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Kim, Young Ae,Yun, Young Ho,Chang, Yoon Jung,Lee, Jongmog,Kim, Moon Soo,Lee, Hyun-Sung,Zo, Jae Ill,Kim, Jhingook,Choi, Yong Soo,Shim, Young Mog,Yoon, Seok-Jun by Lippincott Williams Wilkins. 2014 Annals of surgery Vol.259 No.3
OBJECTIVE:: To investigate the employment status of lung cancer survivors and the work-related problems they face. BACKGROUND:: Although the number of lung cancer survivors is increasing, little is known about their employment and work-related issues. METHODS:: We enrolled 830 lung cancer survivors 12 months after lung cancer curative surgery (median time after diagnosis, 4.11 years) and 1000 volunteers from the general population. All participants completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30-item and a questionnaire that included items relating to their jobs. We used logistic regression analysis to identify independent predictors of unemployment. RESULTS:: The employment rate of lung cancer survivors decreased from 68.6% at the time of diagnosis to 38.8% after treatment, which was significantly lower than the employment rate of the general population (63.5%; adjusted odds ratio = 2.31, 95% confidence interval: 1.66–3.22). The posttreatment unemployment rate was higher for women than for men. Among survivors, employment was inversely associated with older age, household income, number of comorbidities, and poor social functioning. Fatigue (78.6%) was the most common work-related problem reported by survivors. CONCLUSIONS:: Lung cancer survivors experienced more difficulties in employment than did the general population. Age, monthly household income, number of comorbidities, and social functioning appear to be important factors influencing employment status. These findings suggest that lung cancer survivors need support to cope with the financial impact of cancer.
흉벽을 침범한 pT3N0 비소세포폐암 환자에서 수술 후 방사선치료
박영제(Young Je Park),안용찬(Yong Chan Ahn),임도훈(Do Hoon Lim),박원(Won Park),김관민(Kwan Min Kim),김진국(Jhingook Kim),심영목(Young Mog Shim),김경주(Kyoung Joo Kim),이정은(Jeong Eun Lee),강민규(Min Kyu Kang),남희림(Hee Lim Nam),허승 대한방사선종양학회 2003 Radiation Oncology Journal Vol.21 No.4
목 적: 흉벽을 침범한 pT3N0 비소세포폐암 환자에서 수술 후 방사선치료를 추가하는 것이 필요한지의 여부와 적절한 방사선치료의 조사영역에 관 해 서 는 아직 정립된 이론이 없다. 본 연구에서는 종양으로부터 수술 절제연까지 충분한 여유를 얻기가 힘들었던 소견으로 방사선치료를 추가한 흉벽침범 pT3N0 비소세포폐암 환자들에 대한 후향적 분석을 수행하였다. 대상 및 방법 : 1994년 8월부터 2002년 6월까지 성균관의대 삼성서울병원에서 흉벽침범 pT3N0 비소세포폐암으로 수술 후 방사선치료를 추가한 환자는 모두 21명이었다.모든 환자들은 근치적 폐절제술과 흉벽절제술과 함께 동측 폐문 및 종격동림프절 곽청술을 시행받았다. 방사선치료는 수술 3˜4주 후에 시작하여 선택적 림프절 방사선조사를 고려하지 않고 원발종양에 의해 침범된 흉벽과 그 주변조직에만 국한하여 최소 54 Gy를 조사 하도록 예정하였다(1회선량 1.8˜2.0 Gy, 주 5회 치료).환자들의 생존율과 재발양상을 후향적으로 분석하였다. 결 과: 전체 환자의 5년 생존율, 무병생존율, 국소종양억제율, 무원격전이 생존율은 각각 38.8%, 45.5%, 90.2%, 48.1%였다.모두 11명의 환자에서 치료실패를 경험하였는데, 원격전이가 6명, 흉곽내재발이 3명, 원격전이와 흉곽내재발의 동시재발이 2명이었다. 흉곽내재발 환자 5명 중 방사선치료 조사영역 내에서의 국소재발은 2명, 늑막파종이 2명, 종격동 림프절 재발이 1명이었다. 방사선치료와 관련되는 RTOG 3등급 이상의 급성 및 만성 부작용은 없었다. 결 론: 흉벽침범 pT3비소세포폐암의 치료 성공에 있어 가장 중요한 요소는 완전 절제를 통한 국소제어 인바,수술소견상 충분한 여유 절제연의 확보가 불가능한 경우 수술 후 방사선치료를 추가하여 국소 제어율을 높이도록 도모하는 것은 충분한 당위성을 갖는다. 또 방사선치료 조사영역의 결정에 있어서도 선택적 림프절 방사선 조사를 배제함으로써 영역림프절 재발의 과도한 위험부담 없이도 급성 및 만성 부작용의 위험을 현저히 감소시켜 환자의 삶의 질을 향상시킬 수 있었다. Purpose: No general consensus has been reached regarding the necessity of post operative radiation therapy(PORT) and the optimal techniques of its application for patients with chest wall invasi on (pT3cw) and node negative (N0) non-small cell lung cancer (NSCLC). Were trospectively analyzed the pT3cwN0 NSCLC patients who received PORT because of presumed inadequate resection margin on surgical findings. Materials and Methods: From Aug. 1994 till June 2000, 21 pT3cwN0 NSCLC patients received PORT at Samsung Medical Center; all of whom underwent curative en-bloc resection of the primary tumor plus the chest wall and regional lymph node dissection. PORT was typically started 3 to 4 weeks after operation using 6 or 10 MV X-rays from a linear accelerator. The radiation target volume was confined to the tumor bed plus the immediate adjacent tissue, and no regional lymphatics were included. The planned radiation dose was 54 Gy by conventional fractionation schedule. The survival rates were calculated and the failure patterns analyzed. Results Overall survival, disease-free survival, loco-regional recurrence-free survival, and distant metastases-free survival rates at 5 years were 38.8%, 45.5%, 90.2%, and 48.1%, respectively. Eleven patients experienced treatment failure: six with distant metastases, three with intra-thoracic failures, and two with combined distant and intra-thoracic failures. Among the five patients with intra-thoracic failures, two had pleural seeding, t wo had in-field local failures, and only one had regional lymphatic failure in the mediastinum. No patients suffered from acute and late radiation s i de effects of RTOG grade 3 or higher. Conclusion: The strategy of adding PORT to surgery to improve the probability, not only of local control but also of survival, was justified, considering that local control was the most important component in the successful treatment of pT3cw NSCLC patients, especially when the resection margin was not adequate. The incidence and the severity of the acute and late s i de effects of PORT were markedly reduced, which contributed to improving the patients' quality of life both during and after PORT, w ithout increasing the risk of regional failures by eliminating the regional lymphatics from the radiation target volume.
