Lidocaine의 산성도가 경막외 마취에 미치는 영향

이원형,신효철,신용섭 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

The affective factors on regional anesthesia are lipophilic-hydrophilic balance of local anesthetics, protein binding, hydrogen concentration, structure of intermediate chain, and etc. Local anesthetics in solution exit in a chemical equilibrium between the basic uncharged form(B) and the charged cationic form(BH^+) by Henderson-Hasselbalch equation(PH_a=PK+log[B]/(BH^+)). The increasement of uncharged form brig about rapid onset, good quality, and long duration of anesthesia. Eight patients in group Ⅰ were given 2% lidocaine 21.7ml with 1: 200,000 epinephrine(pH 5.1), and eight patients in group Ⅱ were given 2% lidocaine 20ml with 1: 200,000 epinephrine added NaHCO_3 1.7ml(pH 7.2) to determine the epidural analgesic effect of the pH-adjusted solution. The results are summerized as follow 1. The onsets of analgesia and surgical anesthesia were significantly rapid in group Ⅱ. 2. The levels of analgesia were raised more rapidly in group.

유리 광배근피판을 이용한 하지의 재건

이규윤,김용배,이영만,양순재,박종섭 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

Significant soft-tissue defects in the lower extremity including the tibia and the foot are best managed with free skin-muscle of skin-grafted free muscle transfers. While free flap donor sites useful for lower exremity reconstruction include the latissimus dorsi, the rectus abdominis, the gracilis, and the scapular flaps, the latissimus dorsi seems ideal. This muscle has a reliably long vascular pedicle of wide diameter, making microsurgical anastomosis of the thoracodorsal vessels straightforward. Because it is so large, it can cover virtually and size defect. Furthermore, its flat configuration makes it especially easy to fold on itself to that it can be used to closure wounds with complex three-dimensional geometry and dead space. Although the gracilis and rectus abdominis muscles have their roles, in most cases the latissimus dorsi should serve well. We described technical considerations in each case and the advantages of free latissimus dorsi myocutaneous flap on the reconstruction of the soft tissue defect in the lower extremity.

포트폴리오 收支論的 國際收支 調整 理論小考

李鐘燮,林龍澤 군산대학교 산업개발연구소 1987 産業開發硏究 Vol.6 No.-

Xe 평판형 플라즈마 광원에서 전기광학적 특성

이경섭,문종대,최용성 동신대학교 2006 論文集 Vol.16 No.-

The flat panel lamp is used as back light. It is perceived the best type for the wide size LCD of back light system. However, the flat panel lamp has high value of heat. So it need to improve efficiency. Therefore, more researches are requested for the back light of the flat panel lamp. In this paper, the properties of spectrum is investigated according to change in frequency from 30kHz to 60kHz using power supplies voltage with changing from 500V to 700V. As a result, main spectrum peak of plasma showed in 450[nm], 630[nm], 750[nm] and spectrum peak of 750nm is the highest. Discharge of the flat lamp lighting source research are requested very much. For improving brightness, life time, efficiency of flat lamp and plasma diagnosis of the flat lamp lighting source to understand property of lighting source is very important. When a distance of discharge electrode is 5.5mm and width is 16.5mm, we measured electron temperature and electron density measured with single Langmuir probe in flat lamp. We tested the discharge from 100 Torr to 300 Torr pressure. The pulse type was rectangular with frequency 20kHz and duty ratio was 20%.

전력용 VDMOSFET의 온도변화가 트레시홀드 전압에 미치는 영향

李炅燮,姜龍哲 東新大學校 1991 論文集 Vol.10 No.-

전류 모드 CMOS 다치 논리 회로를 이용한 8X8 병렬 승산기

이용섭,곽철호,김정범 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

This paper presents new current-mode CMOS multiple-valued integrated circuits for high-density arithmetic systems. The validity and effectiveness of the proposed circuits are verified through the HSPICE simulation. A 8×8-bit parallel multiplier using the proposed circuits with 2V supply voltage is designed with a 0.25㎛ standard CMOS technology. The performance of the proposed multiplier is evaluated to be about 74% smaller than that of a corresponding binary implementation.

