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Delphinidin inhibits BDNF-induced migration and invasion in SKOV3 ovarian cancer cells
Lim, Won-Chul,Kim, Hyunhee,Kim, Young-Joo,Park, Seung-Ho,Song, Ji-Hye,Lee, Ki Heon,Lee, In Ho,Lee, Yoo-Kyung,So, Kyeong A.,Choi, Kyung-Chul,Ko, Hyeonseok Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.23
<P><B>Abstract</B></P> <P>Brain-derived neurotrophic factor (BDNF), the TrkB ligand, is associated with aggressive malignant behavior, including migration and invasion, in tumor cells and a poor prognosis in patients with various types of cancer. Delphinidin is a diphenylpropane-based polyphenolic ring structure-harboring compound, which exhibits a wide range of pharmacological activities, anti-tumor, anti-oxidant, anti-inflammatory, anti-angiogenic and anti-mutagenic activity. However, the possible role of delphinidin in the cancer migration and invasion is unclear. We investigated the suppressive effect of delphinidin on the cancer migration and invasion. Thus, we found that BDNF enhanced cancer migration and invasion in SKOV3 ovarian cancer cell. To exam the inhibitory role of delphinidin in SKOV3 ovarian cancer migration and invasion, we investigated the use of delphinidin as inhibitors of BDNF-induced motility and invasiveness in SKOV3 ovarian cancer cells <I>in vitro</I>. Here, we found that delphinidin prominently inhibited the BDNF-induced increase in cell migration and invasion of SKOV3 ovarian cancer cells. Furthermore, delphinidin remarkably inhibited BDNF-stimulated expression of MMP-2 and MMP-9. Also, delphinidin antagonized the phosphorylation of Akt and nuclear translocation of NF-κB permitted by the BDNF in SKOV3 ovarian cancer cells. Taken together, our findings provide new evidence that delphinidin suppressed the BDNF-induced ovarian cancer migration and invasion through decreasing of Akt activation.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lim, Won-Chul,Kim, Hyunhee,Kim, Young-Joo,Choi, Kyung-Chul,Lee, In Ho,Lee, Ki Heon,Kim, Mi Kyung,Ko, Hyeonseok Pergamon Press 2017 Bioorganic & medicinal chemistry letters Vol.27 No.15
<P><B>Abstract</B></P> <P>Epithelial-to-mesenchymal transition (EMT), an important cellular process, occurs during cancer development and progression, has a crucial role in metastasis by enhancing the motility of tumor cells. Dioscin is a polyphenolic component isolated from <I>Phyllanthus amarus</I>, which exhibits a wide range of pharmacological and physiological activities, such as anti-tumor, anti-inflammatory, anti-obesity, anti-fungal, and anti-viral activities. However, the possible role of dioscin in the EMT is unclear. We investigated the suppressive effect of dioscin on the EMT. Transforming growth factor-beta 1 (TGF-β1) is known to induce EMT in a number of cancer cell types and promote lung adenocarcinoma migration and invasion. To verify the inhibitory role of dioscin in lung cancer migration and invasion, we investigated the use of dioscin as inhibitors of TGF-β1-induced EMT in A549 lung cancer cells <I>in vitro</I>. Here, we found that dioscin prominently increased expression of the epithelial marker E-cadherin and expression of the mesenchymal marker N-cadherin and Snail during the TGF-β1-induced EMT. In addition, dioscin inhibited the TGF-β1-induced increase in cell migration and invasion of A549 lung cancer cells. Also, dioscin remarkably inhibited TGF-β1-regulated activation of MMP-2/9, Smad2, and p38. Taken together, our findings provide new evidence that dioscin suppresses lung cancer migration, and invasion <I>in vitro</I> by inhibiting the TGF-β1-induced EMT.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects
Lim, Soo,Kim, Min Joo,Lim, Soo,Kim, Min Joo,Choi, Sung Hee,Shin, Chan Soo,Park, Kyong Soo,Jang, Hak Chul,Billings, Liana K,Meigs, James B,Choi, Sung Hee,Shin, Chan Soo,Park, Kyong Soo,Jang, Hak Chul,B Oxford University Press 2013 The American journal of clinical nutrition Vol.97 No.3
Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
Lim Chul Joo,Han Kyungja,Oh Jae Ho,Hwang Myung Sil,Yum Young Na,Kim Sheen Hee,Shin Dong Hwan,Yang Ki Hwa,Kim Yonggoo,Kang Chang Suk,Cho Dae Hyun,Lee Jehoon 대한의학회 2005 Journal of Korean medical science Vol.20 No.4
( Hyung-joo Oh ),( In-jae Oh ),( Min-seok Kim ),( Bo-gun Kho ),( Chul-kyu Park ),( Young-chul Kim ),( Ha-young Park ),( Tae-ok Kim ),( Hong-joon Shin ),( Yong-soo Kwon ),( Yu-il Kim ),( Sung-chul Lim 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0
