흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

계측위치와 자유면 방향에 따른 지반진동 특성 연구

강추원,양해승,이수연 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.2

The free face is an important part in the blasting design and plan. Most of study on the free face is referred to concern with fragmentation volume and determination of charge per delay. But the characteristic of vibration for the direction of the free face short of studies. This study shows the difference and characteristics of the vibration velocity for the measuring point and the direction of the free face. At the velocity of vibration, the back of the free face is over the front (Probably 1.20~1.29 times). A nomogram was made in relation to the maximum charge weight per delay on the basis of the 95% vibration blast equation and the velocity of vibration allowance set 5㎜/sec. Scaled distance was 29.71㎏/m^(1/2), 39.63㎏/m^(1/3) on the front of the free face and 34.03㎏/m^(1/2), 45.20m/㎏^(1/3) on the back of the free face.

염산 Bleomycin 병변내 주입을 이용한 사마귀 치료

강민정,임연순,최혜영,명기범 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.2

연구목적 : 지금까지 난치성을 보이는 사마귀의 치료로 Bleomycin 행변내 주사의 효과가 많은 연구에서 보고된 바 있다. 이에 저자들은 본 치료방법의 효과를 사마귀의 크기, 숫자, 위치 및 유병기간에 따라 판정하여 보다 효과적인 적응 대상을 알아보고자 했다. 방법 : 1995년 3월부터 1998년 2월까지 이화여자대학교 목동병원 피부과에 비성기성 사마귀로 내원한 환자중 다른 치료에 반응하지 않았거나, 재발한 경우, 크기가 0.5㎝ 이상이거나 7개 이상의 다발성 병변 , 혹은 조감 주위 병변을 보인 133명의 환자를 대상으로 Bleomycin 병변내 주사로 치료하였다. 1회 치료후 효과와 치료 종결후 완치율을 병변은 크기, 숫자, 위치, 유병기간에 따라 비교하였다. 결과 : 1) 환자의 연령 분포는 4세에서 45세였고, 남자 59명 여자 74명으로 1:1.24 비율이었다. 2) 첫 주사 치료후 96명의 환자에서 50% 이상의 병변의 수나 크기의 감소를 보였다. 크기별로는 0.5~0.9㎝의 87.5%에서, 병소의 수별로는 단일 병소의 76.9%에서 50% 이상의 병변의 크기나 수의 감소를 보여 가장 좋은 효과를 보였으나 통계적 유의성은 없었다. 또한 조갑주의 병변은 79.1%에서, 수부는 75.8%, 족부는 72.9%에서 50% 이상의 호전을 보였으나 족서부 병변은 53.4%로 가장 낮은 낮은 효과를 보였다. 유행병 기간은 6개월 이하인 31명(86.2%)에서 50% 이상의 효과를 보여 유병기간이 짧을수록 치료효과가 유의하게 증가하였다(p<0.05) 3) 치료 종결시 3개월 이후까지 재발없이 완치된 경우는 총 93명으로 69.9%였고 치료받은 병변의 수가 증가할 수록 완치율이 감소하였다, 부위별로는 조감주위가 77.1%로 가장 높았으며, 병변의 크기에 따른 일괄된 완치율의 차이는 없었다. 병변의 기간에 따른 완치율은 6개월 이하에서 80.6%로 가장 높았으며, 유병기간이 길수록 완치율은 감소하는 양상을 보였다. 4) 부작용은 환자 중 18.4%인 24명의 환자에서 발생하였으며, 유형별로는 3일 이상 지속된 동통과 홍반, 색소 침착 및 감염이 관찰되었으나, 모두 이후 호전되었으며, 1명에서 경한 조갑 능선을 동반한 변형이 관찰되었다. 결론 : 본 연구에서 사마귀에 대한 Bleomycin 병변내 주사효과가 병변의 크기에 따라 뚜렷한 차이를 보이지 않았으며, 심한 부작용이나 전신적인 독작용없이 조감주위병변 및 급성기 병변에서 높은 완치율을 보여 좋은 적응증이 됨을 확인하였다. 아울러 Bleomycin 병변내 주사의 효과 및 안정성에 있어서 시술자가 적당한 양의 약물을 주변부위로 부터 과도한 침습없이 정확히 병변의 기저부에 도달시키는 기술이 또하나의 중요한 변수가 됨을 반영하는 결과라 사료된다. Purpose:This study was to designed to evaluate the efficacy of intralesional injection of bleomycin for common warts and plantar warts according to size, number, location, and duration and to determine the appropriate indication of this treatment for warts. Materials & Methods : The objective patients had warts being refractory to previous treatment or large than 0.5cm in size or 7 or more lesions or periungal lesions. The intralesional injection with bleomycin hydrochloride 1㎎/㎖ had been performed single to six times at 3 week interval until complete resolution. Age of the patients ranged from 4 to 45 years, and male to female ratio was 1 : 1.25(59 : 74). Results : After first treatment of bleomycin intralesional injection, a reduction of 50% or more of the primary wart area was observed in 96(72.2%) of 133 patients. 93(69.9%) of 133 treated patients experienced complete cure after 1 to 7 injections. The efficacy of intralesional bleomycin injection for warts was not closely associated with the size of warts. However the duration and number of warts was inversely correlated with the efficacy of treatment. The highest cure rate was shown in patients with periungal warts(77.1%), and lowest in patients with plantar warts(53.3%). The side effects were observed in 18.4%(24 of 133) including persistent pain(17.3%), pigmentation(3.0%), erythema(1.5%), and mild nail dystrophy(0.8%), but no evidence of systemic toxicity was found. Conclusions : The efficacy of intralesional injection of bleomycin was not significantly related to the size, but closely related to the duration, number and site of the lesion. These results partly suggest that there is some important factors affecting the efficacy of treatment of bleomycin such as duration of the lesion and skillful injection of the agent into the wart tissue.

