http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The burden of symptomatic patients with chronic spontaneous urticaria: a real-world study in Korea
Young-Min Ye,Young-Il Koh,Jeong-Hee Choi,Mi-Ae Kim,Jung-Won Park,Tae-Bum Kim,Young-Hee Nam,Yoon-Seok Chang,Hae-Sim Park 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5
Background/Aims: Chronic spontaneous urticaria (CSU) poses a considerable burden both on the quality of life (QoL) of individual patients and on healthcare systems. Real‑world data evaluating the disease burden of CSU are limited in this country. This study evaluated the disease burden and healthcare resource utilization (HRU) among symptomatic CSU patients. Methods: This multicenter, noninterventional, retrospective, and cross-sectional study assessed CSU patients symptomatic for more than 6 months despite step-wise H1-antihistamine medications. Primary outcomes included Urticaria Activity Score over 7 days (UAS7) and Chronic Urticaria QoL scale (CU-QoL). Secondary outcomes included EuroQol 5-Dimension 5-Level (EQ-5D-5L), Dermatology Life Quality Index (DLQI), association of disease activity with QoL, medications used for the past 6 months, and HRU. Results: Five hundred patients with CSU were enrolled. Mean disease duration was 3.7 years. Based on UAS7, 22.2% of patients were in well-controlled status and 31.2%, 28.4%, and 18.2% of them had mild, moderate, and severe disease, respectively. Mean CU-QoL and DLQI scores were 57.5 ± 29.7 and 10.2 ± 7.6, respectively, while the EQ-5D-5L utility score was 0.8 ± 0.2. H1-antihistamines were prescribed to 95% of patients, while omalizumab was prescribed to 33% of patients. Most patients (98%) had outpatient visits in the past 6 months. Negative correlations were noted between UAS7 and CUQoL, EQ-5D-5L, EQ-5D-5L visual analog scale scores, but a positive correlation was noted with DLQI score (p < 0.001 for all). The number of outpatient department visits increased with disease activity (p = 0.001). Conclusions: CSU affects QoL, leading to increased HRU, particularly in patients with severe disease.
고영초,심보성 대한신경외과학회 1980 Journal of Korean neurosurgical society Vol.9 No.1
Cerebral paragonimiasis and cerebra cysticercosis are two notorious parasitic infestations of the brain in Korea, of which diagnoses were not clarified yet clinically. The authors experienced 25 such parasitic brain disases with their characteristic CT findings, and it was assumed that computed tomography(CT scan) is the procedure of choice for the diagnosis of these parasitic brain diseases.
Sim, Yun-Su,Kim, Su-Young,Kim, Eun-Joo,Shin, Sung-Jae,Koh, Won-Jung The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.3
Background: Healthy individuals who develop nontuberculous mycobacteria (NTM) lung disease are likely to have specific susceptibility factors which can lead to a NTM infection. The aim of the present study was to investigate the mechanism underlying innate immune responses, including the role of mitogen-activated protein kinase (MAPK), in Mycobacterium abscessus lung disease. Methods: Extracellular signal-regulated kinase (ERK1/2) and p38 MAPK expression in monocytes from peripheral blood mononuclear cells were measured by Western blot analysis after stimulation by Mycobacterium avium in five patients with M. abscessus lung disease and seven healthy controls. A M. avium-induced cytokine assay was performed after inhibition of ERK1/2 and p38 MAPK pathways. Results: Mycobacterium avium induced p38 and ERK1/2 expression in monocytes from healthy controls and subsequently upregulated tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6, and IL-10 production. In monocytes from patients with M. abscessus lung disease, however, induction of p38 and ERK1/2 expression, and the production of TNF-${\alpha}$, IL-6, and IL-10 were significantly lower. Conclusion: Decreased activity of MAPK and cytokine secretion in monocytes from patients with M. abscessus lung disease may provide an explanation regarding host susceptibility to these uncommon infections.
판매촉진이용성향에 따른 쇼핑가치 지각 및 소비자만족에 관한 연구
고애란,오영심 한국의류학회 2002 한국의류학회지 Vol.26 No.7
The purposes of this study were 1) to identify the effects of clothing involvement on deal proneness, store images related to promotions and perceived shopping value, and 2) to reveal the effects of antecedent variables on the consumer satisfaction. The data were collected from 624 female consumers living in Seoul, Korea via self-administered questionnaires and were analyzed by frequency, factor analysis, multiple regression analysis and path analysis. The results of the study were as follows (i) Among the factors related to clothing involvement, deal proneness, store images of promotions and perceived shopping values, Clothing importance, Shopping interest, Fashion interest and all three factors of deal proneness had the effects on perceived hedonic shopping values. Clothing importance, Prudent purchase, Shopping interest, store images related to promotions had the effects on perceived utilitarian shopping values. And Prudent purchase had the positive effects and store images related to Display had the negative effects on perceived negative shopping values. (2) From the results of analyzing the effects of antecedent variables on consumer satisfaction, Sweepstakes/gifts proneness, store images related to Price discount/events and Display, perceived hedonic and utilitarian shopping values positively influenced the consumer satisfaction. Store images related to Price discount/events had the most significant effects on consumer satisfaction. From the result of path analysis, clothing involvement had the effects on consumer satisfaction indirectly through deal proneness, store images related to promotions and perceived shopping values.
