中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

A Longitudinal Study on the Prevalence of Major Adult Chronic Disease in Korean Employees between 2001 and 2010

( Gyu-jang Lee ),( Soon-ki Kim ),( Hye-young Kim ),( Chang-kyou Lee ),( Seung-gwan Lee ),( Kyung-jin Cho ) 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.1

The Korean GDP per capita doubled during the last 10 years. As the GDP increases, Korean health behaviors such as, eating, drinking, smoking, and exercise habits changed as well. Compared to the remarkably advanced diagnostic technologies and therapeutics during the last decade, the leading causes of death in Korea scarcely changed. Among the leading causes of death, cerebrovascular disease, heart disease, diabetes, liver disease and hypertension are closely related to health behaviors. Using the database of medical check-up between 2001 and 2010, the authors performed a longitudinal study for the prevalence rates and the trends of major chronic adult diseases among the 2,721 workers along with their health behavior. Among the diagnostic test items, fasting blood sugar, cholesterol and BMI levels showed steady increase and these three test items all showed linear trends (p<0.001). The average blood sugar and cholesterol levels were near worrying levels. Moreover, the average BMI of males was foundto be at the overweight level, intimating the possibility reaching thee Obese Class I level soon if there are no aggressive counter measures. Fasting blood sugar and cholesterol levels were higher in a drinking group as compared to a non-drinking group, and the BMI levels were also higher in the drinking group and the smoking group as compared to the non-drinking and the non-smoking group (p<0.001). Finally, the authors believe that the fasting blood sugar, cholesterol and BMI levels should be designated as target monitoring test items in the medical check-up for Korean employees.

모바일 기기 이용자의 온라인 사회참여에 대한 디지털 리터러시의 영향: 세대 효과의 조절효과를 중심으로

장창기(Jang, Chang Ki) 사이버커뮤니케이션학회 2021 사이버 커뮤니케이션 학보 Vol.38 No.4

본 연구는 한국사회의 저출산과 고령화로 인해 증가하고 있는 1인 가구 및 세대별 특성이 개인의 디지털 리터러시와 상호작용할 경우에 개인의 온라인 사회참여 수준에 미치는 영향을 2019년 한국미디어패널조사 데이터를 이용하여 실증적으로 분석한 것이다. 이에 따라, 본 연구는 인구사회학적 변화로 인한 세대 특성과 디지털 리터러시 수준이 온라인 사회참여에 미치는 영향에 대해 실증적으로 분석하는 것을 목적으로 한다. 분석 결과는 특정 사회적 사건을 경험하거나 공유한 세대 간에는 온라인 사회참여에 관한 관심에 차이가 확인되며, 온라인 활동에 익숙한 젊은 세대일수록 기존 세대에 비해 온라인 사회참여에 적극적인 것으로 확인되었다. 또한, 연령을 중심으로 구분된 세대(generation) 효과를 검증한 결과는 Y세대(20∼30대)와 같이 디지털 환경에 익숙한 세대 특성이 온라인 사회참여에 중요한 요인임을 보여준다. 그러나, 가구 구분에 따른 통계적 유의성은 확인되지 않았다. 따라서, 디지털 정보화시대의 사회참여에는 개인의 성향 및 가치, 이념에 추가하여 정보에 접근할 수 있는 역량에 관한 고려가 필요하다. 지금까지의 디지털 리터러시의 영향에 관한 연구가 주로 연령에 따른 영향을 분석한 반면, 본 연구는 세대 특성을 반영한 디지털 리터러시 수준이 온라인 사회참여 활동에 미치는 영향을 실증적으로 검증했다는 데 의의가 있다. This study empirically analyzes the effect of individual households and generational characteristics, which are increasing due to the low birth rate and aging of Korean society, on individuals’ online social participation level when they interact with individual digital literacy, Using the 2019 Korea Media Panel Survey data. Accordingly, the purpose of this study is to empirically analyze the effects of generational characteristics and digital literacy level on online social participation due to demographic and sociological changes. The results of the analysis show that there may be differences in interest in online social participation between generations who have experienced or shared specific social events. In addition, in the generation divided by age, generational characteristics familiar with the digital environment, such as Generation Y (20-30s), were identified as important influencing factors on online social participation. However, statistical significance according to household classification was not confirmed. Therefore, social participation in the digital information age requires consideration of the ability to access information in addition to individual dispositions, values, and ideologies. This study is meaningful in that it empirically verified the effect of digital literacy levels on online social participation activities through generational characteristics, while studies on the effects of digital literacy so far mainly analyzed the effects of age.