주요 시설물 인접지역의 깊은 터파기굴착에서 변위 및 응력의 계측과 응용

원연호,강추원,양해승 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.2

The excavation works for deep foundation in urban areas have recently increased complaints of blasting vibration and settlement of ground level. Foundation must be excavated approximately up to 24∼28m depths from the surface. The roads and subway line pass through the excavation area. The Dae-chung station is also located at the nearest distance 5∼35m fron the working site. To protect subway station and adjacient some structures from blasting and settlement, the level of ground vibration, displacements and stress were monitored and analyzed. The results can be summarized as follows : 1. An empirical particle velocity equation was obtained by test blasts at Nassan Missi 860 Officetel construction site. V=K(D/√W)^-n, where the values for n and k are estimated to be 0.371 and 1.551 respectively. From this ground vibration equation, the max, charge weight per delay time against distance from blasting point is calculated. Detailed blasting method is also presented. 2. To measure the horizontal displacement in directions in directions perpendicular to the borehole axis, 6 inclinometers installed around working sites. The displacement at the beginning was comparatively high because the installation of struts was delayed, but after its installation the values showed a stable trend. Among them, the displacement by 3 inclinometers installed on a temporary parking area showed comparatively high values, for example, the displacement measrued at hole No. IC-1 recorded the max, 57.33mm for 7 months. So, all of these data was estimated below a safe standard value 103mm. 3. Seven strain gauge meter was installed to measure value of maximum stress was-465㎏f/㎠, -338.4㎏f/㎠, 302.3㎏f/㎠ respectively. In compare to the allowable stress level of steel, they are estimated to be safe.

Enterococcus faecium에서 Vitek GPS Card의 Imipenem에 대한 위감수성

이혜경,박연준,궈희정,이은정,김병기,강창석 대한임상검사정도관리협회 2003 臨床檢査와 精度管理 Vol.25 No.2

초등학생의 월경경험에 관한 주관성 연구 : 5, 6학년 여학생을 대상으로 5th and 6th Grade Elementary Girl Students

김경희,정혜경,김정희,정연강 韓國學校保健學會 1999 韓國學校保健學會誌 Vol.12 No.2

The purpose of this study is present basic data to be used in the development of a sexual education program to create an affirmative sexual egoism. We classified the types of subjectivities and revelation attitudes of menstrual experience in 5th and 6th elementary school girls. The analytic method of data was a Q-method" (William Stephenson). The results of this study classified four-types. The first type is an "open type". Girls of this type accepted menstrual experience as neither disease nor an embarrassment but as an important and natural course for a woman. The second type is the "concealing type". Girls of this type keep silent and conceal menstruation from persons because they consider it shameful or disgrace. The third type is the "conceited type". Girls of this type think that menstruation is painful-but only for them. Also, they accept such pains being grown-up'. The fourth type is the "tomboy type". Girls of this type want to be an eternal child; they hate being born a woman and think menstruation is troublesome. As a result of this research, we have concluded that it is necessary to educate girl students before they experience menstruation in order to develop positive attitudes towards sexuality and so doing, aid them through adolescence.

