류마티스성 승모판 협착증의 치료를 위한 경피적 승모판 성형술의 치료성적

김성은,조흥근,박성훈,박시훈 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.4

연구목적 : 류마티스성 승모판 협착증에 대한 유용한 치료법인 경피적 승모판 성형술의 본원의 단기 치료 성적을 알아보고자 하였다. 방법: 1993년 10월에서 1999년 4월까지의 이대목동병원에 내원한 류마티스성 승모판 협착증 환자 21명에서 투시조명 하에 경피적 승모판 성형술을 시행하였다. 시술전에 경흥부심초음파와 경식도초음파가 시행되었고, 시술후에는 경흉부초음파를 사용하여 혈역학적, 임상학적 변화를 비교하였다. 연구대상의 거의 모두가 NYHA class Ⅱ에 속했고, 5명이 심방세동을 가지고 있었으며, 모두 심초음파점수가 8이하였다. 좌심방에 혈전이 있는 경우로 혈전을 용해시킨 후 시술한 경우가 2예였다. 결과 : 경피적 승모판 성형술 이후의 평균 승모판구면적은 시술전의 1.16±0.36㎠에서 2.06±0.33㎠로 증가되었다. 경승모판 이완기 평균 압력차는 시술전 11.60±5.54mmHg에서 시술 후 4.93±2.53mmHg(p<0.001). 좌심방 크기는 46.41±14.66mm에서 42.03±15.01mm로(p=0.042), 그리고 심박출량은 4.21±1.25L/min에서 6.88±9.57L/min로(p<0.0001) 의미있는 호전을 보였다. 3도 이상의 심한 승모관폐쇄부전이나 심각한 시술후 합병증은 없었다. 결론 : 본원에서 약 6년간 시행된 경피적 승모판 성형술는 그 사례가 적고 시술전 예상되는 난이도 면에서 특이한 것은 없었지만, 시술후 합병증이 거의 발견되지 않았으며 혈역학적 측정상에서도 성공적인 시술을 보여주었다. 승모판구면적에 따른 시술후 단기내 호전의 정도는 거의 예측할 수 없었으나, 심초음파점수는 모두가 8점이하로 높은 성공율의 조건을 제공하였다. Objective : Percutaneous mitral valvuloplasty(PMV) became a treatment modality or mitral stenosis because of its low morbidity, short hospital stay, and low cost. We reviewed clinical and hemodynamic results after PMV for the patients with mitral stenosis in Ewha Womans University Mokdong hospital. Methods : We compared the results of echocardiographic, hemodynamic, and clinical parameters before and after PMV. PMV was performed under fluoroscopic guidance in 21 patients(M:4, F:17, mean age 43±12 years) with mitral stenosis from October 1993 to April 1999. Transesophageal echocardiography(TEE) and Transthoracic echocardiography(TTE) were performed for the evaluation of mitral valve, chamber size, and the presence of left atrial thrombus before procedures. TIE was also used for follow-up evaluation. On presentation, all patients showed at least NYHA class Ⅱ. Five patients had atrial fibrillation. Two patients with thrombus in the left atrium were included to study group after thrombolytic treatment with coumadin. Echo-score of our patients was not greater than 8. Results : Mean mitral valve area(MVA) by 2 dimensional or Doppler echocardiography was increased from 1.16±0.36㎠ before PMV to 2.06±0.33㎠ after PMV. There were marked improvements in transmitral gradients(11.60±5.54mmHg before PMV vs 4.93±2.53mmHg after PMV, p<0.001), left atrial dimension(46.41±14.66mm vs 42.03±15.01mm, p=0.042), and cardiac output(4.21±1.25L/min vs 6.88±9.57L/min, p<0.0001) following PMV, Severe(≥GⅢ) mitral insufficiency or severe postprocedural complications were not noted. This suggested that all procedure was successful. Conclusion : The Procedural success rate of PMV in Ewha Womans University Mokdong hospital was 100%. Low echo score of our patients might explain this high procedural success rate. Long-term-follow-up is warranted in the near future.

격투스포츠 선수의 스포츠맨십 분석

박태훈(Park Tae-Hoon),유기성(Yoo Ki-Seong),유원용(Ryu Won-Yong),김영욱(Kim Young-Wook),이양구(Lee Yang-Gu),공창빈(Kong Chang-Bin),이상호(Lee Sang-Ho),김태영(Kim Tae-Young) 한국체육과학회 2010 한국체육과학회지 Vol.19 No.3

This research examines whether difference that is some in inclination of combat sports player's sportsmanship is, and accordingly is purposeful to clear relation. combat sports (fencing, Taekwondo, boxing, induction, wrestling, wrestling) player who research target is having player life in middle·high·an university 399 people be . Used Korean-made measure (KMSOS) that Seong-changhun (2003) verifies changing based on Vallerand MSOS by a tool to measure sportsmanship of players. Data processing used SPSS 12.0 programs. Did reliability analysis that use Cronbach'a coefficient to verify believability of an irradiation tool, Difference of sportsmanship used t-test, one-way ANOVA. In this research, drew following conclusion. First, man appeared higher level than woman in wave and human desire, decision respect, and woman appeared higher level than man in victory or defeat excessive fondness. Second, exercise immersion, decision respect, victory or defeat excessive fondness appeared level that minority is taller than majority. Third, in exercise immersion high school player decision respect appear, and tendency of level that middle school playing the first stone is high in victory or defeat excessive fondness appeared. Fourth, striking radical type of player appeared higher level than Geuraepeulring type of player in companion respect factor. Fifth, player less than exercise career 4 years appeared higher level than player less than 7 years and player more than 7 years for victory or defeat excessive fondness factor. Sixth, Taekwondo for best and companion respect factor, high level appeared to boxing item players.

