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金世華,姜演植,嚴熙文,林東賢 龍仁大學校 1995 용인대학교 논문집 Vol.11 No.-
Studies on the seasonal distribution of zooplankton were carried out in 1994 in waters off Yongkwang Atomic Power Plant. Zooplankton samples were collected four times seasonally at six selected stations. Forty - three taxa of zooplankton were distributed and 25 species representing 21 copepods, 2 chaetognaths, 1 protozoan and appendicularian were identified to species level. Zooplankton abundance varied between 840-42, 014 indiv. m-3 and were recorded the highest abundance in September and the lowest in February. Seasonal succession in the dominant species was observed from winter and spring with Acartia omorii to summer and autumn with A. pacifica and Paracalanus indicus. With the prevalence of ueritic copepods all the year round, i.e., A. omorii, A. pacifica and P. indicus, the studied waters were revealed to have the typical zooplankton fauna in coastal waters of the Yellow Sea.
Propylthiouracil 투여에 의한 갑상선 기능저하 흰쥐 조직에서 알코올 탈수소효소 활성의 변화
백상현,김동선,이창범,박용수,안유헌,김태화,기춘석,강주섭 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2
Background: Thyroid hormone has been known to affect hepatic alcohol dehydrogenase (ADH) activity. Although the liver is the principal site of ethanol metabolism, stomach is also responsible in part for ethanol oxidation. The effects of thyroid hormone on ADH activity in gastric mucosa and other tissues of rats had not been previously examined. Method: The effects of thyroid hormone on liver, stomach, lung, and kidney ADH activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with propylthiouracil (50 mg/kg) for 14 days. Results: Whereas hepatic ADH activities were not changed by treatment with PTU(42.9(8.6 vs 45.2 (10.1), gastric ADH activities in PTU-treated rats increased by 258.8% of control rat (6.3 ( 0.6 vs 2.2 ( 1.2, p〈0.001). In the activities of other tissues, PTU treatment decreased lung ADH activity by 59.7% of control, and increased kidney ADH activities by 247.1% of control rats. Conclusion: These data suggest that hypothyroidism causes an increase of gastric alcohol metabolism, and that the increase of gastric ADH activity can partly restore the first pass metabolism of ethanol in hypothyroid rats.
崔淳官,李仁洙,李東華,姜得龍 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.3
Neoplasms of the pineal gland are collectively rare, comprising from 0.4 to 1% of all tntracranial tumors, among them the number of pinealoblastoma is extremely small. A case of pinealoblastoma is reported. A 25-year old female with headache, Parinaud's syndrome and voiding disturbance of 1 month's duration is presented. Neurological findings were the vilateral papilledemas and the bilateral pareses of upward gaze. Vertebral angiography, Conray ventriculography and C-T brain scan revealed a posterior 3rd ventricle tumor. Through the right occipital approach a soft pinkish-grey mass on the pineal region was detected, and biopsy was kone. At the same time ventriculoperitoneal shunt was applied. The pathological finding of the specimen was pinealoblastoma. The patient underwent the radiation therapy with good result.
Silent new ischemic lesions after index stroke and the risk of future clinical recurrent stroke
Kang, Dong-Wha,Han, Moon-Ku,Kim, Hye-Jin,Sohn, Hoyon,Kim, Bum Joon,Kwon, Sun U.,Kim, Jong S.,Warach, Steven Ovid Technologies (Wolters Kluwer) - American Acad 2016 Neurology Vol.86 No.3
<P>Objective:To test whether a silent new ischemic lesion (SNIL) on MRI after stroke predicted future recurrent ischemic stroke or vascular events.Methods:In this prospective study, we analyzed data from patients presenting with acute ischemic stroke who underwent MRI <24 hours and 5 and 30 days after symptom onset. The presence of a SNIL at 5 (5D-SNIL) and 30 (30D-SNIL) days was determined on diffusion-weighted and fluid-attenuated inversion recovery images. Patients were contacted every 3-6 months to identify recurrent clinical events. The log-rank test and Cox proportional hazard model were used to estimate the hazard ratio of recurrent ischemic stroke and composites of recurrent ischemic stroke, transient ischemic attack, acute coronary syndrome, and vascular death.Results:The 5D- and 30D-SNILs were found in 24.4% (66/270) and 7.4% (19/256) of patients. During the 5-year follow-up, clinical events were observed in 42 patients (15.6%). The 5D- and 30D-SNIL independently predicted recurrent ischemic stroke (hazard ratio [95% confidence interval] 2.9 [1.3-6.4] and 9.6 [4.1-22.1], respectively) and composite vascular events (2.4 [1.3-4.5] and 6.1 [3.1-12.4], respectively).Conclusions:Patients with a SNIL within the first few weeks after index stroke have an increased risk of recurrent ischemic stroke or vascular events. The presence of a SNIL on MRI could serve as a surrogate endpoint for clinical recurrence in secondary prevention clinical trials.</P>
