겨울철 남해안 호우 발생 분석

김인보,김종석,이봉우,임병문,김좌겸 한국기상학회 2011 한국기상학회 학술대회 논문집 Vol.2011 No.4

한국산 겨우살이 숙주별 렉틴 함량과 지표물질로서의 특성 조사

김인보,윤택준,박춘호,이우경,이소희,김종배,Kim, Inbo,Yoon, Taek Joon,Park, Choon Ho,Lee, Woo Kyoung,Lee, So Hee,Kim, Jong Bae 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.6

겨우살이는 전통적으로 항암활성이 있는 약용식물의 하나로 알려져 왔고, 렉틴은 세포독성 및 면역자극 자극 활성을 가지는 대표성분으로 인정되고 있다. 한국산 겨우살이에 함유되는 렉틴은 유럽산의 그것과는 달리 galactose와 N-acetylgalactosamine(GalNAc) 특이성을 동시에 가지는 렉틴 성분인 KML인 것으로 나타났다. Sandwich ELISA법을 이용하여 각기 다른 종류의 숙주나무에서 유래된 5종의 겨우살이로부터 렉틴 함량을 비교한 결과, 숙주나무별 차이가 인정되어 밤나무 겨우살이는 참나무 겨우살이에 비하여 약 10배 많은 렉틴을 함유하고 있었다. L5178Y-ML25 lymphoma 세포에 약 90%의 세포독성을 나타내는 농도의 KML과 한국산 참나무 유래 겨우살이 추출물인 KM-100에 두 종류의 단일클론 항체(9H7-10 and 8B11-2C5)를 동시처리한 후 세포독성 중화효과를 조사한 결과, KML의 경우 약 10%, KM-110의 경우 약 30%의 세포독성을 보였다. 이러한 결과는 겨우살이에서 렉틴 외에도 세포독성을 가지는 다른 성분이 존재할 것으로 사료되었다. RAW 264.7 대식 세포주에 KM-110과 KM-110으로부터 렉틴이 제거된 분획인 LFKM-110을 자극시킨 결과, LFKM-110에서 $TNF-{\alpha}$ 및 IL-6와 같은 cytokine의 생산을 증진시키는 결과를 보였다. 따라서 KM-110에서 면역 세포를 자극하는 다른 성분의 존재하고 있음을 강하게 제시되었다. Traditionally, mistletoe is known as an effective anti-cancer medicinal plant, and lectin is recognized as a major component with cytotoxic and immuno-stimulant activity in mistletoe. A Korean mistletoe lectin (KML) has specificity to galactose and galactosamine and is distinguish from European mistletoe lectin (EML). When we examined the concentration of lectin in mistletoe originated from five different types of host trees, the result indicate that the lectin concentration is variable depending on the host tree. Noticeably, mistletoe from chestnut tree contains ten folds higher lectins than that of an oak tree. We also tested the concentration of KML and crude extract (KM-110) of Korean mistletoe that shows 90% cytotoxicity in L5178Y-ML25 lymphoma cell. In addition, the cells show 90% and 70% viability by the treatment of two neutralizing antibodies of KML, 9H7-D10 and 8B11-2C5 neutralization effect with two monoclonal antibodies of KML, 9H7-D10 and 8B11-2C5. Therefore, the result expected that the mistletoe contain some other cytotoxic components except lectin. Finally, the production of $TNF-{\alpha}$ and IL-6 by RAW 264.7 cells stimulated with lectin free-crude extract (LFKM-110) following neutralization by 9H7-D10 monoclonal antibody shows higher than that of lectin containing-crude extract (KM-110). These results suggest that the Korean mistletoe lectin ha a great potential to be developed as therapeutic agent of cancer.

iOS Sysdiagnose를 활용한 사용자 행위 추적 방안 연구

김인보,이상진,박정흠 한국디지털포렌식학회 2023 디지털 포렌식 연구 Vol.17 No.4

The more recent mobile devices are, the more difficult it is to secure digital evidence when anti-forensics activities that delete apps and data occur. In the case of iPhones, deleted data cannot be recovered, but user behavior can be tracked by using the system diagnostic log. This paper presents a method of visualizing and using the Sysdiagnose Log as digital evidence so that user behavior can be tracked from the iPhone's iOS Sysdiagnose Log, crime related, and used as indirect evidence. 최신 모바일 기기일수록 앱과 데이터를 삭제하는 안티-포렌식 행위가 발생하면, 디지털 증거를 확보하기는 어려워진다. iPhone의 경우 삭제된 데이터를 복구하지 못하지만 시스템 진단 로그를 이용하면 사용자 행위를 추적할 수 있다. 본 논문에서는 iPhone의 시스템 진단 로그인 iOS Sysdiagnose Log로부터 사용자 행위를 추적하고 범죄 관련 여부를 판단할 수 있도록 Sysdiagnose Log를 시각화하여 간접 증거로 활용하는 방법을 제시한다.

