[MANAGEMENT_이창수의 턴 어라운드 4.0] ‘개방형 혁신’에 불을 당겨라

이창수 (주)엑설런스코리아 2024 인사이트 코리아 : leader & wisdom = Insight Korea Vol.- No.318

記紀神話에 나타난 古代日本社會의 統合論理

이창수 경희대학교 대학원 일어일문학과 일본학논집간행회 1996 일본학논집 Vol.6 No.-

오늘의시인 이창수

이창수 천년의시작 2005 (계간)시작 Vol.4 No.4

조직내적적합성이 물류성과에 미치는 영향 : 환경불확실성의 조절효과를 중심으로

이창수 한국상업교육학회 2012 商業敎育硏究 Vol.26 No.4

전략적 적합성 이론에 의하면 기업은 경쟁우위를 달성하기 위해 외부환경과 내부자원의 적합성이 이루어지도록 전략을 수립하여야 하고, 그 전략을 효과적으로 실행하기 위해서는 정보기술과 조직구조가 전략에 적합하도록 조정되어야 한다. 이러한 관점에서 본 연구는 기업의 물류관리시스템 성과를 극대화하기 위해 환경불확실성, 물류전략과 조직구조간의 관계에서 환경과 물류전략 혹은 환경과 조직구조의 조화 문제를 개별적으로 추구하는 것만으로는 부족하며 물류전략과 조직구조의 적합성은 기업이 처한 환경불확실성에 대한 고려가 보장될 때, 물류성과 향상을 달성할 수 있는가를 주된 연구의 목적으로 한다. 실증분석결과, 기업의 물류전략과 조직구조간의 조직내적적합성에 따른 물류성과에 대한 차이에 관한 연구결과에 의하면 조직내적적합성이 높은 기업의 물류성과가 높다는 연구결과를 보이고 있다. 둘째, 물류전략과 조직구조간의 적합성에 따른 물류성과 차이에서 환경불확실성의 역할에 관한 연구결과를 보면, 기업의 환경불확실성에 대한 고려가 높을수록 물류성과는 더욱 높다는 연구결과를 나타내고 있다. 즉 물류전략과 조직구조간의 적합성을 통해 물류성과 향상을 달성하기 위해서는 기업이 처한 환경불확실성에 대한 고려가 높을수록 기업의 물류성과가 높다는 연구결과이다. 이러한 연구결과는 전략의 수립․실행만을 관심의 대상으로 하고 있는 물류경영실무에 대해서도 환경 불확실성 변수에 대한 명시적인 고려가 필요함을 시사해 주며, 아울러 전략실행의 문제를 배제하고 있는 물류경영실무에 대해서도 성과 함의를 분석하기 위해서는 조직구조에 적합한 물류전략의 선택에 관한 문제를 고려할 필요가 있음을 제시하였다는데 본 연구의 의의가 있다. This paper investigates the moderating effects of environmental uncertainty on the relationship of organizational internal fit and logistics performance, and suggests logistics strategies that would help to achieve the logistics goals. This study uses Korean listed firms as a research sample. Once the firm agreed to participate, the researcher visited the logistics divisional managers within the firm to administer the questionnaires. The questionnaires were primarily designed to collect information about the independent and dependent variables. However, an opportunity to interview many of the leading authorities in logistics management systems also provided an excellent opportunity to gather additional insight into logistics management systems. A total of 500 questionnaires were sent out in January, 2009. 236 valid responses were collected. The findings suggest the following. Firms with high harmony between environmental uncertainty and logistics strategies fit were significantly better in the logistics performance than firms with low harmony. Second, if the environmental uncertainty and the harmonization between logistics strategies and organizational structure supported, then the logistical performance can be maximized. The results of this study will help firms to become aligned and to focus on improving the competitive strategies of logistics systems.

모르핀이 산화적 손상에 의한 신경아종 세포주 SH-SY5Y 의 세포고사에 미치는 영향

이창수,손용,윤재승,김태요,송윤강,정영표,하정량,최덕화,김정훈 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.2

Background: The effect of opioids on nitric oxide (NO)- and peroxynitrite-induced neuronal cell death is largely unknown. In the present study, we examined the effect of morphine on NO- and per- oxynitrite-induced cell death using a human neuroblastoma SH-SY5Y cell line, which abundantly expre- sses μ, 8, κ-opioid receptors. Methods: The cultured cells were pretreated with morphine and exposed to 3-morpholinosydnonimine (SIN-1) that simultaneously generates NO and superoxide, thus possibly forming peroxynitrite. The cell damage was assessed by using MTT assay and crystal violet staining. Morphological nuclear changes and enzymatic evidences of apoptosis of the cells after exposure to SIN-1 for 24 hours were evaluated by using 4', 6-diamidino-2-phenylindole (DAPI) staining and the measurement of pro-apoptotic protease (caspase-3) activity, respectively. Levels of reduced glutathion (GSH) were measured by monochlo- ronimane (MCB) assay. Results: Pretreatrnent of SH-SY5Y with morphine significantly inhited the apoptotic cell death. Morphine also inhibited SIN-1-induced caspase-3 (pro-apoptotic protease) activity in a dose-dependent ma1nner. However, naloxone (20 μM) could not antagonize completely the effect of morphine in SIN- 1-induced cell death. Pre-administered GSH and N-acetylcysteine (NAC) have been found to protect SIN-induced apoptosis, and the neuroblastoma cells treated with morphine had significantly elevated the levels of GSH. Conclusions: The present study shows that morphine protects the human neuroblastoma cell line SH- SY5Y frorn peroxynitrite-induced apoptotic cell death through elevated GSH levels.The protective action of morphine seems to be associated with inhibition of the apoptotic pathway. However, it is suggested that morphine protects the cells possibly via other unknown mechanisms in addition to the activation of opioid receptors. ( Korean J Anesthesion 2000; 38: 356~364 )

