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장지욱,이봉,한창환,이일우,이해방,강길선,이상진 한국생체재료학회 2003 생체재료학회지 Vol.7 No.2
Polymeric scaffolds for tissue engineering must be either manufactured aspectically or sterilized after processing. Biodegradable polymers are necessary to sterilize all medical implants after fabrication prior to their surgical placement to reduce the risk of infections and associated complications. For sterilization processing, the general requirements of polymeric scaffolds are non-toxicity, tissue compatibility, and preservation of its properties. But, sterilization techniques can significantly affect the properties of polymer scaffold. In addition, they can leave harmful residues on these materials causing them to fail in vivo. The goal of this study was to determine the optimal sterilization technique without causing damage slightly to successful tissue engineering. The plasma sterilization method was compared to two well-established techniques; ethylene oxide and -irradiation. We evaluated changes of molecular weight by gel permeation chromatography and change of pore structure by various sterilization methods by scanning electron microscopy. We observed increasing wettability of plasma treated scaffold according to 0.01 w/v% brilliant blue dye dropping method and water absorption. Our results show that plasma treatment is the most suitable sterilization method of polymeric scaffolds for tissue engineering applications.