinal metaplasia, a preneoplastic condition of the stomach. To reduce the incidence of gastric adenocarcinoma, eradication treatment of H. pylori is recommended when there``s a neutrophilic activity in the gastric fundus.

경피내시경하 위루술의 합병증과 감염의 예측인자

최규완(Kyoo Wan Choi),이종철(Jong Chul Rhee),장재권(Jae Kwon Jang),김재준(Jae J . Kim),이준행(Jun Haeng Lee),김영호(Yong Ho Kim),손희정(Hee Jung Son),이풍렬(Poong Lyul Rhee),백승운(Seung Woon Paik),오영륜(Young Lyun Oh) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1

Background/Aims: Telomerase activity has been detected not only in human cancers but also in precancerous lesion (e.g., intestinal metaplasia). It suggests that telomerase activation may be an early event in carcinigenesis, but it is not clear how telomerase is activited. Recently, Helicobacter pylori infection is known to be closely associated with intestinal metaplasia and gatric cancer. Thus, it is possibile that H. pylori infection may induce telomerase activation in intestinal metaplasia. In this study, we evaluated the relationship between telomerase activation and H. pylori infection. Methods: For 129 patients with gastric ulcer (n=20), chronic gastritis (n=34), gastric polyp (n=15), and intestinal metaplasia (n=60), telomerase activity was measured by Telomerase PCR ELISAR kit and H. pylori infection was determined by CLOR kit. Results: Telomerase activity was not detected in the patients with gastric ulcer, and chronic gastritis, gastric polyp, regardless of H. pylori infection. However, in 60 cases of intestinal metaplasia, telomerase activity was detected in 17 samples (28%). Among them, 12 samples were H. pylori positive, and the remaining 5 were H. pylori negative. The telomerase positivity was a little higher in the patients with H. pylori-positive intestinal metaplasia than in those with H. pylori-negative intestinal metaplasia, but the difference was not statistically significant (32% vs. 23% p=0.468). Conclusions: These results indicate that H. pylori infection can play a role partially, but is not the only cause of telomerase activation in intestinal metaplasia. (Korean J Gastroenterol 2001;38:15-22)

위점막에서의 장형 화생 아형과 위암종과의 관계

이정희,김현주,이호용,조중현,고경혁 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.30 No.1

Helicobacter pylori 제균 후 위축위염과 장상피화생의 변화

이용구 ( Yong Gu Lee ),전용철 ( Yong Cheol Jeon ),구태연 ( Tai Yeon Koo ),조현석 ( Hyun Seok Cho ),변태준 ( Tae Jun Byun ),김태엽 ( Tae Yeob Kim ),이항락 ( Hang Lak Lee ),은창수 ( Chang Soo Eun ),이오영 ( Oh Young Lee ),한동수 ( D 대한소화기학회 2007 대한소화기학회지 Vol.50 No.5

목적: Helicobacter pylori 감염이 장기간 지속될 경우 위축위염과 장상피화생을 초래하여 위암 발생 위험이 증가한다. 그러나 H. pylori를 제균하는 것이 위축변화나 장상피화생을 회복시킬 수 있을지는 아직 이견이 많다. 따라서 저자들은 H. pylori 제균 후에 위축과 장상피화생의 변화 여부를 조사하였다. 대상 및 방법: 2001년 3월부터 2006년 4월까지 방문한 107명의 H. pylori 제균에 성공한 환자들을 대상으로 하였다. 전정부 조직검사를 통해 H. pylori 감염 여부를 판단하였으며 동시에 위축변화와 장상피화생의 정도를 updated Sydney System에 따라 점수화하였다. 전정부 조직검사는 제균 후 일정기간 후에 위내시경검사를 통해 재시행하였고, H. pylori 제균 여부도 조직검사로 확인하였다. 결과: 대상환자의 평균 연령은 55.3±11.3세였으며, 평균 추적기간은 28.7±13.9개월이었다. 내시경 진단은 위궤양, 십이지장궤양, 비궤양 전정부위염의 3가지로 구분하였다. 위축변화는 누락된 자료를 제외한 91명 중 41명에서 관찰되었고, 평균 점수는 0.73±0.92였다. 추적한 위축변화 점수는 0.38±0.70로 제균 후 회복되었다(p=0.025). 그러나 107명 중 49명에서 관찰된 장상피화생은 다소 호전되어 보였으나 통계적인 의미는 없었다. 새로이 발생한 위축변화와 장상피화생이 관찰되었으며 그 평균 점수는 제균 전 위축변화나 장상피화생이 있는 환자에서의 평균보다 낮았으나 통계적인 의미는 없었다. 결론: H. pylori 제균 후에 위축변화는 호전되지만 장상피화생은 호전 정도가 미약하여 호전을 확인하기 위해서는 더 오랜기간 관찰이 필요할 것이다. H. pylori 제균과 위 점막의 위축변화 및 장상피화생 사이의 관계를 확립하기 위해서는 추후 더 큰 규모의 대조군 연구가 필요할 것으로 생각한다. Background/Aims: Long-term Helicobater pylori infection results in atrophic gastritis and intestinal metaplasia, and increases the risk of gastric cancer. However, it is still controversial that eradication of H. pylori improves atrophy or metaplasia. Therefore, we investigated histological changes after the H. pylori eradication in patients with atrophy or metaplasia. Methods: One hundred seven patients who received successful eradication of H. pylori infection in Hanyang University, Guri Hospital from March 2001 to April 2006, were enrolled. Antral biopsy was taken before the eradication to confirm the H. pylori infection and grade of atrophy or metaplasia by updated Sydney System. After a certain period of time, antral biopsy was repeatedly taken to confirm the eradication and investigate histological changes of atrophy or metaplasia. Results: Mean age of the patients was 55.3±11.3, and average follow-up period was 28.7±13.9 months. Endoscopic diagnosis included gastric ulcer, duodenal ulcer, non-ulcer antral gastritis. Atrophy was observed in 41 of 91 and their average score was 0.73±0.92. After the eradication of H. pylori, atrophy was improved (0.38±0.70, p=0.025). However, metaplasia which was observed in 49 of 107, did not significantly improve during the follow-up period. Newly developed atrophy (7 of 38) or metaplasia (18 of 49) was observed in patients who without atrophy or metaplasia initially. Their average scores were slightly lower than those of cases with pre-existing atrophy or metaplasia without statistical significance. Conclusions: After the eradication of H. pylori infection, atrophic gastritis may be improved, but change of intestinal metaplasia is milder and may take longer duration for improvement. (Korean J Gastroenterol 2007;50:299-305)

위의 장형화생-이형성증-암종의 구조적 Spectrum에 관한 형태계측학적 연구*

정상우,박동하,이지신,조규혁 대한병리학회 1993 Journal of Pathology and Translational Medicine Vol.27 No.1

A Case Study on Reflux Esophagitis and Intestinal Metaplasia Using Ortho-Cellular Nutrition Therapy (OCNT)

김성훈 셀메드 세포교정의약학회 2024 셀메드 (CellMed) Vol.14 No.8

Objective: Report on a case of improvement in reflux esophagitis and intestinal metaplasia through Ortho-Cellular Nutrition Therapy (OCNT). Methods: A Korean woman in her 50s suffering from reflux esophagitis and intestinal metaplasia underwent OCNT for approximately 9 months. Results: After OCNT, reflux esophagitis and intestinal metaplasia improved. Conclusion: OCNT can aid in alleviating symptoms of reflux esophagitis and intestinal metaplasia.