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7분 선별검사(7 Minute Screen Test) 각 하위 척도의 임상적 유용성
구형모,김지혜,고선규,고혜정,이형석,김상윤,김도관 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2
Objectives : We aimed to provide standard data of the individual tests in 7MS that could generalized for Korean elderly accor-ding to age and education. We also evaluated diagnostic efFicacy of each test in 7MS. Methods : Data on demographic characteristics of 311 normals were gathered for comparison. We also assessed two differences between normal and dementia group in individual tests of 7MS. Results : All individual tests of 7MS showed significant differences in sex, age, and education, except for ECR. But there were no significant differences in sex controlling age and education. As a result of ROC curve, the ability of the ECR test to discriminate between AD and normal subject appeared superior. The scores of the individual tests of 7MS among CDR 0.5 and 1 group and normal group were compared. It was also found that the ECR test stands out among 7MS tests. Conclusion : The 7MS, Particularly ECR, had the highest sensitivity and specificity for diagnosis of AD as well as early de-mentia. It suggests that the individual tests of 7MS are useful to predict early dementia, without using the complex logistic re-gression equation.
자료포락분석을 이용한 간호조직 성과관리: 문헌 분석과 활용 전략
임지영,고국진,이현희,박연홍,양인자,최윤정,Lim, Ji Young,Ko, Gug Jin,Lee, Hyun Hee,Park, Yeon Hong,Yang, In Ja,Choi, Yun Jeong 한국가정간호학회 2015 가정간호학회지 Vol.22 No.1
Purpose: The purpose of this study was to analyze nursing research using data envelopment analysis and suggest directions for future research. Methods: We established -criteria literature search. e reviewed 45 from RISS, KISS, National assembly library and NDSL DB. Data were collected on December 17, 2013. developed analytic framework of literature reviews using Yun's study. This framework had 8 items related to approach of data envelopment analysis. Results: literature established -criteria. Average numbers of input and output variables were 2.4 and 4.2, respectively. All selected research conducted efficiency analysis, analysis, and inefficiency analysis. However only 3 research. Conclusion: he results of studysuggest that data envelopment are needed to enhance efficiencies of nursing organization as follows individual nurse's profiling to develop customized performance management plans; patient centered nursing interventions; and financial performance financial reports.
( Ji Young Lee ),( Do Youn Jun ),( Ki Yun Kim ),( Eun Ji Ha ),( Mi Hee Woo ),( Jee Youn Ko ),( Young Ho Yun ),( In-seok Oh ),( Young Ho Kim ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.1
Exposure of Jurkat T cell clone (J/Neo cells) to acacetin (5,7-dihydroxy-4`-methoxyflavone), which is present in barnyard millet (Echinochloa esculenta (A. Braun)) grains, caused cytotoxicity, enhancement of apoptotic sub-G1 rate, Bak activation, loss of mitochondrial membrane potential (Δψm), activation of caspase-9 and caspase-3, degradation of poly(ADPribose) polymerase, and FITC-Annexin V-stainable phosphatidylserine exposure on the external surface of the cytoplasmic membrane without accompanying necrosis. These apoptotic responses were abrogated in Jurkat T cell clone (J/Bcl-xL) overexpressing Bcl-xL. Under the same conditions, cellular autophagic responses, including suppression of the AktmTOR pathway and p62/SQSTM1 down-regulation, were commonly detected in J/Neo and J/Bcl-xL cells; however, formation of acridine orange-stainable acidic vascular organelles, LC3-I/II conversion, and Beclin-1 phosphorylation (Ser-15) were detected only in J/Neo cells. Correspondingly, concomitant treatment with the autophagy inhibitor (3-methyladenine or LY294002) appeared to enhance acacetin-induced apoptotic responses, such as Bak activation, Δψm loss, activation of caspase-9 and caspase-3, and apoptotic sub-G1 accumulation. This indicated that acacetin could induce apoptosis and cytoprotective autophagy in Jurkat T cells simultaneously. Together, these results demonstrate that acacetin induces not only apoptotic cell death via activation of Bak, loss of Δψm, and activation of the mitochondrial caspase cascade, but also cytoprotective autophagy resulting from suppression of the Akt-mTOR pathway. Furthermore, pharmacologic inhibition of the autophagy pathway augments the activation of Bak and resultant mitochondrial damage-mediated apoptosis in Jurkat T cells.
Yun, Hye Hyeon,Baek, Ji-Ye,Seo, Gwanwoo,Kim, Yong Sam,Ko, Jeong-Heon,Lee, Jeong-Hwa The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1) upon various stresses. Recently, HSF1 was also shown to bind to BIS, but the significance of these protein-protein interactions on HSF1 activity has not been fully defined. In the present study, we observed that complete depletion of BIS using a CRISPR/Cas9 system in A549 non-small cell lung cancer did not affect the induction of heat shock protein (HSP) 70 and HSP27 mRNAs under various stress conditions such as heat shock, proteotoxic stress, and oxidative stress. The lack of a functional association of BIS with HSF1 activity was also demonstrated by transient downregulation of BIS by siRNA in A549 and U87 glioblastoma cells. Endogenous BIS mRNA levels were significantly suppressed in BIS knockout (KO) A549 cells compared to BIS wild type (WT) A549 cells at the constitutive and inducible levels. The promoter activities of BIS and HSP70 as well as the degradation rate of BIS mRNA were not influenced by depletion of BIS. In addition, the expression levels of the mutant BIS construct, in which 14 bp were deleted as in BIS-KO A549 cells, were not different from those of the WT BIS construct, indicating that mRNA stability was not the mechanism for autoregulation of BIS. Our results suggested that BIS was not required for HSF1 activity, but was required for its own expression, which involved an HSF1-independent pathway.
