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Jang, Mi-Hyeon,Lim, Sabina,Han, Seung-Moo,Park, Hi-Joon,Shin, Insop,Kim, Jin-Woo,Kim, Nam-Jae,Lee, Ji-Suk,Kim, Kyung-Ah,Kim, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Harpagophytum procumbens (Pedaliaceae) has been used for the treatment of pain and arthritis. The effect of Harpagophytum procumbens against lipopolysaccharide-induced inflammation was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetazolium bromide assay, reverse transcription-polymerase chain reaction, prostaglandin E_(2) (PGE_(2)) immunoassay, and nitric oxide defection on mouse fibroblast cell line L929. The aqueous extract of Harpagophytum procumbens was shown to suppress PGE_(2) synthesis and nitric oxide production by inhibiting lipopolysaccharide-stimulated enhancement of the cyclooxygenase-2 and inducible nitric oxide synthase ((1)_NOS) mRNAs expressions in L929 cells. These results suggest that Harpagophytum procumbens exerts anti-inflammatory and analgesic effects probably by suppressing cyclooxygenase-2 and (1)_NOS expressions.
Cho, Hyun-Chol,Song, Yun-Kyung,Lim, Hyung-Ho The Society of Korean Medicine 2005 대한한의학회지 Vol.26 No.4
The excessive release of proinflammatory products by activated microglia causes neurotoxicity, and this has been implicated in the pathogenesis of neurodegenerative diseases. Harpagophytum procumbens (Pedaliaceae) has been widely used for the treatment of pain and arthritis in the clinical field. In this study, we investigated the effect of Harpagophytum procumbens against lipopolysaccharide-induced inflammation. From the present results, the aqueous extract of Harpagophytum procumbens was shown to suppress prostaglandin-E2 synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of cyclooxygenase-2 and inducible nitric oxide synthase expressions in mouse BV2 microglial cells. These results suggest that Harpagophytum procumbens may offer a valuable means of therapy for the treatment of brain inflammatory diseases by attenuating lipopolysaccharide-induced prostaglandin-E2 synthesis and nitric oxide production.
Cholinesterase inhibitors from the roots of Harpagophytum procumbens
Bae, Yoon Ho,Cuong, To Dao,Hung, Tran Manh,Kim, Jeong Ah,Woo, Mi Hee,Byeon, Jeong Su,Choi, Jae Sue,Min, Byung Sun 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Inhibition of cholinesterase has been proposed to be a therapeutic target for the treatment of Alzheimer's diseases. In our preliminary screening study on the acetylcholinesterase (AChE) inhibitory activity, an ethyl acetate soluble fraction of the roots of Harpagophytum procumbens (Pedaliaceae) was found to inhibit AChE activity at the concentration of $100{\mu}g/mL$. Ten compounds (1-10) were isolated from the active fraction and evaluated for their inhibitory effect on AChE and butyrylcholinesterase (BChE). Among the isolates, verbascosides (5, 6, and 8) containing a caffeoyl and a 3,4-dihydroxyphenethyl groups in their structures, showed effective AChE inhibitory activity and also possessed BChE inhibitory activity. The findings suggest that verbascoside derivatives may be partially related to the anti-Alzheimer effect of this medicinal plant.
Cholinesterase inhibitors from the roots of Harpagophytum procumbens
배윤호,TODAO CUONG,Tran Manh Hung,김정아,우미희,변정수,최재수,민병선 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Inhibition of cholinesterase has been proposedto be a therapeutic target for the treatment of Alzheimer’sdiseases. In our preliminary screening study on the acetylcholinesterase(AChE) inhibitory activity, an ethyl acetatesoluble fraction of the roots of Harpagophytumprocumbens (Pedaliaceae) was found to inhibit AChEactivity at the concentration of 100 lg/mL. Ten compounds(1–10) were isolated from the active fraction andevaluated for their inhibitory effect on AChE and butyrylcholinesterase(BChE). Among the isolates, verbascosides(5, 6, and 8) containing a caffeoyl and a 3,4-dihydroxyphenethyl groups in their structures, showedeffective AChE inhibitory activity and also possessedBChE inhibitory activity. The findings suggest that verbascosidederivatives may be partially related to the anti-Alzheimer effect of this medicinal plant.
문태영 고신대학교 보건과학연구소 2006 보건과학연구소보 Vol.16 No.-
Devil's claw, Harpagophytum procumbens is an African herbal plant found in most oriental herb medicine markets recently in Korea. It has been known for therapeutic effect on arthritis, providing not only temporal comfort but also to some extent chemo-physical healing to patients. It was reviewed on the systematic status, distribution, ecology, pharmaceutical and medical application and conservation. It is pointed out that Devil's claw plants have therapeutic effect in various symptoms including arthritis but the extracted harpagoside has less effective although it has been known the essential substance with therapeutic function. The different local populations may produce different genotypes regarding therapeutic function.
