수지 첨부 재접합술 101예의 후향적 분석

오세관,김경철,이기준,김주성,문현식,우상현,Oh, Se-Kwan,Kim, Kyung-Chul,Lee, Gi-Jun,Kim, Joo-Sung,Mun, Hyun-Sik,Woo, Sang-Hyun 대한미세수술학회 2006 Archives of reconstructive microsurgery Vol.15 No.1

We retrospectively evaluated our results of replantations of distal digital amputations and analyzed the factors deterrent to the survival of replanted digits. From January 2004 to 2005 June, we performed 101 cases of replantations following complete amputations at or distal to interphalangeal joint level. The study included 98 patients with a mean age of 35.6 years (range 1 to 63 years). Amputation level correlated to zone I (distal to the lunula)in 47 cases and zone II (lunula to distal interphalangeal joint) in 54 cases according to Yamano's classification. According to the mechanism of amputation, 24 cases (22.9%) suffered from guillotine type injury, 27 cases (27.1 %) from avulsion type injury and 50 cases (50%) from crush type injury. In all cases, a single arterial anastomosis was performed. Venous anastomosis on either volar or dorsal side was performed in 12 cases of amputation in zone II. Salvage procedure for venous drainage was performed in 98 cases. The mean duration of salvage procedures was 5.9 days (ranging from 4 to 14 days). Successful replantation was achieved in 96 cases (95.1%), which included 93.7% cases in zone I amputations and 96.3% cases in zone II amputations. A single venous anastomosis was performed in 12 cases of amputation in zone II. All of them survived completely. Among the 5 cases that failed to survive, 3 cases were related with avulsion injury in zone I. Initial mechanism of injury determines the survival rate of amputated parts as it is directly related with the status of vessels and soft tissues. Meticulous precaution during the salvage procedure may affect the overall survival rate of distal digital replantations.

내측 반월상 연골 초음파 상 고에코성 '무리'의 임상적 의의

김정만,오세관,유종민,김필성,김인보,Kim, Jung-Man,Oh, Se-Kwan,Yu, Jong-Min,Kim, Pil-Sung,Kim, In-Bo 대한정형외과초음파학회 2011 대한정형외과 초음파학회지 Vol.4 No.2

목적: 내측 반월상 연골 파열의 초음파적 진단은 매우 어려운 것으로 알려져 있다. 저자들은 내측 반월상 연골의 초음파 영상에서 고에코성 '무리'가 보일 때 어떤 임상적 의의가 있는지 알고자 하였다. 대상 및 방법: 내측 반월상 연골의 초음파 상 고에코성 '무리'가 보이는 28예에서 자기 공명 영상과 수술 소견을 비교하여 그 의의를 찾고자 하였다. 전례 여성이었으며 년령은 55~75세 사이였다. 결과: 고에코성 '무리'의 생성 부위는 수술 소견상 정확히 반월상 연골의 파열된 조각이 모조직과 중첩되는 부위와 일치 하였다. 결론: 고에코성 '무리'가 내측 반월상 연골에 보일 때 이는 연골 파열 파편이 모조직과 중첩된 것을 나타낸다. Purpose: To verify the sinificance of the hyperechoic cluster formation in medial meniscal tear on the sonography. Materials and Methods: The formation of hyperechoic cluster of the medial meniscus on the sonography were compared with the MRI and arthroscopic findings in 28 knees. Results: The cluster formation area coincided with the overlapped torn fragment of the meniscus in all cases. Conclusion: The hyperechoic cluster on the sonography reveals the position of the overlapped torn fragment.

MIPPO 수기를 이용한 원위 경골 골간단 골절의 치료

이호승,김정재,오세관,안형선,Lee, Ho-Seung,Kim, Jung-Jae,Oh, Se-Kwan,Ahn, Hyung-Sun 대한족부족관절학회 2004 대한족부족관절학회지 Vol.8 No.2

