Gynecologic manifestation and identification of genetic causes of Klippel-Trenaunay syndrome

( A Mi Roh ),( Sa Ra Lee ),( Young Mee Lim ),( Kyung Ah Jeong ),( Hye Sung Moon ),( Hyewon Chung ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Klippel-Trenaunay syndrome (KTS) is a congenital disorder characterized by malformations of the arteries, capillaries, veins and lymphatic system, surrounding soft tissue and bone hypertrophy. A. Timur et al. (2005) and others have reported that AGGF1 gene causes excessive angiogenesis in KTS. In addition, Fabio C. Vicentini (2006) and others introduced cases involving bladder and vulva. However, there has been no genetic study of KTS patients who have invaded the clitoris. In this study, whole genome sequencing of KTS patients and their families involving vulva were performed to identify KTS - related genes and to confirm genetic variants in KTS. A 26 year old woman visited OBGY clinic for protruding vaginal mass. On examination, the purplish protruding anterior vaginal wall was noted and a 1.5 x 1.5 cm sized clitoral mass was also noted. A sessile type elevated skin lesion causing itching and irritation symptom was noted on both buttock. She had suffered heavy menstrual bleeding and on pelvic MRI, a upward displacement of uterus was noted near umbilicus level. NSAIDs prescribed onthe first 3 days of menstruation decreased the menstrual blood loss upto 40percent. In this study, whole genome sequencing of a KTS patient involving vulva was performed to identify KTS - related genes and to confirm genetic variation. The patient's peripheral blood and a sessile mass around buttock was sampled and whole genome sequencing was performed. Most KTS has known to be a sporadic one, however some genetic variants has been reported.

Temperature dependent current–voltage characteristics of the Cd/CdO/n–Si/Au–Sb structure

M. Sağlam,A. Ates,M.A. Yıldırım,B. Güzeldir,A. Astam 한국물리학회 2010 Current Applied Physics Vol.10 No.2

In this study, this is the first time, it has been employed Successive Ionic Layer Adsorption and Reaction (SILAR) method in order to prepare Cd/CdO/n–Si/Au–Sb sandwich structure. The sample temperature effect on the current–voltage (I–V) characteristics of Cd/CdO/n–Si/Au–Sb structure has been investigated in a wide temperature range by steps of 20 K. The parameters such as barrier height, ideality factor and series resistance of this structure have been calculated from the forward bias I–V characteristics as a function of sample temperature. With a decreasing temperature, a decreasing in the apparent barrier height (Øb0), an increasing in the ideality factor (n) and a nonlinearity in the activation energy plot have been seen. The experimental values of barrier height and ideality factor for this device have been calculated as 0.871 eV and 1.787 at 300 K and 0.436 eV and 2.221 at 80 K, respectively. These abnormal behaviors can be explain by the barrier inhomogeneities at the metal–semiconductor (M–S) interface. From the temperature dependent I–V characteristics of the Cd/CdO/n–Si/Au–Sb sandwich structure, Øb0 and A*are calculated as 0.790 and 1.160 eV, and 153.90 and 188.42 A/㎠ K2, respectively, by using ln(I0/T2) - q2σ2s/2k2T2 vs. 1/T plot for the two temperature regions. Deviation of experimental values of A* from known value for n–Si has been attributed to the spatial inhomogeneous barrier heights and potential fluctuations at the interface that consist of low and high barrier areas.

Oxidative lipid modification of nicastrin enhances amyloidogenic γ‐secretase activity in Alzheimer’s disease

Gwon, A‐,Ryeong,Park, Jong‐,Sung,Arumugam, Thiruma V.,Kwon, Yong‐,Kook,Chan, Sic L.,Kim, Seol‐,Hee,Baik, Sang‐,Ha,Yang, Sunghee,Yun, Young‐,Kwang,Choi, Yuri,Kim, Sa Blackwell Publishing Ltd 2012 AGING CELL Vol.11 No.4

