청소년 생활역량 진단검사의 표준화 연구

윤명희(Myung hee Yun),서희정(Hee jung Seo),김경희(Keung hee Kim),조정은(Jeong eun Jo) 한국교육평가학회 2015 교육평가연구 Vol.28 No.2

본 연구의 목적은 청소년이 독립된 생활인으로서 필수적으로 갖추어나가야 할 일상생활 속에서의 역량을 구체적으로 진단할 수 있는 '표준화 청소년 생활역량 진단검사'를 개발하는데 있다. 연구의 목적을 달성하기 위해 실험적으로 개발된 228개의 문항에서 내용적ㆍ통계적으로 양호한 114개의 문항을 추출하였고, 1,908명의 중ㆍ고등학생을 대상으로 자료를 수집하여 개별 문항 및 검사도구의 양호도, 검사를 구성하고 있는 요인구조의 적합도 등을 통해 타당성을 확인하고 규준을 개발하였다. 이러한 과정을 통해 개발된 표준화 검사는 자기조절역량, 자기개발역량, 학습역량, 대인관계역량, 민주시민역량, 문제상황대처역량의 6개 하위 생활역량과 이를 실제적으로 함양할 수 있는 19개의 생활기술, 각 생활기술별 6개 문항, 총 114개의 문항으로 구성되어 있다. 규준집단의 생활역량은 대인관계역량이 가장 높았으며, 감정조절기술을 제외한 대부분의 생활기술 및 하위 생활역량에서 남학생보다 여학생의 평균이 유의하게 높았다. 또한, 중학생과 고등학생 간에는 일부 하위 생활역량에 유의한 차이가 있을 뿐 전반적인 생활역량에는 차이가 없는 것으로 나타났다. The purpose of this study is to develop the standardized life competency test for adolescences. For this, 114 items were selected from 228 items previously developed by Yun and Seo's study through the indexes of item goodness and statistical criteria. 1,908 middle and high school students were sampled nationwidely. The coefficients of Cronbach α and construct validity were high, and suitability indexes of item factor structure were high. The concurrent validity with youth activity competency scale was verified. As a result of standardization process, the Life Competency Scale with 6 life competencies, 19 life skills and 114 items was developed. The norm table was made in terms of total group, gender, and school level. The norm groups marked the highest scores in interpersonal relationship area among competencies and life skills. The scores of girls recorded significantly higher than those of boys in most life competencies and life skills except in emotional regulation skill. There were no differences in school level over life competency and life skill between middle and high school students. Students can get informations about their life competencies easily through this standardized test, furthermore, teachers or parents can provide educational programs to enhance student 's deficient competencies or life skills. Also, the collected data from 'The Standardized Life Competency Scale' tests can be used as basic data for youths to develop programs and to make policy in schools or fields of youth.

LC/MS/MS 분석법을 이용한 Amlodipine의 약물동태연구

서정원,윤민혁,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

The aim of this study were to confirm the analysis method and also to estimate the pharmacokinetic parameters of amlodipine in human volunteers. In an open-label single-dose pharmacokinetic study, a group, consisting of 24 healthy volunteers, received single oral dose of 5mg amlodipine. Blood sample were taken for up to 120 hours. The concentration of amlodipine in these body fluids was determinated using a validated high-performance liquid chromatography(HPLC) method with tandem mass spectrometry. Amlodipine and ketoconazole, an internal standard, were extracted from plasma using ethyl acetate in the presence of 0.1M sodium carbonate. After drying the organic layer, the residue was reconstituted in mobile phase(acetonitrile : water = 70 : 30 v/v (0.1% formic acid)) and injected onto a Zorvax C18 column (2.1 × 100 mm, 3.5 ㎛ particles). The isocratic mobile phase was eluted at 0.2ml/min. The ion transitions monitored in multiple reaction-monitoring mode were m/z 410.10 → 294.95 and 532.11 → 81.95, respectively. The coefficient of variance of the assay precision was less than 12%, and the accuracy exceeded 99.1%. The limit of quantification was 0.1 ng/ml. The pharmacokinetic parameters were calculated with non-compartmental(AUC, C_(max), T_(max), CL_(t), V/F) and compartmental(K_(el), K_(a), t_(lag)) pharmacokinetic analysis using WinNonlin program. The estimated means of AUC_(0-120hr), C_(max) and T_(max) were 196.90 ± 5.02 ng·hr/ml, 3.36 ± 0.09 ng/ml and 10.44 ± 0.61 hr, respectively. The means of other pharmacokinetic parameters(V/F, CL_(t), K_(el), K_(a) and t_(lag)) were 1208.06 ± 50.61 L, 25.39 ± 0.65 L/hr, 0.2806 ± 0.0294 hr^(-1), 0.0210 ± 0.0008 hr-1 and 0.4574 ± 0.0635 hours, respectively.