Kang, Dong Woo,Lee, Shin Wha,Hwang, Won Chan,Lee, Bo Hui,Choi, Yong-Seok,Suh, Young-Ah,Choi, Kang-Yell,Min, Do Sik American Association for Cancer Research 2017 Cancer Research Vol.77 No.1
<P>A phospholipase that functions as a nodal modifier of colon cancer susceptibility mediates the cross-talk between two major tumor suppressor and oncogenic pathways, with implications for disease-selective therapeutic targeting.</P><P>The RB1/E2F1 signaling pathway is frequently deregulated in colorectal cancer and has been suggested to intersect with Wnt/β-catenin and PI3K/Akt pathways, but molecular evidence for this link is lacking. In this study, we demonstrate that phospholipase D1 (PLD1), a transcriptional target of β-catenin/TCF4, orchestrates functional interactions between these pathways during intestinal tumor development. Overexpression of PLD1 in intestinal epithelial cells protected cells from apoptosis induced by PLD1 ablation in the <I>Apc<SUP>min/+</SUP></I> mouse model of intestinal tumorigenesis. Mechanistic investigations revealed that genetic and pharmacologic targeting of PLD1 promote the E2F1-dependent apoptotic program via both miR-192/4465–mediated downregulation of RB1 and inhibition of Akt–TopBP1 pathways. Moreover, the miRNA–RB1 axis and Akt pathway also contributed to the PLD1-mediated self-renewal capacity of colon cancer–initiating cells. Finally, PLD1-driven E2F1 target gene expression positively correlated with tumor stage in patients with colorectal cancer. Overall, our findings suggest that PLD1 mediates cross-talk between multiple major signaling pathways to promote the survival and malignancy of colon cancer cells and may therefore represent an ideal signaling node for therapeutic targeting. <I>Cancer Res; 77(1); 142–52. ©2016 AACR</I>.</P>
Kang, Dong-Wha,Yoo, Sung-Hee,Chun, Sail,Kwon, Kyum-Yil,Kwon, Sun U.,Koh, Jae-Young,Kim, Jong S. Ovid Technologies Wolters Kluwer -American Heart A 2009 Stroke Vol.40 No.5
<P>BACKGROUND AND PURPOSE: Early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging after acute ischemic stroke have been suggested as a potential marker of early recurrent stroke. We hypothesized that biomarkers of inflammation or coagulation may be associated with the pathogenesis of ERILs and sought to investigate whether these biomarkers provide prognostic information on the risk of development of ERILs independently of clinical and imaging variables. METHODS: This prospective study enrolled 153 consecutive patients with acute ischemic stroke who underwent diffusion-weighted imaging within 24 hours and subsequently at 5 days after onset and whose plasma or serum for biomarkers (C-reactive protein, fibrinogen, d-dimer, tissue plasminogen activator, and plasminogen activator inhibitor-1) were collected within 24 hours of onset. Those receiving thrombolysis or interventional therapy were excluded. ERILs were defined as new ischemic lesions on 5-day diffusion-weighted imaging separate from the index stroke lesions, which were not accompanied by subsequent recanalization. RESULTS: ERILs were observed in 37 patients (24.2%). In univariate analysis, shorter time from onset to initial MRI (P=0.013), initial acute multiple infarcts (P<0.001), initial larger infarct volume (P=0.005), stroke subtype (P<0.001), elevated d-dimer (P=0.028), and anticoagulation after admission (P=0.001) were associated with ERILs. In multivariate analysis, initial acute multiple infarcts (OR, 16.60; 95% CI, 5.73 to 48.08), large artery atherosclerosis (OR, 4.62; 95% CI, 1.51 to 14.11), and log d-dimer (OR, 3.20; 95% CI, 1.14 to 9.00) remained independent predictors of ERILs. CONCLUSIONS: These data suggest that elevated d-dimer level reflecting increase of thrombin generation and fibrin turnover may be an independent factor predicting ERILs.</P>