다중버스 다중처리시스템을 위한 버스중재 프로토콜의 성능분석

금기호,전창호 漢陽大學校 工學技術硏究所 1996 工學技術論文集 Vol.5 No.1

This paper analyzes the performance of three bus arbitration protocols for least connected multiple-bus systems. A fundamental probabilitic theory is used to derive the probability that independent devices acquire buses. Then mathemetical models for the mean bus access time is obtained to be used as the performance measure. Based on this model the performance of three different bus arbitration protocols are analyzed through simulation with varying numbers of processors and memory modules. The simulation results show that equal priority protocol is most efficient especially when the bus request rate is high with a small number of buses although rotating priority protocol performs better in general.

연구단보 : 건조 및 저장조건에 따른 쌀 저장단백질의 변화양상

신평균 ( Pyung Gyun Shin ),장안철 ( An Cheol Chang ),홍성창 ( Seong Chang Hong ),이기상 ( Ki Sang Lee ),이금희 ( Keum Hee Lee ),이용복 ( Yong Bok Lee ) 한국환경농학회 2008 한국환경농학회지 Vol.27 No.4

Quality of rice grain changes during dry storage with internal physiological changes and external injury by organism. Storage rice changes by condition with respiration via variable temperature, hydrolysis enzyme reaction, lipid peroxidation occurs with change of palatability. During dry storage, physiological change with protein variation pattern was examined by image analysis on proteomic technology. Analysis revealed that protein activity had no change store at room temperature and store at 40℃, but decreased store at 60℃. Analysis of variable hydrophobic protein pattern revealed that protein activity of beta-tubulin, protein disulfide isomerase, vacuolar ATPase b subunit, globulin was not significantly decreased all dry and store condition. However, heat shock protein 70, and glutathione transferase was significantly decreased when rice dried at 60℃ compared with room temperature and 40℃ dry condition.

간암환자에서 Electronic Portal Imaging Device(EPID)를 이용한 자세 오차 및 종양 이동 거리의 객관적 측정

금기창(Ki Chang Keum),이상욱(Sang-wook Lee),신현수(Hyun Soo Shin),김귀언(Gwi Eon Kim),성진실(Jinsil Seong),이창걸(Chang Geol Lee),추성실(Sung Sil Chu),장세경(Sei-Kyung Chang),서창옥(Chang Ok Suh) 대한방사선종양학회 2000 Radiation Oncology Journal Vol.18 No.2

목 적 : 간암의 3차원 입체조형치료계획시 electronic portal imaging device (EPID)를 이용한 검증영상으로 경계여유 결정에 필요한 객관적 기초자료를 얻으므로써 방사선치료의 정확성을 높이고 본 기기를 이용하여 방사선치료의 정도관리 측면에서의 유용성을 알아보고자 하였다. 대상 및 방법 : 10명의 간암 환자에서 EPID를 이용하여 1회 방사선 치료 중 약 4-7회의 검증영상을 획득하였고 총 10회 분할 치료기간 동안 반복하여 시행하였다. 방사선치료 자세 고정시 발생할 수 있는 각 개인의 자세 오차를 구하여 치료간 발생하는 환자의 위치 이동을 분석하였고, 호흡으로 인한 간의 상하 움직임의 정도를 측정하여 계획용표적체적(Planning Target Volume, PTV)의 결정시 필요한 적정 경계여유를 구하였다. 결 과 : 검증영상 분석 결과 간암의 치료시 자세이동에 의한 자세 오차는 x축으로 3.0 mm, 표준편차는 1.70 mm 였고 y축으로 3.7 mm, 표준편차 1.88 mm 였다. 따라서 각 축을 중심으로 5 mm 이내 였다. 또한 호흡에 의한 간의 상하 운동 범위는 평균 8.63 mm이었고 표준편차는 1.48 mm 였다. 따라서 계획용표적체적 결정시 종양에 적어도 15 mm의 경계여유가 더 필요하다 결 론 : EPID는 3차원 입체조형치료계획시 종양의 경계여유 결정에 매우 유용하며 나아가서 방사선치료의 정도관리에도 크게 기여할 것이다. Purpose :The goal of this study was to improve the accuracy of three- dimensional conformal radiotherapy (3-D CRT) by measuring the treatment setup error and physiological movement of liver based on the analysis of images which were obtained by electronic portal imaging device (EPID). Materials and Methods : For 10 patients with hepatocellular carcinoma, 4- 7 portal images were obtained by using EPID during the radiotherapy from each patient daily. We analyzed the setup error and physiological movement of liver based on the verification data. We also determined the safety margin of the tumor in 3- D CRT through the analysis of physiological movement. Results :The setup errors were measured as 3 mm with standard deviation 1.70 mm in x direction and 3.7 mm with standard deviation 1.88 mm in y direction respectively. Hence, deviation were smaller than 5 mm from the center of each axis. The measured range of liver movement due to the physiological motion was 8.63 mm on the average. Considering the motion of liver and setup error, the safety margin of tumor was at least 15 mm. Conclusion : EPID is a very useful device for the determination of the optimal margin of the tumor, and thus enhance the accuracy and stability of the 3- D CRT in patients with hepatocellular carcinoma.

