Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

흡연과 중풍발생의 상관관계에 관한 환자-대조군 연구

양대진(Dae-Jin Yang),배종면(Jong-Myun Bae),이경섭(Kyoung-Sup Lee),조기호(Ki-Ho Cho),김영석(Young-Suk Kim),배형섭(Hyoung-Sup Bae) 대한한의학회 2001 대한한의학회지 Vol.22 No.4

갑상선 유두암에서의 bcl-2와 P53 단백질 발현의 의의

지웅배,배정원,우상욱,손길수,이재복,구범환,채양석<SUP>1<,SUP>,Woong Bae Ji,M,D,Jeoung Won Bae,M,D,Sang Uk Woo,M,D,Gil Soo Son,M,D,Jae Bok Lee,M,D,Bum Whan Koo,M,D,and Yang-Seok Chae,M,D,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2007 The Koreran journal of Endocrine Surgery Vol.7 No.4

Purpose: Papillary thyroid cancer (PTC) has a good prognosis, and it's known to be related to the apoptosis of papillary thyroid cancer. The expression of bcl-2 is thought to be associated with the inhibition of apoptosis. We evaluated the differences of bcl-2 and P53 between PTC and the control (normal tissue and benign lesion). We then analyzed the correlation between the bcl-2 and P53 expressions and the classic prognostic factors. Methods: Between January 2001 and December 2005, 30 patients who underwent total thyroidectomy for the PTC were included in this study and immunohistochemical staining was performed on the tumors. Results: bcl-2 was expressed in 18 cases (60%) in their PTC (P<0.05). The expression of P53 was not significantly related with the clinicopathological factors, but P53 was expressed in 9 cases (30%) of PTC (P<0.05). The positive staining for was noted in 18 cases (62.1%) of the PTC tissue among the 30 patients, and as the TNM stage progresses, the expression rate of was significantly decrease for 7 stage I cases (100%), for 4 stage ll cases (80%) and for 7 stage ll cases (38.9%). Conclusion: bcl-2 was expressed more as the TNM stage of PTC decreases. So bcl-2 is possibly useful as a prognostic factor for PTC, but further studies are needed for confirming its significance. (Korean J Endocrine Surg 2007; 7:231-236)

갑상선 유두암에서 BABA 내시경 갑상선 절제술에 대한 임상적 고찰

천보성,김재홍,박경식,배수연,정성일,유영범,양정현,윤여규<SUP>1<,SUP>,Bo Sung Cheon,Jae Hong Kim,Kyoung Sik Park,Soo Youn Bae,Sung Il Jung,Young Bum Yoo,Jung-Hyun Yang,and Yeo-Kyu Youn,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.3

Purpose: The aim of this study was to evaluate the operative feasibility and safety of endoscopic thyroidectomy via bilateral axillo breast approach (BABA) compared to conventional thyroidectomy in papillary thyroid carcinoma (PTC) patients. Methods: From July 2009 to November 2010, patients underwent BABA endoscopic thyroidectomy (ET group; n=41) or conventional open thyroidectomy (OT group; n=61) for PTC. Clinical and pathologic characteristics of patients, operation time, post-operative complications, cosmetic satisfaction and thyroglobulin (TG) level were analyzed retrospectively. Results: The mean age of the patients was 40.05±9.58 years (range 25∼61 years) and 46.21±13.68 years (range 19∼79 years) for the ET and OT group, respectively. The operative extent in the ET group did not include advanced thyroid cancer or lateral neck dissection. The size of the tumor was 0.78±0.59 cm (range 0.1∼3.00 cm) and 1.54 ±1.05 cm (range 0.3∼6.00 cm) for the ET and OT group, respectively. Extrathyroidal extension and number of retrieved lymph nodes were significantly higher in the OT group. Postoperative radioactive iodine ablation was performed on 25 patients (72.43%) in the ET group and 48 patients (78.69%) in the OT group. There was no abnormal uptake on radioactive iodine scans in the iodine-treated patients and no significant differences in postoperative off-T4 TG levels between the two groups. There were no significant differences in operative time, amount of drainage, postoperative hospitalization period, hypocalcemia, and vocal cord palsy between the two groups. Cosmetic results of ET group were rated as excellent in a 3-month postoperative questionnaire by 25 (72.43%) of 35 patients. Conclusion: Endoscopic thyroidectomy via the bilateral axillo breast approach can be a feasible and effective option for PTC in selected cases. (Korean J Endocrine Surg 2011;11:158-163)

후이개부 회전피판술을 이용한 매몰이의 교정

양순재,이영만,박종섭,강상규,김용배 大韓成形外科學會 1996 Archives of Plastic Surgery Vol.23 No.3

Cryptotia is a rare congenital anomaly among caucasian but it is more common among orientals. Cryptotia characterized by the anterosuperior portion of the auricle lying directly on the head and not apart from it. It has not only aesthethic but also psychologic problems. The cryptotia deformity has two main anatomic characteristics. One is deformity of the auricular cartilage, and the other is a skin deformity. The combination of these two conditions govern the severity of cryptotia and therefore must be considered in each patient at the time of reconstruction. Correction method is divided two main branches and one is the non-surgical treatment and the other is surgical treatment. Conservative therapy for correction of cryptotia includes the use of several devices, and the younger the patient is the better results. Whether conservative therapy is effective or not depends on the time that therapy is initiated, and so in later ages surgical procedures are required in many cases. Key points of treatment are elevation of invaginated ear helix and prevention of stabilized contouring from returning to the previous state. The authors carried cartilage plasty by Fukuda's method that one or two incision are made along the crus, and then the crus is flattened using mattress suture. And then correction of skin deficiency using the retroauricular transposition flap. We find the clinical applications and advantages from this method. Retroauricular transposition flap is better method for the making of auriculocephalic sulcus, the design is simple and the procedure easy, hairline is not disturbed, easy approach to manage the deformed cartilage and muscle and scar is minimal.