신장세포암에서 WT1과 IGF2 유전자의 발현

이정호,김응석,김용섭,장성익,윤환중 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

IGF2 유전자는 제 11번 염색체 단완 (11p15.5)에 위치해 있으며 아버지로부터 유전된 대립형질만 기능을 하는 genomic imprinting되는 유전자이다. 이 유전자는 정상세포에서는 세포증식을 촉진시키는 작용을 하고 몇가지 암에서는 LOI에 기인한 과발현이 있는 것으로 알려져 있다. 한편 WT1 유전자는 제 11번 염색체 단완 (11p13)에 위치해 있으며 어머니로부터 유전된 대립형질만 기능을 하는 즉 IGF2 유전자와는 정반대의 genomic imprinting 되는 유전자이다. 이 유전자는 비뇨생식기관의 발생에 매우 중요한 유전자이며 암화과정에서는 암억제 유전자로서 기능한다. 소아신장에서 발생되는 Wilms 종양에서는 IGF2 유전자와 WT1 유전자의 고장이 주원인으로 생각하고 있다. 이에 근거하여 성인에서 발생되는 신장세포암에서도 Wilms 종양에서의 결과와 같을 것인지의 여부를 알기 위하여 12명의 신장세포암 환자 ( 남자 6명, 여자 6명)로부터 얻은 조직을 이용하여 이들 유전자의 발현정도를 조사하였다. 환자의 연령은 남자에서는 43세에서 56세까지였고 여자에서는 23세에서 61세까지였다. 신장세포암에서 IGF2 유전자와 WT1 유전자의 발현정도는 다같이 성별이나 연령과는 무관하였다. IGF2 유전자는 50%에서 발현되었으며, 그 발현정도는 저발현에서부터 중등도 그리고 과발현까지 다양했으며 주로 신세뇨관 부위에 있는 암세포에서 발현되었다. WT1은 56%에서 발현되었으며 과발현과 중등도 발현이 대부분이었다. IGF2 유전저의 발현과 WT1 유전자의 발현은 각 예에서 상이하게 나타나서 두 유전자간의 작용은 일치하지 않았다. IGF2 gene which was located on chromosome 11p15.5 is expressed by the paternal allele. It stimulates the cell proliferation in normal cells, however, it is over expressed in some cancers due to LOI (loss of genomic imprinting). In contrast, WT1 gene which was located on chromosome 11p13 shows maternal specific monoallelic expression. It is a very much important gene in developing urogenital system, besides, it acts as tumor suppressor gene in some cancers. IGF2 and WT1 genes are the main causative genes in Wilms tumor which is developed in pediatric kidney. To understand the status of IGF2 and WT1 expressions in renal cell carcinoma which is developed in adult life, tissues from 12 cases patients (male 6 cases ; female 6 cases) were detected by immunohistochemistry with antibodies from IGF2 and WT1 genes. To distinguish the different ages between Wilms tumor and renal cell carcinoma, the patients age in renal cell carcinoma was ranged in 43-56 years old in man and 23-61 years old in female. No direct correlation was, in general, between gene expression of IGF2 and WT1 and age or sex of patients in renal cell carcinoma. Expression of IGF2 gene revealed six of twelve (560%) and expression of WT1 gene showed seven of twelve (56%) in renal cell carcinoma, respectively. The status of IGF2 gene expression was varied from low to high expression. In contrast, the status of WT1 gene expression was higher than in IGF2 gene expression. However, there was no apparent correlation between expressions in each cases. In conclusion, IGF2 and WT1 genes are very important in carcinogenesis of renal cell carcinoma, however interaction between two genes was obscure.