국내 중소하천의 유사량 산정 공식 적용에 관한 연구

강창훈 ( Chang-hoon Kang ),장석환 ( Suk-hwan Jang ),신철식 ( Cheol-sik Shin ),이현기 ( Hyeon-ki Lee ),김월봉 ( Wol-bong Kim ) 한국환경기술학회 2013 한국환경기술학회지 Vol.14 No.6

유사란 하천수에 의하여 운반되는 토사를 말하며 유수에 의해 침식, 퇴적이 반복되는 결과를 낳는다. 최근 기후변화와 함께 대규모 홍수가 빈번해 짐에 따라 하천의 유사량이 커지고 4대강 사업처럼 대규모 하천사업으로 인한 하상변동이 심해지고 있다. 하천에서 총유사량 추정은 하상변동의 원인이 되기도 하고 수자원 개발 및 관리를 위한 하천계획에 필요한 기본적 요소이다. 하지만 국내에서는 대규모 하천에서의 유사량은 측정을 실시하고 있지만 중소하천의 경우 유사량을 실측하여 산정할 수 있는 시간적 경제적 부담 때문에 측정할 수 있는 한계가 있다. 본 연구에서는 경기북부에 위치한 차탄천, 포천천, 경기남부에 위치한 남양천의 각 유량에 따른 부유사를 채취하여 시료분석을 통한 결과와 이론식을 적용하여 비교 분석 하였다. 채취한 시료는 입도분석을 실시하였으며 현장 측정 자료와 실내실험 결과를 토대로 수정 아인슈타인공식을 적용한 BORAMEP 프로그램을 사용하여 총유사량을 산정하였다. 분석 결과, 3m³/sec 이하 유량에서는 Yang 공식이 실측자료와 일치성을 나타냈고 3m³/sec 이상에서는 Shen and Hung 공식이 잘 나타났다. 각 이론을 적용하여 총유사량을 추정하고, 실측치를 이용하여 비교·검토함으로써 국내 중소하천에 적합한 산정 방법과 경기북부 지역 중소하천의 유량-총유사량 관계식을 제시하였다. Sediment transport means that the materials of bed and suspended load in the river are transported by flow tractive force, which causes scour and deposition. As the climate changes and dramatic flood occurs frequently, the sediment transport has increased and river bed changed. Sediment transport estimation is essential for the water resources management as well as river bed morphology. However, it is difficult to measure the total sediment in the middle and small river due to time and economic constrain. In this study, field data which were observed in 3 different river in Kyunggi-do were analyzed for comparing with empirical equations. Particle distribution analysis were carried out for the collected the suspended loads. The simulation model BORAMEP(Bureau of Reclamation Automated Modified Einstein Procedure) were used for the total sediment estimation along the field data analysis. As a result, Yang`s equation corresponds to field data under 3m³/sec and the equation of Shen and Hung corresponds to results over 3m³/sec. The results showed the way how sediment were estimated and discharge-total sediment relationship was determined by regression analysis in small and middle river of Kyunggi province region.

