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( Sang-Cheol Bae ),( Jin-Hye Cha ),( Jung-Yoon Choe ),( Sung Jae Choi ),( Soo-Kyung Cho ),( Won-Tae Chung ),( Chung-Il Joung ),( Young-Ok Jung ),( Young Mo Kang ),( Dong-Wook Kim ),( Jinseok Kim ),( Y 대한류마티스학회 2018 대한류마티스학회지 Vol.25 No.2
Objective. Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified. Methods. Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥ 6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups. Results. 84.4% were females, 54.2% had low DAS-28-ESR (<3.2), and 38.2% and 7.6% had moderate (3.2∼5.1) and high DAS-28-ESR (>5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours: 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p<0.0001; monthly costs of LPT in 1,000 Korean won: 1,097±607 vs. 1,302±554 vs. 741±531, p<0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI]: 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI: 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI: 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI: 1.43∼2.54) compared to low DAS-28-ESR. Conclusion. Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA. (J Rheum Dis 2018;25:122-130)
Tae-Hoon Kim,Jung-Hyo Lee,Chung-Yuen Won 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.6
This paper shows the design and control methods of the bidirectional DC-DC converter to generate the proper DC-link voltage of a PMSM drive. Conventionally, because the controllable power of the PWM based voltage source inverter is limited by its DC-link voltage, the DC-DC converter is used for boosted DC-link voltage if the inverter source cannot generate enough operating voltage for the PMSM drive. In this paper, to obtain more utilization of this DC-DC converter, optimal DC-link voltage control for PMSM drive will be explained. First, the process and current path of the DC-DC converter will be illustrated, and a control method of this converter for variable DC-link voltage will then be explained. Finally, an improvement analysis of the optimal DC-link voltage control method, especially on the deadtime effect, will be explained. The DC-DC converter of the proposed control method is verified by the experiments by comparing with the conventional constant voltage control method.
Polymorphisms of GSTM1,GSTT1,GSTP1,NATII and CYP1A1 and the Susceptibility to Asthma
Chung, Hai Won,Ahn, Tai Hui,Kim, Su Young,Kim, Tae Yon,Paek, Domyung 한국유전학회 2002 Genes & Genomics Vol.24 No.3
The associations of asthma with genetic polymorphisms remains unclear. The purpose of this study is to find the association of NA72, GSTM1, GS7T1, GS7P1 and CYP1A1 polymorphism with asthma in Koreans. The genetic polymorphisms of GS7M1, GS7T1, GS7P1, NA7II and CYP1A1 genes among 33 asthma patients and 66 controls were investigated to find the association of the polymorphism with the risk of asthma. The frequency of the GS7Tl null genotype was slightly higher in asthma patients than that in controls, but this difference was not statistically significant. No difference in the frequencies of GS7T1 and GS7Pl was found between patients and controls. Excess risk for the combined GS7T1 and GS7M1 null genotype was found (O.R = 7.62, 95% CI: 1.13-51.46). There was no association with asthma risk by NA72 genotypes. The presence of the homozygous variant type (M/M of CYP1A1 led to the increased risk (O.R = 4.40, 95% CI:1.01-19.29) for asthma compared to wild type (WT) and heterozygous variant type (W/M). An increased risk of asthma for the combined GS7T1 null genotype (MM and CYP1A1 homozygous variant genotype (M/M) was also found (O.R. = 11.61, 95% CI: 1.14 - 118.43). The CYP1AI genotype, combined GS7M1 and GS7T1 genotypes as well as the combination of CYP1A1 and GS7T1 genotypes may be used as susceptible markers for asthma.
Pulmonary Foreign Body Granulomatosis in Dental Technician
Chung, Sung Jun,Koo, Gun Woo,Park, Dong Won,Kwak, Hyun Jung,Yhi, Ji Young,Moon, Ji-Yong,Kim, Sang-Heon,Sohn, Jang Won,Yoon, Ho Joo,Shin, Dong Ho,Park, Sung Soo,Pyo, Ju Yeon,Oh, Young-Ha,Kim, Tae-Hyung The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Occupational lung diseases are caused by several toxic substances including heavy metals; however, the exact pathologic mechanisms remain unknown. In the workplace, dental technicians are often exposed to heavy metals such as cobalt, nickel, or beryllium and occasionally develop occupational lung diseases. We described a case of occupational lung disease in a patient who was employed as a dental technician for over a decade. A 31-year-old, non-smoking woman presented with productive cough and shortness of breath of several weeks duration. Chest computed tomography revealed a large number of scattered, bilateral small pulmonary nodules throughout the lung field, and multiple mediastinal lymph nodes enlargement. Percutaneous needle biopsy showed multifocal small granulomas with foreign body type giant cells suggestive of heavy metals inhalation. The patient's condition improved on simple avoidance strategy for several months. This case highlighted the importance of proper workplace safety.
Measurement of the keV-Neutron Capture Cross-Sections of 156,158Gd
Won-Chung Chung,Guinyun Kim,Masayuki Igashira,Tae-Ik Ro,Toshiro Ohsaki 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.I
The neutron capture cross-sections of $^{156}$Gd and $^{158}$Gd were measured in the neutron energy region from 10 to 90 keV by using the 3-MV Pelletron accelerator of the Research Laboratory for Nuclear Reactors at the Tokyo Institute of Technology. Pulsed keV-neutrons were produced from the $^7$Li(p,n)$^7$Be reaction by bombarding the lithium target with a 1.5-ns bunched proton beam. The incident neutron spectrum on the capture sample was measured by means of a time-of-flight (TOF) method with a $^6$Li-glass detector. The capture $\gamma$-rays were detected with a large anti-Compton NaI(Tl) spectrometer. A pulse-height weighting technique was applied to the measured capture $\gamma$-ray pulse-height spectra to derive the capture yields. The capture cross-sections were obtained by using the standard capture cross-section of $^{197}$Au. The present results were compared with the previous measurements and with the evaluated values of ENDF/B-VII-b2 and JENDL-3.3.