휴대용 근적외분광분석기를 이용한 유탕면의 수분 함량 측정 : Infrared(NIR) System

임현량,김도형,우영아,김효진 동덕여자대학교 종합약학연구소 2002 동덕약학연구지 Vol.6 No.-

This experiment was carried out to determine non-destructively water content in a intact fried noodle in oil by portable near-infrared system. Water content was ranged from 0 to 14.3w/w% and the near infrared (NIR) measurements were made on 70 intact samples over the spectral range 1100-1750nm. We found the variation of absorbance band due to OH vibration of water in the noodles depending on the concentration change around 1450nm in the second derivatives spectra. Partial least squares(PLS) regression models were set up using a calibration set(42 E.A.) and a validation set(28 E.A.) between the NIR response and value from loss on dry. Various pretreatments of the spectra were examined: the smallest stnadard error of prediction(0.35%) was obtained using autoscaling spectra over 1100-1700nm. 10 factors were required for the PLS model to give a good relationship between the spectral information and the noodle water content. In order to validate the developed calibration model, routine analyses were performed using other intact noodles. Water contents from the NIR calibration model were compared with the values from loss on dry and the results showed good correlation with those of loss on dry. This study showed that the rapid and non-destructive determination of water content in a intact fried noodle in oil was successfully performed by portable NIR system.

한베이식 언어 설계 및 명령어 처리에 관한 연구

元裕憲,林海喆,朴道淳 弘益大學校 1983 弘大論叢 Vol.15 No.2

This papaer presents the design of programming language, named HAN-BASIC(HANgul BASIC), which is especially devised for the personal computer users who can't even understand English. This language gives the ability of programming with Korean language, permitting English variable names. In order to respond in real time, HAN-BASIC reserved-words is parrsed using hashing and finite automata method.

생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구

김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.

The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain

( Do Yun Kim ),( Joo Wung Chae ),( Chang Hun Lim ),( Bong Ha Heo ),( Keun Suk Park ),( Hyung Gon Lee ),( Jeong Il Choi ),( Myung Ha Yoon ),( Woong Mo Kim ) 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.3

Background: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action. Here we investigated the role of the spinal dopaminergic neurotransmission in the antinociceptive effect of nefopam administered intravenously or intrathecally. Methods: The effects of intravenously and intrathecally administered nefopam were examined using the rat formalin test. Then we performed a microdialysis study to confirm the change of extracellular dopamine concentration in the spinal dorsal horn by nefopam. To determine whether the changes of dopamine level are associated with the nefopam analgesia, its mechanism was investigated pharmacologically via pretreatment with sulpiride, a dopaminergic D2 receptor antagonist. Results: When nefopam was administered intravenously the flinching responses in phase I of the formalin test were decreased, but not those in phase II of the formalin test were decreased. Intrathecally injected nefopam reduced the flinching responses in both phases of the formalin test in a dose dependent manner. Microdialysis study revealed a significant increase of the level of dopamine in the spinal cord by intrathecally administered nefopam (about 3.8 fold the baseline value) but not by that administered intravenously. The analgesic effects of intrathecally injected nefopam were not affected by pretreatment with sulpiride, and neither were those of the intravenous nefopam. Conclusions: Both the intravenously and intrathecally administered nefopam effectively relieved inflammatory pain in rats. Nefopam may act as an inhibitor of dopamine reuptake when delivered into the spinal cord. However, the analgesic mechanism of nefopam may not involve the dopaminergic transmission at the spinal level. (Korean J Pain 2016; 29: 164-71)

Korean Cancer Patients’ Awareness of Clinical Trials, Perceptions on the Benefit and Willingness to Participate

Lim, Yoojoo,Lim, Jee Min,Jeong, Won Jae,Lee, Kyung-Hun,Keam, Bhumsuk,Kim, Tae-Yong,Kim, Tae Min,Han, Sae-Won,Oh, Do Youn,Kim, Dong-Wan,Kim, Tae-You,Heo, Dae Seog,Bang, Yung-Jue,Im, Seock-Ah 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4

<P><B>Purpose</B></P><P>The purpose of this study was to assess current levels of awareness of clinical trials (CTs), perceptions regarding their benefits and willingness to participate to CTs among Korean cancer patients.</P><P><B>Materials and Methods</B></P><P>From December 2012 to August 2015, we distributed questionnaires to cancer patients receiving systemic anti-cancer therapy at Seoul National University Hospital, Seoul, Korea.</P><P><B>Results</B></P><P>A total of 397 out of 520 requested patients (76.3%) responded to the survey. Among the 397 patients, 62.5% were female and the median age was 52 years. Overall, 97.4% (387/397) answered that they have at least heard of CTs. When asked about their level of awareness, 23.8% (92/387) answered that they could more than roughly explain about CTs. The average visual analogue scale score of CT benefit in all patients was 6.43 (standard deviation, 2.20). Patients who were only familiar with the term without detailed knowledge of the contents had the least expectation of benefit from CTs (p=0.015). When asked about their willingness to participate in CTs, 56.7% (225/397) answered positively. Patients with higher levels of awareness of CTs showed higher willingness to participate (p < 0.001). Heavily treated patients and patients with previous experience regarding CTs also showed a higher willingness to participate (p < 0.001). The perceived benefit of CTs was higher in the group willing to participate (p=0.026).</P><P><B>Conclusion</B></P><P>The patient’s level of awareness regarding CTs was positively related to the positive perception and willingness to participate. Although the general awareness of CTs was high, a relatively large proportion of patients did not have accurate knowledge; therefore, proper and accurate patient education is necessary.</P>