<P><B>Summary</B></P><P>The cause of elevated level of amyloid β‐peptide (Aβ42) in common late‐onset sporadic [Alzheimer’s disease (AD)] has not been established. Here, we show that the membrane lipid peroxidation product 4‐hydroxynonenal (HNE) is associated with amyloid and neurodegenerative pathologies in AD and that it enhances γ‐secretase activity and Aβ42 production in neurons. The γ‐secretase substrate receptor, nicastrin, was found to be modified by HNE in cultured neurons and in brain specimens from patients with AD, in which HNE–nicastrin levels were found to be correlated with increased γ‐secretase activity and Aβ plaque burden. Furthermore, HNE modification of nicastrin enhanced its binding to the γ‐secretase substrate, amyloid precursor protein (APP) C99. In addition, the stimulation of γ‐secretase activity and Aβ42 production by HNE were blocked by an HNE‐scavenging histidine analog in a 3xTgAD mouse model of AD. These findings suggest a specific molecular mechanism by which oxidative stress increases Aβ42 production in AD and identify HNE as a novel therapeutic target upstream of the γ‐secretase cleavage of APP.</P>

A Retrospective Comparative Study of Serbian Underground Coalmining Injuries

Ivaz Jelena S.,Stojadinović Saša S.,Petrović Dejan V.,Stojković Pavle Z. 한국산업안전보건공단 산업안전보건연구원 2021 Safety and health at work Vol.12 No.4

Background: During 2011, a study was undertaken to assess safety conditions in Serbian underground coalmines by analysis of injury data. The study covered all Serbian coalmines, identified week spots from the aspect of safety, and recommended possible courses of action. Since then, Serbia has made changes to safety and health legislation; all coalmines introduced new preventive measures, adopted international standards, and made procedures for risk management. After 10 years a new study has been performed to analyze the impact of these changes. Materials and methods: In this study, the injuries that have occurred in the Serbian underground coal mines over the last 20 years were analyzed. Statistical data analysis was performed by IBM SPSS Statistics v23. The injuries that occurred in the last ten years were compared with the results of the previous study (2000-2009). The average values of injury rates for both periods were compared for each of the categories (severity, age, body part, qualification), and the results were presented as absolute difference or percentile difference. Results: The results showed reduction in the number of injuries in the category of 20-30 years old workers, where the new training procedures for workers, which were set by mandatory legal regulations, certainly contributed. They also showed an increase in the number of injuries in the category of old workers, which indicates that the law did not have a positive effect on this category. Conclusion: The total number of injuries is still high; therefore, it is necessary to introduce mechanization and automation in mines and have a better policy for older workers who retire later nowadays.

Comparative Analysis of Sustainable Cooling Systems in Intermittent Turning of Magnesium Pieces

Eva María Rubio,María Villeta,Diego Carou,Adolfo Saá 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

Cutting fluids have been widely used in machining processes because of their favourable lubrication and cooling properties. However,their high costs, the risk to worker’s health and environmental concerns have necessitated the development of alternative methods ofcooling and lubricating that eliminate or, reduce such drawbacks. In this study, a comparative analysis of two sustainable coolingsystems (dry machining and minimum quantity lubrication (MQL) system) in intermittent turning of UNS M11917 magnesium pieceswas performed. To analyse the influence of the cooling system on intermittent cutting, the surface roughness was selected as theresponse variable. In addition to the cooling system, other parameters such as the feed rate, spindle speed, tool type, interruption typeand measurement zone (defined by the length and the generatrix) were taken into account. A combined L4x32 experimental design withthree nested replications was carried out. The obtained data were analysed using the analysis of variance (ANOVA) method. Mainconclusions include the identification of the feed rate and interruption type as the most important sources of surface roughnessvariability. In addition, it is possible to affirm that, in general, increases in the coolant flow rate, within the range studied, lead toslightly poorer surface roughness results.

두 가지 삼원교잡종 (랜드레이스 x 요크셔 x 두록 및 랜드레이스 x 요크셔 x 우리흑돈)의 육질특성 비교

김정아(Jeong A Kim),조은석(Eun Seok Cho),이미진(Mi-Jin Lee),정용대(Yong Dae Jeong),최요한(Yo Han Choi),조규호(Kyu Ho Cho),정학재(Hak Jae Chung),백선영(Sun Young Baek),김영신(Young Sin Kim),사수진(Soo Jin Sa),홍준기(Jun Ki Hong) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.10

