Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis

Park, H.G.,Yoon, S.Y.,Choi, J.Y.,Lee, G.S.,Choi, J.H.,Shin, C.Y.,Son, K.H.,Lee, Y.S.,Kim, W.K.,Ryu, J.H.,Ko, K.H.,Cheong, J.H. North-Holland ; Elsevier Science Ltd 2007 european journal of pharmacology Vol.574 No.2

In previous studies, we identified sedative effects of Scutellaria baicalensis extracts and found that these extracts or their constituents may also have anticonvulsive effects. Wogonin is a natural product isolated from S. baicalensis, which possesses central nervous system effects such as anxiolytic and neuroprotective activities. In this study, we investigated the effects of wogonin on convulsion related behaviors, such as myorelaxation, motor coordination, and anticonvulsant effects of wogonin on chemical induced seizure and electroshock seizure in mice or rats. The effect of wogonin on membrane potential was also observed. Wogonin was intraperitoneally injected into mice or rats 30 min prior to testing. Animals treated with wogonin did not change locomotor activities as well as endurance times on the rota-rod, which indicates that wogonin did not cause a sedative and myorelaxation effect. Wogonin significantly blocked convulsion induced by pentylenetetrazole and electroshock but not convulsion induced by strychnine. Wogonin also significantly reduced the electrogenic response score, but flumazenil treatment reversed this decrease to the level of the control group. The wogonin treatment increased Cl<SUP>-</SUP>influx into the intracellular area as dose increased. Flumazenil and bicuculline treatment, however, inhibited the Cl<SUP>-</SUP> influx induced by wogonin. These results indicate that the anticonvulsive effects produced by wogonin were mediated by the GABAergic neuron.

Amantadine-resistant influenza A viruses isolated in South Korea from 2003 to 2009

Choi, W.Y.,Kim, S.,Lee, N.,Kwon, M.,Yang, I.,Kim, M.J.,Cheong, S.G.,Kwon, D.,Lee, J.Y.,Oh, H.B.,Kang, C. Elsevier/North-Holland 2009 ANTIVIRAL RESEARCH Vol.84 No.2

To investigate the frequency of amantadine resistance among influenza A viruses isolated in Korea during the 2003-2009 seasons, 369 (16.8%) 2199 A/H1N1 viruses and 780 (14.8%) of 5263 A/H3N2 viruses were randomly selected. The M2 and HA1 genes of each isolate were amplified by reverse transcription-polymerase chain reaction and followed by nucleotide sequencing. The results showed that the resistance rate to amantadine among A/H1N1 viruses increased significantly from 2004-2005 (33.3%) to 2007-2008 (97.8%) and then decreased dramatically in 2008-2009 (1.9%). The A/H1N1 isolates recently detected in 2008-2009 turned amantadine-sensitive containing two new substitutions at specific sites (S141N, G185A) in HA1. Compared with A/H1N1 viruses, the amantadine resistance among the A/H3N2 viruses increased from 2003-2004 (9.7%) to 2005-2006 (96.7%) and decreased in 2006-2007 (57.4%). During 2006-2007, both of amantadine-resistant and -sensitive A/H3N2 viruses co-circulated but clustered in different branches phylogenetically. All of A/H3N2 isolates tested during 2007-2009 appeared to cluster in the same group being resistant to amantadine.

Organic-inorganic hybrid photocatalyst for carbon dioxide reduction

Won, D. I.,Lee, J. S.,Cheong, H. Y.,Cho, M.,Jung, W. J.,Son, H. J.,Pac, C.,Kang, S. Royal Society of Chemistry 2017 Faraday discussions Vol.198 No.-

<P>Efficient hybrid photocatalysts for carbon dioxide reduction were developed from dye-sensitized TiO2 nanoparticles and their catalytic performance was optimized by ternary organic/inorganic components. Thus, the hybrid system consists of (E)-2-cyano-3-(5'(5 ''-(p-(diphenylamino)phenyl)thiophen-2 ''-yl)thiophen-2'-yl)-acrylic acid as a sensitizer and fac-[Re(4,4'-bis(diethoxyphosphorylmethyl)-2,2'-bipyridine)(CO)(3)Cl] as a reduction catalyst (ReP), both of which have been fixed onto TiO2 semiconductors (s-TiO2, h-TiO2, d-TiO2). Mott-Schottky analysis on flat-band potential (E-fb) of TiO2 mesoporous films has verified that Efb can be finely modulated by volume variation of water (0 to 20 vol%). The increase of added water resulted in substantial positive shifts of Efb from -1.93 V at 0 vol% H2O, to -1.74 V (3 vol% H2O), to -1.56 V (10 vol% H2O), and to -1.47 V (20 vol% H2O). As a result, with addition of 3-10 vol% water in the photocatalytic reaction, conversion efficiency of CO2 to CO increased significantly reaching a TON value of similar to 350 for 30 h. Catalytic activity enhancement is mainly attributed to (1) the optimum alignment of Efb by 3-10 vol% water with respect to the E-ox* of the dye and E-red of ReP for smooth electron transfer from photo-excited dye to ReP via the TiO2 semiconductor and (2) the water-induced acceleration of chemical processes on the fixed ReP. In addition, the energy level was further tuned by variation of the dye and ReP amounts. We also found that the intrinsic properties of TiO2 sources (morphology, size, agglomeration) exert a great influence on the overall photocatalytic activity of this hybrid system. Implications of the present observations and reaction mechanisms are discussed in detail.</P>