자궁내막암 환자에서 수술 전 방사선치료와 수술 후 방사선치료의 성적 비교 분석

금기창(Ki chang Keum),이창걸(Chang Geol Lee),정은지(Eun Ji Chung),이상욱(Sang Wook Lee),김우철(Woo Cheol Kim),장세경(Sei Kyung Chang),오영택(Young Taek Oh),서창옥(Chang Ok Suh),김귀언(Gwi Eon Kim) 대한방사선종양학회 1995 Radiation Oncology Journal Vol.13 No.4

목적 : 자궁내막암 1, 2기 환자에서 수술전 방사선 치료와 수술후 방사선 치료의 성적을 후향적으로 비교 분석하여 적합한 치료 방법을 얻고자 본 연구를 시행하였다. 방법 : 1985. 1월부터 1991. 12월까지 연세대학교 의과대학 방사선종양학과에 내원하여 방사선 치료를 받은 자궁내막암 환자 62명을 대상으로 하였으며, 이중 19명(1기 12명, 2기 7명)은 수술전 4-6주전에 방사선 치료를 받았으며(1군), 43명(1기 32명, 2기 11명)은 수술후 4-5주후에 방사선 치료를 받았다(2군). 2군중에 질내조사만 시행된 1명의 환자를 제외한 61명의 환자에서 모두 외부방사선 치료가 시행되었으며, 1군의 70%(13/19)와 2군의 44%(23/42)의 환자에서는 외부방사선 치료와 강내조사가 시행되었다. 외부방사선 조사는 180 CGy를 하루에 한 번씩 주 5회 시행하였으며, 총 방사선 조사선량은 39.6-55 Gy(중앙값 : 45Gy)였다. 강내조사는 1군에서는 Point A에 20-39.6Gy(중앙값 : 39Gy)가 조사되었고, 2군에서는 질 표면에서 0.5mm 깊이에 18-30 Gy(중앙값:21Gy)가 조사되었다. 결과 : 수술전 방사선 치료군과 수술후 방사선 치료군의 5년 생존율은 각각 89%, 98%로 통계적으로 유의한 차이는 없었다(p0.01), 2군에서 림프절의 전이 여부에 따라 5년 생존율이 통계적으로 유의한 차이를 보였다(p Purpose : To obtain the optimal treatment method in patients with endometrial carcinoma(clinical stage FIGO Ⅰ, Ⅱ) by comparative analysis between preoperative radiotherapy (pre-op RT) and postoperative radiotherapy (post-op RT). Material and Methods : A retrospective review of 62 endometrial carcinoma patients referred to the Yonsei Cancer Center for radiotherapy between 1985 and 1991 was undertaken. Of 62 patients., 19 patients(Stage Ⅰ:12patients, Stage Ⅱ:7 patients) received pre-op RT before TAH(Total Abdominal Hysterectomy) and BSO(Bilateral Salphingoophorectomy) (Group 1) and 43 patients(Stage 1:32 patients, stage 2: 11patients) received post-weeks prior to surgery and post-op RT was administered on 4-5 weeks following surgery. All patients except 1 patient(Group 2: ICR alone) received external irradiation. Seventy percent(13/19) of pre-op RT group and 54 percent(23/42) of post-op RT group received external pelvic irradiation and intracavitary radiation therapy(ICR). External radiation dose was 39.6-55 Gy(median 45 Gy) in 5-6. 5weeks through opposed AP/PA fields or 4-field box technique treating daily, five days per week. 180 cGy per fraction. ICR doses were prescribed to point A(20-39.6 Gy, median 39 Gy) in Group 1 and 0.5cm depth from vaginal surface (18-30 Gy, median 21 Gy) in Group 2. Results : The overall 5 year survival rate was 95%. No survival difference between pre-op and post-op RT group.(89.3% vs 97.7%, p>0.1) There was no survival difference by stage, grade and histology between two groups. The survival rate was not affected by presence of residual tumor of surgical specimen after pre-op RT in Group 1 (p>0.1), but affected by presence of lymph node metastasis in post-op RT group(p

