國內藥草의 抗癌成分硏究 (1) : 馬兜鈴, 石蒜, 三稜, 無花果皮, 碧梧桐皮, 人參 등 70餘種에 對하여

丁明鉉,李敦日,金永洙,朱興珪,劉永鐘,金成鎬,鄭鐘南 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

Alcohol, water, ether, and petroleum ether extracts of 75 species Korean medicinal plants have been tested for their antitumor activity. Most of the extracts had slight activity only. Some extracts had more pronounced acitivity. For antitumor activity, ddD-Mice of weighing 18-25g were used. 0.2 ml of cell suspension in 0.9% saline-glucose solution containing 10?? ascites tumor cells of either Sarcoma 180, Ehrlich carcinoma was transplanted intraperitoneally into each mouse. The control group animals in a given experiment consisted of 14 mices and the experimental group, 7 mices. The materials to be tested were administered once a day by intraperitoneal injection, commencing the day after tumor transplantation until the test animal died, and then the control group was received only 0.5% carboxy methyl cellulose (CMC). The mean survival time of each group was calculated according to the formula indicated in the protocols of the Cancer Chemotherapy National Service Center. In the antitumor activity screening, extracts had pronounced greater prolongation of survival time (50%-100%) were Aristo-lochia contorta, Lycoris radiata, Scirpus maritimus, Ficus carica, Firmiana platanifolia, Panax ginseng, Piper nigrum among the 75 species. The antitumor screening result were tabulated in Table II.

복압성요실금에서 Tension Free Vaginal Tape 수술: 초기 결과

이민호,김홍식,주명수 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.3

복압성요실금 환자에서 복막외 복강경 Burch 술식과 개복 Burch 술식의 비교 : 장기 추적결과

김상연,김홍식,주명수 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

여성 복압성요실금 환자에서 안정 시 방광조영술상 Inverted Tear-drop Sign의 의의

오승준,문경현,주명수,조경식 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.4

AgClBr Microcrystal의 결정성장과 Morphology에 관한 연구

송현,권동주,이의수,이명천,임종주 동국대학교 산업기술연구원 2001 산업기술논문집 Vol.12 No.2

감광성 유제(AgClBr)의 제조에 있어 가장 중요한 변수인 할로겐화은염 결정의 크기 및 결정형태 변화를 물리숙성 온도, 반응물의 투입속도, 젤라틴 농도, 할로겐 이온(Cl^-, Br^-)의 농도비등을 변수로 하여 관찰하였다. 실험결과 물리숙성 온도가 증가함에 따라 형성된 AgClBr 결정의 크기는 증가하지만, 반면에 질산은과 할로겐화염의 주입속도의 증가는 AgClBr 결정의 크기가 감소하는 경향을 나타냈다. 또한 젤라틴의 농도 증가는 이온상태로 존재하는 반응물의 이동을 억제하여 결정을 성장하는데 요구되는 회합속도를 저하시켜 결과적으로 생성되는 결정의 크기가 감소하였다. AgClBr의 결정형태는 Cl^-과 Br^- 이온의 농도비에 따라 가장 민감한 변화를 나타냈으며, Br의 농도비가 증가함에 따라 AgClBr 결정은 cubic형에서 round 형태로 변화하는 경향이 관찰되었다. The preparation and the morphology of silver chlorobromide crystals were studied by double-jet method. The crystal size and morphology of silver chlorobromide have been estimated by SEM photos. The influence of physical ripening temperature, rate of addition of reactants, concentration of gelatin and molar ratio of two hailde ions on the crystal growth and change of crystal morphology of obtained silver chlorobromide microparticles were investigated. The crystal size of silver chlorobromide were grown in propotion to increasing of ripening temperature, however the increasing of rate of addition of reactants induced decreasing of crystal size. The crystal morphology of photosensitive silver chlorobromide varied from cubic to round type by the increasing of concentration of bromide ion.

제1형 당뇨병 환자에서 췌도세포 동종이식의 반복시행

양태영,정인경,서인아,오은영,조건영,오승훈,김성주,정재훈,민용기,이명식,이문규,김광원,도영수,주성욱 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

