http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Linh Thi Thao Nguyen,송연우,Thao Anh Tran,김기석,김소미 한국응용생명화학회 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is aspecial form of apoptosis in which cells loose contact with othercells or the extracellular matrix. In the present study, we havefound that the breast cancer stem cell line MCF-7-SC, isolatedfrom MCF-7 breast cancer cells, shows characteristics of anoikisresistance. Treatment of supercritical CO2 extract from Citrushassaku Hort ex Tanaka, locally known as Phalsak, reduced theexpression of ATP-binding cassette sub-family G member 2mRNA and induced apoptosis in MCF-7-SCs, as evidenced by anincrease of apoptotic body formation, increased cell population inthe sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolyticactivation of caspase-9 and caspase-3, and the degradation ofpoly(ADP-ribose) polymerase (PARP) protein. The effects ofsupercritical CO2 extract from Phalsak on anoikis-resistant breastcancer stem cells suggest the use of this extract as a potentialtherapeutic agent for breast cancer stem cell treatment.
Nguyen, Linh Thi Thao,Song, Yeon Woo,Tran, Thao Anh,Kim, Ki-Seok,Cho, Somi Kim The Korean Society for Applied Biological Chemistr 2014 Applied Biological Chemistry (Appl Biol Chem) Vol.57 No.4
Anoikis (or cell-detachment-induced apoptosis) is a special form of apoptosis in which cells loose contact with other cells or the extracellular matrix. In the present study, we have found that the breast cancer stem cell line MCF-7-SC, isolated from MCF-7 breast cancer cells, shows characteristics of anoikis resistance. Treatment of supercritical $CO_2$ extract from Citrus hassaku Hort ex Tanaka, locally known as Phalsak, reduced the expression of ATP-binding cassette sub-family G member 2 mRNA and induced apoptosis in MCF-7-SCs, as evidenced by an increase of apoptotic body formation, increased cell population in the sub-G1 phase, increase in the Bax/Bcl-2 ratio, proteolytic activation of caspase-9 and caspase-3, and the degradation of poly(ADP-ribose) polymerase (PARP) protein. The effects of supercritical $CO_2$ extract from Phalsak on anoikis-resistant breast cancer stem cells suggest the use of this extract as a potential therapeutic agent for breast cancer stem cell treatment.
Thao, Trinh Thi,Kim, Cheolyong,Hwang, Inseong Korean Society of Soil and Groundwater Environment 2017 지하수토양환경 Vol.22 No.1
Persulfate (PS) activated with nanosized zero-valent iron (NZVI) was tested as a reagent to remove phenol from groundwater. Batch degradation experiments indicated that NZVI/PS molar ratios between 1 : 2 and 1 : 5 were appropriate for complete removal of phenol, and that the time required for complete removal varied with different PS and NZVI dosages. Chloride ions up to 100 mM enhanced the phenol oxidation rate, and nitrate of any concentration up to 100 mM did not significantly affect the oxidation rate. NZVI showed greater performance than ferrous iron did as an activator for PS. A by-product was formed along with phenol degradation but subsequently was completely degraded, which showed the potential to attain mineralization with the NZVI/PS system. Tests with radical quenchers indicated that sulfate radicals were a predominant radical. The results of this study suggest that NZVI is a promising activator of PS for treating contaminated groundwater.
Thao Thi Nguyen,이현희,박중욱,박인명,서영수 한국식물병리학회 2017 Plant Pathology Journal Vol.33 No.2
As a step towards discovering novel pathogenesisrelatedproteins, we performed a genome scale computationalidentification and characterization of secretedand transmembrane (TM) proteins, which are mainlyresponsible for bacteria-host interactions and interactionswith other bacteria, in the genomes of six representativeBurkholderia species. The species comprisedplant pathogens (B. glumae BGR1, B. gladioli BSR3),human pathogens (B. pseudomallei K96243, B. cepaciaLO6), and plant-growth promoting endophytes (Burkholderiasp. KJ006, B. phytofirmans PsJN). The proportionsof putative classically secreted proteins (CSPs)and TM proteins among the species were relativelyhigh, up to approximately 20%. Lower proportionsof putative type 3 non-classically secreted proteins(T3NCSPs) (~10%) and unclassified non-classicallysecreted proteins (NCSPs) (~5%) were observed. Thenumbers of TM proteins among the three clusters(plant pathogens, human pathogens, and endophytes)were different, while the distribution of these proteinsaccording to the number of TM domains was conservedin which TM proteins possessing 1, 2, 4, or 12TM domains were the dominant groups in all species. In addition, we observed conservation in the proteinsize distribution of the secreted protein groups amongthe species. There were species-specific differences inthe functional characteristics of these proteins in thevarious groups of CSPs, T3NCSPs, and unclassifiedNCSPs. Furthermore, we assigned the complete setsof the conserved and unique NCSP candidates of thecollected Burkholderia species using sequence similaritysearching. This study could provide new insightsinto the relationship among plant-pathogenic, humanpathogenic,and endophytic bacteria.