$TightRope^{(R)}$를 이용한 관절경적 급성 견봉쇄골 관절 탈구의 치료

김인보,손명환,김문찬,김동준,Kim, In-Bo,Shon, Myung-Hwan,Kim, Moon-Chan,Kim, Dong-Jun 대한관절경학회 2011 대한관절경학회지 Vol.15 No.1

목 적: $TightRope^{(R)}$ (Arthrex, Inc, Naples, FL)를 이용한 급성 견봉쇄골 관절 탈구의 관절경적 오구쇄골 관절 고정술의 방사선학적 및 임상적 결과를 평가하고자 한다. 대상 및 방법: 2009년 2월부터 2010년 2월까지 Rockwood 3형 또는 5형의 급성 견봉쇄골 관절 탈구 환자 20명에 대해 $TightRope^{(R)}$를 이용하여 관절경적 오구쇄골 관절 고정술을 시행하였다. 추시 기간은 평균 13.4(10~22)개월이었다. 방사선학적 평가는 쇄골 관절 부하 사진을 통해 쇄골과 오구돌기 사이 거리를 건측과 비교하였고, 임상적 평가는 KSS(Korean Shoulder Scoring System)를 이용하였으며, 환자들의 미용적 만족도도 평가하였다. 결 과: 방사선학적 평가에서 18예는 매우 우수, 1예는 우수, 1예는 양호의 결과를 보였다. KSS는 평균 98.5(92~100)점이었으며, 전 예에서 만족할 만한 미용적 결과를 보였다. 1예에서 매듭에 의한 피부 압통 및 촉진되는 불편감을 호소하여 시행한 매듭 봉합술 후 국소 감염이 발생하여 국소 마취 하 배농술 및 2주간 항생제 사용으로 치유하였다. 결 론: Rockwood 3형 또는 5형의 급성 견봉쇄골관절 탈구의 치료에 있어 $TightRope^{(R)}$를 이용한 관절경적 오구쇄골 관절 고정술은 만족스러운 방사선학적 및 임상적 결과를 보이며, 술후 합병증이 거의 없고, 조기 재활이 가능하며, 뛰어난 미용적 결과를 보이고, 금속 고정물 제거를 위한 이차적 수술이 필요없는 훌륭한 치료 방법이 될 것으로 생각된다. Purpose: The purpose of this study is to evaluate the radiologic and clinical results of the arthroscopic coracoclavicular fixation of the acute acromioclavicular dislocation using $TightRope^{(R)}$ (Arthrex, Inc, Naples, FL). Materials and Methods: We performed the arthroscopic coracoclavicular fixation using $TightRope^{(R)}$ in twenty patients with the Rockwood type III or V acute acromioclavicular dislocation between February, 2009, and February, 2010. Mean follow-up was 13.4(range 8~22) months. Radiologic results were evaluated by comparing the distances between the clavicle and the coracoid process with those in the contralateral sides using the acromioclavicular stress radiographs. Clinical results were made according to the KSS(Korean Shoulder Scoring System), and the cosmetic satisfaction of the patient was assessed. Results: Radiologically, 18 cases showed excellent, 1 case showed good and 1 case showed fair results. Clinically, KSS was mean 98.5 (range 92~100) points and all cases revealed satisfactory cosmetic results. Because one case complained of skin tenderness and discomfort of palpation, we closed the knot with surrounding muscle & fascia. Then local wound infection occurred, so we treated it by incision and drainage under local anesthesia and antibiotic therapy for 2 weeks. Conclusion: Arthroscopic coracoclavicular fixation using $TightRope^{(R)}$ for treating the Rockwood type III or V acute acromioclavicular dislocation showed satisfactory radiologic and clinical results. It seems to be a good treatment method that has little postoperative complication, provides an early rehabilitation and an excellent cosmetic result, and does not require secondary operation for removal of metal implant.

