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Changes of Serum Mineral Concentrations in Horses during Exercise
Inoue, Y.,Osawa, T.,Matsui, A.,Asai, Y.,Murakami, Y.,Matsui, T.,Yano, H. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.4
We investigated the exercise-induced changes in the serum concentration of several minerals in horses. Four welltrained Thoroughbred horses performed exercise for 5 d. The blood hemoglobin (Hb) concentration increased during exercise, recovered to the pre-exercise level immediately after cooling down and did not change again up till the end of experiment. The changes in serum zinc (Zn) and copper (Cu) concentrations were similar to those of blood Hb during the experiment. The serum magnesium (Mg), inorganic phosphorus (Pi) and iron (Fe) concentrations also increased during exercise. Though the serum Pi concentration recovered to the pre-exercise level immediately after the cooling down, it decreased further before the end of the experiment. The serum Mg concentration was lower immediately after cooling down than its pre-exercise level but gradually recovered from the temporal reduction. The recovery of the serum Fe concentration was delayed compared to that of other minerals and recovered 2 h after cooling down. The serum calcium (Ca) concentration did not change during exercise but rapidly decreased after cooling down. As a result, it was lower immediately after cooling down than its pre-exercise level. It recovered, however, to the pre-exercise level 2 h after cooling down. The temporal increase in the serum concentrations of all minerals except Ca is considered to result from hemoconcentration induced by exercise and the stable concentration of the serum Ca during exercise is possibly due to its strict regulation of homeostasis. These results indicate that the serum concentration of each mineral responds differently to exercise in horses, which may be due to the difference in metabolism among these minerals.
Asai, Tatsuhiko,Choi, Beom K.,Kwon, Patrick M.,Kim, Won Y.,Kim, Jung D.,Vinay, Dass S.,Gebhardt, Bryan M.,Kwon, Byoung S. Blackwell Publishing Ltd 2007 Immunology Vol.121 No.3
<P>Summary</P><P>To explore the roles of 4-1BB (CD137) and CD28 in corneal transplantation, we examined the effect of 4-1BB/4-1BB ligand (4-1BBL) and/or CD28/CD80/CD86 blockade on corneal allograft survival in mice. Allogeneic corneal transplantation was performed between two strains of wild-type (WT) mice, BALB/c and C57BL/6 (B6), and between BALB/c and B6 WT donors and various gene knockout (KO) recipients. Some of the WT graft recipients were treated intraperitoneally with agonistic anti-4-1BB or blocking anti-4-1BBL monoclonal antibody (mAb) on days 0, 2, 4 and 6 after transplantation. Transplanted eyes were observed over a 13-week period. Allogeneic grafts in control WT B6 and BALB/c mice treated with rat immunoglobulin G showed median survival times (MST) of 12 and 14 days, respectively. Allogeneic grafts in B6 WT recipients treated with anti-4-1BB mAb showed accelerated rejection, with an MST of 8 days. In contrast, allogeneic grafts in BALB/c 4-1BB/CD28 KO and B6 CD80/CD86 KO recipients had significantly prolonged graft survival times (MST, 52·5 days and 36 days, respectively). Treatment of WT recipients with anti-4-1BB mAb resulted in enhanced cellular proliferation in the mixed lymphocyte reaction and increased the numbers of CD4<SUP>+</SUP> CD8<SUP>+</SUP> T cells, and macrophages in the grafts, which correlated with decreased graft survival time, whereas transplant recipients with costimulatory receptor deletion showed longer graft survival times. These results suggest that the absence of receptors for the 4-1BB/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival, whereas triggering 4-1BB with an agonistic mAb enhances the rejection of corneal allografts.</P>
Changes in Serum Biochemical Markers of Bone Cell Activity in Growing Thoroughbred Horses
Inoue, Yoshinobu,Asai, Y.,Ohmori, H.,Fujii, H.,Matsui, T.,Yano, H. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.11
We studied the changes in biochemical markers of bone metabolism in growing Thoroughbred horses. Serum osteocalcin (OC), as a marker for bone formation, and carboxy-terminal propeptide of type-I collagen (PICP), as a marker for bone formation, carboxy-terminal telopeptide of type-I collagen (ICTP), as a marker for bone resorption, were determined in nine clinically healthy horses from 3 d to 17 mo of age. The BW and withers height (WH) increased during the study. On the other hand, a rapid reduction in body weight gain (BWG) was observed between 1 mo and 9 mo of age and a rapid reduction in withers height gain was observed between 1 mo and 5 mo of age. The serum markers decreased significantly with increasing age. In particular, dramatic changes in serum markers occurred between 3 d to 1 wk and 5 to 7 mo of age in these horses, which suggests that bone turnover rapidly decreased after birth. On the other hand, the ratio of PICP to ICTP decreased through the experiment. This result suggests that the reduction in bone formation exceeded that of bone resorption. There was a significant correlation between markers and growth parameters, except for the correlation between PICP and BWG on single linear regression analysis. Serum OC and ICTP were affected by the WH in multiple linear regression analysis. These results indicated that the age-related variation in serum biochemical markers of bone metabolism reflected bone growth, but neither BW nor BWG. Therefore, we consider that changes in bone modeling are the major factor affecting the levels of serum biochemical markers by 17 mo of age in horses.
