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Jong-Wook Lee(Jong-Wook Lee),Nayoung Kwak(Nayoung Kwak),Euna Han(Euna Han),Hye-Young Kang(Hye-Young Kang) 대한약학회 2023 약학회지 Vol.67 No.2
Visual impairment (VI) and hearing impairment (HI) are common disabilities whose prevalence increases with age, potentially presenting a major challenge in the future. Identifying the types of obstacles which they encounter during drug administration is essential to improve health outcomes. This systematic literature review aimed to identify types of medication barriers encountered by individuals with VI or HI to improve their health outcomes. Combination of keywords indicating VI or HI, barrier, challenge, or difficulty, and drug or medication were used to identify potential studies up to May 31, 2021, from Ovid Medline, Embase, and Cochrane. Overall, 20 and 17 articles met the predefined eligibility criteria for VI and HI, respectively. Individuals with VI were found to encounter difficulties in the entire process of pharmaceutical therapy, including drug identification, medication management, access to pharmacies, medication instructions, drug information (labeling), and communication. Individuals with HI were found to experience challenges in communication, health literacy, and negative experiences and emotions toward doctors/pharmacists. The drug management needs of individuals with VI and HI remain unmet. For safe and effective medication in individuals with VI and HI, it is essential to establish practical solutions, such as providing identification tools for tablets for those with VI, deploying sign language interpreters at designated healthcare institutions and pharmacies for individuals with HI, utilizing novel technologies, including audio prescription labeling systems or mobile applications, and providing education for both healthcare providers and individuals with disabilities to improve their partnership in drug therapy.
박명화,최은정,정미리,Nayoung Lee,Minjung Kwak,Mihyun Lee,Eun-Chung Lim,Haesung Nam,김동일,구한울,Bong Seok Yang,Junsik Na,Ji Young Kim,Wonpyo Lee 대한의료정보학회 2019 Healthcare Informatics Research Vol.25 No.4
Objectives: This study developed an information and communication technology (ICT)-based comprehensive health and social-needs assessment (CHSNA) system based on the International Classification of Functioning, Disability, and Health (ICF) with the aim of enhancing person-centered community care for community residents and supporting healthcare professionals and social workers who provide healthcare and social services in the community. Methods: Items related to a CHSNA tool were developed and mapped with ICF codes. Experts validated the CHSNA system design and process using the Delphi method, and a pilot test of the initial version of the system was conducted. Results: The following three steps of CHSNA were embedded in the system, which had a user-friendly screen and images: basic health assessment, life and activity assessment, and in-depth health assessment. The assessment results for the community residents were presented with visualized health profiles, including images, graphs, and an ICF model. Conclusions: The developed CHSNA system can be used by healthcare professionals, social workers, and community residents to evaluate the reasoning underlying health and social needs, to facilitate the identification of more appropriate healthcare plans, and to guide community residents to receive the best healthcare services. A CHSNA system can improve the implementation of standardized terminology utilizing the ICF and the accuracy of needs assessments of community residents.
Yongjin Lee,Joohyun Shim,Nayoung Ko,Hyoung-Joo Kim,Jeakyoung Park,Kwak Kyungmin,Kimyung Choi 한국동물생명공학회(구 한국동물번식학회) 2018 발생공학 국제심포지엄 및 학술대회 Vol.2018 No.06
Alanine known as non-essential amino acid was detected at high concentration in reproductive tracts and follicular fluid in developing porcine antral follicle. The purpose of this study was to determine the effect of alanine supplementation during in vitro maturation (IVM) of porcine oocyte. We investigated nuclear maturation, intraoocyte glutathione (GSH) contents in metaphase II (MII) oocytes, and subsequent embryonic development. And also, We detected the gene expression pattern in MII oocytes, early embryo and blastocyst derived parthenogenesis (PA) and somatic cell nuclear transfer (SCNT). The base medium for IVM was North Carolina State University-23 (NCSU-23) medium, modified by supplementing 10 ng/mL EGF, 0.5 ug/mL FSH, and 0.5 ug/ LH, replacing BSA with 0.1% (w/v) PVA, and deleting glutamine. Alanine of various concentrations (0, 0.363, 1, 5, and 10 mM) were added to base IVM medium. The proportion of mature oocyte after IVM did not increase by alanine treatment at various concentrations. However, The intraoocyte GSH content was higher (p<0.05) in oocytes treated with 0.363 mM alanine (1.17±0.01 pixels per oocyte) than non-treated oocytes (1.00±0.02 pixels per oocyte). Blastocyst formation of PA (31.2±2.5% vs. 19.8±2.5%) and SCNT (20.5±1.9% vs. 10.1±2.0%) embryos was significantly (p<0.05) improved by treatment with 0.363 mM alanine during IVM compared with embryos derived from the non-treated oocytes. Supplementation of oocytes IVM medium with 0.363 mM alanine significantly (p<0.05) increased the gene expression of POU5F1 and FGFR2 levels in early embryo and blastocyst derived PA and SCNT embryos. In MII oocytes, transcript levels of POU5F1 and FGFR2 as well as CDK1 gene were significantly (p<0.05) increased in 0.363 mM alanine-treated oocytes. Our results demonstrate that treatment with 0.363 mM alanine during pig oocyte maturation improves developmental competence after PA and SCNT by influencing cytoplasmic maturation, such as improved GSH content in IVM oocyte and increasing gene expression associated with embryonic development in oocyte and embryo.