Inhibitory effects of polyozellin from Polyozellus multiplex on HMGB1-mediated septic responses

Yang, Eun-Ju,Ku, Sae-Kwang,Lee, Wonhwa,Song, Kyung-Sik,Bae, Jong-Sup Springer-Verlag 2015 Inflammation research Vol.64 No.9

역행성 내족장부 도서형 피판을 이용한 제1족지 족장부의 재건

양순재,김재훈,김용배,노봉일,김정태,박종섭 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.2

Reconstruction of the soft tissue defects on the plantar foot continues to be a difficult challenges because of the unique anatomical features. It should endure constant weight loading or alternate stimulus of shoes while standing or walking. The methods used for reconstruction of the soft tissue defects on the plantar foot are skin graft, local flap, cross leg flap, myocutaneous flap, neurovascular island flap and free flap. However, it is very difficult to find a proper method to reconstruct the soft tissue defect of the first toe plantar area. The ideal reconstruction should provide tissue as durable yet sensitive, provide tissue components similar to the original lost tissue, be reliable, result in a donor site that is well tolerated, and entail one operative procedure with minimal morbidity. Although the medial plantar flap was initially described to surface heel defects, many surgeons have used this flap as a cross leg flap or a free flap to recover the first toe plantar area. Its use has always required a secondary surgical procedure or a difficult technique. In order to overcome this inconvenience, we used the flap based on the principle of reversing the direction of blood flow in a distal vascular pedicle to restore a defect of the anteromedial aspect of the foot. We have experienced 3 cases of reverse medial plantar flap for the reconstruction of the great toe plantar area. Good functional and aesthetic results were obtained.

측두두정근막 유리피판술을 이용한 상.하지의 재건

양순재,박병일,이영만,김용배,김광진,박종섭 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.1

The temporoparietal fascia is one of the most ideal donor flap in terms of thin, pliable and well vascularized sheets of the tissue. And microvascular transfer is fascilitated by means of the axial pattern flap with consist, reliable and large calivered vascular·pedicles. It can be transfered alone as an isolated tissue, or it can simultaneously transport periosteum and bone from below or hair bearing skin from above. It leaves an inconspicuous donor site morbidity with in the hair bearing scalp. The flap is useful in covering exposed bone and tendon without unwanted bulk, in providing an ultrathin flap coverage in soft tissue defects, and it provides a good intrinsic blood supply to improve local conditions for healing. And it can establish a fine tendon-gliding mechanism. We have experienced 7 cases of reconstruction of soft tissue defects in hands and lower extremities with this flap. We could gain satisfactory sort tissue coverage wish ultrathin arterialized pedicle flap. Especially in sort tissue defect of hand, we reconstructed index and middle extensor tendon with deep temporal fascia.

Rhei Rhizoma and Chunghyuldan Inhibit Pancreatic Lipase

Yang, Hyung-Kil,Kim, Young-Suk,Bae, Hyung-Sup,Cho, Ki-Ho,Shin, Ji-Eun,Kim, Nam-Jae,Kim, Dong-Hyun WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Pancreatic lipase-inhibitory activity of the rhizome of Rhei Rhizoma and its antihyperlipidemic activity were measured Rhei Rhizoma inhibited pancreatic lipase with IC_(50) value of 6.5 ㎎/㎖ (triolein as a substrate). Rhei Rhizoma significantly inhibited serum TG level in corn oil feeding-induced mice, and serum TG and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, Rhei Rhizoma did not show the hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. When in vitro pancreatic lipase-inhibitory and in vivo antihyperlipidemic activities of Whangryunhaedoktang (WT) and Chunghyuldan (DC) which is consisted of ingredients of WT and Rhei Rhizoma, were measured, CD exhibited more potent inhibitory activities than WT. Therefore these results suggest that antihyperlipidemic activity of Rhei Rhizoma and CD may be more or less originated from the inhibition of pancreatic lipase.

상안검거근 전진법을 이용한 안검하수증의 치험례

양순재,박병일,이영만,이주헌,김용배,박종섭 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.2

The blepharoptosis is a disease which is drooping of the eyelid and is caused the weakness of levator or the Muller's muscle. The author treated 3 patients from june 1992 to august 1992, they were all congenital and one of them was bilateral. The levator function was within 6-9mm, and the degree of ptosis was 4mm. We performed levator advancement procedure. The technique advocated in this paper consists of careful dissection and identification of anatomic landmark, including preaponeurotic. fat, Whitnall's superior transverse ligament, and the veritically oriented blood supply of levator muscle. The attachment of the levator muscle into the cephalad portionof the levator aponeurosis can be identified and easily dissected in order to perform the procedure of detachment and advancement to the tarsal plate. This procedure for ptosis has been successful in management in moderate to severe ptosis and in some cases has actually increased the muscle function, thereby-enhancing the result, In this technique, the full length of the levator muscle remains, so maximum excursion is achieved postoperatively, and medial and lateral horn of levator aponeurosis are untouched, so the postoperative scaring should be minimal in this areas. In addition, there is little or no loss of levator muscle from resection and this technique my be reversible.