정자형성 과정에서 Vascular Endothelial Growth Factor 및 Endothelin-1 발현의 면역조직화학적 연구

박성우,박현준,박남철,Park, Sung-Woo,Park, Hyun-Jun,Park, Nam-Cheol 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.4

Objective: The effects on spermatogenesis by expression of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) were investigated. Materials and Methods: Testicular specimens were obtained from 40 infertile males due to primary testicular failure and from 10 fertile males with other urologic problems. The specimens of infertile males were devided into 4 groups according to histologic findings; Sertoli cell only syndrome (A), maturation arrest (B), hypospermatogenesis (C) and sloughing and disorganization (D). VEGF and ET-1 expression were detected with immunohistochemical stain. Results: VEGF expression on Leydig cell was detected in all cases. But, VEGF expression rates on germ cell were significantly higher in infertile group B, C, D compared to that of the control group (p<0.05). ET-1 expression rates on Leydig cell was significantly lower in all infertile group compared to that of the control group (p<0.05). But, ET-1 expression rates on Sertoli cell was significantly higher in all infertile group compared to that of the control group (p>0.05). In germ cell of infertile group, LH, FSH and prolactin were significantly decreased, and estradiol is increased in positive stain group on ET-1 immunohistochemical stain (p<0.05). VEGF and ET-1 expression were not correlated mean seminiferous tubule diameter (p>0.05). Conclusions: Abnormal spermatogenesis would be reflected in VEGF expression in germ cell.

o-Chlorobenzylidenemalononitrile의 가수분해 및 분석에 관한 연구

박성우,김남이,김동환,홍성욱,성낙도,김일광,오인교,Park, Sung-Woo,Kim, Nam-Yee,Kim, Dong-Hwan,Hong, Sung-Work,Sung, Nack-Do,Kim, Il-Kwang,Oh, In-Kio 한국분석과학회 1992 분석과학 Vol.5 No.4

o-Chlorobenzylidenemalononitrile(CS), chloroacetophenone 및 bromophenylacetonitrile의 이성질체와 같은 최루 자극성 물질들의 가수분해, 산화, 환원, 열분해 및 대사에 의한 화합물의 분석은 법과학적 측면에서 주요한 의미가 있다. 본 실험에서는 10% MeOH-$H_2O$ 및 10% dioxane-$H_2O$ 용액에서 pH 1.0~11.0과 온도 변화에 따른 CS의 가수분해 조건을 검토하고 가수분해 생성물이 o-chlorobenzaldehyde와 malononitrile임을 분광학적 방법 및 전기화학적 방법에 의해 확인하였다. The analysis, hydrolysis mechanism, oxidation, reduction, thermal decomposition and metabolism of irritant materials such as chloroacetophenone isomers, bromophenylacetonitrile isomers, o-chlorobenzylidenemalononitrile(CS), and ethylisothiocyanate, etc. are interested in forensic science. We had studied hydrolysis of CS in 10% MeOH-$H_2O$ and 10% dioxane-$H_2O$ at pH 1.0~11.0 and various temperatures. As a result, we identified o-chlorobenzaldehyde and malononitrile that were formed by hydrolysis of CS by using gas chromatography/mass spectrometry, UV/Vis spectrometry, and polarographic method.

Trimethylgermanium화합물과 ${\beta}$-propiolactone의 반응

박성우,서배석,김갑주,이일규,Sung-Woo Park,Bae-Seok Seo,Ghap-Ju Ghim,Il-Kyu Lee 대한화학회 1985 대한화학회지 Vol.29 No.5

우울증과 항우울작용에 관한 p11(S100A10)의 역할

박성우,서미경,이정구,김영훈,Park, Sung Woo,Seo, Mi Kyong,Lee, Jung Goo,Kim, Young Hoon 대한생물정신의학회 2016 생물정신의학 Vol.23 No.1

p11 protein (S100A10) is downregulated in depressive-like states of human and rodent. Antidepressant drug treatment increases p11 levels in rodent models. We reviewed studies demonstrating that p11 levels are regulated in depression and by antidepressant treatment and that p11 upregulation exerts antidepressant effects. Current studies on p11 underscore the importance of p11 as a potential antidepressant target.