혈청 칼슘 농도가 담즙내 칼슘 농도의 변화에 미치는 영향

조병채,김영진,박용검,지경천,이정효,장인택,김상준,한기정,백광진 중앙대학교 의과대학 의과학연구소 1998 中央醫大誌 Vol.23 No.1

The purpose of this study was to investigate the relationship between the increased serum calcium changes induced by short-term intravenous calcium infusion and the resultant subsequent changes on total and ionized calcium concentration [Ca_TOT] and [Ca^2+]level, and on bile acid changes in the T-tube bile. Ten patients underwent cholecystectomy, common duct exploration, and T-tube insertion. Serum and biliary calcium concentration were measured over an 7-hour period, before, during, and after a 4-hour intravenous infusion of 10% calcium gluconate. During the infusion, serum total calcium[Ca_TOT] increased from 2.17±0.27 mmol/L to 2.30±0.22 mmol/L and serum free ionized calcium[Ca^2+] increased from the preinfusion state, 1.29±0.10 mmol/L to 1.34±0.15 mmol/L. After the infusion, 60 minite later, biliary total calcium [Ca_TOT] increased from 1.54±0.23 to 1.95±0.37 mmol/L and biliary ionized calcium [Ca^2+] increased from 1.08±0.18 to 1.20±0.09 mmol/L. When the data pooled, increased serum total calcium[Ca_TOT] showed significant correlation with serum ionized calcium[Ca^2+] And also serum ionized calcium[Ca^2+] correlated with biliary total calcium[Ca_TOT] And as to bile acid, increased biliary ionized calcium[Ca^2+] related to decreased bile acid. These results support the hypothesis that calcium is freely permeable at biliary excretory system, and that serum ionized calcium level is one of the determinant elements of biliary calcium level.

간암의 정상조직손상확률을 이용한 방사선간염의 발생여부 예측가능성에 관한 연구

금기창(Ki Chang Keum),성진실(Jinsil Seong),서창옥(Chang Ok Suh),이상욱(Sang-wook Lee),정은지(Eun Ji Chung),신현수(Hyun Soo Shin),김귀언(Gwi Eon Kim) 대한방사선종양학회 2000 Radiation Oncology Journal Vol.18 No.4

