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Linh Thi Thao Nguyen,송연우,Thao Anh Tran,김기석,김소미 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is aspecial form of apoptosis in which cells loose contact with othercells or the extracellular matrix. In the present study, we havefound that the breast cancer stem cell line MCF-7-SC, isolatedfrom MCF-7 breast cancer cells, shows characteristics of anoikisresistance. Treatment of supercritical CO2 extract from Citrushassaku Hort ex Tanaka, locally known as Phalsak, reduced theexpression of ATP-binding cassette sub-family G member 2mRNA and induced apoptosis in MCF-7-SCs, as evidenced by anincrease of apoptotic body formation, increased cell population inthe sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolyticactivation of caspase-9 and caspase-3, and the degradation ofpoly(ADP-ribose) polymerase (PARP) protein. The effects ofsupercritical CO2 extract from Phalsak on anoikis-resistant breastcancer stem cells suggest the use of this extract as a potentialtherapeutic agent for breast cancer stem cell treatment.
Nguyen, Linh Thi Thao,Song, Yeon Woo,Tran, Thao Anh,Kim, Ki-Seok,Cho, Somi Kim The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is a special form of apoptosis in which cells loose contact with other cells or the extracellular matrix. In the present study, we have found that the breast cancer stem cell line MCF-7-SC, isolated from MCF-7 breast cancer cells, shows characteristics of anoikis resistance. Treatment of supercritical $CO_2$ extract from Citrus hassaku Hort ex Tanaka, locally known as Phalsak, reduced the expression of ATP-binding cassette sub-family G member 2 mRNA and induced apoptosis in MCF-7-SCs, as evidenced by an increase of apoptotic body formation, increased cell population in the sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolytic activation of caspase-9 and caspase-3, and the degradation of poly(ADP-ribose) polymerase (PARP) protein. The effects of supercritical $CO_2$ extract from Phalsak on anoikis-resistant breast cancer stem cells suggest the use of this extract as a potential therapeutic agent for breast cancer stem cell treatment.
Anti-inflammatory and Immunosuppressive Effects of Panax notoginseng
Thao Quyen Cao,한재혁,이현수,HAMANH TUAN,우미희,민병선 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Here, we designed to examine the anti-inflammatory effects on RAW264.7 cells and the immunosuppressive effects by evaluating interleukin-2 (IL-2) production in Jurkat T cells using a MeOH extract of Panax notoginseng roots. The results showed that the MeOH extract inhibited the synthesis of nitric oxide (NO) in a dose-dependent manner (IC50 value of 7.08 µg/mL) and displayed effects on T cell activation at a concentration of 400 µg/mL. In efforts to identify the potent compounds, bioactivity-guided fractionation of the MeOH extract and chemical investigation of its active CH2Cl2-, EtOAc-, and butanol- soluble fractions led to the successful isolation and identification of eleven compounds, including two polyacetylenes (1, 2), a steroid saponin (3), seven dammarane-type ginsenosides (4 – 10), and an oleanane-type ginsenoside (11). Among them, compound 11 was isolated from this plant for the first time. Compound 2 exhibited potent inhibitory effects on NO synthesis and an immunosuppressive effect with IC50 values of 2.28 and 65.57 µM, respectively.
Thao T. D. Tran,Thinh D. Luu,Beom‑Jin Lee,Phuong H. L. Tran 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.1
Sprouted grains, which is a natural polysaccharide, is the subject of increasing scientific interest due to many benefits for human health. The aim of the present work was to develop sprouted rice (SR) as a safe and useful material for application in dissolution enhancement of anticancer poorly water-soluble drugs such as curcumin by solid dispersions (SDs). SDs were prepared with pure SR and modified sprouted rice (MSR) by the melting method. The dissolution rate, drug crystallinity changes, molecular interactions and wettability were characterized and compared between the formulations. The use of MSR could result in a promising system for improving the dissolution rate of poorly water-soluble drugs. MSR could induce a greater amorphous state and improved wettability of drugs for dissolution enhancement compared to SR. Although both SR and MSR showed hydrogen bonding interaction, insignificant differences between SR and MSR were observed. We found that the crystallinity, interactions and wettability of the drug were significantly affected and modulated by MSR.