Purpose: To evaluate the results of MIPPO (minimal invasive percutaneous plate osteosynthesis) technique for distal tibial metaphyseal fractures. Materials and Methods: It is a retrospective study of 13 patients who were treated by MIPPO technique for distal tibial metaphyseal fractures from Jan. 2001 to Jan. 2003. The average age was 46.7 years and mean follow-up period was 13.3 months. According to AO classification, there were 8 cases of A1, 3 cases of A2, 1 case of B1 and 1 case of C2. One case of A1 was a Gustilo-Anderson type I open fracture and fibular fractures were combined in 12 cases. We applied anatomical reduction and internal fixation for the fibular fractures and internal fixation on the medial side of the tibia by MIPPO technique for distal tibial metaphyseal fractures. Clinical results were evaluated using radiographic results, Neer score, the starting time of postoperative exercise and clinical complications. Results: According to the Neer score, all cases showed satisfactory results. Active ankle ROM was started at average 2.4 weeks ($2{\sim}4$ weeks) and full weight bearing ambulation at average 5.2 weeks ($4{\sim}8$ weeks) postoperatively. Union of fractures was obtained by average 14.4 weeks ($8{\sim}18$ weeks) postoperatively. Two cases showed $5^{\circ}$ limitation of motion without functional deficits and other cases showed satisfactory ROM results. One case had $6^{\circ}$ valgus deformity without functional deficits. There were not any other complications like soft tissue problems and delayed-or non-union. Conclusion: MIPPO technique for the treatment of distal tibial metaphyseal fractures is a feasible technique with a good clinical outcomes.

Antagonism of Analgesic Effect of Morphine in Mice by Ginseng Saponins

김학성,오기완,오세관,Kim, Hack-Seang,Oh, Ki-Wan,Oh, Se-Kwan 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4

Ginseng total saponins(GS), protopanaxadiol saponins(PD) and protopanaxadiol saponins(PT) antagonized the analgesia in mice induced by morphine. The administrations of 2,4-dihydroxyphenylalanine, and 5-hydroxytryptophan reduced the GS, PD and PT antagonisms of morphine analgesia. Possible mechanisms involved in the antagonistic actions of GS, PD and PT on morphine analgesia were described.

증등도 및 중증 무지 외반증 치료에서 원위부 갈매기형 절골술의 적용

윤준오,이호승,류석우,이기원,오세관,Yoon, Jun-O,Lee, Ho-Seung,Leu, Suk-Woo,Lee, Ki-Won,Oh, Se-Kwan 대한족부족관절학회 2003 대한족부족관절학회지 Vol.7 No.2

Purpose: We assessed the treatment result of the distal chevron osteotomy in the patients with moderate to severe hallux valgus. Materials and Methods: In a total of 28 cases of hallux valgus in 20 patients, underwent distal chevron osteotomy between July 1999 and February 2001, were enrolled in this study. 21 cases were moderate and 7 cases were severe. The preoperative average hallux valgus angle and 1st-2nd intermetatarsal angle of the two groups were $31.5^{\circ}$, $15.8^{\circ}$ in moderate cases and $44.1^{\circ}$, $17.3^{\circ}$ in severe cases, respectively. Radiologic evaluation was done preoperatively, postoperatively and on the final follow-up visit using weight-bearing radiographic imaging to determine the hallux valgus angle and 1st-2nd intermetatarsal angle. Results: Radiographic evaluation revealed hallux valgus angle and 1st-2nd intermetatarsal angle in moderate cases to be $13.0^{\circ}$, $11.3^{\circ}$ (postoperatively and in severe cases $15.6^{\circ}$, $10.9^{\circ}C$, postoperatively. On final follow up, the results were $14.5^{\circ}$, $11.6^{\circ}$ in moderate cases and $18.3^{\circ}$, $11.9^{\circ}$ in severe cases, respectively. Conclusion: Distal chevron osteotomy can be usefully applied to the treatment of moderate to severe hallux valgus.

