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이귀주,김정은,김소정 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.4
Rice flour was roasted at different temperatures and times and tarakjuk was made from these roasted rice flours. Chemical composition, in vitro starch digestibility (IVSD) and protein digestibility (IVPD) of the roasted rice flours and tarakjuk were determined. Changes in quality characteristics such as pH, viscosity, IVSD and IVPD of tarakjuk during refrigerated storage were also investigated. For roasted rice flours, the protein content ranged from 6.52~7.13% on a dry basis, while for tarakjuk, the range was 3.74~4.0%. On the other hand, the Ca level of tarakjuk ranged from 1,278.36~1,340.87 ppm. Rice flours showed decreasing IVSD and increasing IVPD on roasting at 145℃ and 165℃, whereas they showed increasing IVSD and decreasing IVPD at 185℃, respectively. Roasting also influenced the pH, viscosity, IVSD and IVPD of tarakjuk made from these roasted rice flours. As the roasting temperature and time increased, tarakjuk showed lower pH and viscosity, however it showed higher IVSD and IVPD. The pH of tarakjuk, except that of control, decreased with storage, whereas viscosity increased significantly. IVSD decreased up to 4 days of storage, after which it increased again until 14 days of storage. On the other hand, IVPD increased up to 7 days of storage, but there was no additional significant increase after 14 days of storage. These results suggest that depending on the nutritional purpose, appropriate conditions for roasting of rice flour and storage of tarakjuk may be recommended for the commercialization of tarakjuk.
Jung Eun Ji,Jung Min Lee,Jong Min Choi,Young Hwa Choi,Eun Kyung Kim,So Jung Chu,Seok Kyun Kim,Kyong Hoon Ahn,Dong Hoon Lee,Ha Hyung Kim,Kyuboem Han,Dae Kyong Kim 한국독성학회 2008 Toxicological Research Vol.24 No.4
Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined the repeated dose toxicity of rhGM-CSF in SD rats. The repeated dose toxicity study was performed at each dose of 50 and 200 ㎍/㎏ subcutaneous administration of rhGM-CSF everyday for 28-days period. The results did not show any changes in food and water intake. There were also no significant changes in both body and organ weights between the control and the tested groups. The hematological and blood biochemical parameters were statistically not different in all groups. These results suggest that rhGM-CSF may show no repeated dose toxicity in SD rats under the conditions.
Ji, Jung-Eun,Lee, Jung-Min,Choi, Jong-Min,Choi, Young-Hwa,Kim, Eun-Kyung,Chu, So-Jung,Kim, Seok-Kyun,Ahn, Kyong-Hoon,Lee, Dong-Hoon,Kim, Ha-Hyung,Han, Kyu-Boem,Kim, Dae-Kyong Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol.25 No.2
Recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) is a glycoprotein and hematopoietic growth factors that regulates the proliferation of myeloid precursor cells and activates mature granulocytes and macrophages. In a previous study, we reported that hGM-CSF could be produced in transgenic rice cell suspension culture, termed rhGM-CSF. In the present study, we examined the repeated dose toxicity of rhGM-CSF in SD rats. The repeated dose toxicity study was performed at each dose of 50 and 200 ${\mu}g/kg$ subcutaneous administration of rhGM-CSF everyday for 28-days period. The results did not show any changes in food and water intake. There were also no significant changes in both body and organ weights between the control and the tested groups. The hematological and blood biochemical parameters were statistically not different in all groups. These results suggest that rhGM-CSF may show no repeated dose toxicity in SD rats under the conditions.
소정훈(So Jung-Hun),임현묵(Lim Hyun-Mook),황혜미(wang Hye-Mi),정영석(Jung Young-Seok),고석환(Ko Suk-Whan),주영철(Ju Young-Chu) 한국태양에너지학회 2013 한국태양에너지학회 논문집 Vol.33 No.5
This paper presents a simple but valid loss calculation method of grid-connected photovoltaic system based on normalized yield model. The proposed method can be represented as a quantitative value for five losses and performance of grid-connected photovoltaic system with three years monitored data. These results will indicate that it is useful to investigate various loss factors causing the performance obstruction, enhance the lifetime yield for changing meteorological conditions, and determine the optimal design and performance improvement of grid-connected photovoltaic system.
