Fine needle aspiration biopsy에 의한 소의 지방간진단(脂肪肝診斷)

황범태,한홍률,Hwang, Bum-tae,Han, Hong-ryul 대한수의학회 1991 大韓獸醫學會誌 Vol.31 No.1

소의 지방간(脂肪肝)의 이환율(罹患率)을 조사(調査)하고 fine needle aspiration biopsy에 의한 지방간(脂肪肝)의 세포학적진단(細胞學的診斷)을 시도(試圖)하였다. 육안적(肉眼的) 또는 부유법(浮遊法)에 의한 간장지방함량(肝臟脂肪含量)에 기초(基礎)한 소의 지방간(脂肪肝)의 발생율(發生率)은 한우(韓牛)암소에서 0.30%, 유우(乳牛)암소에서 4.70%, 유우(乳牛)숫소에서 0.15%였다. 지방간(脂肪肝)은 육안적(肉眼的) 소견(所見)으로 간장(肝臟)이 종대(腫大)되고 변연(邊緣)이 둔하며 가볍고 창백(蒼白)에서 주황색(朱黃色) 색조(色調)를 보이나 간장(肝臟)의 색조(色調)와 지방간(脂肪肝)의 중증도간(重症度間)에 환상(桓常) 상관관계(相關關係)가 인정(認定)되지는 않았다. 대부분의 정상간장(正常肝臟)과 중도(重度)의 지방간(脂肪肝)을 제외(除外)하고는 간장(肝臟)의 지방침윤(脂肪浸潤)은 중심정맥주위(中心靜脈周圍)에서는 거대지방구(巨大脂肪球)와 변연부(邊緣部)에서는 소지방구(小脂肪球) 그리고 맥관부(脈管部)에 지방침윤(脂肪浸潤)의 소견(所見)을 보였다. 부유법(浮遊法)에 의한 간장지방함량(肝臟脂肪含量)과 비교(比較)한 세포학상(細胞學上)의 민감도(敏感度), 특이도(特異度), 정확도(正確度)는 정상(正常)에서 94.4%, 95.2%, 94.9%, 경도(輕度)에서 64.3%, 100%, 87.2%, 중등도(中等度)에서 100%, 83.39%, 82.2%, 그리고 중도(重度)에서 모두 100%였다. 세포학적(細胞學的) 소견(所見)은 조직학적(組織學的) 소견(所見)과 잘 일치(一致)하였다. Fine needle aspiraton biopsy에 의한 합병증(合倂症)은 임상적(臨床的)으로 인지(認知)되지 않았다. 결론적(結論的)으로 needle aspiration biopsy에 의한 세포학적(細胞學的) 진단(診斷)은 소의 지방간(脂肪肝) 진단(診斷)에 있어서 조직학적(組織學的) 기법(技法)과 비교(比較)했을 때 단순(單純)하고 신속(迅速)하며 안전(安全)하며 경제적(經濟的)인 방법(方法)으로 사료(思料)된다. This study was carried out to investigate the morbidity of fatty liver in cattle at the abattoir and on the farm, and to cytodiagnose fatty liver in cattle by fine needle aspiration biopsy. Incidence rates of fatty liver in cattle, detected macroscopically or based on hepatic lipid content by buoyancy, were 0.30% in Korean native cows, 4.70% in dairy cows, and 0.15% in dairy bull. Fatty liver was enlarged, swollen with round edges, light weight, and pale to yellow-orange color, but its color was not always correlated to the severity of fatty liver. The findings of fat infiltration of the hepatic lobule were large droplets around central vein, fine droplets in the periphery, and fat infiltration in the perivascular region execpt for most of normal liver and severe fatty liver. The sensitivty, specificity, and accuracy of cytological finding compared with hepatic lipid content by buoyancy were 94.4%, 95.2%, and 94.9% in normal cases, 64.3%, 100%, and 87.2% in mild cases, 100%, 83.3%, and 87.2% in moderate cases, and 100%, 100%, and 100% in sesvere cases, respectively. Cytological findings were well correlated with histological findings. Complications of fine needle aspiration biopsy were not recognized clinically. Consequently, the cytodiagnosis by fine needle aspiration biopsy is simple, rapid, safe, and economical method compared with histological techniques in the diagnosis of fatty liver in cattle.