본 연구는 외화 낭비를 줄이기 위해 우리흑돈이 종료종모돈으로써 두록을 대체할 수 있는지 조사하고자 하였다. 본 논문에서는 랜드레이스 X 요크셔 X 두록(LYD)과 랜드레이스 X 요크셔 X 우리흑돈(LYW)의 두 삼원교잡종에서 등심의 육질 특성을 비교하기 위해 이화학적 분석을 실시하였다. 공시 동물은 180일령의 LYD 59두와 LYW 60두, 총 119두를 이용하였으며, 도축 후 24시간 동안 냉각시키고, 돈육에 대한 이화학적 분석, 육색, 지방산 조성 및 관능평가를 실시하였다. 일반 성분 결과 수분 및 보수력은 두 품종간의 유의한 차이를 나타내지 않았다. 지방 함량 및 가열감량은 LYW에서 LYD에 비해 유의적으로 높게 나타났고(p <0.05), 전단력 및 pH는 LYW가 LYD보다 유의적으로 낮게 나타났다(p <0.05). 육색지수를 확인한 결과 적색도(a*) 및 황색도(b*)가 LYW에서 유의적으로 높게 나타났다(p <0.05). 두 품종의 지방산 함량을 비교한 결과 Stearic acid(C18:0)가 LYD에 비해 LYW에서 유의적으로 높게 나타났다(p <0.05). 관능검사 결과 LYW가 LYD에 비해 육색과 풍미가 유의적으로 높게 나타났다(p <0.05). 이러한 결과는 LYD와 비교하여 LYW에서 특정 화학적 특징이 개선되었음을 나타낸다. 따라서 우리흑돈이 수입 종돈인 두록의 대체 종돈으로 사용 가능할 것으로 사료된다. This study was undertaken to investigate whether the local Woori black pigs could replace Duroc as the terminal sire in order to reduce foreign currency outgoings. This study compared the physicochemical properties of pork loins in two cultivars of three-way crossbred pigs: Landrace X Yorkshire X Duroc (LYD) and Landrace X Yorkshire X Woori black pig (LYW). A total of 119 pigs (59 LYD and 60 LYW) aged 180 days were used in the experiment. After 24 hours of cooling, pork loins were assessed for their physicochemical traits, meat color, fatty acid and sensory evaluation. The moisture content and water holding capacity showed no significant difference between the two cultivars. Fat content and cooking loss were significantly higher in LYW than in LYD (p<0.05), whereas shear force and pH were significantly lower in LYW than LYD (p<0.05). Redness (a*), yellowness (b*), and stearic acid (C18: 0) content were also significantly higher in LYW than in LYD (p<0.05). Sensory evaluation revealed significantly higher meat color and flavor in LYW than LYD (p<0.05). Taken together, these results indicate that certain physicochemical qualities are improved in the LYW cultivar, as compared to LYD. Therefore, Woori black pig (W) has the potential to be substituted for Duroc, a breeding pig used currently.

Fast fabrication of mesoporous SiC with high and highly ordered porosity from ordered silica templates

Milena Zorko,Saša Novak,Miran Gaberscek 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.6

Three-dimensional (3D) mesoporous SiC samples with highly ordered porosity were prepared using three different routes. The essential difference was in the first step in which sacrificial uniform silica spheres were packed into ordered three-dimensional arrays using: i) sedimentation, ii) centrifugation and iii) electrophoretic deposition (EPD) methods. Regardless of the method used, the quality of arrays was quite high and reproducible. The prepared silica arrays were infiltrated with a pre-ceramic polymer precursor. The infiltration step was followed by a thermal curing step, a pyrolysis step at 850 oC in an Ar atmosphere and, finally, removal of the silica templates by etching with a 3M NaOH solution. The final products were porous 3D SiC samples with typical volumes around 1 cm3 and a pore size of 240 or 650 nm. The synthesized porous SiC was characterized using SEM, TEM and XRD methods.