VEGF is a pathogenic contributor to acute lung injury through assembling NLRP3 inflammasome
( So Ri Kim ),( Hee Jung Kim ),( Yong Chu Lee ),( Yeong Hun Choe ),( Seung Yong Park ),( Jae Seok Jeong ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Purpose: The pathological hallmarks of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are diffuse alveolar damage with interstitial and parenchymal edema, vascular leakage, severe inflammation, and the hyaline membrane. Vascular endothelial growth factor (VEGF) was initially identified as a vascular permeability factor and has been implicated in the pathogenesis of ALI. Although it is well known that the NLRP3 inflammasome is a major intracellular multiprotein inflammatory pathway of the innate immune system and the role of NLRP3 inflammasome and the products of inflammasome activation (IL-1β and IL-18) play a prominent role in promoting ALI, the interaction between VEGF and NLRP3 inflammasome in the pathogenesis of ALI remains mostly unknown. Methods: In this study, we used LPS-instilled mice administered with a VEGF inhibitor, CBO-P11 to define the interaction between VEGF and NLRP3 inflammasome activation in ALI and the role of their interplay in the pathogenesis of LPS-induced ALI. The administration of CBO-P11 decreased the LPS-induced features of ALI, including pulmonary neutrophilia, increased vascular permeability, increased reactive oxygen species, and inflammatory cytokines such as TNF-a and IL-17. In addition, the increases in NLPR3 inflammasome assembly and expression of VEGF were observed in lung tissues from LPS-instilled mice. Interestingly, CBO-P11 significantly inhibited the oligomerization of NLRP3 inflammasome in lung tissues from LPS-instilled mice. Conclusion: These findings suggest that VEGF contribute to the pathogenesis of LPS-induced ALI through the activation of the NLRP3 inflammasome, a crucial player in the innate immune responses linked to induction of further inflammation as well as increased vascular permeability.
최종민,So Jung Chu,Kyong Hoon Ahn,Seok Kyun Kim,Jung Eun Ji,Jong Hoon Won,김형철,백문정,김대경 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.4
Ceramide has been suggested to be not only a tumor-suppressive lipid but also a regulator of phagocytosis. We examined whether exogenous cell-permeable C_6-ceramide enhances the phagocytic activity of Kupffer cells (KCs) and affects the level of cellular ceramides. Rat KCs were isolated by collagenase digestion and differential centrifugation, using Percoll system. Phagocytic activity was measured by FACS analysis after incubating KCs with fluorescence-conjugated latex beads, and the level of cellular ceramide was analyzed by liquid chromatography tandem-mass spectrometry (LC-MS/MS). In this study we found that permeable C6-ceramide increases the cellular levels of endogenous ceramides via a sphingosine-re-cycling pathway leading to enhanced phagocytosis by KCs.
Park, So Young,Nho, Chu Won,Kwon, Dae Young,Kang, Young-Hee,Lee, Ki Won,Park, Jung Han Yoon Cambridge University Press 2013 The British journal of nutrition Vol.109 No.2
<P>Maslinic acid is found in various natural sources, most notably in pomace olive oil, and exerts pro-apoptotic activities in various cancer cells <I>in vitro.</I> In the present study, DU145 human prostate cancer cells were cultured with 0-25 μm-maslinic acid to examine the effects of maslinic acid on the metastatic capacity of prostate cancer cells. Maslinic acid significantly (<I>P <</I>0·05) inhibited the basal and epidermal growth factor (EGF)-induced migration (27-64 %), invasion (23-60 %) and adhesion (8-40 %) of DU145 cells. Maslinic acid significantly (<I>P <</I>0·05) down-regulated both basal and EGF-stimulated secretion of matrix metalloproteinase (MMP)-9 (25-67 %), MMP-2 (50-86 %), urokinase-type plasminogen activator (uPA, about 100 %), vascular endothelial growth factor (VEGF, 98-100 %) and tissue inhibitors of metalloproteinases (TIMP)-1, as well as expression of uPA receptor (uPAR), intercellular adhesion molecules (22-33 %), vascular cell adhesion molecules (23-46 %) and E-cadherin, whereas it increased TIMP-2 secretion. Maslinic acid dramatically reduced the levels of hypoxia-inducible factor-1α (HIF-1α) protein and mRNA; the reduction was accompanied by reduced stability, nuclear levels and transcriptional activity of HIF-1α. The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1α levels and VEGF secretion. The results show that maslinic acid markedly inhibited the migration, invasion and adhesion of DU145 prostate cancer cells. Suppressing HIF-1α activation by inhibiting Akt and ERK activation may be part of the mechanism by which maslinic acid inhibited uPAR, E-cadherin, VEGF and MMP expression in DU145 cells.</P>