체외충격파 쇄석술 시행 후 5년 뒤 발생한 요관 협착 및 농신장 1예

이현승,권균홍,조용건,김봉진,임창섭,김자영,허동,임학 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

A 40-years-old woman was admitted to this hospital with flank pain and high grade fever for 2 weeks. As a matter of her past history, extracorporeal shock wave lithotripsy (ESWL) was performed for treatment of renal stones 5 years ago. Her abdominal CT findings were hydronephrosis with pyonephrosis and renal stones. Antibiotics administered for 5 days had no effects on her symptom improvement. A right ureteral stricture was noticed by ultrasonography follow up. We inserted double J stent and continued antibiotics therapy for 10 days, and then her fever was disappeared and flank pain was improved. ESWL is one of the most important treatment of renal and ureteral stone. However, its complications should not be negligible including bleeding, pain, ureteral obstruction, infection and so on. Complications of ESWL can be divided into acute and chronic courses. When we treat pyelonephritis patient with past history of ESWL, possibility of ureteral stricture must also be considered. In this study we report a case of pyelonephritis caused by ureteral stricture, possibly as a chronic complication of ESWL performed 5 years earlier

Vecuronium에 의한 기관내 삽관시 안압 및 심맥관계에 미치는 영향

신용섭,이정은,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

The effects of muscle relaxants(vecuronium, pancuronium, d-tubocurarine, and succinylcholine) for endotracheal intubation on intraocular pressure, blood pressure, heart rate, and arrhythmia were studied in 60 patients undergoing general anesthesia, The patients were divided into 4 groups : vecuronium group (0. 1 mg/kg), pancuronium group (0.08 mg/kg), d-tubocurarine group(0.4 mg/kg), and succinylcholine group(1 mg/kg) according to be administrated. Before induction of anesthesia, initial measurement of intraocular pressure (control value) was taken with Schiotz tonometer after instilling of a 0. 5% pontocaine on conjunctival sac. Subsequent measurement were undertaken as soon as the lid reflex was lost after thiopental sodium injection and then at 75-100% depression of first twitch height of train-of-four after intravenous administration of muscle relaxants. It was measured at 1, 3, 5, 10 minutes after endotracheal intubation too. Blood pressure (systolic and diastolic), heart rate, and ECG abnormalities were observed in all cases. The results were as follows; 1. After thiopental sodium injection, intraocular pressure(IOP) decreased than the control value. 2. At 70-100% depression of first twitch height, IOP decreaeed significantly in vecuronium, pancuronium and d-tubocurarine group, but increased significantly in succinylcholine group than the control value. 3. After 1 minute of endotracheal intubation, IOP increased in all groups. There was no stastistical significance in vecuronium group compared with the control value. 4. After 3 minutes of endotracheal intubation, IOP decreased in all groups. 5. The changes of systolic and diastolic blood pressure and heart rate in vecuronium group were the smallest value among all groups. 6. There was no arrythmia in vecurouium group.

Xe 평판형 플라즈마 광원의 전극 구조에 따른 전자계 특성

최용성,이경섭 동신대학교 2006 論文集 Vol.16 No.-

Discharge of the flat lamp lighting source research are requested very much. For improving brightness, life time, efficiency of flat lamp and plasma diagnosis of the flat lamp lighting source to understand property of lighting source is very important. In this paper, we changed a tip shape of an electrode for production by the most suitable LCD backlight surface light source, and confirmed discharge characteristic along discharge gas pressure and voltage, and confirmed electric field distribution and discharge energy characteristic through a Maxwell 2D simulation. Therefore the discharge firing voltage characteristic showed a low characteristic than a rectangular type and round type in case of electrode which used tip of a triangle type, and displayed a discharge electric current as a same voltage was low. When a distance of discharge electrode is 5.5mm and width is 16.5mm, we measured electron temperature and ion density measured with single Langmuir probe in flat lamp. We tested the discharge from 100 Torr to 300 Torr pressure. The pulse type was rectangular with frequency 20kHz and duty ratio was 20%. In result, electron temperature decreased and electron density increased as increase the gas pressure and electron temperature decreases and electron density increase as increase the voltage.