경피적 신동맥 혈관 성형술로 치료한 신혈관 고혈압증 1례

박성우,정수호,전용선,전용훈,홍영진,이지은,Park, Sung-Woo,Jeong, Su-Ho,Jeong, Young-Sun,Jun, Yong-Hoon,Hong, Young-Jin,Lee, Ji-Eun 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.1

신성 고혈압은 소아기 이차성 고혈압의 흔한 원인이며, 그 중 신동맥 협착에 의한 신혈관성 고혈압은 치료 가능한 고혈압의 가장 흔한 원인이다. 신혈관성 고혈압 치료로 최근 경피적 신동맥 혈관 성형술은 비침습적인 방법으로 각광 받고 있다. 저자들은 작은 직경을 가진 신동맥 분지 혈관 협착에 의한 신혈관성 고혈압 소아에서 관상동맥용으로 쓰이는 풍선 카테터를 이용하여 경피적 신동맥혈관 성형술을 성공적으로 시행한 경험을 하였으므로 보고하는 바이다. Renovascular hypertension results from a lesion that impairs blood flow to a part of or all, of one or both kidneys. Renal artery stenosis is the major cause of renovascular hypertension and the most common cause of treatable secondary hypertension. Recently, percutaneous transluminal renal angioplasty(PTRA) with or without stent placement, has become the preferred choice for correcting symptomatic renal artery stenosis since it is less invasive than surgical reconstruction. PTRA with balloons designed for the dilatation for the dilatation of the coronary artery can be tried in small sized renal artery stenosis. We report a case of renovascular hypertension in a 13-year-old male who had small sized renal artery stenosis. Hypertension was controlled by PTRA with balloon dilatation.

빅데이터 분석을 통한 코로나 이전과 이후 메타버스에 대한 소비자의 인식에 관한 연구

박성우,박준호,류기환,Park, Sung-Woo,Park, Jun-Ho,Ryu, Ki-Hwan 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

The purpose of this study is to find out consumers' perceptions of "metaverse," a newly spotlighted technology, through big data analysis as a non-face-to-face society continues after the outbreak of COVID-19. This study conducted a big data analysis using text mining to analyze consumers' perceptions of metaverse before and after COVID-19. The top 30 keywords were extracted through word purification, and visualization was performed through network analysis and concor analysis between each keyword based on this. As a result of the analysis, it was confirmed that the non-face-to-face society continued and metaverse emerged as a trend. Previously, metaverse was focused on textual data such as SNS as a part of life logging, but after that, it began to pay attention to virtual reality space, creating many platforms and expanding industries. The limitation of this study is that since data was collected through the search frequency of portal sites, anonymity was guaranteed, so demographic characteristics were not reflected when data was collected.

Trimethylgermanium 화합물과 Chloral의 반응

박성우,이일규,Sung Woo Park,Kyu Il Lee 대한화학회 1984 대한화학회지 Vol.28 No.1

삽입형 평면 트러스를 이용한 철근콘크리트 무량판 구조의 슬래브-기둥 접합부 전단보강 공법

박성우,강수민,김효락,Park, Sung-Woo,Kang, Soo-Min,Kim, Hyo-Rak 한국공간구조학회 2012 한국공간구조학회지 Vol.12 No.2

경구투여 $\beta$-glucan이 잉어와 넙치의 비특이적 면역활성에 미치는 영향

박성우,곽중기,구재근,조만기,PARK Sung-Woo,KWAK Jung-Ki,KOO Jae-Geun,CHO Man-Gi 한국수산과학회 2001 한국수산과학회지 Vol.34 No.4