P032 : Association between chronic urticaria and thyroid autoimmunity

( Do Hun Kim ),( Nam Hee Sung ),( Won Suk Lim ),( Sang Yun Jin ),( Hyo Seung Shin ),( Seung Ho Lee ),( Ai Young Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Chronic urticaria is a common disorder in which most cases were considered to be idiopathic. Recent studies suggest that chronic urticaria has an autoimmune etiology at least in a subset of cases. The association between chronic urticaria and thyroid autoimmunity has been a subject of debate. Objectives: To examine the possible association between chronic urticaria and thyroid autoimmunity. Methods: We conducted a retrospective study in attempt to determine the frequency of thyroid autoantibodies and thyroid dysfunction in the chronic urticaria and investigate the clinical response of urticaria to treatment of thyroid dysfunction. Medical records of patients with chronic urticaria, who were evaluated for thyroid autoimmunity and thyroid function, were collected and reviewed. Results: Of 184 patients with chronic urticaria, 43 patients(23.3%) had thyroid autoantibodies and 26 patients(14.1%) were found to have thyroid dysfunction. 2 of 10 patients with hypothyroidism showed improvement urticaria after treatment with levothyroxine. None of 5 patients with hyperthyroidism demonstrated any improvement of urticaria after treatment with antithyroid drugs. Conclusion: The high prevalence of thyroid autoantibodies in chronic urticaria and improvement of urticaria after levothyroxine treatment in some patients implys the association between chronic urticaria and thyroid autoimmunity.

FCP 5 : A case of cold urticaria caused by Mycoplasma pneumoniae

( Do Hun Kim ),( Tae Han Kim ),( Nam Hee Sung ),( Won Suk Lim ),( Hyo Seung Shin ),( Seung Ho Lee ),( Ai Young Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

Cold urticaria is a common form of physical urticarial, local whealing and itching occur within a few minutes of applying cold stimulus to the skin. It may also occur in the oropharynx after a cold drink. There may be a recent history of an intercurrent infection such as Mycoplasma pneumoniae. Various types of urticaria are present in M. pneumoniae infections, including generalized urticaria, cold urticaria and urticarial vasculitis. A 5-year-old girl visited our department due to wheals when she was exposed to cold. The ice cube test was strong positive. Routine blood examinations, ANA, cryoglobulin, VDRL and chest radiography were all normal. But cold agglutinin titer was elevated (1:128) and M. pneumoniae IgM was positive. She was treated with oral clarithromycin (Klaricid®) for 2 weeks and oral chlorpheniramine (peniramin®) for 6 weeks. 6 weeks later, the ice cube test was week positive and symptoms were improvement. Herein, we report a case of cold urticaria which was caused by M. pneumoniae treated with clarithromycin and chlorpheniramine.

P611 : Successful treatment of nail psoriasis with methotrexate

( Do Hun Kim ),( Tae Han Kim ),( Nam Hee Sung ),( Won Suk Lim ),( Hyo Seung Shin ),( Ai Young Lee ),( Seung Ho Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

P382 : A case of giant folliculosebaceous cystic hamartoma

( Do Hun Kim ),( Tae Han Kim ),( Nam Hee Sung ),( Won Suk Lim ),( Hyo Seung Shin ),( Ai Young Lee ),( Seung Ho Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

FCP 12 : Identification of LSP1-positive cells:a clue to the origin of dermatofibroma

( Do Hun Kim ),( Nam Hee Sung ),( Won Suk Lim ),( Sang Yun Jin ),( Hyo Seung Shin ),( Ai Young Lee ),( Seung Ho Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Dermatofibroma (DF) is heterogenous group of mesenchymal tumors composed of fibroblastic and histiocytic elements in varying proportions. The cell origin of DF remained unclear. Objectives: The present study attempted to evaluate the expression of leukocyte-specific protein 1(LSP1), which is a marker of fibrocyte, and other cell markers in DF. Methods: Immunohistochemical staining was performed on 20 cases of DFs using antibodies to LSP1, CD68, and factor XIIIa (FXIIIa). Results: 18 of 20(90%) tumors stained positive for LSP1 despite variation in the intensity of expression. CD68 was positive in 8 cases (40%), and FXIIIa was expressed in all cases of DF. There was difference in the regional expression pattern within individual tumor between three markers. Conclusion: LSP1-positive cells in DF might be fibrocyte-like cells. Expression of FXIIIa and CD68 has suggested that dermal dendritic cells and hitiocytes are constituent cells of DF. Fibrocytes, dermal dendritic cells and histiocytes are all derived from monocytes. Therefore, we suggest that DF is originated from monocytes.