여주(Momordica charantia) 추출물이 생쥐의 지구력 운동수행능력 향상 효과에 미치는 영향

김인보,박춘호,정회윤,정주성,홍환웅,김종배,Kim, Inbo,Park, Choon-Ho,Jung, Hoe-Yune,Jeong, Juseong,Hong, Hwan-Ung,Kim, Jong Bae 한국식품영양학회 2016 韓國食品營養學會誌 Vol.29 No.4

Bitter melon (Momordica charantia) is used in traditional herbal medicine in many Asian countries for the treatment of several diseases such as diabetes, eczema, night blindness, psoriasis, and rheumatism. Especially, most reports concerning the biological activities of bitter melon have focused on its effects on diabetes and hyperglycemia. Also, bitter melon is regarded as a longevity food, suggesting that it has several beneficial effects on anti-aging and the maintenance of a healthy state. Thus, we investigated whether bitter melon could increase the capacity of exercise in this study. Interestingly, bitter melon fruit extract activated AMP-activated protein kinase (AMPK), which is important for regulating glucose homeostasis, mitochondrial content and exercise capacity. In addition, bitter melon extract increased the expression of enzymes involved in fatty acid oxidation such as mitochondrial uncoupling protein 3 (UCP3), carnitine palmitoyl transferase 1b (CPT1b), and pyruvate dehydrogenase lipoamide kinase isozyme 4 (PDK4). Moreover, exercise tolerance was much more enhanced in bitter melon treated animals compared to the non-treated control group. These results suggest that bitter melon is a promising candidate for the development of functional foods beneficial for physical strength and the enhancement of exercise capacity.

다양한 변환 공진기에 형성되는 비등방성 속삭임의 회랑 모드

김인보,최무한,Kim, Inbo,Choi, Muhan 한국광학회 2018 한국광학회지 Vol.29 No.3

이 논문에서는 변환 광학의 기본 원리를 설명하고 이를 적용하여 공진기 모양이 원형으로부터 크게 변형되어도 속삭임의 회랑 모드(WGM)의 특성을 유지할 수 있는 다양한 변환 공진기 설계 기법을 소개한다. 특정 등각 변환 하에서 다양한 변환 공진기를 얻는 방법으로서 초기 정의역을 평행 이동시키는 방법과, 타원을 정의역으로 잡고 회전시키는 방법을 제시하였고, 이를 통해 설계된 몇 가지의 공진기 모드에 대한 내부 파형 및 원거리장 출력 특성을 수치해석적으로 계산하였다. 이러한 결과로부터, 하나의 주어진 등각 좌표변환과 관련된 다양한 GRIN 공진기가 가능하다는 것을 확인하였다. We explain the basic principle of transformation optics, and introduce several design techniques for transformation cavities that can maintain the characteristics of whispering gallery modes (WGMs) even if the cavity is strongly deformed from a circular shape. As a method of obtaining various transformation cavities under a specific conformal mapping, we suggest a method of parallel movement of the initial cavity domain, and a method of rotating the ellipse as a cavity domain. The internal wave pattern and the far-field output characteristics of several designed resonant modes are numerically calculated. From these results, it is confirmed that a variety of GRIN resonators are possible for a given conformal coordinate transformation.

영남문집해제 : 둔수일고

김인보 영남대학교 민족문화연구소 1988 민족문화연구소 자료총서 Vol.4 No.-

연구논문 : 한국산 겨우살이 추출물의 안전성 평가

김인보 ( In Bo Kim ),정주성 ( Ju Seong Jeong ),윤택준 ( Taek Joon Yoon ),김종배 ( Jong Bae Kim ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.3

Mistlero C was shown to be non-genotoxic in a series of genotoxicity tests, including a bacterial reverse mutation test and a combined in vivo mammalian erythrocyte micronucleus test. In a bacterial reverse mutation assay, no significant increases in the number of revertant colonies, compared to the negative control, was detected in 5,000 ㎍/plate of Mistlero C. In addition, with Mistlero C, no changes were shown in the number of micronucleated polychromatic erythrocytes (MNPCE) among 2,000 polychromatic erythrocytes compared to the negative control. Mistlero C was administered orally in rats to investigate acute toxicity. The LD50 values in rats were above 2,000 ㎎/㎏. In a repeated dose, 13-week, oral toxicity study conducted in rats, no compound-related adverse effects were shown at doses of Mistlero C of up to 1,000 ㎎/㎏ body weight/day. The results of these studies support the safe use of Mistlero C in food for human consumption.