연구배경:췌도세포 이식은 시술이 간편하고 안전하기 때문에 반복이식이 가능하여 그 동안 여러 센터에서 반복이식의 성공을 보고한 바 있다. 국내에서도 본 병원을 비롯하여 몇몇 센터에서 췌도세포 이식이 활발히 시도되고 있으나 사람에서의 동종이식 및 동종 이식의 반복시행은 보고된 바 없는 실정이다. 저자 등은 국내 최초로 췌도세포 동종이식을 시행하여, 혈청 C­펩타이드가 증가하고 인슐린 요구량이 감소하였으며, 혈당농도와 당화혈색소의 안정을 보였다. 그러나 이식 70일 후 다시 인슐린 요구량이 증가하고 C­펩타이드가 감소하여 췌도세포 이식을 다시 시행한 바 있다. 2차 이식 후 70여일이 지난 현재 다시 혈청 C­펩타이드가 증가하고, 인슐린 요구량이 더 감소되어 췌도세포 이식에서 반복 시행의 유용성을 보고하는 바이다. 방법:환자는 32세 남자로 17년전 당뇨병 진단 후 인슐린 치료 중이었으며, 3년전 부터는 만성신부전증으로 혈액툭석을 하고있었다. 1999년 12월 25일 신장이식을 하였고 3일 후 췌도이식을 하였으며, 두번째 이식은 70일 후 시행하였다. 췌도분리는 변형된 Recordi방법과 비연속성 자당 농도차(discontinuous density gradient)를 이용하였으며 분리한 췌도는 배양 후 환자의 신장기능이 정상화되고 미생물학 검사에서 음성을 확인한 후 경피경간으로 간문맥을 접근하여 16G 폴리 에틸렌 카테터를 이용하여 간실질에 이식하였다. 결과:1차 췌도이식시 순수분리전 췌도수는 210,000개, 순수분리후 획득한 췌도수는 90,000개, 순도 95%, 세포양 1.0mL 이었고, 2차 췌도이식시 순수분리전 췌도수는 420,000개, 순수분리후 획득한 췌도수는 370,000개, 순도 95%, 세포양 1.5mL 이었다. 1,2차 모두 간문맥을 통해 약 20분에 걸쳐 간실질에 주입하였다. 췌도이식전 인슐린요구량은 75∼75U/일, HbA1e 8∼10%, C­펩타이드 0.6ng/mL 였으며, 1차 췌도이식수 7일째 인슐린 요구량은 40U/일, C­펩타이드 1.5ng/mL, FPS 109mg/mL 였고, 40일 추적관찰 후 인슐린 요구량이 36U/일, C­펩타이드 1.8ng/mL, HbA1e 6.5∼7.0%로 안정되었다. 그러나 이식 50일째부터 인슐린 요구량이 50∼56U/일, C­펩타이드 0.6ng/mL, FPS 130∼200mg/dL로 혈당 조절이 불안정하여 다시 췌도이식을 시행하였다. 2차 이식후 50일이 경과한 현재, 인슐린 요구량은 26U/일, C­펩타이드 1.8ng/mL, FPS 90∼120mg/dL로 다시 안정되었다. 결론:췌도이식은 반복이식이 가능하며, 본 환자의 경우 인슐린요구량 감소, 혈당의 안정화 및 C­펩타이드가 상승하여 이식한 췌도의 기능을 확인할 수 있었고, 향후 스테로이드 등 면역억제가 유지 용량으로 감량되면 인슐린 요구량은 더 감소될 것으로 기대된다. Over the past 20 years, significant advances have been made in human islet transplantation. However, cases of prolonged insulin independence after islet allotransplantation have rarely been reported and over time, a slight, gradual decrease in insulin secretion appears to occur, as suggested by the lower C-peptide. Although preliminary clinical success achieved over the past few years has been considerably higher with whole pancreatic transplant than with isolated islet grafts, both approaches remain experimental. Islet grafts might gain, over time, increasing credibility and might eventually provide an easier alternative in terms of grafting procedures and patient management, as compared with the more "traumatizing" whole-pancreas transplantation. Also, using islet, re-transplantation is possible. But it is not known whether re-transplantation of islet could be suitable for those patients who lost grafted islet function. The aim of the present study was to investigate the benefits of re-transplantation of islet in previously simultaneous islets-kidney transplant (SIK) patient who have lost graft function. Methods : The recipient was a 32 year old male. First islet transplantation was underwent at December 25, 1999. However, the grafted islets lost function after 70 days. So we performed re-transplantation of islets. The isolation of islet was conducted sterilely on a laminarflow hood and isolated by a modified Recordimethod. The islet was injected slowly into the liver via a cannular placed in the potalvein for 20 minutes. Results : Transplanted islets were 90,000 IEq at first islet transplantation, 370,000 IEq at second islet transplantation. The insulin requirement was reduced from 75-85 to 35-40 U/day, the basal C-peptide level was 1.5 ng/mL at 7 days posttransplant Unfortunately, the grafted islets lost function after 70 days. After second transplantation, the insulin requirement was reduced to 26 U/day. Conclusions : Despite the continuous need for exogenous insulin therapy, islet transplantation can prevent wide glucose fluctuations, thus resulting in normalization of glycemic control and improvement in HbAlc, and also, show that islets can be successfully and safely re-transplanted intraportally in patients who have lost previously grafted islet function (J Kor Diabetes Asso 457~466, 2000).