현호색, 창출, 천수근 약욕이 체성내장통에 미치는 영향
김익환,이택현,김창주,이충열,Kim, Ick-Hwan,Lee, Taeck-Hyun,Kim, Chang-Ju,Lee, Choong-Yeol 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
As an effective non-pharmacological method of pain relief, hydrotherapy was widely used. And bath additive has been used for enhancing the efficacy of hydrotherapy, In the present study, as a bath additive, the analgesic activity of HAC, which composed of Corydalis turtschaninovii, Atractylodes japonica, and Harpagophytum procumbens(HAC), was investigated in the ventrolateral periaqueductal gray (VIPAG), lateral PAG (IPAG), central nuclei of amygdala (CeA), and the paraventricular nucleus of the hypothalamus (PVN) in mice, using writhing test and immunohistochemistry for c-Fos. Male C57BU6 mice weighing $25{\;}{\pm}{\;}2g$ (8 weeks of age) were used for this experiment. The animals were divided into five groups: the control group, the acetic acid treatment group, the acetic acid treatment and 0.01 g/L HAC-immersed group, the acetic acid treatment and 0.1 g/L HAC-immersed group, and the acetic acid treatment and 1.0 g/L HAC-immersed group. To induce somato-visceral pain in the experimental animals, a single intraperitoneal (i.p.) injection of acetic acid was administrated to each animal, and the animals of the control group received injections of equivalent doses of normal saline. The animals of the HAC-immersed groups were immersed the water with HAC powder at the respective doses deep enough to cover the mice body, and those of the control group and the acetic acid treatment group immersed the water without HAC powder at 10 min immediately after the acetic acid injection. Our present study has shown that the HAC reduced the acetic acid-induced abdominal constrictions and the acetic acid-Induced increase of numbers of c-Fos-positive cells in the VIPAG, IPAG, PVN, and CeA. The most potent analgesic effect appeared with the treatment of 1.0 g/L KB-immersed group. Based on our present results, it is very possible that HAC can be a potent therapeutic bath additive for alleviating pain without the fear of addiction to the drugs and side-effects associated with the prescription of multiple analgesic drugs.
천수근이 중심회백질 신경세포에서 이온통로 조절작용에 미치는 영향
신민철 ( Min Chul Shin ),장현경 ( Hyun Kyung Chang ),장미현 ( Mi Hyeon Jang ),김창주 ( Chang Ju Kim ),김연희 ( Younhee Kim ),김이화 ( Ee Hwa Kim ) 대한경락경혈학회 2004 Korean Journal of Acupuncture Vol.20 No.4
목적: 천수근은 염증성 관절염과 염증성 장 질환 등에 사용되어왔다. 천수근이 중심회백질 신경세포에서 하행성 진통작용에 미치는 영향을 연구하였다. 방법: 중심회백질 신경세포를 분리하여 전위고정하에서 nystatin-perforated patch-clamp technique을 시행하였다. 결과: 천수근에 의하여 유발되는 이온전류는 GABA, glycine, 그리고 glutamate 수용체를 모두 활성화시켰다.
신민철,장현경,장미현,김창주,김연희,김이화,Shin Min-Chul,Chang Hyun-Kyung,Jang Mi-Hyeon,Kim Chang-Ju,Kim Youn-hee,Kim Ee-Hwa 경락경혈학회 2003 Korean Journal of Acupuncture Vol.20 No.4
목적:천수근은 염증성 관절염과 염증성 장 질환 등에 사용되어왔다. 천수근이 중심회백질 신경세포에서 하행성 진통작용에 미치는 영향을 연구하였다. 방법: 중심회백질 신경세포를 분리하여 전위고정하에서 nystatin-perforated patch-clamp technique을 시행하였다. 결과: 천수근에 의하여 유발되는 이온전류는 GABA, glycine, 그리고 glutamate 수용체를 모두 활성화시켰다.
SD (Sprague-Dawley) 랫드와 비글견을 이용한 신바로3 약침의 단회 근육투여 독성실험
이진호 ( Jin Ho Lee ),이인희 ( In Hee Lee ),이재웅 ( Jae Woong Lee ),김은지 ( Eun Jee Kim ),김민정 ( Min Jeong Kim ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.2
Objectives To assess the safety of Shinbaro3 Pharmacopuncture by analyzing the potential single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture at various dose levels in SD (Spraque-Dawley) rats and Beagle dogs. Methods For evaluation of single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture, 40 SD rats (20 male and 20 famale) and 4 Beagle dogs (2 male and 2 female) were used. The rats were divided in four groups of 10 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.3, 0.6 and 1.2 mg/kg in distilled water, and distilled water as a vehicle control group, respectively. The Beagle dogs were divided into two groups of 2 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.15, and 0.3 mg/kg in distilled water, respectively, and signs of toxicity were observed. After a wash-out period of 3 days, the procedure was repeated with Shinbaro3 Pharmacopuncture at doses of 0.6, and 1.2 mg/kg in distilled water, respectively. Mortality, body weight changes, and necropsy findings were examined during the study period. Results There were no mortalities in either the SD rats or Beagle dogs. There were also no significant differences in adverse effects, body weight, or necropsy findings between the Shinbaro3 Pharmacopuncture and control groups. Conclusions There results suggest that the lethal dose 50 (LD50) and approximate lethal dose (ALD) value of the test substance Shinbaro3 Pharmacopuncture are higher than 1.2mg/kg in SD rats and Beagle dogs. (J Korean Med Rehab 2015;25(2):73-80)