Assignment of phosphatidylinositol glycan, class K (PIGK) gene to porcine chromosome 6q32 by somatic cell and radiation hybrid panel mapping

Park, E.W.,Kim, J.H.,Lim, H.T.,Seo, B.Y.,Cho, I.C.,Lee, J.G.,Oh, S.J.,Cheong, I.C.,Lee, J.H.,Jeon, J.T. S. Karger AG 2004 CYTOGENETIC AND GEN0ME RESEARCH Vol.108 No.4

<P> </P><P>Copyright © 2005 S. Karger AG, Basel</P>

H13/Cu 경사기능재료의 레이저 응용 적층 제조

신기훈(K. H, Shin),이남주(N. J. Lee),정성균(S. K. Cheong) Korean Society for Precision Engineering 2018 한국정밀공학회 학술발표대회 논문집 Vol.2018 No.10월

Rb-Sr isotopic study of the Hwacheon granite in northern Gyeonggi massif, Korea: A case of spurious Rb-Sr whole rock age

S.-T. Kwon,C.- S. Cheong,H. Sagong 한국지질과학협의회 2006 Geosciences Journal Vol.10 No.2

Sagong, H., Kwon, S.-T., and Ree, J.-H., 2005, Mesozoic episodicmagmatism in South Korea and its tectonic implication. Tecton-ics, 24, TC5002, doi:10.1029.

대학생 커플 간의 성 의사소통 양상에 따른 성 태도, 성적 자율성 및 성 만족도의 상관관계에 관한 연구

이은하,이지연,정지영,강시원,한현민,김소연,김동미,방소현,박예찬,지혜민 이화여자대학교 간호과학대학 2015 이화간호학회지 Vol.- No.49

Purpose: The purpose of this study was to investigate sexual communication among college student couples and to analyze the relationship among sexual communication, sexual attitude, sexual autonomy and sexual satisfaction. Methods: Using a descriptive correlation study design, 281 college student couples were recruited through convenience random sampling from September 18th to October 3rd, 2014. Data were analyzed using average, standard deviation, percentage, t-test, ANOVA, Scheffe test, Duncan’s test and Pearson’s correlation using the SPSS 21.0 program. Results: In both genders, it is identified that high scores for sexual communication is related to sexual openness (male: R= .347, p<0.01 / female: R=.337, p<0.01) higher sexual satisfaction (male: R= .349, p<0.01 / female: R=.336, p<0.01) and sexual autonomy (male: R= .336, p<0.01 / female: R=.364, p<0.01). The same outcome is found when each male and female are grouped as a couple. Among sub-categories of sexual attitude, sexual pleasure was related to sexual communication the most in male (R=.337, p<0.01), female groups (R=.317, p<0.01) and couples (R=.402, p<0.01). Among sub-categories of sexual satisfaction, psychological factor was related to sexual communication the most in the male group (R=.342, p<0.01) and interactive factor was related to sexual communication the most in the female group (R=.317, p<0.01) and couples (R=.402, p<0.01). Conclusion: The significance of this research is that the relations of sexual communication with the other three dependent variables among each gender and couples are shown. In addition, this study suggests the importance of sexual communication between couples which will lead to healthier and better quality of sexual relationships. However, with the lack of sufficient advanced research, there are limitations of analyzing each variables divided by demographic characteristics.