Nb-Si-B계에서 Nb+T2 공존 영역의 미세조직 특성

주수현 ( Soo Hyun Choo ),김영도 ( Young Do Kim ),오승탁 ( Sung Tag Oh ),이성 ( Seong Lee ),류성수 ( Sung Soo Ryu ),석명진 ( Myung Jin Suk ) 대한금속재료학회(구 대한금속학회) 2015 대한금속·재료학회지 Vol.53 No.1

Intermetallic-based materials are interesting for high temperature structural applications because of their good mechanical properties and enhanced oxidation resistance. In this study microstructural examination of the Nb-Si-B alloys at Nb-rich compositions was performed. The Nb-rich corner of the Nb-Si-B system is very attractive because the constituent phases are Nb (a ductile and tough phase with a high melting temperature) and T2 (a very hard intermetallic compound with favorable oxidation resistance), which make a good combination for high temperature structural materials. At compositions lower than 82 at%Nb the microstructure shows the T2 primary phase and eutectic (T2+Nb), while the Nb primary phase and eutectic were formed at higher compositions. Hardness tests (Rockwell A-scale and micro Vickers) were carried out to estimate the optimal composition for good mechanical properties. (Received January 13, 2014)

운동이상형 소화불량증을 호소하는 당뇨병 환자에서 주석산 시사프리드의 효과

김선명(Sun Myung Kim),추교영(Kyo Young Choo),최명규(Myung Gyu Choi),김진일(Jin Il Kim),방춘상(Choon Sang Bhang),한석원(Sok Won Han),김병욱(Byung Wook Kim),최황(Hwang Choi),김성수(Sung Soo Kim),이동수(Dong Soo Lee),최규용(Kyu Yong Ch 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.1

N/A evaluated the effects of cisapride tartrate on gastrointestinal symptoms and gastric emptying times in diabetic patients with dysmotility like dyspeptic symptoms. Methods: Cisapride was administered before each meal in 61 patients for 4 weeks. The intensity of gastrointestinal symptoms before and after cisapride administration was scored from 0 to 4, in the order of increasing severity of symptoms. In addition, a gastric emptying test was performed. Results: A significant reduction in the total intensity score of symptoms was observed during the first two weeks, from 8.5±2.1 to 4.0±3.0 (p<0.05), and a further reduction was noted during the next two weeks, to 2.8±2.8 (p<0.05). Good to excellent improvement was obtained in 70.4% of the patients, but the improvement in symptoms was not related to age, duration of diabetes, glucose, Hb A1c, neuropathy, or retinopathy. Treatment with cisapride induced a significant regression of symptoms and a significant improvement of delayed gastric emptying from 104.0± 31.7 minutes to 79.5±17.1 (p<0.05). However, there was a lack of association between the changes in gastric emptying times and improvements in symptoms(r2=0.00186). Only 3 patients complained of loose stool, nausea, or dizziness. Conclusions: Cisapride was effective in improving dysmotility like dyspeptic symptoms in diabetic patients without serious side effects. (Korean Journal of Gastrointestinal Motility 2001;7:56-64)

우리나라 농촌지역사회 주민의 위장관 증상의 유병률

추교영(Kyo Young Choo),최명규(Myung Gyu Choi),최황(Hwang Choi),이동수(Dong Soo Lee),김진일(Jin Il Kim),김성수(Sung Soo Kim),방춘상(Choon Sang Bhang),박수헌(Soo Heon Park),김재광(Jae Kwang Kim),한석원(Sok Won Han),최규용(Kyu Yong Cho 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.1

N/A Background/Aims: Chronic gastrointestinal (GI) symptoms are believed to be common in the general population, but there is a lack of data from Korea. The aim of this study was to es1imate the prevalence of chronic gastrointestinal symptoms in a rural community in Korea by using the Bowel Symptom Questionnaire (BSQ), which was based on the multinational diagnotic Rome criteria for functional bowel disorders, as a measure of GI symptoms. Methods: A cross-sectional survey, using a reliable and valid questionnaire based on the fulfillment of the Rome criteria, was performed in a densely populated district in a Korean rural community on the residents aged l8-69 yr (mean 48±14 yr). 95,5% responded (n=420). All respondents were interviewed at their home or offices by a team of interviewers. Results: Two thirds of Korean rural residents experience gastrointestinal symptoms and one fifth of them visit a clinic or hospital at least once a year. Prevalences of weekly heartburn, gastroesophageal reflux disease, dyspepsia, irritable bowel syndrome (IBS), and chronic constipation were 5.2% (95% confidence interval [CI], 3.l-7.4, 2.6% (95% Cl, 1.1-4.2), 15.5% (95% CI, 11.9-19.0), 8.6% (95% CI, 3.8-11,3), and 24.3% (95% CI, 20.1-28.5) respectively. The prevalence of dyspepsia was 25%, taking medication usage into consideration. Ulcer-like dyspepsia (11.2%) was the most common subtype and 40% of the subjects with dyspepsia were classified into more than one subtype of dyspesia. There was an overlap between subjects with IBS and dypepsia with 6.1% of dypeptics having IBS and ll,l% of IBS patients having dypepsia. Conclusions: The prevalence of GERD was low in Korea compared with that of the Western countries. The prevalences of dyspepsia and IBS were similar to those of the Western countries. The most common gastrointestinal symptom in a rural community in Korea is dyspepsia, (Korean Journal of Castrointestinal Motility 2000;6:31-43)

Symposium 11 : Plant Biochemistry ; Characteristics of tobacco class I small heat-shock proteins

( Choo Bong Hong ),( Keun Pill Kim ),( Soo Min Park ),( Myung Kook Joe ) 생화학분자생물학회 2001 생화학분자생물학회 춘계학술발표논문집 Vol.2001 No.-