Insecticidal activity of oriental medicinal plants against Myzus persicae
Ji Yun Min(민지윤),Jun Young Kim(김준영),Young Min Goo(구영민),Seung Kyu Ahn(안승규),Hyo Hyung Lee(이효형),Keon Hee Ko(고건희),Min Ji Kim(김민지),Yun Geun Kim(김윤근),Mi Young Yoon(윤미영),Gyeong Seon Kim(김경선),Kyeong Yeol Oh(오경 한국약용작물학회 2013 한국약용작물학회 학술대회논문집 Vol.2013 No.1
Ko, Ji-Yun,Lee, Jungsun,Lee, Jimin,Im, Gun-Il 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.13 No.6
<P>Adipose-derived stromal cells (ASCs) have been investigated as a cell source for tissue regeneration. The purpose of this study was first to confirm if medial meniscectomy induces osteoarthritis (OA) in goats within a relative short period of time, and more importantly, to investigate if systemic treatment with immunosuppressive drugs is necessary in intra-articular ASC xenotransplantation for successful regeneration of articular cartilage and prevention of joint inflammation. Eight Korean native black goats 1-2 years of age underwent medial meniscectomy. To evaluate the gross and histological appearance of articular cartilage, knee joints were re-exposed by a medial parapatellar incision at 8 weeks. After macroscopic scoring of gross appearance, cartilage biopsy specimens 6 mm in diameter were obtained from the femoral condyle in four goats. The goats were injected with single intra-articular dose of 7x10(6) human ASCs (hASCs) 7 days after the second arthrotomy. Four animals were treated with daily injections of cyclosporin A 10 mg/kg for 7 days, followed by a reduced dose of 5 mg/kg for another 7 days, while other 4 animals did not receive immunosuppressive therapy. All animals were sacrificed for analysis 8 weeks after injection of hASCs. OA was successfully induced 8 weeks after medial meniscectomy. Eight weeks after injection of hASCs, various signs of articular cartilage regeneration were observed. There were no significant macroscopic and histological differences between goats treated with cyclosporine and untreated goats. Interleukin-1 and tumor necrosis factor-alpha level from synovial fluid did not differ between cyclosporine-treated and untreated goats. The results indicate that immunosuppressive therapy did not influence the result of ASC xenotransplantation to treat OA.</P>
Ko, Ji-Yun,Lee, Hyun-Seob,Park, Chang-Hwan,Koh, Hyun-Chul,Lee, Yong-Sung,Lee, Sang-Hun Academic Press 2009 MOLECULAR THERAPY Vol.17 No.10
<P>We have previously demonstrated derivation of neural precursor (NP) cells of a midbrain-type from human embryonic stem (hES) cells to yield an enriched population of dopamine (DA) neurons. These hES-derived NPs can be expanded in vitro through multiple passages without altering their DA neurogenic potential. Here, we studied two aspects of these hES-NP cells that are critical issues in cell therapeutic approaches for Parkinson's disease (PD): cell survival and tumorigenic potential. Neuroepithelial rosettes, a potentially tumorigenic structure, disappeared during hES-NP cell expansion in vitro. Although a minor population of cells positive for Oct3/4, a marker specific for undifferentiated hES cells, persisted in culture during hES-NP cell expansion, they could be completely eliminated by subculturing hES-NPs under differentiation-inducing conditions. Consistently, no tumors/teratomas are formed in rats grafted with multipassaged hES-NPs. However, extensively expanded hES-NP cells easily underwent cell death during differentiation in vitro and after transplantation in vivo. Transgenic expression of Bcl-XL and sonic hedgehog (SHH) completely overcame the cell survival problems without increasing tumor formation. These findings indicate that hES-NP cell expansion in conjunction with Bcl-XL+SHH transgene expression may provide a renewable and safe source of DA neurons for transplantation in PD.</P>
Ko, Ji-Yun,Park, Chang-Hwan,Koh, Hyun-Chul,Cho, Youl-Hee,Kyhm, Jee-Hong,Kim, Young-Soo,Lee, Inchul,Lee, Yong-Sung,Lee, Sang-Hun Blackwell Publishing Ltd 2007 Journal of Neurochemistry Vol.103 No.4
<P>Abstract</P><P>Human embryonic stem (hES) cells can be guided to differentiate into ventral midbrain-type neural precursor (NP) cells that proliferate <I>in vitro</I> by specific mitogens. We investigated the potential of these NP cells derived from hES cells (hES-NP) for the large-scale generation of human dopamine (DA) neurons for functional analyses and therapeutic applications. To address this, hES-NP cells were expanded <I>in vitro</I> for 1.5 months with six passages, and their proliferation and differentiation properties determined over the NP passages. Interestingly, the total hES-NP cell number was increased by > 2 × 10<SUP>4</SUP>-folds over the <I>in vitro</I> period without alteration of phenotypic gene expression. They also sustained their differentiation capacity toward neuronal cells, exhibiting <I>in vitro</I> pre-synaptic DA neuronal functionality. Furthermore, the hES-NP cells can be cryopreserved without losing their proliferative and developmental potential. Upon transplantation into a Parkinson’s disease rat model, the multi-passaged hES-NP cells survived, integrated into the host striatum, and differentiated toward the neuronal cells expressing DA phenotypes. A significant reduction in the amphetamine-induced rotation score of Parkinson’s disease rats was observed by the cell transplantation. Taken together, these findings indicate that hES-NP cell expansion is exploitable for a large-scale generation of experimental and transplantable DA neurons of human-origin.</P>