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內.外的 刺戟에 따르는 스트레스호르몬 尿排池量에 關한 硏究
李揆文,金昌範 忠北大學校 平生體育敎育硏究所 1988 平生體育硏究所 論文集 Vol.3 No.-
This experiments were carried out for the purpose to investigate the excretion amout of urinary stress hormone as to factor impulse for intrinsic(written examination) and extrinsic(all-out exercise). Twenty subjects volunteered for this experiment, who were five female non-trained students and five trained students, 18∼19 years old. Their urine was collected during 24 hours ordinary times, after all-out exercise, and during written examination respectively. The results were as follows: 1. It appeared that the level of excretion amount urinary 17-OHCS was in the normal level ordinary times both in the non-trained and trained group. 2. It appeared that the level of excretion amount urinary 17-OHCS was in the normal level(13.36±3.12mg/24h) after all-out exercise in the trained group, but in the abnormal level(22.36±5.54mg/24h) in the non-trained group. 3. It appeared that the level of excretion amount urinary 17-OHCS was in the normal level during written examination in the trained group, but in the non-trained group was 35.5% higher than that in the trained group.
Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis
Kim, Sang-Heon,Kim, Sang-Hoon,Bahn, Joon-Woo,Kim, Yoon-Keun,Chang, Yoon-Seok,Shin, Eun-Soon,Kim, Youn-Seup,Park, Jae-Seuk,Kim, Bo-Hyung,Jang, In-Jin,Song, Junghan,Kim, Seung-Hyun,Park, Hae-Sim,Min, Ky Future Medicine 2009 Pharmacogenomics Vol.10 No.11
<P>AIMS: Although some genetic risk factors have been reported for the development of hepatitis due to anti-TB drugs, an extensive candidate gene approach evaluating drug-metabolizing enzymes has not been attempted. This study aimed to investigate the association of genetic polymorphisms in drug-metabolizing enzymes with anti-TB drug-induced hepatitis. MATERIALS & METHODS: We compared genotype distributions of tagging SNPs in promoter, exons and haplotypes in seven drug-metabolizing enzyme genes (CYP2C9, CYP2C19, CYP2D6, CYP2E1, NAT2, UGT1A1 and UGT1A3) between 67 cases and 159 controls. RESULTS: Among four tagging SNPs of N-acetyltransferase 2 (NAT2), -9796T>A in promoter and R197Q were significantly associated (p = 0.0016 and p = 0.0007, respectively). NAT2 haplotype 2 [A-A-A-G] carrying A allele of -9796T>A and A allele of R197Q showed significant association (p = 0.0004). However, there was no significant association between genotypes of other enzyme-metabolizing genes and anti-TB drug-induced hepatitis. The constructs containing -9796A of NAT2 showed significantly lower luciferase activity (p < 0.01), suggesting decreased expression of NAT2. The variant alleles and haplotype 2 showed significantly higher peak serum levels of isoniazid, lower acetyl isoniazid:isoniazid ratio and lower isoniazid clearance compared with wild-types. CONCLUSION: These findings suggest that genetic variants in the promoter and exons of NAT2 increase the risk of anti-TB drug-induced hepatitis by modifying acetylation phenotypes and/or gene expression of NAT2, and there is no essential role for genetic mutation of the other metabolizing enzymes in the development of this adverse reaction.</P>
Childhood Sexual Abuse and Cortical Thinning in Adults With Major Depressive Disorder
Jinyi Kim(Jinyi Kim),Chanju Lee(Chanju Lee),Youbin Kang(Youbin Kang),Wooyoung Kang(Wooyoung Kang),Aram Kim(Aram Kim),Woo-Suk Tae(Woo-Suk Tae),Byung-Joo Ham(Byung-Joo Ham),Jisoon Chang(Jisoon Chang),Ky 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.3
Objective A growing body of evidence reports on the effect of different types of childhood abuse on the structural and functional architecture of the brain. In the present study, we aimed to investigate the differences in cortical thickness according to specific types of childhood abuse between patients with major depressive disorder (MDD) and healthy controls (HCs). Methods A total of 61 patients with MDD and 98 HCs were included in this study. All participants underwent T1-weighted magnetic resonance imaging, and the occurrence of childhood abuse was assessed using the Childhood Trauma Questionnaire. We investigated the association between whole-brain cortical thickness and exposure to any type of childhood abuse and specific type of childhood abuse in the total sample using the FreeSurfer software. Results No significant difference was reported in the cortical thickness between the MDD and HC groups nor between the “any abuse” and “no abuse” groups. Compared to no exposure to childhood sexual abuse (CSA), exposure to CSA was significantly associated with cortical thinning in the left rostral middle frontal gyrus (p=0.00020), left (p=0.00240), right fusiform gyri (p=0.00599), and right supramarginal gyrus (p=0.00679). Conclusion Exposure to CSA may lead to cortical thinning of the dorsolateral prefrontal cortex, which is deeply involved in emotion regulation, to a greater extent than other types of childhood abuse.
계란 알레르기 환아에서 인플루엔자 백신 접종의 안정성에 대한 연구
장수진 ( Soo Jin Chang ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박현빈 ( Hyun Bin Park ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children`s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.