세침 흡인 생검을 이용한 안와 후반부 종양의 진단

사호석,오동은,김윤덕,Ho-Seok Sa,Dong-Eun Oh,Yoon-Duck Kim 대한안과학회 2005 대한안과학회지 Vol.46 No.9

Purpose: To evaluate the effectiveness and safety of fine-needle aspiration biopsies of mass lesions located in the posterior orbit. Methods: Eight patients with mass lesions in the posterior orbit underwent fine-needle aspiration biopsy with 21-gauge needles using the freehand technique. Results: Fine-needle aspiration biopsies were performed easily and safely. One patient developed subconjunctival hemorrhage following biopsy, but no major complications were observed. Diagnostic specimens were obtained in 6 patients (75%). Of these diagnostic cases, 3 were benign, and the other 3 were malignant. In 3 of 6 patients we performed surgical excisions, while in the others we performed radiotherapy and/or chemotherapy. In 2 patients (25%) the cytologic specimens were inadequate. Conclusions: Fine-needle aspiration biopsy is useful and safe in evaluating orbital mass lesions, especially when they are not surgically accessible due to their location in the posterior orbit.

Comparison of the Diagnostic Yield of the Standard 22-Gauge Needle and the New 20-Gauge Forward-Bevel Core Biopsy Needle for Endoscopic Ultrasound-Guided Tissue Acquisition from Pancreatic Lesions

( Shinya Fujie ),( Hirotoshi Ishiwatari ),( Keiko Sasaki Junya Sato ),( Hiroyuki Matsubayashi ),( Masao Yoshida ),( Sayo Ito ),( Noboru Kawata ),( Kenichiro Imai ),( Naomi Kakushima ),( Kohei Takizawa 대한간학회 2019 Gut and Liver Vol.13 No.3

Background/Aims: To compare the diagnostic yield of 20-gauge forward-bevel core biopsy needle (CBN) and 22-gauge needle for endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) of solid pancreatic masses. Methods: The use of 20-gauge CBN was prospectively evaluated for 50 patients who underwent EUS-FNA from June 2016 to December 2016. Data were compared with those obtained by a retrospective study of 50 consecutive patients who underwent EUS-FNA using standard 22-gauge needles between December 2016 and April 2017. At least two punctures were performed for each patient; the sample from the first pass was used for cytology with or without histology and that from the second pass was used for histology. Sample quantity was evaluated using the sample obtained from the second pass. Results: There was no significant difference in the diagnostic accuracy rate between the first and second passes (20-gauge CBN: 96% [48/50]; standard 22-gauge needle: 88% [44/50]). Samples >10× power fields in length were obtained from 90% (43/48) and 60% (30/50) of patients using the 20-gauge CBN and standard 22-gauge needle, respectively (p=0.01). Technical failure occurred for two patients with the 20-gauge CBN. Conclusions: Diagnostic accuracy of the 20-gauge CBN was comparable to that of the 22-gauge needle. However, two passes with the 20-gauge CBN yielded a correct diagnosis for 100% of patients when technically feasible. Moreover, the 20-gauge CBN yielded core tissue for 90% patients, which was a performance superior to that of the 22-gauge needle. (Gut Liver 2019;13:349-355)

세침흡인검사 후 호흡곤란을 동반한 일측성 갑상선 혈종 2례

고윤우(Yoon Woo Koh),권계원(Kye Won Kwon),변장열(Jang Yul Byun) 대한두경부종양학회 2007 대한두경부 종양학회지 Vol.23 No.1

Fine needle aspiration biopsy(FNAB) has been used for many decades in the diagnosis of benign and mal-ignant tumors of thyroid gland. Complications of thyroid fine-needle aspiration biopsy(FNAB) are extremely rare. Hematoma formation is the most commonly encountered complication. However, massive intrathyroid uni-lateral hemorrhage and hematoma formation inducing upper airway distress rarely occurs. Here, we report two cases diagnosed as having hematoma that caused upper airway distress after FNAB for thyroid nodule.