무시멘트 근위조합 원위고정형 스템을 이용한 인공고관절 재치환술

이수호 ( Soo Ho Lee ),조수현 ( Su Hyun Cho ),오세관 ( Se Kwan Oh ) 대한고관절학회 2004 Hip and Pelvis Vol.16 No.3

Correlation between Tear of Lateral Discoid Meniscus and Cartilage Damage in Patients Under 40 Years Old

Seong-Il Bin(빈성일),Tae-Seok Nam(남태석),Ji-Hyun Ahn(안지현),Se-Kwan Oh(오세관) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.8

15세 이상 40세 이하의 활동기 연령에서 외측 원판형 반월상 연골 파열과 동반된 연골 손상 정도의 상관 관계에 대해서 알아 보고하고자 하였다. 1998년 10월에서 2004년 7월까지 외측 원판형 반월상 연골 파열로 관절경하 반월상 연골 절제술을 받은 144예 중 외측 원판형 반월상 연골에 단독 손상을 보인 15세 이상 40세 이하의 환자 56명, 65예에서 나이, 증상 기간, 관절경하 반월상 연골 파열 형태, 하지 정열 상태와 동반된 연골 손상의 정도를 조사, 분석하였다. 수술 전 가장 흔한 증상은 동통(89.2%)이었다. 관절경 검사에서 완전 원판형 반월상 연골 파열은 22예였으며, 파열 양상은 선형(longitudinal) 파열이 11예로 가장 많았다. 불완전형 원판형 반월상 연골 파열은 43예로, 이중 방사형(radial) 파열이 18예로 가장 많았다. 선형 파열로 분류된 전례에서 양동이 손잡이형(bucket-handle) 파열의 형태를 보였다. 65예 중 33예(47%)에서 경골 혹은 대퇴골 외과의 연골이 Outerbridge 분류상 3, 4등급의 소견을 보였으며, 21예의 선형 파열 중 15예(65%)에서 다른 형태의 파열에 비해 많은 비율에서 관절 연골의 손상이 관찰되었다. 증상 기간은 연골 손상 정도와 의미 있는 상관 관계를 보였으나, 나이, 방사선 검사상 하지 정열 상태는 동반된 연골 손상의 정도와는 상관 관계가 없었다. 15세 이상 40세 이하의 활동기 연령에서의 외측 원판형 반월상 연골 파열 중 선형 파열(양동이 손잡이형)에서 외측 경골 및 대퇴골 연골의 손상이 비교적 많았으며, 증상 기간과 연골 손상 정도가 상관 관계가 있어, 이 경우 비교적 조기에 적절한 외과적 치료를 시행하는 것이 바람직할 것으로 사료된다. Purpose: To report the correlation between tears in the lateral discoid menisci and cartilage damage in patients under 40 years old. Materials and Methods: Arthroscopic meniscectomy was performed on 144 cases of tears in lateral discoid menisci from September 1998 to July 2004, of which 65 cases were in 56 patients aged 15 to 40 year old and showed isolated tears of lateral discoid menisci. For these 65 cases, we inspected clinical symptoms and tear patterns and analyzed the relationships among age, duration of clinical symptoms, tear pattern of the meniscus on arthroscopic findings, the alignment of the lower extremities on X-rays and the severity of associated cartilage damage. Results: The most common pre-operative symptom was pain (89.2%), followed by locking (32.3%), a clicking sound (16.9%), and giving way (16.9%). Arthroscopic findings showed, 22 cases of complete type-discoid meniscus, consisting of 11 longitudinal tears, 5 simple horizontal tears, 5 complicated horizontal tears, 1 radial tear and no complex or degenerative tears. There were 43 cases of incomplete type-discoid meniscus, consisting of 18 radial tears, 10 longitudinal tears, 8 complicated horizontal tears, 3 simple horizontal tears, 3 complex tears and 1 degenerative tear. All longitudinal tears showed a pattern of bucket-handle tears. Associated cartilage damage greater than grade 3 according to the Outerbridge classification was observed in 33 cases, 11 complete and 22 incomplete discoid-type, on the lateral femoral condyle or tibial plateau. Of the 21 cases of longitudinal tear, 15 had associated cartilage damage significantly increased rate in comparison with other types of clinical tear pattern. Of the 15 cases of grade 4 cartilage damage, 9 had longitudinal tears. The duration of clinical symptoms was correlated with cartilage damage, but there was no significant associated between cartilage damage and age or the alignment of the lower extremities on X-rays. Conclusion: Longitudinal (bucket-handle) tears of the lateral discoid meniscus inpatients 15 to 40 years old, showed significant associated with cartilage, damage. The duration of symptoms was also correlated with cartilage damage, indicating that prompt initiation of appropriate surgical treatment should be considered in these cases.

