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      • 장애인복지관의 보조공학서비스 프로그램 실태조사

        공진용,안나연,오현정,정승민,조재덕 대한재활공학회 2008 보조공학저널 Vol.2 No.1

        본 연구는 장애인복지관에 근무하는 재활전문가틀의 보조공학 인식정도와 복지관에서 이루어지는 보조공학서비스 프로그램 운영 실태를 조사하고, 보조공학서비스의 필요성 및 활성화 방안을 제시하고자 하였다. 본 연구는 전국 22곳의 장애인복지관에 근무하는 재활전문가를 대상으로 설문조사하여 연구 분석하였다. 실제 서비스를 시행하고 있는 담당자들은 대부분 보조공학 전문가가 아닌 일반 재활전문가에 의해 이뤄지고 있었으며, 프로그램 운영실태도 단순한 기기 대여 프로그램에 국한되어 있는 실정이었다. 앞으로 보조공학서비스 프로그램 세부영역으로 기기대여, 맞춤 및 제작, 기금제공, 사후관리 등의 전문적인 프로그램 운영이 되어야 하며 프로그램의 효율적 운영을 위해 보조공학 전문 센터의 필요성이 강조되고 있다. The purpose of this study is to investigate an assistive technology awareness of rehabilitation specialists, to investigate an assistive technology service of operating, to present assistive technology service of necessity and activation plan. 22 have participated rehabilitation special in rehabilitation center in Korea. In fact, service operating person performed most normal rehabilitation and program operating state performed only simple lending assistive technology device. In future, assistive technology service program subject will operate lending assistive technology device, funding for assistive technology and special assistive technology center of necessity for program of performance.

      • 입원 환자 영양검색 전산 프로그램 개발

        안수미,윤기영,신연명,최경현,임근승,장문경,송윤미,공은희 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

        Background : About 30% of patients in the hospital are under nourishment. A large portion of people are undernourished when they are admitted to the hospital and in the majority of these, undernutrition develops further while in hospital. Patient-Generated subjective global assessment(PG-SGA), a method of nutritional assessment based on clinical judgment, has been widely used to assess the nutritional status of adults for both clinical and research purposes. Modified PG-SGA can be used as a nutrition screening tool, and a comprehensive nutrition assessment is desirable for those who are malnourished. The purpose of this study is to develop a simple, reliable and valid nutrition screening program(NSP). Methods : We applied the nutrition screening program(NSP) to adult inpatients who are at risk of malnutrition using the Modified Patient-Generated subjective global assessment(PG-SGA) and objective assessment(electrical medical record data). Results : Therefore simple and beneficial NSP is developed for patients with severe malnutrition. Using NSP. nutritional information of the severe malnutrition patient should be shared with the physicians and they should be taken care of by clinical dietitians to improve their nutritional status. Conclusion : The Modified PG-SGA and nutrition screening tool are simple, reliable and valid nutrition screening program(NSP).

      • Validity and Reliability of the Korean version of the Self-Care of Diabetes Inventory