목 적 : 방사선간염(radiation hepatitis)의 발생에는 방사선 조사량, 조사체적 등의 요인이 작용하는 것으로 알려져 왔으나 이러한 요인들의 관계를 양적으로 나타내지는 못하였다. 그러나 최근 3차원 입체조형 치료계획체계의 발전으로 간암의 방사선조사시 간의 선량-체적에 대한 분석이 가능하게 되었고 나아가 이를 이용한 수학적 변수인 정상조직손상확률을 계산할 수 있게 되었다. 이에 저자들은 정상조직손상확률값을 연계시켜서 방사선간염의 예측 가능성을 평가하고자 본 연구를 진행하였다. 대상 및 방법 : 1992년 3월부터 1994년 12월 사이에 방사선 치료를 받은 환자중에서 간암 환자 10명, 담도암 환자 10명을 대상으로 하였다. 치료 전 혈청학적 검사에서 간암 환자 2명에서 간경화가 있었고 (각각의 prothrombin time 73%, 68%) 다른 18명의 간기능은 정상이었다. 조사된 방사선량은 1일 1.8∼2.0Gy씩 22회에서 30회를 시행하여 39.6∼60.0 Gy (중앙값은 50.4 Gy)였으며, 조사면수는 2∼6 ports (중앙값은 4 ports)였다. 이 환자들의 치료 전 전산화단층촬영을 이용하여 간의 선량체적분석 및 Lyman의 공식을 적용하여 정상조직손상확률값을 구하였다. 방사선간염은 alkaline phosphatase의 값이 2배이상 증가 되고 비암성 복수가 동반된 경우로 정의하였으며 환자의 병력 기록을 이용하여 방사선간염 발생여부를 파악하여 정상조직손상확률값과 상관 관계를 분석하였다. 결 과 : 정상조직손상확률값은 0.001∼0.840까지 분포하였고 중앙값은 0.05였다. 방사선간염은 방사선 치료후 약1주에서 5주사이에 20명중 3명에서 발생하였으며, 이들의 정상조직손상확률값은 각각 0.390, 0.528, 0.844 (평균값 0.58±0.23)이었고, 방사선간염이 생기지 않은 환자의 정상조직손상확률값은 0.001∼0.308 (평균값 0.09±0.09) 사이에 분포하였다. 정상조직손상확률을 체적인자가 0.32로 계산한 경우에는 비교적 높은 값인 0.39이상에서 방사선 간염이 발생한 것을 알 수 있으나, n 을 0.69로 하여 계산한 경우에는 비교적 낮은 정상조직손상확률(0.03, 0.18)에서도 방사선 간염이 발생하는 것을 보여 체적인자 0.32가 비교적 임상적 결과와 일치하는 값이었다. 결 론 : 정상조직손상확률값이 일정값 이상의 환자에서 방사선간염이 발생하는 것으로 보아 정상조직손상확률값으로 방사선간염의 발생을 예측할 수 있을 것이다. Purpose :Although It has been known that the tolerance of the liver to external beam irradiation depends on the irradiated volume and dose, few data exist which quantify this dependence. However, recently, with the development of three dimensional (3- D) treatment planning, have the tools to quantify the relationships between dose, volume, and normal tissue complications become available. The objective of this study is to investigate the relationships between normal tissue complication probability (NTCP) and the risk of radiation hepatitis for patients who received variant dose partial liver irradiation. Materials and Method : From March 1992 to December 1994, 10 patients with hepatoma and 10 patients with bile duct cancer were included in this study. Eighteen patients had normal hepatic function, but 2 patients (prothrombin time 73%, 68%) had mild liver cirrhosis before irradiation. Radiation therapy was delivered with 10MV linear accelerator, 180∼200 cGy fraction per day. The total dose ranged from 3,960 cGy to 6,000 cGy (median dose 5,040 cGy). The normal tissue complication probability was calculated by using Lyman's model. Radiation hepatitis was defined as the development of anicteric elevation of alkaline phosphatase of at least two fold and non-malignant ascites in the absence of documented progressive. Results :The calculated NTCP ranged from 0.001 to 0.840 (median 0.05). Three of the 20 patients developed radiation hepatitis. The NTCP of the patients with radiation hepatitis were 0.390, 0.528, 0.844 (median : 0.58±0.23), but that of the patients without radiation hepatitis ranged from 0.001 to 0.308 (median : 0.09±0.09). When the NTCP was calculated by using the volume factor of 0.32, a radiation hepatitis was observed only in patients with the NTCP value more than 0.39. By contrast, clinical results of evolving radiation hepatitis were not well correlated with NTCP value calculated when the volume factor of 0.69 was applied. On the basis of these observations, the volume factor of 0.32 was more correlated to predict a radiation hepatitis. Conclusion :The risk of radiation hepatitis was increased above the cut- off value. Therefore the NTCP seems to be used for predicting the radiation hepatitis.

1998, 1999년도 우리나라에서 시행된 근치적 유방 전절제술 후 방사선치료 현황 조사

금기창(Ki Chang Keum),심수정(Su Jung Shim),이익재(Ik Jae Lee),박원(Won Park),이상욱(Sang-wook Lee),신현수(Hyun Soo Shin),정은지(Eun Ji Chung),지의규(Eui Kyu Chie),김일한(Il Han Kim),오도훈(Do Hoon Oh),하성환(Sung Whan Ha),이형식(Hyung 대한방사선종양학회 2007 Radiation Oncology Journal Vol.25 No.1

