일반인구의 심박동수 변이의 결정인자들

전형준,김상섭,성지동,백도명 대한순환기학회 2001 Korean Circulation Journal Vol.31 No.1

Heart Rate Variability and the Efficacy of Biofeedback in Heroin Users with Depressive Symptoms

I-Mei Lin,Jiun-Min Ko,Sheng-Yu Fan,Cheng-Fang Yen 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.2

Objective: Low heart rate variability (HRV) has been confirmed in heroin users, but the effects of heart-rate-variability–biofeedback in heroin users remain unknown. This study examined (1) correlations between depression and HRV indices; (2) group differences in HRV indices among a heroin-user group, a group with major depressive disorder but no heroin use, and healthy controls; and (3) the effects of heart-rate-variability–biofeedback on depressive symptoms, HRV indices, and respiratory rates within the heroin group. Methods: All participants completed a depression questionnaire and underwent electrocardiogram measurements, and group differences in baseline HRV indices were examined. The heroin group underwent electrocardiogram and respiration rate measurements at baseline, during a depressive condition, and during a happiness condition, before and after which they took part in the heart-rate-variability–biofeedback program. The effects of heart-rate-variability–biofeedback on depressive symptoms, HRV indices, and respiration rates were examined. Results: There was a negative correlation between depression and high frequency of HRV, and a positive correlation between depression and low frequency to high frequency ratio of HRV. The heroin group had a lower overall and high frequency of HRV, and a higher low frequency/high frequency ratio than healthy controls. The heart-rate-variability–biofeedback intervention increased HRV indices and decreased respiratory rates from pre-intervention to post-intervention. Conclusion: Reduced parasympathetic and increased sympathetic activations were found in heroin users. Heart-rate-variability– biofeedback was an effective non-pharmacological intervention to restore autonomic balance.

정상 성인의 심박변화율과 운동량 척도 및 인체계측적 요소와의 관계

김상규,박희남 대한스포츠의학회 1998 대한스포츠의학회지 Vol.16 No.2

To know the relations between the heart rate variability and physical activity score, the heart rate variabilities were measured through the R-R interval variation(R-RIV) at rest, deep breathing and Valsalva maneuvering state. The subjects included in this study were 60 normal non-sedentary persons who had no my systemic diseases. And the values of heart rate variabilities were correlatively analysed with age, weight, height, body mass index(BMI), physical activity score(PAS) and amplitude of R-wave. And the results were as follows; The mean heart rate variabilities of subjects were 0.176±0.085, 0.314±0.146, and 0.322±0.174 at rest, deep breathing and Valsalva maneuver, respectively. There are significant gender difference in heart rate variabilities at deep breathing and Valsalva maneuvering. The heart rate variabilities were negatively correlated with age(p<0.05) and BMI(p>0.05), but positively correlated with the height(p<0.05), weight, physical activity score and amplitude of R-wave. The physical activity score of the subjects was positively correlated with heart rate variability during deep breathing and Valsalva maneuvering state with statistical significance.(p<0.05) As a conclusion this study that the physical activity score had significant correlativity with the heart rate variability and the heart rate variablity could be used as a useful tool to measure the training effects of exercise on the heart.

정신과에서 심박 변이도(Heart Rate Variability)의 이용

김원,우종민,채정호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

The analysis of heart rate variability is a useful tool to investigate the physiologic phenomena related with autonomic func-tions. At first, it was developed to evaluate the relation between cardiovascular disease and autonomic balance. Nowadays, the application of it's use has been considered in psychiatric practice. And its convenient usage and non-invasiveness gathered more interest of clinicians and investigators. However, no systematic review of the studies on the heart rate variability in psychiatric field is tound. Thus we reviewed the literatures on the usage and it's limitations of the heart rate variability in terms of the spplication in psychiahc practice and research, Interviews with experts on autonomic functions were also included to supplement the review. Studies found that patients with schizophrenia showed reduced heart rate variability while taking clozapine, and severely depressed patients showed more reduced heart rate variability than normal control. Patients with various anxiety disorders including panic disorder and posttraumatic stress disorder showed eleated sympathetic autonomic tone compared with normal control subjects. However these findings remained controversial because of many confounding factors including drug effects and individual and situational factors affecting heart rate variability. With further studies after successful control of Confound-ing variables, the analysis of heart rate variability would be a useful physiologic parameter of asessing psychiatric patients in clinical practice and research.

