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Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4
Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.
이기환,김영유,두영뢰,우배매 公州大學校 基礎科學硏究所 1998 自然科學硏究 Vol.7 No.-
The photoluminescence (PL) spectra from p-type a-porous silicon carbides prepared under UV photo-assisted process and under dark-current condition are investigated in detail. Emission bands with peak energies of 2.35, 2.50, 2.70, and 3.43 are resolved. The PL stability in tune and the PL difference arising from different tuning excitation energies are studied. It is found that the PL spectra of the a-porous silicon carbide depend strongly on the preparation conditions for electrochemical etching. The PL spectrum of the sample prepared under photo-assisted process has an enhancement on the lower-energy side of the emission; on the contray, another one under dark-current condition has an enhancement at the higher energy side, and the former stability is better than the latter one, and the latter PL intensity decreases with the increase of the time in the air. The reasons about these differences are discussed.
Wu, Si-Ying,Park, Gil-Yong,Kim, So-Hee,Hulme, John,An, Seong Soo A Dove Medical Press 2016 Drug design, development and therapy Vol.10 No.-
<P>The aim of this study was to investigate the bacteriostatic and bactericidal effects of diminazene aceturate (DA) against five strains of pathogenic bacteria and two strains of nonpathogenic bacteria. The results showed that 5 μg/mL of DA suppressed the growth of pathogenic <I>Escherichia coli</I> by as much as 77% compared with the controls. Enterohemorrhagic <I>E. coli</I> EDL933 (an <I>E. coli</I> O157:H7 strain) was the most sensitive to DA with a minimum inhibitory concentration of 20 μg/mL. Additional investigations showed that DA induced the highest level of intracellular reactive oxygen species in EDL933. A positive correlation between the reactive oxygen species levels and DA concentration was demonstrated. DA (5 μg/mL) was also a potent uncoupler, inducing a stationary phase collapse (70%–75%) in both strains of <I>E. coli</I> O157:H7. Further investigation showed that the collapse was due to the NaCl:DA ratio in the broth and was potassium ion dependent. A protease screening assay was conducted to elucidate the underlying mechanism. It was found that at neutral pH, the hydrolysis of H-Asp-pNA increased by a factor of 2–3 in the presence of DA, implying that DA causes dysregulation of the proton motive force and a decrease in cellular pH. Finally, a commercial verotoxin test showed that DA did not significantly increase toxin production in EDL933 and was a suitable antibacterial agent for Shiga-toxin-producing <I>E. coli</I>.</P>
Wu Bin Ying,장지욱,이민우,황택성,이경진,이범재 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.47 No.-
The sulfonated phenyl functionalized polystyrene-butadiene random copolymer was synthesized forapplication asflexible ion-exchange material. The polymer was prepared through phenyl functionalizationvia thiol-ene reaction and sulfonation of the base polystyrene-butadiene copolymer with differentvinyl contents and phenyl contents. Sulfonation on phenyl functionalized polystyrene-butadienecopolymer was carried out in 1,2-dichloroethane at room temperature using the acetyl sulfonate as thesulfonation agent which was prepared from the reaction of acetyl acetate with sulfuric acid. Thesulfonation degrees were adjusted from 7.3 mol% to 24.3 mol% determined by elemental analysis (EA)with great ion exchange capacity (0.60–2.26 meq/g), conductivity (0.47–6.1 mS/cm) and lower wateruptake (5.1–12.8 wt.%). These excellent characteristics lead to great potential using as theflexibleion-exchange material.
Wu Bin Ying,배기현,고나영,김수희,류삼곤,Jin Zhu,Ruoyu Zhang,이범재,이경진 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Polymer-based catalysts have been of special interest because of their several advantages such as easyprocessibility. Inorganic catalyst generally have been introduced into polymer-based media to endowcatalytic activity. Surface decoration or sol–gel reaction have been performed so far, but inherent lowaffinity between organic/inorganic causes low efficiency in loading amount, resulting in low catalyticactivity. Herein, we synthesized easily processible and highly functionalizable polyoxazoline as polymernonwovenfiber-based catalytic supporter. Zr(OH)4 was grown on surface offiber-web via sol–gelreaction. The Zr(OH)4 grownfiber exhibited not only excellent mechanical properties but also effectivedecontamination efficiency against organophosphate-based toxic agents.
Ying, Wu Bin,Jang, Ji Uk,Lee, Min Woo,Hwang, Taek Sung,Lee, Kyung Jin,Lee, Bumjae Elsevier 2017 Journal of industrial and engineering chemistry Vol.47 No.-
<P><B>Abstract</B></P> <P>The sulfonated phenyl functionalized polystyrene-butadiene random copolymer was synthesized for application as flexible ion-exchange material. The polymer was prepared through phenyl functionalization via thiol-ene reaction and sulfonation of the base polystyrene-butadiene copolymer with different vinyl contents and phenyl contents. Sulfonation on phenyl functionalized polystyrene-butadiene copolymer was carried out in 1,2-dichloroethane at room temperature using the acetyl sulfonate as the sulfonation agent which was prepared from the reaction of acetyl acetate with sulfuric acid. The sulfonation degrees were adjusted from 7.3mol% to 24.3mol% determined by elemental analysis (EA) with great ion exchange capacity (0.60–2.26meq/g), conductivity (0.47–6.1mS/cm) and lower water uptake (5.1–12.8wt.%). These excellent characteristics lead to great potential using as the flexible ion-exchange material.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Magnetic Resonance Image Manifestations of the Atypical Meningioma
Wu, Qing-Wu,Yan, Rui-Fang,Li, Qiang,Hu, Ying,Zhou, Feng-Mei,Ren, Ji-Peng,Yang, Rui-Min,Zhang, Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Through retrospective analysis of 13 cases of magnetic resonance image (MRI) manifestations of atypical meningiomas confirmed by operation and pathology in the First Affiliated Hospital of Xinxiang Medical University, the objective of this study was to evaluate the diagnostic value of MRI in order to improve the accuracy rate of preoperative diagnosis. In this retrospective analysis of MRI findings for atypical meningiomas in First Affiliated Hospital of Xinxiang Medical University from January to July in 2012, the location, morphology and tumor signals and other tumor imaging characteristics were covered. In 13 cases of atypical meningioma patients of this group, most tumors were located at typical sites (10/13), mainly the falx cerebri, parasagittal, convexity, saddle area. Only two cases were at atypical locations, 1 in the cerebellar hemisphere and 1 in a lateral ventricle. Most of the tumors showed T1 and T2 isointensity signals, and necrosis, calcification, and peritumoral edema were always featured. DWI showed isointensity in 11 cases (11/13), and hyperintensity in 2. Some 9 cases had dural tail signs, 12 had accurate positioning (12/13), and 2 were postoperative recurrences. MRI has high value in the diagnosis of atypical meningiomas, with important roles in early clinical diagnosis, treatment and prognosis evaluation.