Background Lorlatinib is a third generation ALK or ROS1 tyrosine kinase inhibitor (TKI) to treat TKI refractory non-small-cell lung cancer (NSCLC). We report efficacy and safety of lorlatinib in patients previously treated with first or second generation ALK-TKIs. Methods Advanced NSCLC patients who initiated lorlatinib between April 2018 and January 2020 were retrospectively analyzed in a single institution. Results A total of 14 patients were included and the median age was 62.5 years (range, 40-79). All patients were ALK-positive NSCLC and had been treated with more than two ALK-TKIs previously. Excluding one patient who expired before response evaluation, 5 experienced partial response (objective response rate: 35.7%), and 6 had stable disease (disease control rate: 78.6%). The median duration of treatment was 7.5 months (range, 0.6-23.9) and the median progression-free survival was 7.7 months (range, 1.1-22.3). Among six patients who had brain metastasis, two had partial response and other two had stable disease. Among 2 cases that underwent next generation sequencing before loratinib, G1202R mutation was founded in one patients as an on-target resistance mechanism after alectinib. The most common adverse event was hypercholesterolemia (76.9%). In most patients (80%), total cholesterol rose to the highest level within the 2 months after lorlatinib and it could be controlled by lipid-lowering agents. Conclusions Lorlatinib could be a novel therapeutic option for patients with ALK-positive advanced NSCLC whose disease progressed after first and second generation TKIs. Hypercholesterolemia was manageable common adverse event.
임철현 ( Chul Hyun Lim ),이화영 ( Hwa Young Lee ),김원철 ( Won Chul Kim ),조성훈 ( Soung Hoon Cho ),정희선 ( Hee Sun Jeong ),전연주 ( Yeon Joo Jeon ),이장은 ( Jang Eun Lee ),김상우 ( Sang Woo Kim ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.2
Hydrogen peroxide is commonly used as a disinfectant that has been reported to cause chemical colitis. We report a case of 49 year-old man who presented with chemical colitis caused by self-inflicted hydrogen peroxide enema. In the sigmoidoscopic examination, diffuse erythematous and edematous mucosal change with multiple ulcerations and easy touch bleeding was noted from the rectum to the proximal sigmoid colon. Abdominal computed tomography showed diffuse wall thickening of the rectum and the sigmoid colon with inflammatory and reactive change at surrounding. The patient was treated with NPO, intravenous fluid, and antibiotic therapy. On 5th hospital day, abdominal pain and bloody stool disappeared, and the patient started oral feeding. He discharged on 6th hospital day with fully recovered state. (Korean J Gastroenterol 2011;58:100-102)
임철희(Lim, Chul Hee),문주연(Moon, Joo Yeon),임윤진(Lim, Yoon Jin),김세진(Kim, Sea Jin),이우균(Lee, Woo Kyun) 대한공간정보학회 2015 대한공간정보학회지 Vol.23 No.4
본 연구는 안동댐 유역을 대상으로 수문기상 정보의 조밀한 시공간분포를 추정하여 수문기상에서 나타나는 시계열적 공간분포 특성을 규명하고자 한다. 국립기상과학원에서 설치·운영하고 있는 낙동강 상류 안동댐 유역의 수문기상 관측소 7곳의 기상정보와 인근 두 곳의 종관기상관측소(ASOS) 정보를 활용하여 분석을 실시하였으며, 공간적 자기상관성에 기반한 Semi-Variogram을 추정하여 시공간분포를 확인하였다. 유역에서 변이성을 관찰할 수 있는 기상요소인 온도와 습도를 시간과 각 월에 따라 분석하였다. 계절에 관계없이 온도의 경우 14시, 습도의 경우 10시에 가장 균일한 공간분포를 나타내고, 18시에 온도와 습도 모두 가장 불균일성이 높게 확인되었다. 월별 공간분포에서는 온도의 경우 1월에 가장 불균일하였고, 9월에 가장 균일한 것으로 확인되었으며, 습도의 경우 5월에 가장 불균일하고, 1월에 가장 균일한 것으로 나타났다. 수문기상에서는 일반 산림에서와 달리 계절적 공간분포특성이 적게 나타나며, 온도와 습도가 각각의 특성을 보이는 차이가 있었다. This study investigates characteristics of time series spatial distribution on climate factors in Andong Dam basin by estimating precise spatio-temporal distribution of hydro-meteorological information. A spatio-temporal distribution by estimating Semi-Variogram based on spatial autocorrelation was examined using the data from ASOS and 7 hydro-meteorological observatories in Andong Dam basin of upper Nakdonggang River, which were installed and observed by NIMR(National Institute of Meterological Research). Also, temperature and humidity as climate variables were analyzed and it was recognized that there is a variability in watershed area by time and months. Regardless of season, an equal spatial distribution of temperature at 14 o"clock and humidity at 10 o"clock was identified, and nonequal distribution was noticed for both variables at 18 .o"clock. From monthly spatial analysis, the most unequal distribution of temperature was seen in January, and the most equal distribution was detected in September. The most unequal distribution of humidity was identified in May, and the most equal distribution was seen in January. Unlike in forest, seasonal spatial distribution characteristics were less apparent, but temperature and humidity had respective characteristics in hydro-meteorology.