Cytological Positive Result in Ultrasound-guided Transtoracic Fine Needle Aspiration Biopsy in Lung and Mediastinal Tumors Diagnostic

( Rahma Ayu Indahati ),( Menaldi Rasmin ),( Mia Elhidsi ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Introduction The early and accurate diagnostic procedure is important in lung cancer management. Transthoracic fine-needle aspiration biopsy (TTFNAB) under the guidance of thoracic ultrasonography (USG) is quite easy and can be performed bedside. This study aimed to investigate the diagnostic value of USG-guided TTFNAB for the diagnosis of lung and mediastinal tumors. Methods This was an observational study taken from primary data at the interventional pulmonology clinic in Persahabatan Hospital. All patients with lung or mediastinal tumors whose TTFNAB performed under USG-guided were included in the study. Demographical characteristics, lesion sizes, sonographic patterns, cytological Results, and complications were recorded. Results Forty-six patients were included in the study. USG-guided TTFNAB has been performed in 37 (80%) subjects with lung tumors and 9 (20%) subjects with mediastinal tumors. There were 33 (72%) lesions were detected in hypoechoic appearance. The mean long axis was 9,1 ± 2,3 (3-15 cm) cm. The cytological positive Results were found in 36 (78%) of these patients, consist of Adenocarcinoma (44%), Squamous cell carcinoma (31%), Lymphoma (8%), Neuroendocrine carcinoma (3%), Thymoma (3%), and other (12%). Hemoptysis was occurred in 2 patients (5%) one hour after procedures which only required monitoring. Conclusions USG-guided TTFNAB performed for lung and mediastinal tumors have high rate of success (78%) and safe to perform.

폐종괴에 대한 경피적 세침흡인세포검사와 자동총부착 침생검의 비교

남은숙,김덕환,신형식,Nam, Eun-Sook,Kim, Duck-Hwan,Shin, Hyung-Sik 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1

To compare the diagnostic yields and complication rates of transthoracic fine needle aspiration cytology(FNAC) and gun biopsy in the diagnosis of pulmonary mass, a retrospective review was performed in 125 cases. Under the fluoroscopic guide, FNAC was performed by 20G Chiba needle in 91 cases, core biopsy was done by 18.5 G vaccum needle attached with automated biopsy gun in 74 cases and both procedures were done together in 37 cases. Overall sensitivity was 88.4% in FNAC and 87.5% in gun biopsy. For malignant pulmonary tumors, correct type correlation with final diagnosis was obtained in 33(76.7%) out of 43 cases by FNAC and 30(75.0%) out of 40 cases by gun biopsy. For benign pulmonary lesions, there were correct type correlation in 14(35.0%) out of 40 cases by FNAC and 14(53.8%) out of 26 cases by gun biopsy. The complication was pneumothorax and hemoptysis. Pneumothorax occured in 11.1% of FNAC, 10.9% of gun biopsy and 10.9% of both technique, among which chest tube drainages were necessary in one patient by gun biopsy and in three patients by both technique. Although no significant difference of diagnositc accuracy and complication rate was found between FNAC and gun biopsy, gun biopsy was more helpful in the diagnosis of pulmonary benign lesions than FNAC.

Endoscopic Ultrasound-Guided Fine Needle Biopsy Needles Provide Higher Diagnostic Yield Compared to Endoscopic Ultrasound-Guided Fine Needle Aspiration Needles When Sampling Solid Pancreatic Lesions: A Meta-Analysis

Benjamin D. Renelus,Daniel S. Jamorabo,Iman Boston,William M. Briggs,John M. Poneros 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.2