강삼식(Sim Sik Kang),고영민(Young Min Koh),김주선(Ju Sun Kim),이명환(Myung Whan Lee),이동선(Dong Sun Lee) 한국생약학회 1995 생약학회지 Vol.26 No.1
6-Hydromykynurenic acid and ginkgolide B together with flavonol glycosides and biflavonoids were isolated from the yellow leaves of Ginkgo biloba and identified by means of spectroscopic methods. The correctness of Ho¨lzl`s <sup>13</sup>C-NMR assignments for 6-hydroxykynurenic acid was confirmed by HMQC and HMBC techniques. Based on our present findings, it may be considered that the yellow Ginkgo leaves may contribute to be a source of high medicinal values.
복합미생물발효 제제식품이 인체건강 및 장내미생물균총에 미치는 영향
박영인 ( Young-in Park ),알핀엠마뉴엘 ( Aalfin Emmanuel ),심혜경 ( Hye Gyeong Sim ),고성철 ( Sung-cheol Koh ) 한국미용학회 2020 한국미용학회지 Vol.26 No.5
The purpose of this study was to investigate the effects of “H” fermented food product of Bayo Co., Ltd., on human health and intestinal microflora, and their relationships. Waist size was measured for the 90 applicants from Seongsangu, Changwon before and after taking the “H” product for 15 days. They were also surveyed to identify the demographic, physical and personal characteristics, and health characteristics. Microbial community structures were analyzed by a pyrosequencing method for the stools collected for some representative applicants. The greatest waist size reduction of 3.3 cm observed in the 40s. Overall satisfaction for the formula food was above average. Especially relief of atopy symptoms was highest in the 20s, constipation relief in the 40s, and digestion promotion in the 60s. In addition, the beneficial enteric bacteria (Faecalibacterium sp., Bifidobacterium sp. and Alistipes sp.) appeared to increase overall after the ingestion by all these ages. The microbial community structure of the 60s was significantly different from those of the 20s and 40s. Ingestion of this fermented food appeared to cause beneficial microbial community structures that could maintain a good intestinal health. Development of various intestinal health indicators based on this study will greatly contribute to the development and utilization of customized functional fermented foods.
태반유착에 관한 임상적 연구 -유착태반, 감입태반 및 침투태반에 관하여-
서영훈 ( Young Hoon Suh ),송언호 ( Eun Ho Song ),김동희 ( Dong Hee Kim ),이연희 ( Yeon Hee Lee ),박혜영 ( Hye Young Park ),고경심 ( Kyung Sim Koh ),박충학 ( Choong Hak Park ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1
Objective : The objective of this study is to investigate the clinical characteristics of placental adhesions in order to improve maternal and fetal well-beings. Methods : We reviewed the medical records of twenty cases of placental adhesions from January
( Insuk Sim ),( Keun-tae Park ),( Gayeung Kwon ),( Jong-ho Koh ),( Young-hee Lim ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.6
Probiotics, including Enterococcus faecium, confer a health benefit on the host. An Enterococcus strain was isolated from healthy chicken cecum, identified as E. faecium by 16S rDNA gene sequence analysis, and designated as E. faecium L11. To evaluate the potential of E. faecium L11 as a probiotic, the gastrointestinal tolerance, immunomodulatory activity, and lifespan extension properties of the strain were assayed. E. faecium L11 showed >66% and >62% survival in artificial gastric juice (0.3% pepsin, pH 2.5) and simulated small intestinal juice (0.5% bile salt and 0.1% pancreatin), respectively. Heat-killed E. faecium L11 significantly (p < 0.05) increased immune cell proliferation compared with controls, and stimulated the production of cytokines (IL-6 and TNF-α) by activated macrophages obtained from ICR mice. In addition, E. faecium L11 showed a protective effect against Salmonella Typhimurium infection in Caenorhabditis elegans. In addition, feeding E. faecium L11 significantly (p < 0.05) extended the lifespan of C. elegans compared with the control. Furthermore, genes related to aging and host defense were upregulated in E. faecium L11-fed worms. In conclusion, E. faecium L11, which prolongs the lifespan of C. elegans, may be a potent probiotic supplement for livestock.