계란 알레르기 환아에서 인플루엔자 백신 접종의 안정성에 대한 연구
장수진 ( Soo Jin Chang ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박현빈 ( Hyun Bin Park ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children’s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination. (Allergy Asthma Respir Dis 2013;1:333-338)
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma
Hwa, Jeong Seok,Kim, Hyun Joon,Goo, Bo Mee,Park, Hyo Jin,Kim, Choong Won,Chung, Ky Hyun,Park, Hyung Chul,Chang, Se-Ho,Kim, Yeon Woong,Kim, Deok Ryong,Cho, Gyeong Jae,Choi, Wan Sung,Kang, Kee Ryeon WILEY-VCH Verlag 2006 Proteomics Vol.6 No.3
<P>For identification and targeting of tumor-associated marker proteins, the proteome of clear cell type of renal cell carcinoma (RCC) and normal kidney tissues was analyzed by 2-DE. Ketohexokinase (also called fructokinase), which catalyzes the phosphorylation of fructose to fructose 1-phosphate, was identified by MALDI-TOF MS and found to be expressed at low rates in the renal tumor tissues. We found a decreased amount of ketohexokinase mRNA in RCC compared to that observed in the normal kidney tissues by Northern blot. The activity of ketohexokinase in 20 clear cell RCC specimens and the 20 corresponding normal kidneys was investigated, and its activity was shown to be approximately 1.4-fold lower in the RCC specimens than in the normal kidney. Ketohexokinase activity in tumor stage pT3 RCC was 1.5-fold lower than in pT1 RCC. The level of ketohexokinase activity in histological grade 3 RCC was 1.8-fold lower than that in grade 1 cancer. In addition, using in situ hybridization, it was revealed that ketohexokinase in the normal kidney tissue was confined to the proximal tubular epithelial cells, while the expression of ketohexokinase in RCC tissues was extremely low. Our research results show that the expression of human ketohexokinase was diminished in clear cell RCC.</P>
연구보문 : 자연과학 ; 간척지에서 퉁퉁마디 재배시 적정 염농도 및 질소시비량 구명
정재혁 ( Jae Hyeok Jeong ),김택겸 ( Taek Kyum Kim ),최원영 ( Weon Young Choi ),김선 ( Sun Kim ),백남현 ( Nam Hyun Baek ),양창휴 ( Chang Hyu Yang ),김두호 ( Doo Ho Kim ),김영두 ( Yoang Doo Kim ),이상복 ( Sang Bok Lee ),이경보 ( Ky 한국국제농업개발학회 2013 韓國國際農業開發學會誌 Vol.25 No.1
본 연구는 염생식물인 퉁퉁마디를 대상으로 하여 신간척지에서 안정적인 재배법을 구명하고자 수행하였다. 먼저 퉁퉁마디의 발아특성을 알아보기 위해 염농도(NaCl 0 ∼ 3% 농도) 별 발아율 시험을 수행하였다. 10℃에서는 모든 염농도에서 발아 속도는 느리나 15일까지 발아가 지속되어, 78 ∼ 90%의 발아율을 나타내었다. 20℃이상에서는 4일 안에 최대의 발아율을 나타내었으며, NaCl 3%에서 온도가 올라갈수록 발아율이 저하되는 경향을 보였다. 퉁퉁마디의 질소시비량 별 생육특성을 알아보기 위해 온실 포트실험을 실시한 결과, 퉁퉁마디 파종 후 5일 후부터 발아가 시작하였고, 퉁퉁마디의 생육은 질소시비량이 증가할수록 초장 및 분지 등이 증가하는 경향을 나타내었다. 또한 염농도에 따른 생육특성을 조사하기 위해 양액 재배 조건에서 염농도에 따른 퉁퉁마디 생육을 실험하였다. 양액조건 상태에서 NaCl을 처리하지 않으면 생육이 저조하여 1개월 이후에 고사하기 시작했으며, NaCl을 처리한 구에서는 NaCl 200mM에서 생육이 좋았고, NaCl 500mM 이상의 염농도에서도 재배가 가능할 것이라 생각된다. 신간척지에서 퉁퉁마디의 어린 싹을 6월에 이식하여 질소시비량이 퉁퉁마디 생육에 미치는 영향을 조사하였다. 퉁퉁마디의 초장 및 분지수 등이 질소시비량이 증가할수록 유의적으로 증가하였으나, 인산을 비롯한 무기성분 함량은 유의적인 차이가 없었다. Now in Korea, halophytes such as Salicornia herbacea and Spergularia marina are being cultivated as new income crops in southwestern coastal regions. So basis studies on halophytes` growth characteristics is needed for developing a standard cultural practices of them. This study was carried out to investigate on cultivation of Salicornia herbacea, representative halophytes at new reclaimed land. First, in order to examine the characteristics of Salicornia herbacea germination by salinity (NaCl concentration 0 ∼ 3%), germination tests were carried out. At the low-temperature 10℃, germination of Salicornia herbacea was slow but lasted for 15 days at all salinities, and final germination rates were of 78 ∼ 90%. At higher than 20℃, maximum germination rate was showed within four days. Germination inhibition by salt was showed at NaCl concentration 3% and 30℃. The second, to investigate on the growth characteristics of Salicornia herbacea by nitrogen fertilization, port experiments were conducted at the greenhouse. Salicornia herbacea`s buds began to be found after five days after sowing. Salicornia herbacea growth such as plant height, number of braches, etc. increased with increasing nitrogen fertilization. In order to investigate the growth characteristics by salinities, cultivation test of Salicornia herbacea was conducted in nutriculture with different salinities. In the plot without NaCl, the growth of Salicornia herbacea was very low, and it began to wither within one month. In plots with NaCl, the growth of Salicornia herbacea was well until concentrations of NaCl 500mM, and optimum NaCl concentration was 200mM for growth of Salicornia herbacea. Field verification experiments about the effect of nitrogen fertilization on transplanted Salicornia herbacea were conducted at the Saemangeum reclaimed land in Korea. There was a tendency to increase number of branches and plant length with increasing nitrogen fertilization. Amount of P2O5 and mineral element such as CaO, Na2O, K2O and MgO tended to increase with increasing nitrogen fertilization. However, there was no statistically significant difference.