Quantification of Aging-Related Decreases in Sensory Innervation of the Bladder Trigone in Rats

Mathijs M. de Rijk,Saša Peter,Amanda Wolf-Johnston,John Heesakkers,Gommert A. van Koeveringe,Lori A. Birder 대한배뇨장애요실금학회 2024 International Neurourology Journal Vol.28 No.-

Purpose: The prevalence of lower urinary tract symptoms (LUTS), characterized by problems regarding storage and/or voiding of urine, is known to significantly increase with age. Effective communication between the lower urinary tract and the central nervous system (CNS) is essential for the optimal function of this system, and heavily relies on the efficient interaction between the bladder urothelium and the afferent nerve fibers situated in close proximity to the urothelium within the lamina propria. Methods: We aimed to quantify aging-related differences in the expression of calcitonin gene-related peptide (CGRP, an established marker for sensory nerve fibers) in the trigonal mucosal layers of young (3–4 months) and aged (25–30 months) rats. We evaluated trigonal tissue from 3 animals per age group. Tissue was serially sectioned at 10 μm and stained for CGRP. Images were taken along the full length of the tissue. For each image we computed the total CGRP-positive area (μm2 ) and the median value for each animal was used for further analysis. Results: Upon statistical analysis the aged rats show a significantly lower CGRP-positive area compared to young rats (P=0.0049). These results indicate that aging has a negative effect on the area of CGRP-positive signal in the trigone. Conclusions: The structural and functional integrity of the sensory web in the trigonum of rats is negatively affected by the aging process, potentially leading to impaired communication between the bladder urothelium the CNS. Consequently, these perturbations in the sensory system may contribute to the pathogenesis or exacerbation LUTS.

Influence of different surface treatments on bond strength of novel CAD/CAM restorative materials to resin cement

Meltem Bektaş Kömürcüoğlu,Elçin Sağırkaya,Ayça Tulga 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.6

PURPOSE. To evaluate the effects of different surface treatments on the bond strength of novel CAD/CAM restorative materials to resin cement by four point bending test. MATERIALS AND METHODS. The CAD/CAM materials under investigation were e.max CAD, Mark II, Lava Ultimate, and Enamic. A total of 400 bar specimens (4×1.2×12 mm) (n=10) milled from the CAD/CAM blocks underwent various pretreatments (no pretreatment (C), hydrofluoric acid (A), hydrofluoric acid + universal adhesive (Scotchbond) (AS), sandblasting (Sb), and sandblasting + universal adhesive (SbS)). The bars were luted end-to-end on the prepared surfaces with a dual curing adhesive resin cement (Variolink N, Ivoclar Vivadent) on the custom-made stainless steel mold. Ten test specimens for each treatment and material combination were performed with four point bending test method. Data were analyzed using ANOVA and Tukey’s test. RESULTS. The surface treatment and type of CAD/CAM restorative material showed a significant effect on the four point bending strength (FPBS) (P<.001). For LDC, AS surface treatment showed the highest FPBS results (100.31 ± 10.7 MPa) and the lowest values were obtained in RNC (23.63 ± 9.0 MPa) for control group. SEM analyses showed that the surface topography of CAD/CAM restorative materials was modified after treatments. CONCLUSION. The surface treatment of sandblasting or HF acid etching in combination with a universal adhesive containing MDP can be suggested for the adhesive cementation of the novel CAD/CAM restorative materials.

Diagnostic Yield and Therapeutic Impact of Rectal Retroflexion: A Prospective, Single-Blind Study Conducted in Three Centers

Félix Téllez-Ávila,Josué Barahona-Garrido,Sandra García-Osogobio,Gustavo López-Arce,Jesús Camacho-Escobedo,Angela Saúl,Salvador Herrera-Gómez,Javier Elizondo-Rivera,Rafael Barreto-Zúñiga 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.1

Background/Aims: No clear data have been established and validated regarding whether rectal retroflexion has an important and therapeutic impact. The aim of the present study was to evaluate the diagnostic yield and therapeutic impact of rectal retroflexion compared with straight view examination. Methods: A prospective single-blind study was conducted. Consecutive patients evaluated between October 2011 and April 2012 were included. Results: A total of 934 patients (542 women [58%]) were included. The mean age was 57.4±14.8 years. Retroflexion was successful in 917 patients (98.2%). Distinct lesions in the anorectal area were detected in 32 patients (3.4%), of which 10 (1%) were identified only on retroflex view and 22 (2.4%) on both straight and retroflex views. Of the 32 identified lesions, 16 (50%) were polyps, nine (28.1%) were angiodysplasias, six (18.8%) were ulcers, and one (3.1%) was a flat lesion. All 10 patients (1%) in whom lesions were detected only by rectal retroflexion showed a therapeutic impact. Conclusions: Rectal retroflexion has minimal diagnostic yield and therapeutic impact. However, its low rate of major complications and the possibility of detecting lesions undetectable by straight viewing justify its use.