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강성홍,김원중 한국보건정보교육학회 1999 보건정보교육학회지 Vol.1 No.1
The main purpose of this paper is to explore the general methodology of developing protocol for medical service activities by using information technology and to actually develop a protocol for the case of cesarean section patients. Data for the study were obtained from a large university hospital located in Seoul, Korea. The data items include discharge summaries, prescriptions, and medical fee records of discharged cesarean section patients for the period of January through March, 1999. We analyzed the data by using newly developed method of 'SAS Enterprise Miner' as well as ordinary statistical programs of SAS. We performed cluster analysis on the basis of length of stay and the amount of medical fees in order to determine the most appropriate group, and the results for the group were used in the development of the protocol. The protocol(major result of this study) is as follows: 1) basic prescriptions -lst day of hospitalization : BR, V/S CHECK, etc. -2nd day of hospitalization : NPO, BR, etc. -3rd day of hospitalization : BR with WA, NPO -4th day of hospitalization : BR with WA, V/S CHECK, SOW -5th and 6th days of hospitalization : BR with WA, V/S CHECK 2) examinations -1st day of hospitalization : NST, FAST, TYPE & SCREENING -2nd day of hospitalization ABGA 3) medication/injection -1st day of hospitalization 5% dextrose -2nd day of hospitalization : metronidazole, methylergometrin maleate, etc. -3rd day of hospitalization : dextrose/ sodium chloride, aminosteril, etc. -5th day of hospitalization : iron protein succinylate, methylergometrin maleate
이광흠,박영근,윤명오,현성호,김동일 한국화재소방학회 2003 한국화재소방학회논문지 Vol.17 No.2
본 연구는 다중이용업소에서 사용하고 있는 실내내장재료 중 소파커버의 인조가죽 5종에 대하여 연소시 위험성 요소인 착화성, 난연성, 열방출율, 독성가스를 평가하였다. 연구결과 Artificial Leather 1~5의 착화온도는 427~43℃, 산소지수는 19~20%로 나타났다. 또한 25 kw/m²의 복사열에서 착화시간은10~16초, 최대열방출율은 147~277 kW/ m²이었으며, 35 kW/ m²의 복사열에서 착화시간은 6~9초, 최대열방출율은 176~296 kw/m² 및 일산화탄소(CO)는 5,550~6,290 ppm, 이산화탄소(CO²)는 18,5OO~23,400 ppm, 염화수소(HCl)는 110~140 ppm, 시안화수소(HCN)은 13~65 ppm, 질소산화물(NO_(x))은145~220 ppm이 발생하는 것으로 나타났다. In this study, we tried to evaluate the ignitibility, flammability, heat release rate, and toxicity of five different types of burning artificial leather sofa covers that are widely used in entertainment service industry buildings. As the results of this study; Putting the artificial leathers under fire conditions we found out following results : auto-ignition temperature was 427~437℃, limiting oxygen index was 19~20%; at heat flux of 25 kW/ m², ignition time was 10~16s and peak heat release rate was 147~277 kW/m²; and at heat flux of 35 kW/ m², ignition time was 6~9s and peak heat release rate was 176~296 kW/ m². The toxic materials discharged from the burning leathers were 5,550~6,290 ppm of CO, 18,500~23,400 ppm of CO², 110~140 ppm, of HCl, 13~65 ppm of HCN and 145~220 ppm of NO_(x).
PAS1-modified optical SIS sensor for highly sensitive and specific detection of toluene
Dung, Tran Thi,Lee, Ui Jin,Kim, Myung Hee,Kim, Kyoon Eon,Cho, Hyun Mo,Fermin, Cesar D.,Kim, Dong Hyung,Kim, Moonil Elsevier 2019 Biosensors & bioelectronics Vol.141 No.-
<P><B>Abstract</B></P> <P>We report on a novel solution immersed silicon (SIS) sensor modified with bio-receptor to detect toluene. To perform this approach, bio-receptor PAS1 which specifically interacts with toluene was chosen as a capture agent for SIS ellipsometric sensing. We constructed wild PAS1 and mutant PAS1 (F46A and F79Y) which are toluene binding-defective. Especially, we utilized an easily accessible capturing approach based on silica binding peptide (SBP) for direct immobilization of PAS1 on the SiO<SUB>2</SUB> surfaces. After the immobilization of SBP-tagged PAS1 to the sensing layers, PAS1-based SIS sensor was evaluated for its ability to recognize toluene. As a result, a significant up-shift in Psi (Ψ) was clearly observed with a low limit of detection (LOD) of 0.1 μM, when treated with toluene on wild PAS1-surface, but not on mutant PAS1-sensing layers, indicating the selective interactions between PAS1 and toluene molecule. The PAS1-SIS sensor showed no changes in Psi (Ψ), if any, negligible, when exposed to benzene, phenol, xylene and 4-nitrophenol as negative controls, thereby demonstrating the specificity of interaction between PAS1 and toluene. Taken together, our results strongly indicate that PAS1-modified ellipsometry sensor can provide a high fidelity system for the accurate and selective detection of toluene.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SIS sensor modified with bio-receptor (PAS1) was developed for highly sensitive and specific detection of toluene. </LI> <LI> PAS1 receptor was tagged with silica binding peptide (SBP) to immobilize directly on the biosensing layers. </LI> <LI> The biosensing performance of SIS coupled with PAS1 represented a low detection limit of 0.1 μM to toluene. </LI> <LI> The PAS1-based SIS sensor showed an analytical specificity to toluene without cross-reactions by other toxic molecules. </LI> </UL> </P>