Thao Phan Thi Dieu LE,Hieu Luong Minh TRAN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
Using a DCC – GARCH model analysis, this paper examines the existence of financial contagion from the U.S. stock market to the Vietnamese and the Philippine stock markets during the global financial crisis and the COVID-19 pandemic crisis. We use daily data from the S&P 500 (U.S.), VN-Index (Vietnam), and the PSEi (the Philippines). As a result, there is no evidence of contagion from the U.S stock market to the Philippine stock market that can be found during global financial crisis, while the Vietnamese market is influenced by this effect. Besides, both these developing stock markets (the Vietnamese and Philippine stock markets) are influenced by the contagion effect in COVID-19 pandemic crisis. Another finding is that the contagion effect during the coronavirus pandemic crisis in Vietnam is smaller than that during the global financial crisis, however, the opposite is the case for the Philippines. It is noticed that the Philippines seems to be more affected by the contagion effect from the COVID-19 pandemic than Vietnam at the time of this study. Because financial contagion is important for monetary policy, asset pricing, risk measurement, and portfolio allocation, the findings in this paper may give some useful information for policymakers and investors.
Thao Nguyen Vu,Jung-Hyun Byun,Roshan D’Souza,Naina Adren Pinto,Le Phuong Nguyen,DongeunYong,Yunsop Chong 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.1
Background: The existing modified carbapenem inactivation methods (mCIMs) recommended by the CLSI for detecting carbapenemase production have not been applicable for Acinetobacter baumannii. We evaluated the influence of matrices used in mCIMs and CIMTris on the stability of the disks for detecting carbapenemase producers and suggested optimal mCIM conditions for detecting carbapenemase-producing A. baumannii. Methods: Seventy-three A. baumannii isolates characterized for antimicrobial susceptibility and carbapenemase encoding genes were tested for carbapenemase production using mCIM and CIMTris. The influence of the matrices (Tryptic soy broth [TSB] and Tris-HCl) used in these methods on the stability of the meropenem (MEM) disk was also evaluated. The mCIM conditions were adjusted to enhance screening sensitivity and specificity for detecting carbapenemase-producing A. baumannii. Results: The matrices had an impact on the stability of the MEM disk after the incubation period (two or four hrs). TSB nutrient broth is an appropriate matrix for mCIM compared with Tris-HCl pH 7.6, which leads to the loss of MEM activity in CIMTris. The sensitivity and the specificity of the optimal mCIM were both 100%. Conclusions: We established optimal mCIM conditions for simple, accurate, and reproducible detection of carbapenemase-producing A. baumannii.
Recovering Incomplete Data using Tucker Model for Tensor with Low-n-rank
Thao Nguyen Thieu,Hyung-Jeong Yang,Tien Duong Vu,Sun-Hee Kim 한국콘텐츠학회 2016 International Journal of Contents Vol.12 No.3
Tensor with missing or incomplete values is a ubiquitous problem in various fields such as biomedical signal processing, image processing, and social network analysis. In this paper, we considered how to reconstruct a dataset with missing values by using tensor form which is called tensor completion process. We applied Tucker factorization to solve tensor completion which was built base on optimization problem. We formulated the optimization objective function using components of Tucker model after decomposing. The weighted least square matric contained only known values of the tensor with low rank in its modes. A first order optimization method, namely Nonlinear Conjugated Gradient, was applied to solve the optimization problem. We demonstrated the effectiveness of the proposed method in EEG signals with about 70% missing entries compared to other algorithms. The relative error was proposed to compare the difference between original tensor and the process output.
Genome-Wide Analysis of Type VI System Clusters and Effectors in Burkholderia Species
Thao Thi Nguyen,이현희,박인명,서영수 한국식물병리학회 2018 Plant Pathology Journal Vol.34 No.1
Type VI secretion system (T6SS) has been discovered in a variety of gram-negative bacteria as a versatile weapon to stimulate the killing of eukaryotic cells or prokaryotic competitors. Type VI secretion effectors (T6SEs) are well known as key virulence factors for important pathogenic bacteria. In many Burkholderia species, T6SS has evolved as the most complicated secretion pathway with distinguished types to translocate diverse T6SEs, suggesting their essential roles in this genus. Here we attempted to detect and characterize T6SSs and potential T6SEs in target genomes of plantassociated and environmental Burkholderia species based on computational analyses. In total, 66 potential functional T6SS clusters were found in 30 target Burkholderia bacterial genomes, of which 33% possess three or four clusters. The core proteins in each cluster were specified and phylogenetic trees of three components (i.e., TssC, TssD, TssL) were constructed to elucidate the relationship among the identified T6SS clusters. Next, we identified 322 potential T6SEs in the target genomes based on homology searches and explored the important domains conserved in effector candidates. In addition, using the screening approach based on the profile hidden Markov model (pHMM) of T6SEs that possess markers for type VI effectors (MIX motif) (MIX T6SEs), 57 revealed proteins that were not included in training datasets were recognized as novel MIX T6SE candidates from the Burkholderia species. This approach could be useful to identify potential T6SEs from other bacterial genomes.