한우 간 및 등심 조직에서 불포화지방산의 조성비율과 Stearoyl-CoA Desaturase mRNAd의 발현 양상

이승환,윤두학,황수한,정은영,김언현,이창수 한국동물자원과학회 2004 한국축산학회지 Vol.46 No.1

The Stearoyl-CoA Desaturase(SCD) is a key enzyme, which converting palmitic acid(16:0) and stearic acid(18:0) to palmitoleic acid(16:1) and oleic acid(18:1), respectively. The concentration of oleic acid(18:1) in meat of beef cattle could influence both palatability and perception of meat. This experiment has conducted to determine relationship between the compositions of monounsaturated fatty acids and the SCD mRNA level in bovine liver and loin muscle tissue. The compositions of palmitoleic acid(16:1) and oleic acid(18:1) in loin muscle were 5% and 45% of total lipid and in liver were 2% and 20% of total lipid, respectively. On the other hand, the compositions of palmitic acid(16:0) and stearic acid(18:0) in loin muscle were 25% and 45% of total lipid and in liver were 14% and 43% of total lipid, respectively. The ratio of monounsaturated to saturated fatty acids(the desaturation index) was used as a measure of SCD activity in tissues. The average desaturation index in loin muscle was higher about 3.6-fold than that in liver. The desaturation index of oleate/stearate and palmitoleate/palmitate in loin muscle were higher 8-fold and 1.8-fold than those in liver, respectively, showing that the substrate specificity of SCD enzyme was very different between liver and muscle tissues. To determine whether the composition of monousaturated fatty acids in liver and muscle are dependent on SCD expression, SCD mRNA level was examined by RT-PRC analysis. The SCD mRNA level in loin muscle was higher about 3-fold than that in liver. Thus, the quantitative relationship between the desaturation index of fatty acid SCD mRNA was observed in liver and muscle. The difference in the compositions of monounsaturated fatty acids between bovine liver and muscle tissues may by due to different level of Stearoyl-CoA Desaturase mRNA.

제주도에서 사육되는 마의 질병과 기생충 감염에 관한 연구

이경갑,정종태,우호춘,김희석,양기천,김승호 濟州大學校 農科大學 動物科學硏究所 1995 動物科學論叢 Vol.10 No.1

The disease mobility and parasitic infection, and normal blood biochemistry values were investigated in Cheju horse. The ratio of the diseased horse was 23.3% in 1992 and 25.2% in 1993. The disease incidences of the digestive system, the respiratory system and the traumatic disease were 14.3%, 5.6% and 4.7%, respectively in the diseased horses. The rate of parasitic infection was 82.7% in Strongylus vulgaris, and 9.3% in Ascaris equiutn. The rate of bot's eggs on the equine hairs of Gastrophzlus spp. was 100% in the horses and the rate of infected larvae of Gastrophdus spp. was 37.5% in slaughtered horses. In the healthy horses, the values of RBC was 801.1 k79.1 l0^(4)/㎕, WBC was 9,090±1.533/㎕. PCV was 38.8±3.5%, hemoglobin was 13.0±1.5g/l00ml, total protein was 7.2±0.6g/l00ml, fibrinogen was 195.0±80.5mg/l00ml, sorbitol dehydrogenase was 0.62 ± 0.35IU/L, bilirubin was 2.5±0.5mg/100ml, blood urea nitrogen was 19.1±4.4mg/l00ml, creatinine was 1.1±0.2mg,/l00ml and glucose was 46.3±7.8mg/l00ml.

Large scale production of highly conductive reduced graphene oxide sheets by a solvent-free low temperature reduction

Lee, K.H.,Lee, B.,Hwang, S.J.,Lee, J.U.,Cheong, H.,Kwon, O.S.,Shin, K.,Hur, N.H. Pergamon Press ; Elsevier Science Ltd 2014 Carbon Vol.69 No.-

A novel one-pot process that can produce freestanding reduced graphene oxide (RGO) sheets in large scale through a mechanochemical method is presented, which is based on a 1:1 adduct of hydrazine and carbon dioxide (H<SUB>3</SUB>N<SUP>+</SUP>NHCO<SUB>2</SUB><SUP>-</SUP>, solid hydrazine). We were able to synthesize RGO sheets by grinding solid hydrazine with graphene oxide (GO), followed by storing the mixed powder at 50<SUP>o</SUP>C for 10min. No solvents, nor large vessels, nor post-annealing at high temperatures are required. The resulting RGO sample was characterized by elemental analysis, X-ray diffraction, X-ray photoelectron spectroscopy, Raman spectroscopy, Brunauer-Emmett-Teller measurement, thermo gravimetric analysis, Fourier transform infrared spectroscopy, solid state nuclear magnetic resonance spectroscopy, and conductivity measurement. It exhibits excellent conductivity and possesses a high specific surface area. This reduction method was successfully applied for the fabrication of inkjet-printed RGO devices on a flexible substrate.