Dung, Tran Huu,Kim, Jina,Kim, Myong Su,Kim, Joon Seop,Yoo, Hoon American Scientific Publishers 2008 Journal of Nanoscience and Nanotechnology Vol.8 No.10
<P>A series of pluronic F127 conjugated PAMAM dendrimer generation 5 were prepared to evaluate the potential use of dendrimer-pluronic conjugates as a delivery agent of antisense oligonucleotides. The structural features of the conjugates were identified by FT-IR and 1H-NMR spectra. The prepared dendrimer generation 5-pluronic F127 conjugates showed particle size in the range of 50 to 130 nm with reduced zeta potential. The electrophoretic property of conjugates was further confirmed by capillary zone electrophoresis (CZE), demonstrating the decrease in electrophoretic mobility of conjugates as the number of pluronic F127 on surface of dendrimer increases. The number of free amino groups on a pluronic F127 conjugated dendrimer was quantitatively determined by fluorescamine assay, measuring the fluorescence intensity of amino groups reactive to fluorescamine on dendrimer generation 5-pluronic F127 conjugates. In MTT assay, dendrimer G5-pluronic F127 conjugates were safe on gingival fibroblast cells and acute toxicity was reduced as the mole ratio of dendrimer to pluronic increased. Complex formation of dendrimer G5-pluronic F127 conjugates with oligonucleotides was dose dependent.</P>
비신뢰성 링크를 가진 로우 듀티사이클 무선센서네트워크 환경에서 향상된 동적 스위칭 기반 플러딩 방법
( Dung T. Nguyen ),( Kim-tuyen Le-thi ),염상길 ( Sanggil Yeum ),김동수 ( Dongsoo Kim ),주현승 ( Hyunseung Choo ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
Duty-cycling could efficiently prolong the life time of Wireless Sensor Networks (WSNs) by let nodes be in dormant state most of the time, and only wake up (for sending or receiving) for a very short period. Flooding is one critical operation of WSNs. Many studies have been studied to improve the delay and/or energy efficiency of flooding. In this paper, we propose a novel time slot design, and the switching decision that reduce energy consumption for the schedule-based flooding tree. Each node, if failed to receive from its parent, will look for other candidate, among its siblings to overhear the flooding packet. By accurately collect information from other siblings, each node can make the best as possible switching decision; therefore the energy efficiency of the network is improved.
Dung, D.T.M.,Dung, P.T.P.,Oanh, D.T.K.,Vu, T.K.,Hahn, H.,Han, B.W.,Pyo, M.,Kim, Y.G.,Han, S.B.,Nam, N.H. Elsevier 2017 Arabian journal of chemistry Vol.10 No.4
<P>A series of novel 5'(7')-substituted-2'-oxospiro[1,3] dioxolane-2,3'-indoline-based N-hydroxypropenamides were designed, synthesized and evaluated for histone deacetylase (HDAC) inhibition and cytotoxicity. It was found that the compounds in this series displayed potent inhibitory effects against HDAC2 with IC50 values as low as 0.284 mu M, almost comparable to that of SAHA (IC50, 0.265 mu M), a positive control. In Western blot analysis, these compounds also exhibited noted inhibition toward histone deacetylation and this inhibition was found to correlate well with the cytotoxicity of the compounds in three human cancer cell lines. Docking studies indicated the compounds in this series bound to HDAC2 with high binding affinities (similar to -9.8 kcal/mol) compared to SAHA (-7.4 kcal/mol). (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.</P>
Chitosan-TPP Nanoparticle as a Release System of Antisense Oligonucleotide in the Oral Environment
Dung, Tran Huu,Lee, Seung-Rok,Han, Suhk-Dong,Kim, Seon-Jeong,Ju, Yeon-Mi,Kim, Myong-Soo,Yoo, Hoon American Scientific Publishers 2007 Journal of Nanoscience and Nanotechnology Vol.7 No.11
<P>Antisense oligonucleotide loaded chitosan nanoparticles were prepared and the release of oligonucleotide from chitosan-TPP/oligonucleotide nanoparticles was investigated. Morphological property, zeta potential and particle size of the prepared chitosan/oligonucleotide nanoparticles were investigated using Field Emission-Scanning Electron Microscope (FE-SEM) and particle size analyzer. The interaction between chitosan and oligonucleotide was confirmed by using capillary zone electrophoresis (CZE), and the released oligonucleotides were determined by spectrophotometric method. Oligonucleotides formed the complexes with chitosan with a unique morphological property. The release of oligonucleotides from nanoparticles was dependent on loading methods and pH conditions. Chitosan/oligomer-TPP nanoparticles, which was prepared by adding TPP after the formation of chitosan/oligonucleotide complex, showed the lowest release percent of oligonucleotides with 41.3% at pH 7.0 among the loading methods. The percent release of oligonucleotide from oligonucleotide loaded chitosan nanoparticle at pH 10 was higher than the one in acidic condition (pH 5.0). The released oligonucleotides from chitosan/oligonucleotide nanoparticles were stable enough for 12 h under the 20% saliva solution. Our results suggest that the sustained release of oligonucleotide from chitosan nanoparticles may be suitable for the local therapeutic application in periodontal diseases.</P>