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유상영,신희철,윤보현,전종관,박교훈,이동원,박서영 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10
Moyamoya disease is a rare condition characterized by angiographic evidence of bilateral narrowing and occlusion of the internal carotid arteries, along with the presence of an abnormal capillary network of vessels at the base of the brain. Clinically, this disease is found with a higher incidence in young female, but there are few cases of moyamoya disease in pregnancy. We describe two cases of pregnancy with known moyamoya disease, which have delivered successfully by elective cesarean section with epidural anesthesia.
A Case of Paracentric Inversion of Chromosome 18 (q21.1q22.1)
( Gh An ),( Kh Choi ),( My Kim ),( Jy Han ),( Hk Ahn ),( Jh Chung ),( Mh Kim ),( Sw Lee ),( Yj Han ),( Dw Kwak ),( Yh Chae ),( Sy Park ),( Hm Ryu ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
We report on a case with a paracentric inversion of the long arm of chromosome 18: 46,XX,inv(18)(q21.1q22.1). A karyotype 46.XX.add(18) was found during antenatal diagnosis (amniocentesis) performed at local clinic because of advanced maternal age (38 years). And the pregnant woman visited our hospital at 18.4 weeks to confirm the result. We performed the amniocentesis and found the karyotype 46,XX,inv(18)(q21.1q22.1). The inversion was also found in the mother and the maternal grandmother of the fetus by chromosome studies from peripheral blood . The high resolution ultrasonography performed at 20.5 weeks showed normal findings. The diagnosis of paracentric inversion can be difficult and might be incorrect because of the variety of unpredictable unbalanced chromosome products that can result from a paracentric inversion. The vast majority of paracentric inversions are likely to be harmless. The risk of having an abnormal child for carriers of paracentric inversions is expected to be low. but sometimes by the variation of breakpoint or recombination process, various clinical phenotype can be seen : 18q- syndrome including: microcephaly, epicanthal folds, midface hypoplasia, and abnormally modeled ears, dermatoglyphic whorls on fingertips, clubfeet, hearing loss, and developmental delay. The mother is now ongoing pregnant state and the baby needs long term follow up after birth. This report underlines the importance of careful antenatal diagnosis and genetic counseling for parental and fetal paracentric inversion.
오기석,유희석,권혁찬,양현원,장기홍,황경주,유정현,손성향 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
Introduction : In human IVF-ET only a few oocytes develop to be good quality embryos depending on the incubation conditions and the quality of ovum and sperm, while the rest show abnormal morphology due to unequal cell division or fragmentation of the cell. Fragmented em- bryos limit developmental potential and rarely result in implantation. Such abnormal embryo development have been reported to be due to genetic defects or inadequate culture environment. This in-vitro environment differs from in-vivo conditions in that the oxygen concentration is higher(20 %) and in such conditions, the mouse embryos show a higher ROS in simple culture media. ROS is believed to cause damage to the cell membrane and DNA fragmentation in somatic cells. This study was conducted to ascertain the level of ROS within embryos and morphological features of cell damage induced by ROS. Materials & Methods : A total of 53 human oocytes and embryos(31 fragmented and 10 nonfragmented embryos, 12 unfertilized oocytes) were obtained in IVF-ET programs. The relative intensity of ROS within embryos was reassured using 2,7-dichlorodihydrofluorescein diacetate (DCHFDA ; Molecular Probes, USA) by Quanti cell 500(Imaging Co. UK), and DNA fragme- ntation was observed via TEM(Zeiss EM 902A, Germany) and ApopTag kit(Oncor Co. USA). Results : The ROS levels was significantly higher in fragmented embryos(72.21±9.62) compared to nonfragmented embryos(31.30±3.50, p$lt;0.05) and unfertilized oocytes(30.75±2.67, p$lt;0.05). Apoptosis was only observed in fragmented embryos, and was absent in nonfragmented embryos. Also the DAPI staining showed that the nuclei of fragmented embryos were broken up into irregular shapes, and the EM showed confirmation of apoptotic bodies and cytoplasmic condensation in the fragmented blastomeres. Conclusion : We conclude that there is a direct relationship between increased ROS and apoptosis, and that further studies should be undertaken.