관상동맥질환에서 안정시 심박변동 및 최대운동 후 심박수 회복에 대한 베타차단제의 영향

김철 ( Chul Kim ),방인걸 ( In Keol Bang ),김영주 ( Young Joo Kim ) 한국스포츠정책과학원(구 한국스포츠개발원) 2006 체육과학연구 Vol.17 No.3

본 연구는 관상동맥질환 환자에서 안정시 심박변동 및 최대운동 후 심박수 회복을 통해 베타 차단제가 자율신경계에 미치는 영향을 알아 보고자 시행되었다. 연구의 대상자는 정상군 16명, 관상동맥질환 환자 중 베타차단제 비투여군 13명, 관상동맥질환 환자 중 베타차단제 투여군 9명의 세군으로 구분하여 안정시 심박변동 및 최대강도의 트레드밀 운동 후 5분간의 심박수 회복을 평가하였다. 심박변동은 시간영역 분석방법을 통한 RR간격의 표준편차(the standard deviation of the NN interval; SDNN), RMSSD(the root mean square successive differences)와 주파수영역 분석방법을 통한 저주파영역 전력(low frequency power; LF), 고주파영역 전력(high frequency power; HF), 저주파영역/고주파영역 비(LF/HF ratio)를 구하여 평가하였다. 심박수 회복은 최대심박수와 회복기 심박수의 차이로 최대운동 후 5분 동안 1분 간격으로 심박수를 측정하여 구하였다. 심박수 회복의 평가에서 개개인의 최대심박수 차이에 따른 영향을 극복하기위해 여유심박수 백분율[(회복기 심박수-안정시 심박수)/(측정된 최대심박수-안정시 심박수)×100]을 구하여 이용하였다. 결과는 다음과 같다. SDNN과 저주파영역 전력은 관상동맥질환 환자군에서 정상군보다 유의하게 낮았으나 베타 차단제 투여군과 비투여군 사이에는 심박변동의 모든 지표에서 유의한 차이가 없었다. 반면 최대강도운동 후 회복기에 매분마다의 심박수는 베타차단제 투여군이 정상군에 비하여 유의하게 낮았고, 심박수 회복은 정상군이 베타차단제 비투여군과 투여군에 비하여 유의하게 높았다. 회복기 여유심박수 백분율은 베타차단제 비투여군이 정상군에 비해 최대운동 후 회복기 1분, 2분, 3분대에서 유의하게 낮았으며, 정상군과 베타차단제 투여군 사이에는 유의한 차이가 없었다. 이상의 결과로 관상동맥질환 환자는 정상인에 비하여 교감신경 활동도는 증가되어 있고, 부교감신경 활동도는 감소되어 있는 것을 알 수 있었으며, 베타 차단제는 자율신경계를 정상화시켜 관상동맥질환 환자의 심박수 회복율을 증가시키는 것으로 생각한다. The purpose of this study was to evaluate the effect of beta blocker on autonomic nervous activity with using heart rate recovery(HRR) after maximum exercise and heart rate variability(HRV) at rest for coronary artery disease(CAD) patients. The 38 subjects were divided into three groups. The control group consisted of 16 normal subjects. The non beta blocker group consisted of 13 CAD patients who didn`t take beta blocker. The beta blocker group consisted of 9 CAD patients who took beta blocker. Time domain and frequency domain of HRV were measured in three groups at rest. The time domain consisted of the standard deviation of the NN interval(SDNN) and the root mean square successive differences(RMSSD). The frequency domain consisted of low frequency power(LF), high frequency power(HF), and LF/HF ratio. Heart rate, HRR(maximum heart rate-heart rate at recovery stage), the percent of heart rate reserve{(heart rate at recovery stage-resting heart rate)/(measured maximum heart rate-resting heart rate)×100} were evaluated during five minutes after maximum exercise. The criteria for maximum exercise were a respiratory exchange ratio of 1.1 or 90% of the age determined maximum heart rate. The SDNN and LF were significantly lower in both beta and non beta blocker groups than in control group. However, there was no significant difference between beta blocker group and non beta blocker group. Heart rate during five minutes after maximum exercise was significantly lower in beta blocker group than in control. HRR from the maximal heart rate during five minutes after exercise was significantly higher in control group than in beta blocker and non beta blocker groups. The percent of heart rate reserve in control group was significantly lower than non beta blocker group at 1, 2 and 3 minutes after exercise. There was no significant difference between beta blocker group and control group for the percent of heart rate reserve. This study demonstrated reduced control of the autonomic nervous activity and delayed heart rate recovery in CAD patients. HRR in CAD patients was normalized by beta blocker. Beta blocker improve balance of autonomic nervous activity in CAD patients.