A Longitudinal Study on the Prevalence of Major Adult Chronic Disease in Korean Employees between 2001 and 2010

Lee, Gyu-Jang,Kim, Soon-Ki,Kim, Hye-Young,Lee, Chang-Kyou,Lee, Seung-Gwan,Cho, Kyung-Jin 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.1

The Korean GDP per capita doubled during the last 10 years. As the GDP increases, Korean health behaviors such as, eating, drinking, smoking, and exercise habits changed as well. Compared to the remarkably advanced diagnostic technologies and therapeutics during the last decade, the leading causes of death in Korea scarcely changed. Among the leading causes of death, cerebrovascular disease, heart disease, diabetes, liver disease and hypertension are closely related to health behaviors. Using the database of medical check-up between 2001 and 2010, the authors performed a longitudinal study for the prevalence rates and the trends of major chronic adult diseases among the 2,721 workers along with their health behavior. Among the diagnostic test items, fasting blood sugar, cholesterol and BMI levels showed steady increase and these three test items all showed linear trends (p<0.001). The average blood sugar and cholesterol levels were near worrying levels. Moreover, the average BMI of males was found to be at the overweight level, intimating the possibility reaching thee Obese Class I level soon if there are no aggressive counter measures. Fasting blood sugar and cholesterol levels were higher in a drinking group as compared to a non-drinking group, and the BMI levels were also higher in the drinking group and the smoking group as compared to the non-drinking and the non-smoking group (p<0.001). Finally, the authors believe that the fasting blood sugar, cholesterol and BMI levels should be designated as target monitoring test items in the medical check-up for Korean employees.

상피성 암세포주에 대한 녹차 Catechin의 효과

박정현(Jeong Hyun Park),김대중(Dae Joong Kim),한장희(Jang Hee Hahn),김홍태(Hong Tae Kim),정용욱(Yong Wook Jung),성훈기(Hoon Ki Sung),김주영(Joo Young Kim),송인환(In Hwan Song),성언기(Eon Gi Sung),이융창(Yung Chang Lee) 대한해부학회 2001 Anatomy & Cell Biology Vol.34 No.5

Catechin은 녹차에서 추출되는 폴리페놀의 주요성분으로 고혈압 및 동맥경화의 예방효과, 당뇨억제효과, 항산화작용, 항암작용 등에 직접 관여하는 물질이다. 본 연구에서는 태평양에서 제공받은 녹차 catechin을 이용하여 상피성 암세포주인 A549 (폐암)와 EATC (복수암)세포에 투여한 후 처리농도와 시간에 따른 변화를 비교, 관찰함으로써 녹차의 효과와 작용기전을 밝혀내는데 목적이 있었다. 본실험은 A549 세포와 EATC 세포를 배양한 후 녹차 catechin을 1, 10, 100, 500 μg/ml의 농도로 48시간 동안 처리하였고, 광학현미경, 공초점현미경, 전자현미경 등을 이용하여 세포의 구조적 변화를 확인하였으며 MTT분석, 전기영동, 유세포분석기 등을 사용하여 세포 손상정도를 파악하였다. A549 세포에서는 catechin 1 μg/ml와 10 μg/ml 농도에서는 대조군에 비하여 큰 변화를 관찰할 수 없었다. 100 μg/ml catechin을 처리하였을 때 세포내의 검은 과립들의 수가 증가하였고 층판소체의 손상이 나타났다. 세포주기의 장애가 나타나 DNA 합성전기에 있는 세포들의 수가 급격히 증가하였다. 500 μg/ml 농도에서는 층판소체와 사립체의 파괴가 심하게 나타났으며 세포생존율이 감소하였고 세포주기의 장애도 관찰되었다. EATC 세포에서는 catechin의 농도가 A549 세포의 경우보다 낮은 농도에서도 세포증식 억제 및 세포손상 효과가 나타났다. 10 μg/ml 농도에서도 세포의 위축과 생존율의 감소가 일어났으며 전기영동상에 괴사되는 세포들이 파악되었다. 100μg/ml catechin을 처리하였을 때 자연사의 형태학적 관찰, 전기영동, 유세포분석 등에서 자연사 과정에 있는 세포들이 많이 나타났다. 결과적으로 녹차 catechin을 배양한 상피성 암세포에 투여함으로서 세포의 생존율과 증식이 억제되었고 그 과정에서 괴사, 자연사, 세포주기의 장애 등이 관여하는 것으로 생각된다. 그러나 일련의 세포손상과정을 유도하는 데 있어 세포의 종류, 처리 시간, 농도에 따라 다소 차이가 있음을 확인하였다. Catechin is main component of polyphenol extracts from green tea, it is associated with prevention of hypertension and atherosclerosis, anti-diabetic effect, antioxidant, antitumor. The purpose of this research is to investigate the effect and its mechanism of green tea catechin on epithelial cancer cell lines in various concentrations and durations. For this study, epithelial cancer cell lines, A549 (lung cancer), EATC (Ehrlich-Lettre ascites tumor cell) were used. Inverted, light, confocal and electron microscopes were applied to find morphological changes. MTT assay, flowcytometric analysis, gel electrophoresis were used to compare severity of cellular damages to control after exposure to 1, 10, 100 and 500 μg/ml catechin for 48 hours. In the A549 cells, after 1 μg/ml and 10 μg/ml catechin treatments, there was no notable changes. However, exposure to 100 μg/ml catechin induced increase of cytoplasmic granules, destruction of lamellar body, inhibition of cell cycle, especially G0/G1. In the early phase of 500 μg/ml catechin administration, decrease of cell population, severe destruction of lamellar bodies and mitochondria, derangement of cell cycle were shown. In the EATC, such as those effects occurred after exposure to lower concentration of catechin than in that of A549 cells. After exposure of 10 μg/ml catechin, rounded-up cells and necrotic cells were found. Whereas, most of cells were under apoptotic changes-cytoplasmic condensation, nuclear fragmentation, cellular shrinkage, ladder pattern in the electrophoresis, when administrated 100 μg/ml catechin. These results suggested that exposure of catechin induced severe cellular damage and growth inhibition in dose- and time-dependent manner. And we confirmed that these effects of catechin were involved with apoptosis, necrosis and cell cycle arrest and were quite different according to cancer type. Therefore, much more research would be demanded before clinical application of catechin to human cancer therapy and this study would be the basic source for further study of green tea.