        Seung Yeon Kong 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

        Background: Self-care in daily life is important for diabetic patients to maintain target blood sugar, prevent complications, and improve their quality of life. AADE proposes seven areas of self-care. Among self-care tools currently used, the majority of them only focus on one part of self-care. Therefore, a tool that enables practical evaluation and understanding of self-care, including psychological area, problem solving ability, and complication prevention is needed. Purpose: To evaluate validity and reliability of the Korean version of Self-Care of Diabetes Inventory (SCODI). Methods: Type 2 diabetic patients (N = 210) from a university hospital who agreed to participate in this study from November 1st, 2018 to June 30th, 2019 were enrolled. Content validity, construct validity, and criterion-related validity were evaluated. Cronbach’s α was used to assess reliability. IBM SPSS Amos and SPSS WIN 22.0 software were used for data analyses. Results: The SCODI Korean version consisted of 40 items in four dimensions. Four factors (activity-nutritional behavior, health-adherence behavior, health-promotion behavior, diet-restriction behavior) in the dimension of self-care maintenance, two factors (health status monitoring, symptom recognition) in the dimension of self-care monitoring, three factors (glucose self-control, problem solving behavior, consultative self-care) in the self-care management dimension, and one factor (Self-care Confidence) in the dimension of confidence were extracted. Confirmatory factor analysis supported good fit and reliable scores for the Korean version of the SCODI model (χ²/df <5, RMSEA < 0.1, CFI ≥ 0.9, GFI ≥ 0.9). The Korean SCODI showed a high positive correlation coefficient of .75 with SDSCA, confirming the convergent validity. Cronbach’s α was 0.92 for the overall scale and 0.69 to 0.90 for the four dimensions. Conclusions: The Korean version SCODI is a valid and reliable instrument for assessing self-care of patients with type 2 diabetes in Korea.

      • KCI등재

        블랙푸드가 첨가된 약콩청국장분말의 영양소 및 생리활성물질 분석

        공현주(Hyun-Joo Kong),박현숙(Heyun-Sook Park),김태훈(Tae-Hoon Kim),신승렬(Seung-Ryeul Shin),홍주연(Ju-Yeon Hong),양경미(Kyung-Mi Yang) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.11

        본 연구는 대두청국장분말, 약콩청국장분말, 그리고 흑미, 흑임자, 다시마와 같은 블랙푸드를 첨가한 약콩청국장분말의 일반성분과 영양소 및 항산화 물질을 분석ㆍ비교하여 향후 알츠하이머성 치매관리나 인지능력 향상을 위한 블랙푸드가 첨가된 청국장분말의 in vivo 실험을 위한 기초자료로 활용하고자 실시하였다. 그 결과 대두와 약콩청국장에 비해서 블랙푸드를 첨가한 약콩청국장에서 수분함량이 높았으며, 유리당 중 sucrose, fructose, glucose, maltose 함량이 높았다. 또한 수용성과 조단백질 함량은 P<0.05 수준에서 약콩청국장과 블랙푸드를 첨가한 약콩청국장에서 높았다. 불포화지방산과 포화지방산의 비율은 대두청국장에 비해서 약콩청국장과 블랙푸드를 첨가한 약콩청국장에서 높았다. 무기질 함량은 대두청국장이 가장 높았으나 약콩청국장에서는 Zn, Cr, Mn이, 블랙푸드를 첨가한 약콩청국장에서는 Fe의 함량이 높았다. Isoflavone 중 diadzein 함량은 약콩청국장에서 가장 높았으나, genistein과 anthocyanin 함량은 블랙푸드를 첨가한 약콩청국장에서 가장 높았다. 따라서 본 연구에서는 일반 및 영양적 특성에서 대두청국장에 비해서 블랙푸드로 만든 청국장분말이 유리당과 뇌조직의 구성과 기능에 필요한 수용성 및 단백질 함량과 불포화지방산과 포화지방산의 비율이 높을 뿐만 아니라 우수한 항산화력으로 보고되고 있는 diadzein, genistein 그리고 anthocyanin 함량이 높은 것으로 나타났다. 그러므로 향후 알츠하이머성 치매의 원인 및 치료기전으로 보고되고 있는 산화적 스트레스조절에 대한 in vivo 실험에 블랙푸드청국장분말을 활용할 수 있을 것으로 판단된다. This study is carried out to investigate the analysis of nutrition and antioxidants of soybean Chungkukjang powder (SCP), Yak-Kong Chungkukjang powder (YCP) and Yak-Kong Chungkukjang powder added black foods (YCBP) for the management of Alzheimer"s disease. The water content of YCBP was higher than that of SCP and YCP. The soluble and crude protein contents of YCP were the highest among three Chungkukjang powders. In SCP, YCP and YCBP, the ratios of unsaturated and saturated fatty acids were 5.17, 5.76, and 5.78, respectively. The mineral content of SCP was higher than that of YCP and YCBP. Antioxidants analysis showed that the content of diadzein was the highest in YCP and genistein, and anthocyanin contents were higher than the others in YCBP. In conclusion, YCP and YCBP had higher contents than SCP in soluble and crude proteins, and unsaturated fatty acids, which are needed for composition and function of the brain tissue. Also, it was found that the contents of diadzein, genistein and anthocyanin with outstanding antioxidative ability were high. Thus, this study suggests that Chungkukjang powder, which is made with Yak-Kong, black sesame, black rice and sea tangle, can be utilized for in vivo experiment for the control of oxidative stress, reported as cause and therapy for Alzheimer"s Disease.