태아 폐성숙평가에 있어서 Lamellar Body Count의 임상적 효용성
오기석,유희석,권혁찬,양정인,장기홍,김행수,김지영 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
From July 1994 through August 1995, 31 patients who delivered before 37 weeks gestation at the Ajou University Hospital were tested for lamellar body count in the amniotic fluid. The obtained results are summarized as follows; 1. Lamellar body count was associated with 1 minute Apgar score(p=0.02). 2. There was no sexual, gestational and birth weight differences in the incidence of respi- ratory distress syndrome. 3. Lamellar body count showed that the positive predictive value for respiratory distress syndrome was 90.0 %, the negative predictive value was 95.2 %, and the sensitivity was 90.0 %, and the specificity was 95.2 %, therefore it may be regarded as more accurate than other previously employed methods. This study suggests that the lamellar body count reflects fetal lung maturity sufficiently to assure that the neonate will not develop respiratory distress syndrome, and can be used as a quick screening test or one in series of tests for thorough assessment of fetal lung maturity.
부정기적 자궁출혈 환자에서의 경질 초음파 자궁조영술 (Sonohysterography) 의 진단적효용성
이은주,오기석,유희석,권혁찬,양정인,장기홍,이희춘,정태영,유정현,주희재 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.11
경질 초음파 자궁조영검사의 유용성여부를 보기위해 1994년 7월부터 1995년 2월까지 아주대학병원 산부인과를 내원한 환자중 비정상 자궁출혈을 호소하는 환자를 대상으로 경질 초 음파를 시행하였다. 자궁내막 병변이 의심되는 33예환자에 대하여 경질 초음파 자궁조영검사를 시행하였으며 각 환자의 상태에 따라 부인과적 시술을 시행하였고, 그 조직검사 결과를 각각 비교관찰하여 다음과 같은 성적을 얻었다. 1. 대상환자의 연령분포는 29세에서 66세로서 평균연령은 41.5세였다. 2. 조직병리 결과는 정상소견 6예, 자궁내막 풀립 19예, 자궁근종 3예, 자궁내막증식증 2예, 혼합 소견 2예, 및 자궁내막유착증 1예였다. 3. 기존의 경질 초음파와 경질 초음파 자궁조영술을 비교해 볼 때 경질 초음파소견상 hypertrophy 소견(9/10), hyperechoic 소견(10/10), nodular 소견(4/4), mixed소견(2/2) 등에서는 경질초음파 자궁조영술검사와 잘 일치하는 소견을 보였다. 4. 경질 초음파의 진단적 예민도는 33예 중 22예가 병리소견과 일치하여 66%였다. 5. 경질 초음파 자궁조영술는 33예중 28예에서 병리소견과 일치하여 진단적 예민도는 85% 였으며 이는 통계학적으로 유의하게 경질 초음파에 비해 진단적 예민도가 증가하였다. 6. 이 시술의 과정에서 1예의 하복부 통증, 6예의 경한 질출혈, 1예에서 경한 골반염증을 호소하였다. The comparison between Sonohysterography assesment and transvaginal sonohysterography was made in 33 women with abnormal vaginal bleeding and spotting. Surgical intervention(endometrial biopsy, hysteroscopy, total abdominal hysterectomy) was performed after Sonohysterography according to each patients condition between July 1994 and February 1995. The main results were as follows; 1. The distribution of pathology were ;normal(6), endometrial polyp(19), submousal mayoma(3), endometrial hyperplasia(2), mixed pattern(2), endometrial synechia(1). 2. In the comparison of transvaginal sonography with Sonohysterography, hypertrophy(9/10), hyperechoic(10/10), nodular(4/4) mixed (2/2) patterns were correlated with Sonohysterography findings. 3. The diagnostic sensitivity of transvaginal sonography and Sonohysterography in endometrial pathology was 66% and 85% (p$lt;0.05). 4. Complications of sonohysterography were lower abdominal pain, uterine bleeding and mild pelvic inflammatory disease. In conclusion, sonohysterography is more efficacious diagnostic tool than transvaginal sonography in the evaluation of abnormal uterine bleeding.