목 적: 유방암에 대한 방사선치료의 적정성과 안전성을 보장하고 궁극적으로 치료효과를 향상시키기 위한 방사선 치료 기술 표준화를 위하여 우리나라 전국 병원을 대상으로 하는 치료형태 조사연구(patterns of care study, PCS) 를 계획하였다. 그 두 번째 단계로 근치적 유방 전절제술 후 시행한 방사선치료 방법에 대하여 조사하고 분석하였다. 대상 및 방법: 조사하고자 하는 입력 문항을 개발하였고 동시에 인터넷을 통하여 조사자가 직접 입력할 수 있도 록 Web 기반 입력 프로그램(www.pcs.re.kr)을 개발하였다. 대상 환자들은 1998년도에 근치적 유방 전절제술 후 방 사선치료를 받은 환자로 전수 조사를 하지 않고 임의 추출하여 조사하였다. 입력 문항은 149개로 병력과 이학적 소견, 수술 소견과 병리소견, 항암화학요법, 호르몬요법, 방사선치료계획, 방사선치료, 치료 중 부작용, 치료 효과, 합병증 등 9군으로 나누어져 있다. 17개 병원에서 입력된 286명의 데이터를 분석하였다. 결 과: 연령은 20∼81세(중앙값 44세)였다. 환자의 병기는 AJCC (American Joint Committee on Cancer) 6판에 따라 분류하였으며 T1: 9.7%, T2: 59.2%, T3: 25.6%, T4: 5.2%이었으며 T0가 1예 있었다. 액와림프절 곽청술에서 떼어낸 림프절이 10개 미만인 환자가 10.5%, 10개 이상인 환자가 86.7%이었으며 7.3% 환자에서 림프절 전이가 없었고, 림프절 전이가 3개 이하인 경우가 14%, 4∼9개가 38.8%, 10개 이상 전이된 경우가 38.5%였다. 따라서 병기 I기: 0.7%,IIa기: 3.8%, IIb기: 9.8%, IIIa기: 43.0%, IIIb기: 2.8%, IIIc기: 38.5%이었다. 방사선치료가 시행된 시기에 따라서는 수술후에 항암약물치료를 마치고 방사선치료를 한 경우가 47.9%로 가장 많았고, 수술 후 약물치료를 시행하고 방사선 치료를 시행한 후에 다시 약물치료를 시행한 경우가 35.0%로 그 다음으로 많았다. 수술 전 약물치료를 시행하고 그 후에 방사선치료를 시행한 경우도 12.5%였다. 방사선치료 범위는 전체의 5.6%가 흉벽만 치료받았고 20.3%는 흉벽과 쇄골상 림프절을, 27.6%는 흉벽과 쇄골상 림프절과 내유방림프절을, 25.9%에서는 흉벽과 쇄골상 림프절을 치료하면서 액와 후방조사를, 19.9%에서는 흉벽과 쇄골상 림프절과 내유방림프절을 치료하면서 액와 후방조사를 시행하였다. 2예(0.7%)에서는 내유방림프절만 치료하였다. 흉벽의 방사선치료 방법에 있어서는 57.3%에서 양쪽 접선조사를 사용하였고, 42%에서는 전자선으로 치료하였다. 양쪽 접선조사를 시행한 경우에는 54.8%에서 조직보상체를 사용하였고, 전자선으로 치료한 경우는 52.5%에서 사용하였으며 흉벽에 조사된 방사선량은 91.3%에서 45∼50.4 Gy이었으며, 5.9%에서 그 이상이 2.8%에서 그 미만이 조사되었다. 쇄골상 림프절에 조사된 방사선량은 89.5% 에서 45∼50.4 Gy이었으며, 2.4%에서 그 이상이 8%에서 그 미만이 조사되었다. 결 론: 유방 보존술 후 방사선치료와는 달리 근치적 유방 전절제술 후 방사선치료는 다양한 형태로 시행되고 있음을 알 수 있었다. 향후 치료방법에 따른 치료성적을 분석함으로써 적절한 방사선 치료 방법을 제시할 수 있을 것이다. P urpose: To determine the patterns of evaluation and treatment in patients with breast cancer after mastectomy and treated with radiotherapy. A nationwide study was performed with the goal of improving radiotherapy treatment. Materials and Methods: A web- based database system for the Korean Patterns of Care Study (PCS) for 6 common cancers was developed. Randomly selected records of 286 eligible patients treated between 1998 and 1999 from 17 hospitals were reviewed. R esults: The ages of the study patients ranged from 20 to 80 years (median age 44 years). The pathologic T stage by the AJCC was T1 in 9.7% of the cases, T2 in 59.2% of the cases, T3 in 25.6% of the cases, and T4 in 5.3% of the cases. For analysis of nodal involvement, N0 was 7.3%, N1 was 14%, N2 was 38.8%, and N3 was 38.5% of the cases. The AJCC stage was stage I in 0.7% of the cases, stage IIa in 3.8% of the cases, stage IIb in 9.8% of the cases, stage IIIa in 43% of the cases, stage IIIb in 2.8% of the cases, and IIIc in 38.5% of the cases. There were various sequences of chemotherapy and radiotherapy after mastectomy. Mastectomy and chemotherapy followed by radiotherapy was the most commonly performed sequence in 47% of the cases. Mastectomy, chemotherapy, and radiotherapy followed by additional chemotherapy was performed in 35% of the cases, and neoadjuvant chemoradiotherapy was performed in 12.5% of the cases. The radiotherapy volume was chest wall only in 5.6% of the cases. The volume was chest wall and supraclavicular fossa (SCL) in 20.3% of the cases; chest wall, SCL and internal mammary lymph node (IMN) in 27.6% of the cases; chest wall, SCL and posterior axillary lymph node in 25.9% of the cases; chest wall, SCL, IMN, and posterior axillary lymph node in 19.9% of the cases. Two patients received IMN only. The method of chest wall irradiation was tangential field in 57.3% of the cases and electron beam in 42% of the cases. A bolus for the chest wall was used in 54.8% of the tangential field cases and 52.5% of the electron beam cases. The radiation dose to the chest wall was 45∼59.4 Gy (median 50.4 Gy), to the SCL was 45∼59.4 Gy (median 50.4 Gy), and to the PAB was 4.8∼38.8 Gy, (median 9 Gy) Conclusion: Different and various treatment methods were used for radiotherapy of the breast cancer patients after mastectomy in each hospital. Most of treatment methods varied in the irradiation of the chest wall. A separate analysis for the details of radiotherapy planning also needs to be followed and the outcome of treatment is needed in order to evaluate the different processes.