타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성

박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

리튬이차전지용 부극재료로서 은분말에 대한 전기화학적 특성

박철완,도칠훈,문성인,윤문수 한국공업화학회 2003 응용화학 Vol.7 No.2

Silver powders have been extensively studied as an anode active material for lithium secondary batteries. In the present study, a unique attempt is made to develop silver negative electrode by slurry method, because the silver electrode is a good candidate to replace the commercial graphite electrode for lithium rechargeable batteries. Silver electrode was prepared and its electrochemical properties were characterized gradual increasing test state of charge (GISOC) analysis method. Charge-discharge performance indicates that the initial charge potential range of Li/Ag cells has showed similar behaviors compared with Li/Graphite system and the irreversible capacity facd is also higher than Li/Graphite system.

당귀와 천궁 및 시호의 병용 경구 투여에서 흰쥐 혈중 Decursinol 농도의 비교 검토

박노정,김남재,이경태,서성훈 경희대학교 경희동서약학연구소 2001 경희약대 논문집 Vol.29 No.-

This study was performed to elucidate the influence on the plasma decursinol concentration after administration of combined decursin and Cnidii Rhizoma or decurisin and Bupleuri Radix extracts in comparison with single decursin administration. The identification of decursinol in the plasma after oral administration was determined by HPLC. The value of area under the plasma concentration (AUC) and the maximal concentration (Cmax) of decursinol after administration of methanol and ether Angelicae Gigantis Radix extract was higher than those of single decursin-treated group. It was also found that the AUC and the Cmax of decursinol after combined administration with decursin and Cnidii Rhizoma were higher than those of decursin administration, whereas those of combined with decursin and Bupleuri Radix was lower. Moreover, the studies were performed with decursinol only or with combined decursinol and Cnidii Rhizoma/Bupleuri Radix, both of combined treatment increased the plasma decursinol concentrations compared with decursinol-treated group in rats. On the basis of these results, it is concluded that co-existing substances or co-administration with other drugs may influence the plasma levels of decurisinol after oral administration.

급성대동맥박리증에서 수술전 경식도심초음파도의 역할

박성훈,원태희,원용순,한재진,안재호,이귀용 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.1

급성대동맥박리증은, 특히 상행대동맥을 침범한 경우, 응급수술을 요하는 질환으로서 수술전 대동맥판의 손상여부, 질환의 범위, 내벽파열부위의 위치 및 가지혈관의 상태등을 파악하여 수술계획을 수립하여야 한다. 저자들은 상행대동맥을 침범한 3례의 급성대동맥박리증 환자에서 전산화단층촬영과 함께 수술전 또는 필요에 따라 수술후 경식도심초음파도를 시행하여 환자의 치료에 도움을 받았기에 문헌고찰과 함께 보고하는 바이다. Acute type A arotic dissection is a condition which requires emergency surgery. Surgeons want to know not only the extent of the disease but also the exact site of intimal tear as well as the presence of side branch involvement to plan the extent of surgery. Various non-invasive diagnostic tools(transthoracic and transesophageal echocardiography, conventional and spiral computed tomography and magnetic resonance imaging) and invasive angiography are available for the evaluation of the extent of dissection, site of intimal tear and side branch involvement. Each technique has its advantage and disadvantage. Especially, MRI has been accepted as a gold standard for the diagnosis of aortic dissection, but it is immobile and sometimes it cannot give us the information about the small intimal tear site. Transesophageal echocardiography has the advantage of movability and high resolution in addition to the ability of providing comprehensive information about the cardiac function. Because of these advantages, it has been widely utilized for the evaluation of patients with aortic dissection. We performed preoperative transesophageal echocardiography in addition to computed tomography in 3 cases of acute type A aortic dissection and report these cases with the review of articles.

DEA를 이용한 천주교 서울대교구 본당 운영의 효율성 평가

박해철,김성훈 中央大學校經營硏究所 2003 經營學論集 Vol.29 No.2

한의 진단의 추론 형식과 실재성

박경모,최승훈,안규석 현곡학회 1997 제3의학 Vol.2 No.1

좌전하행지 관동맥 개구부위의 망사형의 관(Slotted Tube)스텐트와 나선형 코일(Coil)스텐트 삽입후 단기 및 장기 암상 경과의 비교

박훈기,박성욱,이일수,이상곤,김진우,이근,정상식,이철환,홍명기,김재중,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6