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( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2
Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)
Comparative proteomic analysis of plant responses to sound waves in Arabidopsis
권영상,Mi-Jeong Jeong,Jaeyul Cha1,Sung Woo Jeong,박수철,신성철,정우식,배한홍,Dong-Won Bae 한국식물생명공학회 2012 식물생명공학회지 Vol.39 No.4
Environmental factors greatly influence the growth,development, and even genetic characteristics of plants. The mechanisms by which sound influences plant growth,however, remain obscure. Previously, our group reported that several genes were differentially regulated by specific frequenciesof sound treatmentusing a sound-treated subtractive library. In this study, we used a proteomic approach to investigate plant responses to sound waves in Arabidopsis. The plants were exposed to 250-Hz or 500-Hz sound waves,and total proteins were extracted from leaves 8 h and 24 h after treatment. Proteins extracted from leaves were subjected to 2-DE analysis. Thirty-eight spots were found to be differentially regulated in response to sound waves and were identified using MALDI-TOF MS and MALDI-TOF/TOF MS. The functions of the identified proteins were classified into photosynthesis, stress and defense, nitrogen metabolism,and carbohydrate metabolism. To the best of our knowledge,this is the first report on the analysis of protein changes in response to sound waves in Arabidopsis leaves. These findings provide a better understanding of the molecular basis of responses to sound waves in Arabidopsis.
Cha, Jang-Gyu,Hong, Hyun-Sook,Kwon, Kye-Won,Park, Seong Jin,Kim, Jun-Bum,Hong, Jeon-Chan,Paik, Sang-Hyun,Park, Jai Soung 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2
We describe an intra-articular schwannoma involving the knee, an extremely unusual location for this lesion. This case shares the typical magnetic resonance (MR) findings of neural tumors, but also involves atypical features not previously highlighted, related to its solitary involvement and relatively larger size. Schwannoma should be included in the differential diagnosis of intra-articular masses in the knee joint.
Effects of Calcining Temperature on SnO₂ Sensors for CO and NO_(x) Gases
Cha, Geon-Young,Bui, Anh-Hoa,Baek, Won-Woo,Lee, Sang-Tae,Lee, Duk-Dong,Huh, Jeung-Soo 대한금속재료학회 2004 METALS AND MATERIALS International Vol.10 No.2
Nitrogen oxides (NO,) and carbon monoxide (CO) are among the most dangerous chemical species to human health present in the atmosphere. Acute GO toxicity leading to unconsciousness, respiratory failure or death can occur after 1 hr of exposure when ambient CO levels reach l000 ppm, whilst increase of NO, emissions can contribute to acid deposition, pollution of groundwater, eutrophication of surface waters, and tropospheric ozone and ecosystem damage. In this work, pure SnO₂ sensors for CO and NO, were prepared by spin coating solutions derived from a washed Gel-precipitate followed by a calcining step. SnO₂ sensors of nanometer grain size prepared by this process showed good sensitivity to CO and NO, gases. The increase of calcining temperature not only affected grain size and surface morphology, but also caused a decrease in sensitivity of the SnO₂ sensors.
Study of Moving Boundary Problem using Integral Merhod (Ⅱ) : Second Order Solution
Cha, Sang-Won 水原大學校 1999 論文集 Vol.17 No.-
차가운 액체 속을 운동하는 연속된 Wire에 생성되는 결빙피막과정은 이동경계문제의 일종으로서 지금까지의 연구는 유한차분법에 의존하여 왔으며 많은 계산시간이 소요되었다. 그러나 Biot수가 작은 경우에는 Wire의 반경방향 온도변화를 무시할 수 있으므로, [1]에서 karman-Pohlhausen의 적분법을 이용하여 결빙피막 생성과정을 해석하였다. 한편 [1]은 생성되는 결빙피막의 여러 변수를 1계(first order)에 국한하였으나 본 연구에서는 해의 정확성을 높이기 위해 2계(second order)까지 전개한 후 (1)의 계산결과와 비교하였다.