봉합이 불가능한 광범위 회전근 개 파열에서 관절경적 이종 이식 봉합

김인보(In Bo Kim),김동준(Dong Jun Kim) 대한견주관절의학회 2011 대한견주관절의학회지 Vol.14 No.2

목적: Permacol<SUP>®</SUP>을 이용한 봉합 불가 광범위 회전근 개 파열의 관절경적 가교 봉합 술식의 단기결과를 보고하고자 한다. 대상 및 방법: 2010년 10월부터 2011년 4월까지 6명의 봉합 불가 광범위 회전근 개 파열 환자에 Permacol<SUP>®</SUP>을 이용한 관절경적 가교 봉합 술식을 시행하였다. 전 환자에 술전 및 술후 KSS (Korean Shoulder Scoring System)를 측정하였다. 술후 평균 4.2 (2~10)개월에 MRI를 시행하였다. 결과: 평균 7 (4~12)개월 추시시, 평균 KSS는 술전 평균 53.0점에서 술후 평균 72.3점으로 유의한 증가를 보였다 (p=0.046). 통증 (p=0.066) 및 운동 범위 (p=0.336)는 유의성 없는 향상을 보였다. 술후 MRI상 2예는 이식물이 온전히 유지, 1예는 부분 파열, 3예는 완전 파열되었다. 부작용이나 관절 감염 같은 합병증은 없었다. 결론: 돼지 진피 이종 이식물인 Permacol<SUP>®</SUP>은 건 치유를 위해 인체 다른 영역에서는 유용할지라도, 봉합 불가 광범위 회전근 개 파열의 가교 봉합 술식에의 사용은 신중히 선택되어야 하고 추가연구가 필요하리라 생각된다. Purpose: Our purpose was to assess the short-term results of arthroscopic bridging repair of massive, irreparable rotator cuff tears by use of a Permacol<SUP>®</SUP>. Materials and Methods: Between October 2010 and April 2011, 6 patients with massive, irreparable rotator cuff tears were treated with arthroscopic bridging repair using a Permacol<SUP>®</SUP>. All were evaluated preoperatively and postoperatively by use of the Korean Shoulder Scoring System (KSS). Magnetic resonance imaging was performed postoperatively at mean 4.2 months (range, 2 to 10 months) after operation. Results: At a mean follow-up of 7 months (range, 4 to 12 months), the mean KSS increased significantly from preoperatively mean 53.0 to postoperatively mean 72.3 (p=0.046). Statistically insignificant improvements were seen in pain (p=0.066) and range of motion (p=0.336). As documented on magnetic resonance imaging, there were two patients with full incorporation of the graft into the native tissue, 1 partial retear, and 3 complete retear. There were no complications such as adverse inflammatory or septic joint in these patients. Conclusion: Although Permacol<SUP>®</SUP>, porcine dermal xenograft may be effective in other areas of the body for tendon healing, its use in bridging repair of massive, irreparable rotator cuff tears seems to have to be chosen prudently and warrants further evaluation.

Usefulness of Anteromedial Portal for Femoral Tunneling in Anterior Cruciate Ligament Reconstruction

강민수,김인보,김경택,Kang, Min-Soo,Kim, In-Bo,Kim, Kyung-Taek Korean Arthroscopy Society 2008 대한관절경학회지 Vol.12 No.2

Purpose: Recent development and advances in the arthroscopic surgical techniques for anterior cruciate ligament(ACL) reconstruction have led to the ideal location for more oblique anatomic point of the femur from 10 to 10:30 o'clock(in the right knee) and from 2 to 1:30 o'clock(in the left knee) in the frontal plane. This study was performed to compare the operative methods and the radiologic results of the femoral tunnels made through the tibial tunnel(trans-tibial approach) and the anteromedial portal. Materials and Methods: From January 2003 to May 2004, on hundred reconstructions of ACL were performed. Group I(the femoral tunnel made through the tibial tunnel) consisted of 50 cases and group I(the femoral tunnel made through the anteromedial portal) consisted of 50 cases. The operative methods and the radiographic results of the femoral tunnels were compared. Results: Femoral tunnel was made more easily at more oblique anatomic point in group II than in group I. In group II, better visual field was achieved at the angle of 100? flexion of the knee joint, the risks of the posterior cortical breakage and the tunnel-graft mismatching were reduced more, and the divergence of femoral interference screw from the radiograph decreased more than in group I(p<0.05). The angle between the femoral tunnel and the longitudinal axis of ACL increased in group II. Conclusion: Anteromedial portal technique was useful for femoral tunneling toward 10 to 10:30 o'clock(in the right knee) and 2 to 1:30 o'clock(in the left knee) in ACL reconstruction. Level of Evidence:Level III, case-control study.