http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jung Kyeongmin,Yoon Joohyun,Ahn Yeeun,Kim Soyeon,Shim Injeong,Ko Hyunwoong,Jung Sang-Hyuk,Kim Jaeyoung,Kim Hyejin,Lee Dong June,Cha Soojin,Lee Hyewon,Kim Beomsu,Cho Min Young,Cho Hyunbin,Kim Dan Say,K 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between irritability and various traits, including psychiatric disorders; and 3) identify additional and shared genetic variants for irritability and psychiatric disorders. We conducted a genome-wide association study (GWAS) using 379,506 European samples (105,975 cases and 273,531 controls) from the UK Biobank. We utilized various post-GWAS analyses, including linkage disequilibrium score regression, the bivariate causal mixture model (MiXeR), and conditional and conjunctional false discovery rate approaches. This GWAS identified 15 independent loci associated with irritability; the total SNP heritability estimate was 4.19%. Genetic correlations with psychiatric disorders were most pronounced for major depressive disorder (MDD) and bipolar II disorder (BD II). MiXeR analysis revealed polygenic overlap with schizophrenia (SCZ), bipolar I disorder (BD I), and MDD. Conditional false discovery rate analyses identified additional loci associated with SCZ (number [n] of additional SNPs = 105), BD I (n = 54), MDD (n = 107), and irritability (n = 157). Conjunctional false discovery rate analyses identified 85, 41, and 198 shared loci between irritability and SCZ, BD I, and MDD, respectively. Multiple genetic loci were associated with irritability and three main psychiatric disorders. Given that irritability is a cross-disorder trait, these findings may help to elucidate the genomics of psychiatric disorders.
Kyeongmin Kim,Se Hoon Kim,Jung-Yun Lee,Yoo-Na Kim,Seung-Tae Lee,박은향 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4
Objective: The RAD51 assay is a recently developed functional assay for homologous recombination deficiency (HRD) that reflects real-time HRD status. We aimed to identify the applicability and predictive value of RAD51 immunohistochemical expression in pre- and post-neoadjuvant chemotherapy (NAC) samples of ovarian high-grade serous carcinoma (HGSC). Methods: We evaluated the immunohistochemical expression of RAD51/geminin/γH2AX in ovarian HGSC before and after NAC. Results: In pre-NAC tumors (n=51), 74.5% (39/51) showed at least 25% of γH2AX-positive tumor cells, suggesting endogenous DNA damage. The RAD51-high group (41.0%, 16/39) showed significantly worse progression-free survival (PFS) compared to the RAD51-low group (51.3%, 20/39) (p=0.032). In post-NAC tumors (n=50), the RAD51-high group (36.0%, 18/50) showed worse PFS (p=0.013) and tended to present worse overall survival (p=0.067) compared to the RAD51-low group (64.0%, 32/50). RAD51-high cases were more likely to progress than RAD51-low cases at both 6 months and 12 months (p=0.046 and p=0.019, respectively). Of 34 patients with matched pre- and post-NAC RAD51 results, 44% (15/34) of pre-NAC RAD51 results were changed in the post-NAC tissue, and the RAD51 high-to-high group showed the worst PFS, while the low-to-low group showed the best PFS (p=0.031). Conclusion: High RAD51 expression was significantly associated with worse PFS in HGSC, and post-NAC RAD51 status showed higher association than pre-NAC RAD51 status. Moreover, RAD51 status can be evaluated in a significant proportion of treatment-naïve HGSC samples. As RAD51 status dynamically changes, sequential follow-up of RAD51 status might reflect the biological behavior of HGSCs.
양정훈,Kyeongmin Byeon,Hye Ran Yim,Jung Wae Park,Seung-Jung Park,허준,김준수,온영근 대한의학회 2012 Journal of Korean medical science Vol.27 No.6
Limited data are available on inappropriate shocks in Korean patients implanted with an implantable cardioverter-defibrillator (ICD). We investigated the impact of inappropriate shocks on clinical outcomes. This retrospective, single-center study included 148 patients treated between October 1999 and June 2011. The primary outcome was a composite event of all-cause mortality or hospitalization for any cardiac reason. The median followup duration was 29 months (interquartile range: 8 to 53). One or more inappropriate shocks occurred in 34 (23.0%) patients. A history of atrial fibrillation was the only independent predictor of inappropriate shock (hazard ratio [HR]: 4.16, 95% confidence interval [CI]: 1.89-9.15, P < 0.001). Atrial fibrillation was the most common cause of inappropriate shock (67.7%), followed by supraventricular tachycardia (23.5%), and abnormal sensing (8.8%). A composite event of all-cause mortality or hospitalizations for any cardiac reason during follow-up was not significantly different between patients with or without inappropriate shock (inappropriate shock vs no inappropriate shock: 35.3% vs 35.4%, adjusted HR: 1.06, 95% CI: 0.49-2.29, P = 0.877). Inappropriate shocks do not affect clinical outcomes in patients implanted with an ICD, although the incidence of inappropriate shocks is high.