Lim, Guh-Hwan,Kwak, Sung Soo,Kwon, Nayoung,Kim, Taekyung,Kim, Han,Kim, Seong Min,Kim, Sang-Woo,Lim, Byungkwon Elsevier 2017 Nano energy Vol.42 No.-
<P><B>Abstract</B></P> <P>A patchable triboelectric nanogenerator (TENG) is highly promising for self-powered human-motion detection, but it may undergo repeated stretching/releasing cycles during daily activities of a human, which may lead to mechanical fracture of each component and degradation in electrical output performance of the TENG device. Here, we report a fully stretchable and durable triboelectric nanogenerator (TENG) with gold (Au) nanosheets (NSs) embedded into both PDMS matrix and micropyramid-patterned PDMS. It was found that a new design of the Au NS electrodes dramatically improves the mechanical flexibility and stretchability, enabling to achieve the outstanding output stability of the Au NS electrode-based TENG (Au NS-TENG) during 10,000 cycles of repeated pushing and stretching tests. Our fully stretchable and durable Au NS-TENGs were successfully applied to the hand joints that can be used in the self-powered human-motion detection processes for wearable applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report a fully stretchable and durable triboelectric nanogenerator (TENG). </LI> <LI> The TENG consisted of gold nanosheet (Au NS)-embedded elastomer electrodes. </LI> <LI> Au NS-TENG showed excellent output stability during pushing and stretching tests. </LI> <LI> Au NS-TENGs were successfully applied for self-powered human-motion detection. </LI> </UL> </P> <P><B>Graphic abstract</B></P> <P>Fully stretchable and durable triboelectric nanogenerator with gold nanosheet embedded into both PDMS matrix and micro pyramid patterned PDMS has been successfully demonstrated in both pushing and stretching modes, then the durability test with 10,000 cycles. As our device is applied to hand joints, the possibility of self-powered systems as power source for wearable applications has been shown.</P> <P>[DISPLAY OMISSION]</P>
2인 이상 탑승 상황의 공유 킥보드 운행 정지를 위한 사용자 경험 연구
김용환(Yonghwan Kim),김대희(Daehee Kim),곽나영(Nayoung Kwak),박찬호(Chanho Park),이민창(Minchang Lee),전병현(Byunghyun Jun),장순규(Soonkyu Jang) 한국HCI학회 2023 한국HCI학회 학술대회 Vol.2023 No.2
최근 전동 킥보드의 사용량이 급증함에 따라 많은 문제점이 나타나고 있다. 이 중, 킥보드에 2 인 이상 탑승하는 문제는 법적 제약이 있음에도, 이를 무시하는 고객이 늘어나는 상황이다. 이에 본 연구는 2 인 탑승 시 킥보드가 작동하지 않는 문헌 조사에서 제시된 기술과 관련 앱에서 정보를 전달하는 방식을 통해 이를 개선하고자 하였다. 실험은 프로토타입 앱에서 제공하는 2인 이상 탑승 상황 전달, 또한 시나리오 설명을 통해서 느끼는 점을 수집하는데 집중하였다. 실험 결과, 인터뷰 대상자는 2 인 이상 탑승 문제를 해결하는데 있어 킥보드가 멈추는 방안에 적극 동의하였다. 또한 앱에서 정보를 주는 방향을 보다 긍정적임을 확인 하였다.
Hyoung-Joo Kim,Joohyun Shim,Nayoung Ko,Yongjin Lee,Jae-Kyung Park,Kyungmin Kwak,Jun-Hyeong Kim,Pulip Kang,Jeong-Woong Lee,Hyunil Kim,Kimyung Choi 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
The COVID-19 pandemic is caused by SARS-CoV-2, which continues to raise, public health concerns worldwide. Coronaviruses have an outer crown-like spike protein that binds to the human Angiotensin-converting enzyme 2 (ACE2) gene, resulting in infection via endocytosis. Therefore, research on hACE2 is expected to be critical for developing our understaining of COVID-19. To facilitate this, we developed Yucatan miniature pigs expressing hACE2 as animal models for COVID-19 research. First, vector containing hACE2 gene, FLAG tag, and GFP was constructed using the CMV promoter. Three lines of stable cell lines with hACE2 protein expression were created by transfecting Yucatan miniature pig ear fibroblasts with the constructed vector. The established cells then underwent somatic cell nuclear transfer, and were transferred to surrogate sows as donor cells, resulting in the successful production of four transgenic cloned pigs. PCR analysis confirmed that the hACE2 gene was inserted into the genome, and that hACE2 mRNA was well-expressed in the lung, heart, and small intestine. In addition, differences in protein expression between transgenic clones and wild-type pigs were confirmed using ear fibroblasts. Finally, karyotyping and fluorescence in situ hybridization analysis revealed that the transgenic cloned pigs had the same number of chromosomes as normal pigs (36 chromosomes, plus two sex chromosomes), and that the hACE2 gene was inserted into chromosome 17. In this study, we succesfully produced transgenic Yucatan miniature pigs expressing the hACE2 gene for use as prelinical COVID-19 target models. *This work has supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2020M3A9I2105803).