α-amylase를 이용하여 제조한 쌀 페이스트의 품종에 따른 휘발성비휘발성 향미성분 비교분석

손은영 ( Eun Young Son ),김혜원 ( Hye Won Kim ),김선아 ( Sun Ah Kim ),이상미 ( Sang Mi Lee ),백세희 ( Se Hee Paek ),김선희 ( Sun Hee Kim ),서용기 ( Yong Ki Seo ),박혜영 ( Hye-young Park ),오세관 ( Sea-kwan Oh ),김영석 ( Young-suk 한국응용생명화학회(구 한국농화학회) 2017 Journal of Applied Biological Chemistry (J. Appl. Vol.60 No.3

쌀은 전세계 인구의 절반이 주식으로 사용하고 있으며, 대부분 아시아에서 생산되고 소비되고 있다. 그러나 최근 식생활이 다양해지면서 쌀 소비량은 감소하고 있는 추세이다. 이에 쌀의 활용도를 높이기 위한 다양한 시도가 요구되고 있다. 본 연구에서는 α-amylase로 처리된 9종의 서로 다른 품종의 쌀 페이스트를 고체상 미세추출법과 가스 크로마토그래피-질량분석법을 이용하여 휘발성 성분들을 프로파일링하고, 아미노산, 당류 및 당알콜 등의 비휘발성 향미성분들은 유도체화 처리 후 가스 크로마토그래피-시간 비행형-질량분석법을 이용하여 비교분석을 수행하였다. 총 46종의 휘발성 성분들이 검출되었으며, 이에는 6종의 알콜류, 6 종의 알데히드류, 4종의 에스터류, 4종의 퓨란류, 4종의 케톤류, 1 종의 산, 1종의 황 함유 성분, 7종의 탄화수소류, 5종의 벤젠류 및 8종의 터핀류 등을 포함되어 있다. 비휘발성 향미성분들에는 12종의 아미노산, 6종의 당, 4종의 당알콜이 동정되었다. 휘발성 및 비휘발성 향미성분 분석에 근거한 주성분분석에 의해 서로 다른 쌀 페이스트 시료들을 구분할 수 있었다. 휘발성 성분의 경우 pentanal과 4,7-dimethylundecane는 서농 17호 백미와 서농 17호 현미를 구분 짓는 성분이었으며, 이에 비해 일품은 다른 품종들과 달리 ethanol, 6-methylhep-5-en-2-one, tridecane과 같은 성분에서 차이를 보였다. 비휘발성성분의 경우 glycine, serine, γ-aminobutyric acid 같은 아미노산들과 sucrose, fructose 같은 당류가 다른 품종들과 단미를 구분 짓는데 기여하는 성분이었다. 한편, galactose, arabitol, mannose는 서농 17호 현미에 비해 서농 17호 백미와 관련이 높은 성분들이었다. Rice that the half of population in the world eats as a staple food is mostly produced and consumed in Asia. However, its consumption is nowadays decreasing mainly due to diet diversity. Accordingly, some attempts are in demand to enhance the utilization of rice. In this study, profiling of volatile and nonvolatile flavor components in rice pastes obtained by α-amylase was performed and compared according to nine different rice cultivars domestically cultivated in Korea using gas chromatographymass spectrometry combined by solid phase microextraction and gas chromatography-time of flight-mass spectrometry after a derivatization, respectively. In total, 46 volatile compounds identified included 6 alcohols, 6 aldehydes, 4 esters, 4 furan derivatives, 4 ketones, 1 acid, 1 sulfur-containing compound, 7 hydrocarbons, 5 aromatics and 8 terpenes. The non-volatile flavor components found were composed of 12 amino acids, 6 sugars and 4 sugar alcohols. In principal component analysis, rice paste samples could be discriminated according to cultivars on the score plots of volatile and non-volatile flavor compounds. In particular, some volatile compounds such as pentanal and 4,7-dimethylundecane could contribute to distinguish Senong 17 white and Senong 17 brown, whereas ethanol, 6-methylhep-5-en-2-one, and tridecane could be highly related to the discrimination of Iipum from other cultivars. Among non-volatile compounds, some amino acids such as glycine, serine and γ-aminobutyric acid and some sugars such as sucrose and fructose were mainly responsible for the discrimination of Danmi from the other cultivars. On the other hand, galactose, arabitol and mannose were more closely related to Senong 17 white than Senong 17 brown.