[ $\beta$ ]-glucan을 시판의 배합사료에 $0.1\%$ 첨가한 다음 담수어인 잉어 (평균체중 1.0g 및 68.7g)와 해산어인 넙치 (평균 체중, 12.1 g 및 54.0g)에 2주간 첨가사료, 1주간 무첨가사료, 2주간 첨가사료 투여의 투여방법으로 5주간 경구투여한 다음 인위감염에 대한 생잔율을 조사하였다. 또 투여기간중의 말초혈액의 백혈구수와 혈중리소자임의 활성과 5주간 투여후에 채취한 백혈구의 식작용능을 조사하였다. $\beta$-glucan첨가사료 투여군에 $1\times10^6$cells의 Aeromonas hydrophila를 접종한 평균체중 68.7g의 잉어군과 $1\times10^5$cells의 Edwardsiella tarda를 접종한 평균체중 68.7g의 넙치군에서 $\beta$-glucan첨가사료 투여군이 무첨가투여군에 비해 생존율이 높았고 (P<0.05),그 외의 접종군에서는 무첨가투여군과 차이가 없었다. $\beta$-glucan첨가사료 투여기간 동안 말초혈액중의 마크로파아지와 호중구수는 투여기간에는 증가, 무투여기간에는 감소하는 경향이었으며 특히 마크로파아지의 증가가 현저하였다. 혈중 리소자임은 잉어에서는 $\beta$-glucan첨가사료 투여기간에는 상승하고 무투여기간에는 감소하였지만, $\beta$-glucan첨가사료를 다시 투여한 후 급격히 상승하여 높은 활성을 유지하였다 그러나 넙치는 잉어보다는 활성의 증가는 현저하지 않았고 무투여기간에도 변동이 없었지만 무첨가투여군보다는 항상 높은 활성을 나타내었다. The effects of dietary $\beta$-glucan administration on non-specific immune parameters in common carp, Cyprinus carpio, (1.0 g and 68.7 g of body weight) and flounder, Paralichthys olivcaces (12.1 g and 54.0 g of body weight) were evaluated. All fishes were fed an experimental diet supplemented with $\beta$-glucan at $0.1\%$ per kg diet for 5 weeks. A week intermission with basal diet occurred between first 2 weeks and second 2 weeks of $\beta$-glucan administration, The changes in the numbers of peripheral neutrophils and macrophages were counted under light microscopy and serum lysozyme activity was also analysed at a week of interval during the experiment. Phagocytic activities of leucocytes from the swimm bladder of carp and the peritonium of flounder were measured 5 weeks after feeding. The oral adminisration of $\beta$-glucan induced significant reduction in mortality after an artificial challenge with $1\times10^6$ cells of Aeromonas hydrophila in larger carp and $1\times10^5$ cells of Edwardsiella tarda in larger flounder but did not in other groups. The numbers of peripheral macrophages and neutrophils, phagocytic acitivies of leucocytes, and the activity of serum lysozyme were greatly increased in the fish fed a $\beta$-glucan supplemented diet. These suggest that $\beta$-glucan administration by oral route can enhance leucocyte phagocytic activity, serum lysozymal activity, and survival rate against artificial infections depending on the infected fish size and challenged bacterial concentration.

Triethylgermyldiphenylphosphine과 Phenylisocyanate의 반응

박성우,이일규,Sung Woo Park,Il Kyu Lee 대한화학회 1983 대한화학회지 Vol.27 No.1

Triethylgermyldiphenylphosphine과 phenylisocyanate를 1:10 mole 비로 ampoule 속에서 혼합하여 여러 온도에서 반응시켰다. 그 결과 $0^{\circ}C$에서는 phenylisocyanate의 고리화 2합체인 N, N-diphenyluretidine-2,4-dione만이, $20^{\circ}C$에서는 phenylisocyanate의 고리화 3합체인 triphenylisocyanurate가 함께 생성되었으며, $50^{\circ}C$에서는 위의 생성물 이외에 diphenylcarbodiimide가 생성되었다. 또한 $100^{\circ}C$이상에서는 2합체는 생성되지 않고, diphenylcarbodiimide와 1,3,5-triphenyl-2,4,6-tris(phenylimino) hexahydro-1,3,5-triazine이 주로 생성되었다. 그리고 Triethylgermyldiphenylphosphine은 상기 고리 화합물들의 생성에 촉매로 작용하였다. Triethylgermyldiphenylphosphine was reacted with phenylisocyanate at various temperatures for three days in sealed ampoules. At $0^{\circ}C$, only N, N-diphenyluretidine-2,4-dione, a cyclic dimer of phenylisocyanate (35%), was formed. But at $20^{\circ}C$, phenylisocyanutrate, a cyclic trimer of phenylisocyanate (30%), was formed along with the dimer. At $50^{\circ}C$, diphenylcarbodiimide (55%) was given together with the compounds described above. At the higher reaction temperatures than $100^{\circ}C$, instead of the dimer and trimer of phenylisocyanate, 1,3,5-triphenyl-2,4,6-tris(phenylimino) hexahydro-1,3,5-triazine, a cyclic trimer of diphenylcarbodiimide (30%) and diphenylcarbodiimide (70%) were mainly produced. Triethylgermyldiphenylphosphine appears to act as a catalyst for the formation of the above cyclic compounds.