네오디뮴 자석 스크랩에서 희토류 원소 선택적 침출 신공정 기술
김철주 ( Chul-joo Kim ),윤호성 ( Ho-sung Yoon ),정경우 ( Kyeong Woo Chung ),임병철 ( Byung-chul Lim ),김정모 ( Jeong-mo Kim ),전수병 ( Su-byung Jeon ) 한국폐기물자원순환학회(구 한국폐기물학회) 2018 한국폐기물자원순환학회 춘계학술발표논문집 Vol.2018 No.-
네오디뮴 자석(Nd<sub>2</sub>Fe<sub>14</sub>B)의 가공·성형시 다량의 스크랩이 발생하는데 발생량이 투입되는 양의 최대 40%를 나타내어 경제적·환경적 측면에서 발생 스크랩의 재활용은 필수적이다. 가공스크랩은 폐자석과는 달리 분말형태로 수집되어 파/분쇄 단계가 필요치 않은 장점이 있으며, 또한, 가공 단계에서 투입된 절삭유에 의해 산소와의 접촉이 억제되어 산화가 발생되지 않은 금속 상태로 존재한다는 특징을 갖고 있다. 이에 본 연구에서는 NaOH 침지후 산화배소 공정을 적용하여 네오디뮴 자석 스크랩의을 직접 산화시킬 시 나타나는 희토류-철 혼합산화물(NdFeO<sub>3</sub>)의 생성을 억제하고 희토류 산화물(Nd<sub>2</sub>O<sub>3</sub>)와 철산화물(Fe<sub>2</sub>O<sub>3</sub>)를 분리 생성시킴으로서 침출단계에서 철의 침출은 억제하고 희토류만을 선택적으로 침출시켜 향후 희토류 분리정제 및 고순도화 단계에서 희토류/비희토류 분리정제 단계를 생략하고 바로 용매추출에 의한 희토류 고순도화 공정으로의 적용이 가능한 신공정 연구를 수행하였다.
Kim, Min Joo,Moon, Min Kyong,Kang, Geun Hyung,Lee, Kwan Jae,Choi, Sung Hee,Lim, Soo,Oh, Byung-Chul,Park, Do Joon,Park, Kyong Soo,Jang, Hak Chul,Park, Young Joo Humana Press 2014 CARDIOVASCULAR TOXICOLOGY Vol.14 No.2
<P>In epidemiological studies, there is growing concern regarding the association between human exposure to bisphenol A (BPA) and an increased risk for cardiovascular disease. Therefore, we investigated whether BPA accelerates atherosclerosis in mouse model. Apolipoprotein E knockout (ApoE(-/-)) mice were fed a high-fat and high-cholesterol diet with or without 50 μg/kg body weight/day BPA for 12 weeks. Atherosclerotic lesions of the aorta and aortic sinus were evaluated by Oil red O staining. After the 12-week BPA treatment, BPA significantly increased atherosclerotic lesions in the aortas of ApoE(-/-) mice by 1.7-fold (p = 0.03). Non-high-density lipoprotein (HDL) cholesterol levels in the BPA group were significantly higher compared to those in the control group (1,035 70 vs. 484 48 mg/dL, p = 0.02) although body weight and blood glucose levels were not different between groups. Human umbilical vein endothelial cells (HUVECs) were treated with 0.1-10 nM BPA but BPA did not affect HUVEC proliferation or migration. BPA could accelerate atherosclerosis in ApoE(-/-) mice, which may have resulted from an increase in non-HDL cholesterol levels.</P>