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경경정맥 간내 정맥문맥 단락술이 간경변증의 전신 혈역학에 미치는 영향
김영주,박성진,김현수,서정인,백순구,어영,김재우,권상옥,이동기,박중화 대한소화기학회 2001 대한소화기학회지 Vol.37 No.1
Background/Aims: We conducted this prospective study to identify whether hemodynamic changes occur immediately after transjugular intrahepatic portosystemic shunt (TIPS) in patients with liver cirrhosis and to find out the factors that contribute to the changes. Methods: TIPS procedure was performed for 9 cirrhotic patients for the control of recurrent bleeding. Cardiac index, systemic vascular resistance index and pulmonary capillary wedge pressure were measured before and 20 minutes after TIPS using Swan-Ganz catheterization. Concentration of nitric oxide which is known as one of potent vasodilators was measured in the blood of femoral artery using the Griess reaction before and 20 minutes after TIPS. Results: At 20 minutes after the procedure, the cardiac index was increased from 4.89±0.89 to 5.91±1.29 L/min/m2 (p=0.012), and the systemic vascular resistance index was decreased from 776.63±297.91 to 586.13±180.39 dyne·s/cm5/m2 (p=0.012). There was no significant change in the pulmonary capillary weressure which reflects the preload of the left ventricle. The nitric oxide level was increased from 186.25±112.37 to 226.02±126.73 μmole/L (p=0.038). Conclusions: The cardiac output was increased and the systemic vascular resistance index was decreased immediately after TIPS. These circulatory hyperdynamic changes may have resulted from increased quantity of vasodilators such as nitric oxide. Therefore, we consider that adequate fluid replacement is needed for preventing the systemic vascular complications due to a decrease of effective circulating volume followed immediately after TIPS.
( Hun Soo Chang ),( Suh Young Lee ),( Ji-yong Moon ),( Jong Sook Park ),( Soo-taek Uh ),( Young Hoon Kim ),( Choon-sik Park ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.-
Background: Leukotrienes and prostaglandins are known to be involved in development and progression of asthma. However, other metabolites in eicosanoids pathways have not been revealed in terms of asthma severity. In this study, we tried to identify eicosanoid metabolite associated with refractory asthma. Methods: 110 Plasma of 57 controlled and 45 refractory asthmatics and 6 normal subjects were used in this study, which were obtained from a biobank of Soonchunhyang University Bucheon Hospital. Forty three eicosanoid metabolites in the samples were analyzed using LC-MS/MS. Results: In plasma samples, 29 of 43 eicosanoids were detected, which were higher in asthmatics than in normal controls. Among them, the levels of PGJ2 (metabolized by COS), 5-oxo-ETE, 12-oxo-ETE, LXA4, 5-HETE, LTB4 (metabolized by LOX) and 8(9)-DHET (metabolized by CYP-sEH) were significantly higher in refractory asthma than those in controlled asthma. Conclusion: Inflammatory mediators such as 5-HETE and 5-oxo-ETE were elevated in refractory asthma, which suggest that the metabolites play key roles in pathophysiology. However, anti-inflammatory metabolites such as LXA4 also increase in refractory asthma, which may be protection against the development of the disease. Although further replication and systemic functional study should be necessary, we discovered refractory asthma-related eicosanoids, which may be useful to understand underlying mechanisms of refractory asthma. [funded by 2015-ER7402-00)].
Kim, Soo Hyun,Shin, Jong Hee,Kim, Eui-Chong,Lee, Kyungwon,Kim, Mi-Na,Lee, Won Gil,Uh, Young,Lee, Hye Soo,Lee, Mi-Kyung,Jeong, Seok Hoon,Jung, Sook In,Park, Kyung Hwa,Lee, Jin-Sol,Shin, Myung Geun,Suh, Oxford University Press 2009 Medical mycology Vol.47 No.3
<P>There have been very few multicenter studies of the relationship between the use of antifungals and resistance to them. We investigated the antifungal susceptibility of 1,301 clinical isolates of Candida collected from nine Korean hospitals during a 3-month period in 2006 to explore the existence of this type of relationship. Antifungal usage in the preceding year, defined as the daily dose per 1,000 patient days (DDD/1,000 PD), was calculated for each hospital. Resistance to fluconazole, itraconazole, and amphotericin B was detected in 2, 9, and 0.2% of the isolates, respectively. The MIC(50)/MIC(90) values were 0.03/0.125 mg/L for voriconazole, 0.06/0.25 mg/l for caspofungin, and 0.03/0.125 mg/l for micafungin. The total usage of systemic antifungals varied considerably among the nine hospitals, ranging from 6.1 to 96.2 DDD/1,000 PD. No relationship was found between the use of fluconazole (MIC> or =64 mg/l) or itraconazole (MIC> or =1 mg/l) and resistance in the Candida species (P>0.05). However, significant correlations were found between the percentage of Candida isolates that were non-susceptible to fluconazole (MIC> or =16 mg/l) and fluconazole usage (r=0.733, P=0.025) or total antifungal usage (r=0.767, P=0.016).</P>