Background/Aims: Studies comparing the utility of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) andendoscopic ultrasound-guided fine needle biopsy (EUS-FNB) for solid pancreatic lesions have been inconclusive with no clearsuperiority. The aim of this meta-analysis was to compare the diagnostic accuracy and safety between the two sampling techniques. Methods: We performed a systematic search of randomized controlled trials published between 2012 and 2019. The primaryoutcome was overall diagnostic accuracy. Secondary outcomes included adverse event rates, cytopathologic and histopathologicaccuracy, and the mean number of passes required to obtain adequate tissue between FNA and FNB needles. Fixed and randomeffect models with pooled estimates of target outcomes were developed. Results: Eleven studies involving 1,365 participants were included for analysis. When compared to FNB, FNA had a significantreduction in diagnostic accuracy (81% and 87%, p=0.005). In addition, FNA provided reduced cytopathologic accuracy (82% and89%, p=0.04) and an increased number of mean passes required compared to FNB (2.3 and 1.6, respectively, p<0.0001). There wasno difference in adverse event rate between FNA and FNB needles (1.8% and 2.3% respectively, p=0.64). Conclusions: FNB provides superior diagnostic accuracy without compromising safety when compared to FNA. FNB should bereadily considered by endosonographers when evaluating solid pancreatic masses.

Fine-Needle Biopsy: Should This Be the First Choice in Endoscopic Ultrasound-Guided Tissue Acquisition?

Eun Young Kim 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.5

Endoscopic ultrasound (EUS)-guided tissue acquisition is an indispensable technique for the diagnosis of many diseases of the gastrointestinal tract and adjacent structures. EUS-guided fine-needle aspiration (EUS-FNA) is known for its high accuracy and low complication rate. However, the outcome of EUS-FNA highly depends on several factors such as the location and characteristics of the lesion, endosonographer’s experience, technique of sampling and sample preparation, type and size of the needle used, and presence of a cytopathologist for rapid on-site examination. EUS-guided fine-needle biopsy is useful to obtain core tissue samples with relatively fewer passes. Aspiration of core tissue with preserved architecture is beneficial for the diagnosis of certain diseases and the performance of ancillary testing such as tumor molecular profiling. Issues related to needle size, type, and their acquired samples for cytologic and histologic evaluation are discussed here.

세침 흡인 생검을 이용한 안내 종양의 진단

이종현,양우익,이성철 대한안과학회 2006 대한안과학회지 Vol.47 No.7

Purpose: To evaluate the efficacy and safety of fine-needle aspiration biopsy in the diagnosis of suspected intraocular malignancy and simulating conditions. Methods: We performed a retrospective study of the medical records of patients who underwent diagnostic pars plana transvitreal biopsy. Results: A total of 12 biopsies were performed in 11 eyes of 11 patients with intraocular tumor and the final diagnosis was confirmed by cytologic examination in 10 eyes. There was insufficient amount of material for cytologic examination in one case. In another case, biopsy was repeated to obtain the final result due to false negative result of the first biopsy. Localized intraocular hemorrhage was found to be the most common complication, but resolved spontaneously in most cases. Retinal detachment and tumor recurrence were not observed. Conclusions: Transvitreal fine-needle aspiration biopsy is an accurate diagnostic procedure in the evaluation of intraocular tumors difficult to diagnose with other non-invasive diagnostic technique and it can be performed safely with minimal complication.

골 병변에서 세침흡인 세포검사의 유용성

김봉희,공경엽,Kim, Bohng-Hee,Gong, Gyung-Yub 대한세포병리학회 2002 대한세포병리학회지 Vol.13 No.2

To determine the usefulness on fine needle aspiration cytology(FNAC) of bone lesions and the complementary role of FNAC and percutaneous needle biopsy, 75 cases of FNAC taken from bone lesions were analyzed. Correlations with histopathology were possible in 47 cases, including 14 cases of simultaneous core biopsy and 33 cases of subsequent open biopsy due to inadequate aspirates. Among 75 cases, 4 cases were benign tumors and tumor-like lesion, 11 cases were malignant primary bone tumors, 17 cases were metastatic tumors, and 43 cases were nonneoplastic bone lesions. The aspirates were adequate in 35 cases(46.7%), in all of which the discrimination between benignancy and malignancy was possible. The main reason for Inadequate aspirates was due to hypocellularity. In the cases of aspiration and core biopsy simultaneously done, the diagnostic accuracy of aspiration, core biopsy, and both were 57%(8/14), 78.6%(11/14), and 92.9%(13/14), respectively. We conclude that a final diagnosis based on cytology is possible with the adequate aspirates and the clinical and radiological findings. Also we confirm the complementary role between FNAC and core biopsy in bone lesions.