      • Prognostic significance of c‐Met expression in glioblastomas

        Kong, Doo‐,Sik,Song, Sang‐,Yong,Kim, Duk‐,Hwan,Joo, Kyeung Min,Yoo, Jin‐,San,Koh, Jong Sung,Dong, Seung Myung,Suh, Yeon,Lim,Lee, Jung‐,Il,Park, Kwan,Kim, Jong Hyun Wiley Subscription Services, Inc., A Wiley Company 2009 Cancer Vol.115 No.1

        <P><B>Abstract</B></P><P><B>BACKGROUD:</B></P><P>The authors investigated whether expression of c‐Met protein in glioblastomas is associated with overall survival and biologic features representing tumor invasiveness in patients with glioblastomas.</P><P><B>METHODS:</B></P><P>Paraffin‐embedded specimens of glioblastomas from 62 patients treated in a single institution were assessed by immunohistochemical (IHC) analysis of c‐Met expression. On the basis of the clinical data for these patients, the association between c‐Met expression and clinicobiologic features representing tumor invasiveness was analyzed.</P><P><B>RESULTS:</B></P><P>c‐Met overexpression was detected in 29.0% (18 of 62) of glioblastomas. In patients with c‐Met overexpression, the median survival was 11.7 months (95% confidence interval [95% CI], 9.9 months‐13.5 months), compared with a median survival of 14.3 months (95% CI, 7.6 months‐21.0 months) for patients whose tumors had no or little expression of c‐Met (<I>P</I> = .031). On the radiographic analysis, 9 of 18 patients (50%) with tumors overexpressing c‐Met demonstrated invasive and multifocal lesions on the initial magnetic resonance images, whereas only 9 of 44 patients (20.5%) with tumors that expressed no or little c‐Met demonstrated these features (<I>P</I> = .030). Using immunohistochemistry, we also found a significant association between c‐Met expression and matrix metalloproteinase‐2,‐9 (<I>P</I> = .020 and <I>P</I> = .013). Furthermore, Myc overexpression was found to be closely correlated with c‐Met overexpression on IHC analysis (<I>P</I> = .004).</P><P><B>CONCLUSIONS:</B></P><P>The authors suggest that c‐Met overexpression is associated with shorter survival time and poor treatment response in glioblastomas, the mechanism for which is elevated tumor invasiveness on the molecular and clinical phenotypes. This implies that more effective therapeutic strategies targeting c‐Met receptors may have important clinical implication. Cancer 2009. © 2008 American Cancer Society.</P>