장경민(Kyeongmin Jang),김희진(Heejin Kim),김수현(Soohyeon Kim),정은상(Eunsang Jung) 한국추진공학회 2019 한국추진공학회 학술대회논문집 Vol.2019 No.5
ADN은 친환경 추진제로 유럽을 중심으로 연구 · 개발되고 있으며, 고체 산화제나 액체 단일추진제로 모두 사용이 가능하다. ADN 단일추진제의 비추력은 259 sec로 하이드라진 이상의 성능을 보여주며, 촉매 분해 온도 또한 450 K로 우수하다. 본 연구에서는 친환경 추진제인 ADN의 생산성을 높이기 위해 전구물질인 KDN 합성 조건을 최적화 하고, UV-Vis, TGA 분석을 통해 수율을 측정하였다. 고 농도 질산(99%) 조건에서 KDN의 수율이 43.8%로 가장 높았으며, 질산의 농도가 진할수록 나이트로화 반응이 빠르기 때문이다. To center of Europe ADN is researched and developed as a green propellant, and ADN also used solid oxidizer and liquid monopropellant. ADN monopropellant’s specific impulse is 259 sec which is greater than hydrazine and catalytic decomposition temperature is 450 K. In this research, for improving of ADN productivity we optimized KDN synthesis condition which is used a precursor to ADN and, analyzed KDN yield using UV-Vis and TGA. The synthesis yield of KDN recorded the highest at 43.8% in 99% nitric acid condition. As the more nitric acid is condensed the more nitration rate is accelerated.
광대역 격리 특성을 갖는 기판 집적 도파관 전력 분배기
김경민(Kyeongmin Kim),변진도(Jindo Byun),정경영(Kyung-Young Jung),이해영(Hai-Young Lee) 한국전자파학회 2009 한국전자파학회논문지 Vol.20 No.8
본 논문에서는 광대역 격리 특성을 갖는 개선된 기판 집적 도파관(substrate integrated waveguide) 전력 분배기를 제안한다. 제안된 전력 분배기는 2단 윌킨슨 전력 분배기의 구조를 기판 집적 도파관에 적용함으로써 우수한 입출력 정합 특성과 광대역 격리 특성을 갖는다. 측정 결과, 13.12~16.14 ㎓의 주파수 대역에서 삽입 손실은 4±0.5 ㏈, 입력 반사 손실은 10 ㏈ 이상으로 나타났다. 또한, 10.37~17.64 ㎓의 주파수 대역에서 출력 반사손실과 격리 특성은 10 ㏈ 이상을 나타냈다. In this paper, we propose a substrate integrated waveguide(SIW) power divider to yield excellent broadband isolation performance. In order to achieve high broadband isolation, a two stage Wilkinson power divider is employed in SIW. The measurement results show the insertion loss(S21, S31 to be 4.0±0.5 ㏈) and input return loss(S11 of 10 ㏈) from 13.12 ㎓ to 16.14 ㎓. Moreover, the results show that the output return loss and isolation between output ports are larger than 10 ㏈ between 10.37 ㎓ and 17.64 ㎓.
Baek Yae Jee,Kim Kyeongmin,Nam Bo Da,Jung Jongtak,Lee Eunjung,Noh Hyunjin,Kim Tae Hyong 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.3
Late-onset Pneumocystis jirovecii pneumonia (PCP) can be developed in solid organ transplant (SOT) patients. Granulomatous P. jirovecii pneumonia (GPCP) can occur in immunocompromised patients, but has rarely been reported in SOT recipients. The diagnosis of GPCP is difficult since the sensitivity of sputum and bronchoalveolar lavage is low and atypical patterns are shown. A 60-year-old man, who had undergone renal transplantation 24 years ago presented with nodular and patchy lung lesions. He was asymptomatic and stable. After empirical treatment with a fluoroquinolone, the condition partially resolved but relapsed 4 months later. The pulmonary nodule was resected, and GPCP was confirmed. The pathogenesis of GPCP remains unclear, but in SOT recipients presenting with an atypical lung pattern, GPCP should be considered. This case was discussed at the Grand Clinical Ground of the Korean Society of Infectious Disease conference on November 3, 2022.
김희진(Heejin Kim),장경민(Kyeongmin Jang),김수현(Soohyeon Kim),정은상(Eunsang Jung) 한국추진공학회 2019 한국추진공학회 학술대회논문집 Vol.2019 No.5
본 연구에서는 5 N급 ADN 기반 단일추진제 추력기 설계 · 제작 기초연구로 전산유체역학 시뮬레이션을 통해 노즐 성능해석을 진행하였다. ADN 기반 단일추진제인 LMP-103S(ADN-물-메탄올-암모니아)와 FLP-106(ADN-물-메탄올)을 선정하였고, 혼합 비율은 LMP-103S(63%, 18.4%, 14%, 4.6%), FLP-106(64. 6%, 11.5%, 23.9%)로 결정하였다. LMP-103S와 FLP-106 추진제 분해 시 발생하는 가스의 성상에 따른 연소생성물 및 조성을 고려하여 노즐 요소별 치수를 설계하였다. 노즐 성능 해석을 위해 ANSYS Fluent 19.0 software k-ω SST 모델을 이용하였고, LMP-103S가 FLP-106보다 우수한 성능을 나타내었다. In this paper, nozzle performance analysis was carried out through the computational fluid dynamics simulation as a basic research on 5 N level ADN based monopropellant thruster design and fabrication. LMP-103S(ADN-water-methanol-ammonia) and FLP-106(ADN-water-methanol) were selected as the monopropellant based on ADN, and each mixing ratio of LMP-103S is (63%, 18.4%, 14%, 4.6%), and FLP -106 is (64.6%, 11.5%, 23.9%). The dimensions of the nozzle elements were designed considering the combustion products and composition according to the properties of gas generated during the decomposition of LMP-103S and FLP-106 propellants. For nozzle performance analysis, ANSYS Fluent 19.0 software k-ω SST model was used and LMP-103S have better performance than FLP-106.