강직성 슬관절에서의 슬관절 전치환술

조우신,박종희,김정민,오세관 대한슬관절학회 2003 대한슬관절학회지 Vol.15 No.1

목적: 강직이 동반된 슬관절염 환자에서 슬관절 전치활술의 문제점, 결과 및 합병증을 분석하고자 하였다. 대상 및 방법: 1994년 1월부터 2000년 12월까지 슬관절 강직(운동 범위 50도이하)이 있는 환자에게 슬관절 전치환술을 시행하여 2년 이상 추시가 가능하였던 16례를 대상으로 하였다. 수술은 관절 강직이 발생한지 평균 12.2년(1~40년)에 시행하였으며, 추시기간은 평균 3.3년(2~6년)이었다. 16례 중 남자 3례, 여자 13례였고, 평균 나이는 55.8세(34세~75세)였다. 감염에 의한 후유증 6례로 가장 많았고 그 외 퇴행성 관절염 4례, 외상 후 관절염 3례, 류마티스성 관절염 3례의 순이었다. 술 후 평가는 추시기간 중의 운동 범위와 HSS score 및 합병증을 분석하였다. 결과: 관절 운동 범위는 술 전 평균 31.6도(0~50도)에서 추시시 평균 95.4도(80~120도)로 증가하였으며, 1례에서만 5도의 굴곡 구축이 있었다. HSS score는 술 전 평균 59.6점(43~76점)에서 추시시 평균 84.6점(76~92점)으로 향상되었다. 1례에서 수술 중 슬개건 부분파열이 있었으나 보조기 착용과 적극적 재활로 술 후 1년째 90°의 관절 운동이 가능했다. 표재성 감염 1례는 창상의 변연절제술 후 피부이식으로 치유되었고, 심부 감염된 3례는 추후 관절 유합술을 시행하였다. 결론: 슬관절 전지환슬은 강직된 슬관절의 기능을 회복시킬 수 있는 좋은 술기이지만 감염등의 합병증을 고려해서 시행되어야 한다. Purpose: To evlauate the results of TKRA (Total knee replacement arthroplasty) for the treatment of stiff knee. Methods & Materials : TRKA has been performed for 18 cases of stiff knee ( ROM < 50° ) between January 1994 and December 2000. 16 cases which have been followed up for more than 2 years were analysed. Average follow-up was 3.3 years(2~6 years). 3 were male and 13 female. The average age was 55.8 years(34~75 years). Sequales of infection were most with 6 cases and followed by osteoarthritis (4 cases, 2 cases had been performed arthroscopic debridement) and rheumatoid arthritis (3 cases) and traumatic arthritis (3 cases) in order. TKRA was performed on average 12.2 years (1~40 years) after knee stiffness has been developed. We evaluate the results with ROM, HSS score and complications. Results : Average ROM was increased from 31.6°(0°~50°) preoperatively to 95.4°(80°~120°) postoperatively. 5° of flexion contracture was present in only 1 cases. Average HSS score was improved from 59.6 points preoperatively to 84.6 points postoperatively. The patella tendon was partially ruptured in 1 case surgery, but by brace application and rehabilitative exercise, ROM was improved to 90°, 1 year post operatively. There were 1 superficial skin infection which was resolved by revision of wound and skin graft, and deep infection in 3 cases, which needed knee fusion finally. Conclusion : TKRA is a good method for improving function in knee stiffness although infection risk is high.

인삼 사포닌의 몰핀 길항작용

김학성,오기완,오세관 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4

Ginseng total saponins(GS), protopanaxadiol saponins(PD) and protopanaxatriol saponins (PT) antagonized the analgesia in mice induced by morphine. The administrations of 2, 4-dihydroxyphenylalanine, and 5-hydroxytryptophan reduced the GS, PD and PT antagonisms of morphine analgesia. Possible mechanisms involved in the antagonistic actions of GS, PD and PT on morphine analgesia were described.