      • KCI등재SCOPUS
      • SCOPUSKCI등재

        내당능장애군 및 새로 진단된 제2형 당뇨병 환자에서 혈장 프로인슐린의 분비양상

        공병호,최승진,김재택,오연상,신순현 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

        연구배경:제2형 당뇨병의 병인은 크게 췌장베타세포의 인슐린분비장애와 말초조직에서의 인슐린저항성으로 설명되며 현재 이들 중에 어느 것이 더 중요한지는 명확히 증명되어지고 있지 않으며 민족에 따라 차이가 있는 것으로 알려져 있다. 저자 등은 제2형 당뇨병의 병인에서 베타세포의 기능이상의 역할을 알아보기 위하여 새로 진단된 제2형 당뇨병 환자, 내당능장애군과 정상인에 있어서 경구 당부하검사시 인슐린, C­펩타이드와 프로인슐린의 분비이상을 측정 비교하였다. 방법:새로 진단 받은 제2형 당뇨병 환자군 47명과 내당능장애군 9명, 정상 대조군 13명을 대상으로 75g 경구당부하검사를 실시하여 혈당, 혈장 인슐린, C­펩타이드 및 프로인슐린 농도를 측정하였다. 결과:1)내당능장애군에서 경구당부하검사 후 인슐린, C­펩타이드와 프로인슐린의 현격한 증가를 보인 반면, 제2형 당뇨병 환자군에서는 그 분비양상이 둔화되어 거의 증가되지 않았다. 2)공복시 프로인슐린 농도는 정상대조균에서 7.7±4.4poml/L였으며, 내당능 장애군은 15.2±6.9poml/L(p=0.005), 제2형 당뇨병 환자군은16.9±8.4poml/L(p<0.005)로 두군 모두 정상대조군에 비해 의미있게 높았으며 경구당부하후 60분, 90분, 120분에는 내당능장애군에서 의미있게 높았다. 3)혈장 공복시 프로인슐린/인슐린비는 내당능장애군에서 공복시와 경구당부하후 30분에 그리고 제2형 당뇨병 환자군에서는 공복시, 경구당부하구검사 후 30분, 60분과 90분에 정상대조군에 비해 의미있는 증가를 보였다. 4)프로인슐린 반응면적은 내당능장애군에서 110.7±13.1poml/L/hr로 정상대조군의 73.6±5.1poml/L/hr 및 제2형 당뇨병 환자군의 80.5±5.9poml/L/hr에 비해 의미있게(p=0.048)증가되었다. 결론:내당능장애군에서 이미 베타세포의 프로인슐린의 분비능에 이상이 있으며 인슐린 분비양상의 변화가 제2형 당뇨병의 병인에 관여함을 알 수 있었다. Background : Type 2 diabetes mellitus is characterized beta cell dysfunction and insulin resistance but the relative roles of the two factors are different in various ethnic groups. The changes in plasma proinsulin levels is thought to be a market for the beta-cell dysfunction. To study the role of beta cell dysfunction in the pathogenesis of type 2 diabetes mellitus we compared the concentrations of plasma insulin, C-peptide and proinsulin among the control group, impaired glucose to lerance (IGT) group and newly diagnosed Type 2 Diabetes Mellitus (DM) group during the oral glucose to lerance test. Methods : In 47 newly diagnosed patients with type 2 DM, 9 IGT and 13 controls the 75g oral glucose to lerance test (OGTI) were performed and samples were analyzed for glucose, insulin, C-peptide and proinsulin. Results : 1) In IGT group plasma insulin, C-peptide and proinsulin concentrations were increased markedly during OGTT but were blunted i type 2 diabetes group. 2) The basal plasma proinsulin level was 7.7±4.4 pmol/L in control group, 15.2±6.9 pmol/L (p<0.005) in IGT group, amd 16.9±8.3 pmol/L (p<0.005) in type 2 DM group, and the proinsulin levels at 60 min, 90 min, 120 min during OGTT were significantly elevated in IGT group than those of control group. 3) The plasma proinsulin/ insulin ratio were significantly increased in IGT group and type 2 DM group at basal and 30 min during OGTT> 4) The proinsulin response areas were significantly increased in IGT group (110.7±13.1 pmol/L/hr, p=0.048) than those of control group (73.6±5.1 pmol/L/hr) and type 2 DM group (80.5±5.9 pmol/L/hr). Conclusion : Beta cell secretory defects such as proinsulin secretion were present in impaired glucose to lerance and changes of insulin secretory function might have a role in the pathogenesis of type 2 DM (J Kor Diabetes Asso 467~475, 2000).

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