TRISS Method를 이용한 외상 환자 관리의 평가

윤영국,서강석,이정헌,김종근,감신 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Trauma is well known as a major cause of death and disability in Korea, but we do not have a optimal method to evaluate the trauma patients effectively. The purpose of this study was to predict the prognosis and mortality of the trauma patients and to evaluate the quality of trauma care by TRISS method. A retrospective study of 100 cases of trauma victims who visited to emergency room and was admitted to surgical intensive care unit of Kyungpook University Hospital from January 1994 to December 1995 by TRISS method was made. In this study, we have found out following results. 1. Sex ratio of male to female was 4:1 and the mean age was 44 years. 2. Analysis of injury mechanism showed high incidences of traffic accident(71%), fall down(14%), cultivator(5%), penetrating trauma(3%) in order of frequency. 3. A comparison between survivors and deaths showed difference in TS(14.81±1.31 vs.13.64±1.43), RTS(7.26±0.82 vs. 6.78±10.24 vs. 37.45±11.05), TRISS Ps-1 TS and ISS(0.93±0.11 vs. 0.79±0,15), and TRISS Ps-2 by RTS and ISS(0.89±0.15 vs. 0.73±0.19). 4. By TRISS method, unpredicted outcomes occurred in 11 of 100 with 10 unpredicted deaths and 1 unpredicted survivor by TRISS-1 and unpredicted outcomes occurred in 14 of 100 with 9 unpredicted deaths and 5 unpredicted survivors by TRISS-2. 5. The most common cause of death was chest trauma(36.4%). 6. The Z statics, quantitating the difference in the actual number of deaths and the predicted number of death, using TRISS-1 method was 0.84 and using TRISS-2 method was -0.57. The authors conclude that the real dead patients exceeded the predicted outcome in TRISS-1 and the real dead patients were less than the predicted outcome in TRISS-2, and our patient management as well as application of this method should be analyzed for accurate outcome. In conclusion, TRISS method offers a good approach for predicting the prognosis and mortality of the trauma patient and evaluating trauma care.

순차 컴비네이터를 기반으로 하는 병렬 그래프 리덕션

徐正勳,鄭盛允,尹英雨 嶺南大學校 工業技術硏究所 1992 연구보고 Vol.20 No.1

This study discusses the graph reducer to improve the execution speed of functional languages. We develop the G-machine compiler which translates serial combinator to a sequence of instructions. The SubMiranda, which is a subset of the Miranda, is chosen as a test language. The implemented G-machine compiler translates serial combinator to an intermediate code, G-code, and then does macro-expansion to create a target code, C-code.

뇌졸중 환자에서 아포지단백 E의 유전자형에따른 혈중 지질과 예후

김연희,박성희,신용일,서정환,김달식 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.4

전기진단검사로 확인된 한랭 예민성 양성 국소성 근위축증-증례 보고-

서정환,신용일,김연희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.6

체육 전공 대학생의 식습관에 관한 조사 연구

서정숙,이정윤 서울保健大學 1987 論文集 Vol.7 No.1

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

편마비 환자의 보행시 신발 교정에따른 에너지 소모의 감소

서정환,고명환,김연희 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.1

응급실 내원 환자의 만족도 평가 및 관련 요인에 대한 연구

서강석,감신,박정배,이정헌,김종근,윤영국,곽경숙,이원기,우석정 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Background: To examine the influencing factors on patients' satisfaction in the emergency department(ED) for quality assurance. Methods: Patients who visited to the ED were prospectively investigated from November 1 to December 31, 1997. Authors developed questionnaire to investigate influencing factors on patients' satisfaction. A Chi-square test and LISREL 7.0 were applied for statistical analysis. Results: Patients' satisfaction was significantly related to physical environment variables, accessibility variables, kindness of hospital personnel variables, and patient's trust for doctors variables. In path analysis, willingness for revisit was influenced by patients' satisfation, accessibility, physical environment, patients' trust for doctors in order, and willingness for recommendation was influenced by accessibility, patients' satisfaction, and kindness of hospital personnel in order. Conclusions: The influencing factors on patients' satisfaction are physical environment, accessibility, kindness of hospital personnel, and patient's trust for doctors. Willingness for revisit and willingness for recommendation are influenced by patients' satisfation. In spite of some limitations, the results of this study can be used as a baseline information for exploring the influencing factors on patients' satisfaction. Further comprehensive research efforts should be made on the study of patients' satisfactoin in the ED.