한국목록규칙 4판에 반영된 목록의 유용성

이창수 한국도서관·정보학회 2005 한국도서관정보학회지 Vol.36 No.3

In this paper we outline the evolving process of the cataloguing rules in Korea focused on the standardization. We analyzed the new and updated rules under the KCR4(Korean Cataloguing Rules, 4th edition) in terms of usability of the catalogue. Our findings can be summarized as follows: ① Since there are the rules of the unlimited number of the statement of responsibility, the access point is expanded and may bring the high searchability as a result, ② Since the rules of the general material designations are added, the catalogue users may easily identify the material, ③ Since the rules of the material specific details area are added, the catalogue users may easily understand the characteristics and other features of a publication, ④ The KCR4 seems a kind of the integrated cataloguing rules for diverse types of materials including the monographs, ⑤ Since the rules of choice and forms of the access point treated in the authority control, there seem some problems in usability of the catalogue, ⑥ The concept of the uniform heading is eliminated which seems considered only for the convenience of the cataloguers not for usability of the catalogue. 이 연구는 한국에서의 목록규칙의 발전과정을 개관하면서 표준화의 과정을 살펴 본 후 가장 최근에 개정하여 출판된 한국목록규칙 4판을 중심으로 이 규칙에 반영되어 있는 중요한 몇 가지 목록의 유용성 문제를 분석하였다. 목록의 유용성 고려라는 측면에서 KCR4는 저록에 포함되는 책임표시의 수에 원칙적으로 제한을 가하지 않은 점, 기술 대상자료의 유형을 제시한 점, 자료의 서지적 특성을 제시하는 기술사항을 추가한 점, 단행본뿐만 아니라 다양한 유형의 자료를 대상으로 하는 통합 목록규칙이라는 점 등은 긍정적인 반면, 접근점의 선정과 형식을 전거에서 처리하도록 미룬 점, 통일표목의 개념을 배제한 점 등은 부정적인 면으로 분석되었다.

모르핀이 백서 뇌 별아교 세포의 세포죽음에 미치는 영향

이창수,손용,김귀순,이강창,김태요,정영표,김명선,최덕화,정대관 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.38 No.2

Background : Astrocytes, representing a major non-neuronal cell population in the central nervous system (CNS), contain opioid receptors and are actively involved in several brain functions. This study is designed to evaluate the effects by which morphine contributes to cytotoxicity of nitric oxide (NO) species including NO and peroxynitrite (ONOO) in primary astrocytes isolated from the cerebral cortexes of 1-2 day sprague-Dawley rats. Methods : The cultured cells were pretreated with morphine and exposed to 3-morpholinosydnonimine (SIN-1) which simultaneously gene,rates NO and superoxide, thus possibly forming peroxynitrite. The cell damage was assessed by using an MTT (methylthizol-2-y1-2, 5-diphenyl, tetrazolium bromide) assay. Morphological nuclear changes of the cells after exposure to SIN-I for 24 hours was evaluated by using 4, 6-diamidino-2-phenylindole (DAPI) staining. Results : Morphine significantly protected primary rat astrocytes in a dose-dependent manner from the death mediated by sodum nitroprusside (SNP), a donor of nitric oxide, and SIN-1. Moreover, it was found that naloxone antagonized the protective effect of morphine on SIN-1-induced cell death, revealed as apoptosis by the occurrence of morphological nuclear changes characteristic of apoptosis. Morphine also inhibited the nuclear condensation of SIN-1-treated cells, however the action of morphine was antagonized by pretreatment of naloxone. The protective role of morphine on SIN-1-induced cyto- toxicity was inhibited by DL-Buthionine-[S, R]-sulfoximine (BSO). Furthermore, the effects of morphine on SIN-1-induced cytotoxicity were blocked by pretreatment of Gi protein inhibitor, pertussis toxin, and phosphoinositide 3-kinase (PI3 kinase) inhibitors, Wortmannin and LY294002. Conclusions : These results suggest that morphine may protect primary rat astrocytes from NO species via the signaling cascades involving G-protein and PI3-kinase, and possibly regulates the anti-oxidant, glutathione (GSH). (Korean J Anesthesiol 2000; 38: 348-355)

군 공항 이전사업의 선결조건

이창수 대한국토·도시계획학회 2015 도시정보 Vol.- No.396

울혈성심부전증에서 대동맥후벽 심에코도에 관한 연구

이창수,박옥규 全南大醫大 1981 전남의대학술지 Vol.18 No.3

자원절약형 도시계획

이창수,이재길,오규식,서충원 대한국토도시계획학회 1998 도시정보 Vol.192 No.-