ESR, ESEM을 이용한 이온 교환된 MoH-SAPO-34에 대한 Mo의 화학종, 위치 및 흡착상호작용에 관한 연구

장창기,원태진,백건호 昌原大學校 基礎科學硏究所 2001 基礎科學硏究所論文集 Vol.13 No.-

A solid-state reaction of MoO3 with as-synthesized H-SAPO-34 generated paramagnetic Mo(V) species. The dehydration resulted in weak Mo(V) species, and subsequent activation resulted in the formation of Mo(V) species such as Mo(V)5c and Mo(V)6c that are characterized by ESR. The data of ESR and ESEM show the oxomolybdenum species, to be (MoO2)+ or (MoO)3+. The (MoO2)+ species seems to be more probable. Since H-SAPO-34 has a low framework negative charge, (MoO)3+ with a high positive charge can not be easily stabilized. A solution reaction between the solution of silico-molybdic acid and calcined H-SAPO-34 resulted in only MoO2+ species. A rhombic ESR signal is observed on adsorption of D2O, CD3OH, CH3CH2D and ND3. The Location and coordination structure of Mo(V) species has been determined by three-pulse electron spin-echo modulation data and their simulations. After the adsorption of methanol, ethylene, ammonia, and water for MoH-SAPO-34, three molecules, one molecule, one and one molecule, respectively, are directly coordinated to (MoO2)+.