방사선조사와 Paclitaxel의 병합요법에 의한 신내막 과증식억제

장기육,승기배,강동헌,임상현,정해억,임효영,김태균,김연실,채장성,김재형,홍순조,윤세철,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

Clinical Strategies in Gene Screening Counseling for the Healthy General Population

Hae Yeon Kang,Eun Kyung Choe 대한가정의학회 2024 Korean Journal of Family Medicine Vol.45 No.2

The burgeoning interest in precision medicine has propelled an increase in the use of genome tests for screening purposes within the healthy population. Gene screening tests aim to pre-emptively identify those individuals who may be genetically predisposed to certain diseases. However, as genetic screening becomes more commonplace, it is essential to acknowledge the unique challenges it poses. A prevalent issue in this regard is the occurrence of false-positive results, which can lead to unnecessary additional tests or treatments, and psychological distress. Addition-ally, the interpretation of genomic variants is based on current research evidence, and can accordingly change as new research findings emerge, potentially altering the clinical significance of these variants. Conversely, a further prominent concern regards false assurances in genetic testing, as genetic tests can yield false-negative results, po-tentially posing a significant clinical risk. Moreover, the results obtained for the same disease can vary among differ-ent genetic testing services, due to differences in the types of variants assessed, the scope of tests, analytical meth-ods, and the algorithms used for predicting diseases. Consequently, whereas genetic testing holds significant promise for the future of medicine, it poses unique challenges. If conducted without a full understanding of its im-plications, genetic testing may fail to achieve its purpose potentially hindering effective health management. There-fore, to ensure a comprehensive understanding of the implications of genetic testing within the general population, sufficient discussion and careful consideration should be given to counseling based on gene test results.

Thyroidectomy stimulates glucagon-like peptide-1 secretion and attenuates hepatic steatosis in high-fat fed rats

Kang, Jong Yeon,Kim, Mikyung,Kang, Yuna,Lee, Wonmok,Ha, Tae Kyung,Seo, Ji Hae,Son, Young Gil,Ha, Eunyoung Elsevier 2017 Biochemical and biophysical research communication Vol.493 No.1

<P><B>Abstract</B></P> <P>Thyroid hormones (THs) as a therapeutic intervention to treat obesity has been tried but the effect of THs on body weight and the mechanistic details of which are far from clear. This study was designed to determine and elucidate the mechanistic details of metabolic action of THs in high-fat diet (HFD) fed Sprague Dawley (SD) rats. Rats were made surgically hypothyroid (thyroidectomy, Thx). Body weights and food and water intake profoundly decreased in HFD fed thyroidectomized group (HN Thx). Results showed that delayed insulin response, increased total cholesterol, high-density lipoprotein, and low-density lipoprotein in HN Thx. Unexpectedly, however, Thx reduced serum and hepatic triglyceride concentrations. Further studies revealed that Thx dramatically increased circulating GLP-1 as well as increased expressions of GLP-1 in small intestine. Diminished hepatic expressions of lipogenic genes, were observed in HN Thx group. Beta-catenin and glutamine synthetase, a known target of β-catenin, were up-regulated in the liver of HN Thx group. The expressions of gluconeogenic genes G6P and PCK were reduced in the liver of HN Thx group. The results may suggest that surgery-induced hypothyroidism increases GLP-1, the actions of which may in part be responsible for the reduction in water intake, appetite and hepatic steatosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surgically-induced hypothyroidism in rats decreased food and water intakes. </LI> <LI> Surgically-induced hypothyroidism dramatically lowered triglyceride while increased total cholesterol, HDL and LDL. </LI> <LI> Surgically-induced hypothyroidism increased glucagon-like peptide 1 possibly through β-catenin signaling. </LI> </UL> </P>

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

Kang, Ji Yeon,Lee, Jae Sung,Kang, Hyejin,Lee, Hae-Woo,Kim, Yu Kyeong,Jeon, Hong Jin,Chung, June-Key,Lee, Myung Chul,Cho, Maeng Je,Lee, Dong Soo RAVEN PRESS PUBLISHERS 2012 ALZHEIMER DISEASE AND ASSOCIATED DISORDERS Vol.26 No.3

The aim of this study was to identify brain areas related to apathy or depression in patients with Alzheimer disease (AD). Eighty-one AD patients were enrolled in this prospective study. Tc-HMPAO single photon emission computed tomography was performed to evaluate regional cerebral blood flow (rCBF). According to the Neuropsychiatric Inventory subscores of apathy and depression, 9 patients were classified as clinically significant (cs) depressed and non-cs-apathetic (D+) groups and 9 were classified as cs-apathetic and non-cs-depressed (A+) groups. In addition, 18 patients were classified as age-matched and Mini-Mental State Examination-matched disease control groups (D−, A−). The significance of rCBF differences between groups and the correlation between rCBF and subscores in 81 AD patients were estimated by SPM (uncorrected P<0.005) analysis. D+ patients had significantly lower perfusion in the right orbitofrontal and inferior frontal gyri than D− patients, whereas A+ patients had this in the right amygdala, temporal, posterior cingulate, right superior frontal, postcentral, and left superior temporal gyri than A− patients. The negatively correlated areas with depression subscores included the left inferior frontal and the right middle frontal gyri and those with apathy subscores included the right temporal and right medial frontal gyri. We suggest that this finding may indicate that apathy and depression in AD patients involve distinct functional circuits.