Thao Tram Le Nguyen,Xuan Loc Vu Doan,Vy Thuc Nguyen 아시아심장혈관영상의학회 2021 Cardiovascular Imaging Asia Vol.5 No.3
In the published article, “Anomalous Left Coronary Artery from the Pulmonary Artery Syndrome: A Case Report in a 49-Year-Old Woman”, the affiliation was published incorrectly. 1Diagnostic Imaging Department, Vinmec Nha Trang International Hospital, Nha Trang, Vietnam The affiliation should be corrected as follows. Changes are marked by underlines: 1Diagnostic Imaging Department, Vinmec Nha Trang International Hospital, Vinmec Healthcare System, Nha Trang, Vietnam
Thao, Le Quang,Lee, Changkyu,Kim, Bomi,Lee, Sungin,Kim, Tae Hwan,Kim, Jong Oh,Lee, Eun Seong,Oh, Kyung Taek,Choi, Han-Gon,Yoo, Sun Dong,Youn, Yu Seok Elsevier 2017 Colloids and surfaces Biointerfaces Vol.152 No.-
<P><B>Abstract</B></P> <P>Anticancer drug targeting to liver asialoglycoprotein receptors (ASGPR) is viewed as a good approach for hepatocellular carcinoma (HCC) treatment. Lactose residue is a promising ASGPR ligand due to its high receptor affinity. Herein, we introduce doxorubicin and paclitaxel co-bound lactosylated albumin (Lac-BSA) nanoparticles (Dox/Pac Lac-BSA NPs) with good liver targetability. Lac-BSA was synthesized by conjugating lactobionic acid to naïve BSA then characterized by mass spectrometry. Dox/Pac Lac-BSA NPs were fabricated utilizing high-pressure homogenization and evaporation with Nab<SUP>®</SUP> (nanoparticle albumin bound) technology. Dox/Pac Lac-BSA NPs were spherical and well-dispersed, with a 148.7±13.8nm particle size and −54.1±0.7mV zeta potential at a 100% Lac-BSA feed ratio. Combined Dox and Pac synergistic cytotoxicity was confirmed in Hep G2 cells. Specifically, the inhibitory concentration (IC<SUB>50</SUB>; 0.21±0.02μg/ml) for Dox/Pac Lac-BSA NPs was 3.2 time lower than plain Dox/Pac BSA NPs (IC<SUB>50</SUB>; 0.68±0.04μg/ml). Also, Dox/Pac Lac-BSA NPs exhibited better internalizing in Hep G2 cells (61.8% vs. 14.4% for Dox) and spheroids compared to Dox/Pac BSA NPs. Finally, Dox/Pac Lac-BSA NPs displayed much greater localization into ICR mice livers compared to Dox/Pac BSA NPs. This was indicated by the presence of NP lactose residues revealed by a galactose inhibition study. Based on these results, we suggest that lactose-modified albumin-based nanoparticles fabricated with the Nab<SUP>®</SUP> technique can be a potential therapeutic vector for treating HCC via hepatocyte targeting.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Thao-Vy PHAM,Yung-Fu HUANG,Manh-Hoang DO 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.1
This paper aims to evaluate the effects of Critical work factors on Work Motivation and Job Satisfaction of young Vietnamese employees. The four most essential work aspects were consisting of the Work environment, Employee empowerment, Salary, and Promotion opportunities. To empirically evaluate the proposed research model, the authors assemble data through conducting questionnaire interviews with young employees working in Vietnamese firms. A sample of 216 respondents was constructed using the PLS-SEM program to highlight the testing of thirteen hypotheses. The testing results indicate that four Critical work factors positively impact the job motivation of young employees, especially two factors as Salary and Promotion opportunities. Surprisingly, the hypothesis regarding the positive direct relationship between Promotion opportunities and Job satisfaction is not supported. Meanwhile, the rest influence factors have a significant connection with the Vietnamese worker’s job satisfaction. The mediation role of Work motivation was also tested by examining the indirect positive relationship between four Critical work factors and Job satisfaction. This paper is the first study that focuses on young employees; hence, these research findings provide Vietnamese human resource managers some suggestions for reference, which can be considered the dynamic factors on the young Vietnamese employees.
An Evaluation Approach for Prediction of Process Parameters with Genetic Algorithm
Thao, D.T.,Kim, Il Soo Trans Tech Publications, Ltd. 2008 Materials science forum Vol.580 No.-
<P>Gas Metal Arc (GMA) welding process has widely been employed due to the wide range of applications, cheap consumables and easy handling. A suitable mathematical model to achieve a high level of welding performance and quality should be required to study the characteristics for the effects of process parameters on the bead geometry in the GMA welding process. The objective of this paper is to present development of three empirical models (linear, curvilinear and intelligent model) based on full factorial design with two replications to estimate process parameters on top-bead width in robotic GMA welding process. Regression analysis was employed for optimization of the coefficients of linear and curvilinear models, but Genetic Algorithm (GA) was utilized to estimate the coefficients of intelligent model. ANOVA analysis using experimental data were carried out representation of main and interaction effects between process parameters on top-bead width. Resulting solutions and graphical representation showed that the developed intelligent model can be used for prediction on top-bead width in robotic GMA welding process</P>