New Concepts for Diagnosis and Prognosis of HCC : Clinical Application of "NeoNovo" System for Molecular Diagnosis of HCC: a New DNA Chip Method

금기창 ( Ki Chang Keum ),( So Young Yoo ),( Nae Choon Yoo ),( Won Min Yoo ),( Sang Yup Lee ) 대한간암연구회 2006 대한간암연구회 학술심포지엄 Vol.9 No.-

진행된 후두암과 하인두암의 환자에서 유도화학 요법 후 방사선 치료와 수술 후 방사선 치료의 성적 비교 및 고찰

금기창(Ki Chang keum),이창걸(Chang Geol Lee),김귀언(Gwi Eon Kim),이경희(Kyung Hee Lee) 대한방사선종양학회 1993 Radiation Oncology Journal Vol.11 No.2

Background: We peformed a retrospective study in patients with previously untreated advanced (Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+ RT) with those of conventional laryngectomy and postoperative radiation therapy (OP + RT). Method: Between 1985 and 1990, twenty-four patients were treated with two or three courses of chemotherapy and radiation therapy (66-75 Gy). Twenty-five patients were received laryngectomy and radical neck dissection (except 3 patients) and postoperative radiation therapy (55~64 Gy). Result: After a median fellow-up of 20 months, the actusrial 5-year overall survival rate was 24% (chemotherapy group) and 36%, (op group). (P<0.1). The local control rate was the 65%, (13/20) and 68.2%, (15/22). (p<0.1). The rate of laryngeal preservation was 65% (13/20) in chemotherapy group. Conclusion: Induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients with advanced laryngeal and hypopharyngeal cancer.

상악동의 선양낭성암종

금기창(Ki Chang Keum),박희철(Hee Chul Park),김귀언(Gwi Eon Kim),서창옥(Chang Ok Suh),정은지(Eun Ji Chung),김세헌(Se Heon Kim),김영호(Young Ho Kim),홍원표(Won Pyo Hong) 대한두경부종양학회 1996 대한두경부 종양학회지 Vol.12 No.2

A retrospective analysis was performed to assess the relationship between the treatment modalities and treatment results in patients with adenoid cystic carcinoma of the maxillary sinus. From Feb. 1977 to March 1994, 10 patients with the disease were treated at the Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine. Six men and 4 women were presented with median age of 57 years. According to AJCC TNM system, all patients except one had advanced T3 and T4 disease. Only one patient had the regional metastasis to lymph node but none of them had hematogenous metastasis on initial admission. One patient(Group 1) was treated with surgery alone, 3 patients(Group 2) were treated with definitive radiotherapy and 6 patients(Group 3) were treated with combination of surgery and radiotherapy. One patient who was treated with surgery alone had experienced a locoregional recurrence 9 months later and 3 patients who were treated with radiation therapy alone had PRs(partial response) followed by the subsequent progression of the local disease. Whereas all patients who were treated with combination of surgery and radiation therapy had CRs(complete response). Among them, only one patient was recurred in the primary site, who was salvaged by reoperation and reirradiation therapy. In conclusion, combination of surgery and radiotherapy resulted in the best treatment modality for adenoid cystic carcinoma of the maxillary sinus. Improved radiotherapy technique and development of multimodality treatment are needed to improve the local control and the survival rate in patients with advanced adenoid cystic carcinoma of the maxillary sinus.