장기 침상안정이 심박 변화율에 미치는 효과

김상규,최양묵,이경무,신철진,김용민 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.2

주요우울장애 환자에서 심박변이도와 증상 심각도의 관련성

정철홍,민정아,서호준,채정호 대한우울조울병학회 2010 우울조울병 Vol.8 No.2

Objectives:There have been several previous reports about heart rate variability (HRV), which is related to change of autonomic nervous system, was decreased in major depressive disorder (MDD) patients. The present study was based on a hypothesis that severity of symptoms of MDD had effect on decrement of heart rate variability. Methods:Thirty seven patients who were diagnosed with MDD under DSM-IV criteria were selected for our study. All patients underwent HAMD and CGI scale to assess the severity of MDD, and drug history was investigated. Time domain and frequency domain method analyses were used to determine heart rate variability at same time interval,and its relationship with the scores of Hamilton Depression Rating Scale (HAM-D) was compared. Results:Significant relationship between HAM-D scores and norm low frequency (LF) scale of heart rate variability was observed. Drugs that subjects administered did not have any influence on heart rate variability. Conclusion:The results of this study revealed that heart rate variability might be affected by improvement or aggravation of severity of depressive symptoms in patients with major depression. However, significance of various factors that affect heart rate variability need further study.

가토에서 심박수 변이율에 대한 전정기관의자극 효과

오경아,정진원,박옥규,이문영,김민선,박병림 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

Heart Rate Variability and Psychometric Analysis in Patients with Hyperactive Heart Fire Syndrome

Oliverio Medina Martínez,Ruben Fossion,Yolanda García Piceno,Rosa E. Lopez-Gomez,Emma López-Espinosa,Ismael Jiménez-Estrada,Salvador Quiroz-González 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.4

Background: Hyperactive heart fire syndrome is characterized by anxiety, insomnia, dream-disturbed sleep, tongue ulcers, heat in the hands, and palpitations. However, syndrome differentiation is often subjective due to a lack of objective, quantifiable variables. Objectives: To identify changes in heart rate variability (HRV) and psychometric analysis in patients with hyperactive heart fire syndrome. Methods: Healthy controls (n = 33) were compared to patients with hyperactive heart fire syndrome (n = 48) from the Integrative University Clinic of the State University of Ecatepec Valley (CIU-UNEVE). Physiological outcome measures included heart rate (HR), the standard deviation of the normal-to-normal heartbeat intervals (SDNN), low (LF) and high frequency (HF) power, and the LF/HF ratio. Psychometric outcome measures included the Athens Insomnia Scale (AIS) and the Hamilton Anxiety Rating Scale (HARS). Results: Compared to controls, hyperactive heart fire patients had higher HR (9.6 ± 2.62%), LF (22 ± 4.21%) and LF/HF ratio (23 ± 3.14%), and lower SDNN (21 ± 2.33%) and HF (18 ± 4.61%). Patients showed increased anxiety, both with somatic (33 ± 11.2%) and psychic symptoms (39 ± 10.5%) with more difficulty falling asleep (47 ± 9.9%) and diurnal impact of sleep (31 ± 9.6%). Conclusion: Hyperactive heart fire patients may have a sympathovagal imbalance due to a reduced parasympathetic tone and/or adominant sympathetic tone, which may be at the origin of the observed symptoms of insomnia and anxiety.

심박변이도의 운동부하 의존성

권정훈(J. H. Kwon),김철승(C. S. Kim),엄광문(G. M. Eom) 한국정밀공학회 2006 한국정밀공학회 학술발표대회 논문집 Vol.2006 No.5월

The purpose of this work is to investigate the effect of work load on heart rate variability (HRV) which is widely used marker of the autonomic nervous system activity. Average heart rate, rating of perceived exertion, and the power spectrum of heart rate variability were investigated in seven healthy males during exercise at various work loads. The subjects were divided into two groups according to the average heart rate during exercise, group 1 with lower heart rate and group 2 with higher heart rate. HF component showed decrease followed by increase with workload. Accordingly, the LF/HF ratio showed increase followed by decrease with workload. The peak in LF/HF ratio of group 1 was at the lower workload than that of group 2.