Kim, Hojoong,Kwon, Young Mi,Kim, Jin Seuk,Han, Joungho,Shim, Young Mog,Park, Joobae,Kim, Duk-Hwan Wiley Subscription Services, Inc., A Wiley Company 2006 Cancer Vol.107 No.5
<B>BACKGROUND.</B><P>Despite many reports about the involvement of DNA methyltransferases (DNMTs) in human cancers, including nonsmall cell lung cancer (NSCLC), the clinicopathologic significance of DNMTs in primary NSCLC remains to be elucidated.</P><B>METHODS.</B><P>The relation between the mRNA levels of DNMTs (1 and 3b) and the promoter methylation of the p16, RARβ2, H-cadherin, GSTP1, RIZ, and FHIT genes and the clinicopathologic features in 102 fresh-frozen tissues and paraffin blocks were retrospectively studied. The mRNA levels of the DNMTs were assessed via semiquantitative reverse-transcription polymerase chain reaction (RT-PCR), and the methylation status of the CpG islands were determined by methylation-specific PCR.</P><B>RESULTS.</B><P>The mRNA levels of DNMT1 and DNMT3b were elevated in 53% and 58% of 102 NSCLCs, respectively. Hypermethylation of p16, RARβ2, H-cadherin, GSTP1, RIZ, and FHIT occurred in 37%, 38%, 34%, 18%, 9%, and 31% of patients, respectively. Univariate analysis showed that elevated DNMT mRNA levels were not significantly associated with the hypermethylation of 6 genes. However, the elevated mRNA levels of DNMT1 were determined to be significantly associated with the hypermethylation of the p16 promoter (odds ratio [OR] = 2.70, 95% confidence interval [95% CI], 1.02–7.15; P = .02), after controlling for age, gender, pack-years smoked, histology, and pathologic stage. The hazard of failure in cases with elevated mRNA levels of DNMT1 was 3.51 (95% CI, 1.18–12.76; P = .02) times higher than that in those without. The elevated mRNA levels of DNMT3b were not ultimately associated with patient prognosis.</P><B>CONCLUSIONS.</B><P>Elevated mRNA expression of DNMT1 may be an independent prognostic factor in NSCLC and CpG island hypermethylation in NSCLC may be maintained by a complex interaction of several factors rather than by a simple transcriptional up-regulation of DNMT1. Cancer 2006. © 2006 American Cancer Society.</P>
Giant Fibrovascular Polyp of the Hypopharynx: Surgical Treatment with the Biappoach
이호석,Jin Sun Kim,Young Mog Shim 대한의학회 2006 Journal of Korean medical science Vol.21 No.4
Fibrovascular polyps of the esophagus and hypopharynx are benign tumors of the upper digestive tract. The majority of these polyps are located in the upper part of the esophagus but the hypopharyngeal fibrovascular polyps are only rarely seen. Most of them are surgically treated and this is usually done through a cervical inci-sion, although some of them have been removed endoscopically. The authors report here on a case of a 63-yr-old-man with a giant fibrovascular polyp of the hypophar-ynx that extended into the stomach; this polyp was removed through simultaneous transcervical and transabdominal approaches because of the huge size of the polyp. The man presented with progressive dysphagia of 1 yr duration. The preoperative assessment revealed a giant polyp arising from the left arytenoid and extending into the stomach. The dimension of the polyp was about 26 ××10 ××4 cm. The complete resection of the polyp with the simultaneous transcervical and transabdominal app-roaches was successful, and it was diagnosed as a fibrovascular polyp. The patient has been followed up without any recurrence for 6 month postoperatively.
조경자,김영환,장자준,이진오,강태웅,조재일,심영목,은진호,조희준 대한내과학회 1990 대한내과학회지 Vol.39 No.3
Since its early description by O' Brien and Staut in 1964 as a distinct form of sarcoma, malignant fibrous histiocytoma is the most common disease of a pleomorphic sarcoma occurring in the deep-seated soft tissue of late-life adults. The histiogenesis of malignant fibrous histiocytoma has been considered to be of histiocytic origin or primitive mesenchymal cell origin. This tumor involves principally the extremities, abdominal cavity, and retroperitoneum and usually metastasizes to the lung and lymphnodes, but primary lung lesion is extremely rare. The reported prognosis in patients with primary lung lesion is very poor, but early surgical resection does offer the possibility of cure. We report a case of primary malignant histiocytoma of the lung, confirmed pathologically by operation, along with a review of the literature.