Matsui, A.,Inoue, Y.,Asai, Y. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.6
This study was designed to test the effects of changes in energy and protein intake levels on the maternal milk amino acid concentrations over the short-term in lactating mares. Three lactating mares were enrolled for the study 7 weeks after parturition. A low-energy and low-protein diet (LEP) was administered during the first week of the study, followed by administration of a high-energy and high-protein diet (HEP), again for a week (day 1 to day 7), and milk was sampled thrice daily at intervals of 8 h during the study period. The mean amino acid concentrations in the maternal milk, except for those of proline, serine and valine, were significantly higher in the HEP feeding period than during the LEP feeding period (p<0.05). The sum of the concentrations of all the amino acids (TAA) in the maternal milk samples during the HEP and LEP feeding periods was 1,644.9${\pm}$26.9 and 1,542.3${\pm}$36.0 mg/100 g, respectively, the difference between the two was not significant. When the ratio of each amino acid concentration to the TAA in the maternal milk was analyzed, there were significant differences between the HEP and LEP feeding periods for all amino acids, except glycine, serine, alanine and histidine. It was found that the concentrations of glutamic acid+glutamine, serine, threonine, arginine and valine were significantly higher (p<0.05) on day 1 than on day 7 during the LEP feeding period, and there were no such differences during the HEP feeding period. In regard to the effects of changes in the energy and protein intake levels in lactating mares, no changes in milk amino acid concentrations were found following administration of HEP for a week, whereas 7 days of administration of LEP was associated with a decrease in the amino acid concentrations.
Nagao, K.,Takahara, Y.,Asai, H.,Hayashi, N.,Kitayama, T.,Yoshimura, Y.,Yokota, H.,Kita, Kazumi Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.8
The effect of dietary fatty acid supplementation on milk production, milk composition and plasma constituents in dairy cows was examined. Dietary fatty acids including mainly palmitic acid and stearic acid were given to cows from 2 weeks before and 8 weeks after parturition. Weekly gain of daily milk production was increased gradually during early lactation period and reached a plateau at 4 weeks after parturition. Weekly gain of daily milk production in lactating cows received dietary fatty acids was significantly higher than that of cows given a control diet alone. Although milk lactose concentration was slightly decreased by dietary fatty acid supplementation, milk fat and protein were not significantly influenced by dietary fatty acid supplementation. Dietary fatty acids did not affect plasma concentrations of triglyceride, non-esterified fatty acids, total cholesterol, high-density lipoprotein cholesterol and glucose during postpartum. It is suggested that dietary fatty acid supplementation has the potency to enhance energy balance and improve milk yield without any adverse effects on milk composition.
C. J. Yoon,H. Akikawa,K. Aoki,Y. Fukao,H. Funahashi,M. Hayata,K. Imai,K. Miwa,H. Okada,N. Saito,H. D. Sato,K. Shoji,H. Takahashi,K. Taketani,J. Asai,M. Kurosawa,M. Ieiri,T. Hayakawa,T. Kishimoto,A. Sa 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We determined scattering length and effective range of ΛΛ scattering for the ΛΛ relative energy (M_(ΛΛ)-2M_Λ) from ΛΛ threshold to 30 MeV/c_2. Phase shift of the ΛΛ wave function which described by scattering length and effective range was determined by fitting the ΛΛ mass spectrum. The obtained scattering length -0.10^(+0.37)_(-1.56) ± 0.04, and effective range 13.90 ^(+14.35)_(-9.13) ± 10.53 fm is the most consistent with the values predicted by using a series of the Nijmegen soft core models NSC97's. However the predicted values by using the Nijmegen hard core model ND (G-matrix), the extended soft core model ESC00, and the Kyoto-Niigata FSS are out of three standard deviations from the determined scattering parameters. Further, we determine ΛΛ potential by fitting the ΛΛ invariant mass spectrum using numerically solved ΛΛ wave function with two-Gaussian shaped potential well. The ΛΛ scattering parameters derived from the wave function are found to be scattering length -0.09, and effective range 29.34 fm with a maximum phase shift of 2.4 deg.
Search for theH-dibaryon resonance inC12(K−,K+ΛΛX)
Yoon, C. J.,Akikawa, H.,Aoki, K.,Fukao, Y.,Funahashi, H.,Hayata, M.,Imai, K.,Miwa, K.,Okada, H.,Saito, N.,Sato, H. D.,Shoji, K.,Takahashi, H.,Taketani, K.,Asai, J.,Kurosawa, M.,Ieiri, M.,Hayakawa, T. American Physical Society 2007 PHYSICAL REVIEW C - Vol.75 No.2