FAH-전지의 효율파라미터에 대한 광세기 및 온도특성

장지근,김장기,김민영 단국대학교 신소재기술연구소 1991 신소재 Vol.1 No.-

위성전원용 태양전지로 사용할 수 있는 새로운 구조의 FAH-전지로부터 효율파라미터 특성이 입사 광전력의 세기(I=20∼1000 mW/㎠)와 온도 (T=0∼140℃)에 따라 어떻게 변화되는가를 측정하고 이 결과를 분석하였다. 일정한 온도(T=30℃)에서 광세기가 증가할 때 FAH-전지의 개방전압(V_oc)은 20∼200 mW/㎠ 범위에서 v_oc=0.66+0.067·log(I/20) [V]로, 200∼600mW.㎠ 에서는 V-oc=0.727+0.04·log(I/200) [V]의 관계로 증가하는 특성을 나타내고 600 mW/㎠ 이상에서는 0.75 [V]로 포화되었다. 충실도(F·F)는 100mW/㎠ 이하에서 F·F=0.815∼0.0858·log(I/20)으로, 300 mW/㎠이상에서는 F·F=0.65∼0.5164·log(I/300)의 관계로, 광세기에 따라 감소하는 특성을 보였다. T=30℃일 경우 전지의 효유(EFF.)은 100mW/㎠이하의 광세기에서 거의 일정한 값으로 나타나고(EFF.≒EFF_*ref=EFF.|I=100 mW/㎠) 300mW/㎠ 이상의 광세기에서는 EFF.=Eff_*ref·[0.9-0.412·log(I/300)]로 효율이 급격히 저하되었다. 또한 일정한 광세기(I=100 mW/㎠)에서 단락전류(I_se는 온도가 증가함에 따라 단조증가하며 T<30℃에서 dI_se/dT=0.0006 mA/℃로 나타났다. 개방전압의 감소율은 전체 측정온도 범위(T=0∼140℃)에서 dV_oc/dT=-0.002 V/℃로 나타났으며, 충실도(F·F)는 T=0∼20℃, 20∼90℃, 90∼140℃의 각 영역에서 -0.275%/℃, -0.1357%/℃, -0.1 %/℃의 율로 감소하였다. 전지의 효율은 T=30℃의 갑(EFF. |T=30℃=EFF.ref)을 기준할 때 T<20℃에서 EFF.=EFF.ref·[1-0.0034·(T-30)]의 관계로 나타나고 그 이하의 온도에서는 효율이 1.05·EFF.ref의 값으로 포화되는 현상을 보였다. The effect of light intensity(I=20∼1000mW/㎠) and temperature(T=0∼140℃) on the efficiency parameters of a new FAH-solar cell is exeprimentally and theoretically investigated n this paper. Under the constant temperature(T=30℃), the increase of light intensity gives the open circuit voltage(V_oc) varing with the relation of 0.66+0.067·log(I/20) [V] and 0.727+0.04·log[I/200] [V] in each range of I=20∼200[mW/㎠] and I=200∼600[mW/㎠]. The open circuit voltage is, however, nearly saturated to 0.75[V] above 600[mW/㎠]. The fill factor is decreased with the relation of 0.815∼0.0858·log[I/20] below 10[mW/㎠ and 0.65-0.5164·log[I/300] above 300[mW/㎠]. The conversion efficiency(EFF.) shows the constant value of EFF-*ref=EFF.|_I=100mW/㎠ below 100[mW/㎠], but decreases with the relation of EFF.=EFF_*ref·(0.9-0.412·log[I/300]) above 300[mW/㎠]. Under the constant light intensity(i=100mW/㎠), the increase of temperature gives the short circuit current increasing with the rate of dI_sc/dT=0.0225[mA/℃] below 30[℃], and dI_sc/dT=0.006[mA/℃] in the range of 30∼140[℃]. The open circuit voltage is decreased with the rate of dV_oc/dT=-0.002[V/℃] The fill factor is decreased with the rate of -0.275[%/℃], -0.1357[%/℃], and -0.1[%/℃] in the ranges of 0∼20[℃], 20∼90[℃], and 90∼140[℃], respectively. The conversion efficiency is decreased with the relation of EFF.=EFF_*ref'·[1-0.0034·(T-30)] above 20[℃], and saturated to 1.05 EFF_*ref' below 20[℃].

방사선조사와 Paclitaxel의 병합요법에 의한 신내막 과증식억제

장기육,승기배,강동헌,임상현,정해억,임효영,김태균,김연실,채장성,김재형,홍순조,윤세철,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6