전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

초등학생의 매체 문식 활동에 관한 조사 연구

정현선 ( Hyeon Seon Jeong ),정혜승 ( Hye Seung Chung ),김정자 ( Jeong Ja Kim ),민병곤 ( Min Byeong Gon ),손원숙 ( Won Sook Sohn ) 한국독서학회 2014 독서연구 Vol.0 No.33

이 연구는 초등학교 3~6학년 학생들의 학년별 발달과 성별 차이에 따른 매체 문식 활동(literacy practices)의 실태를 보다 구체적으로 파악하기 위한 목적으로, 초등학생들의 매체 이용을 컴퓨터와 휴대전화 이용 시간에 따라 가장 적게 이용하는 집단(집단 1)에서 가장 많이 이용하는 집단(집단 4)까지 구분하고, 집단별 읽기.쓰기 태도 및 구체적인 읽기.쓰기 활동과 연관해서 분석하였다. 이 연구의 주요 결과들은 다음과 같다. 첫째, 컴퓨터와 휴대전화를 가장 많이 사용하는 집단 4의 이용 시간이 집단 1, 2, 3에 비해 현저히 많았고, 집단 4의 읽기와 쓰기 태도는 현저히 낮은 것으로 나타났다. 또한 휴대전화와 컴퓨터를 많이 이용하는 집단일수록매체 이용에 대한 긍정적 인식과 부정적 인식이 모두 높은 것으로 나타났다. 둘째, 초등학생은 학년이 올라갈수록 매체를 많이 이용하는 집단 3과 4에 속하는 비중이 높았고, 학년이 낮을수록 매체를 적게 이용하는 집단 1과 2에 속하는 비중이 높게 나타났다. 또한 매체 선택의 성별 차이가 두드러져, 여학생은 휴대전화, 남학생은 컴퓨터의 최고 이용자 집단 비율이 높은 것으 로 나타났다. 셋째, 휴대전화의 경우 적게 이용하는 집단일수록 많이 이용하는 집단보 다 읽기, 쓰기 태도 및 자발적 읽기, 쓰기 활동이 통계적으로 유의하게 높은 것으로 나타났다. 그러나 컴퓨터 매체의 경우, 컴퓨터 이용을 가장 적게 하는 집단 1보다는 두 번째로 적게 하는 집단 2의 읽기, 쓰기 태도 및 자발적 읽기, 쓰기 활동이 가장 높은 것으로 나타났다. 이는 컴퓨터 매체의 경우무조건 쓰지 않는 것보다는 적절하게 사용하는 것이 읽기, 쓰기에 긍정적인 영향을 미친다는 것을 보여준다. 넷째, 휴대전화 이용을 많이 하는 집단일수록, 그리고 컴퓨터 이용을 많이 하는 집단일수록, ‘문자메시지, 카카오톡, 이메일, SNS, 인터넷 자료 및 만화’ 등 매체로 할 수 있는 읽기를 많이 하는 것으로 나타났다. 또한 휴대전화와 컴퓨터 이용을 가장 많이 하는 집단이 블로그 쓰기와 만화 그리기를 많이 하는 것으로 나타났다. 이는 매체 이용을 많이 하는 집단이 매체로 할 수 있는 읽기와 쓰기를 많이 하고 있고 긍정적 인식과 부정적 인식이 모두 높은 만큼, 매체를 읽기, 쓰기 활동과 연계할 수 있는 긍정적 활용 방안의 모색이 필요함을 보여준다. 이 연구의 결과들은 가정과 학교에서 문식 활동을 위해 매체를 도입하거 나 활용할 때 학년에 따른 발달과 성차를 고려하여야 하며, 학생들의 적절한 매체 이용에 대해 가정과 학교에서 적절한 지도가 필요하고, 학생들이 자발 적으로 하고 있는 매체 문식 활동들을 문식성 학습의 생산적 자원으로 삼는 연계 방안 또한 필요함을 보여준다. The purpose of the study was specifically to analyze the status of the media literacy practices in development according to grade and gender differences among 3rd ~ 6th grade elementary school students. The students were classified into groups from those with the least use of computers and mobile phones (group 1) to those with the most use (group 4), and analysis was carried out related to the reading, writing, attitude and specific reading and writing activities for each group. The major results of the study are as follows. First, group 4 spent remarkably higher amounts of time with computers and mobile phones than groups 1, 2 and 3, and presented a much lower attitude toward reading and writing. In addition, it was found that the group with higher use of mobile phones and computers marked highly positive and negative recognitions about their media use. Second, older students tended to be included in groups 3 and 4, while higher proportions of the younger students were found to be in the groups 1 and 2 with the least use of media. The survey results also showed remarkable gender differences in media selection, indicating that a high proportion of girls marked interest in mobile phones, whereas a high proportion of boys marked interest in computers. Third, it was discovered that the group with less use of mobile phones showed remarkably higher activities in reading, writing, and voluntary reading and writingactivities compared to the group with more use. However, group 2, with the second least use of computers, showed the highest reading, writing, and voluntary reading and writing activities among the groups. This suggests that computers positively affected reading and writing when used appropriately rather than not being used at all. Fourth, it was found that the group with higher use of mobile phones and computers did more reading of media like ‘text messages, Kakao Talk, e-mail, SNS, and Internet articles and comics’. Consequently, this group was also found to write more on blogs, and drew comics. This means that the group with more use of the media did more reading and writing with use of the media, and showed both positive and negative recognition, requiring positive utilization to link the media with reading and writing activities. The results of this study can be used to consider the development and gender differences while introducing or implementing media for literacy practices at home and school. It also showed that a guide is required at home and school for appropriate media use by students, as well as plans related to utilization of media literacy practices as resources of literacy learning voluntarily performed by students.

전방내 Carbachol 또는 Acetylcholine 주입이술후 조기 안압에 미치는 영향

손정현(Jeong Hyeon Sohn),김지영(Jee Young Kim),윤동호(Dong Ho Youn) 대한안과학회 1994 대한안과학회지 Vol.35 No.9

일회용 콘택즈렌즈가 상층각막상피성형술 후 각막 상피재생시간 및 속도에 미치는 영향

손정현(Jeong Hyeon Sohn),최상경(Sang Kyoung Choi),이진학(Jin Hak Lee) 대한안과학회 1995 대한안과학회지 Vol.36 No.8

망막 분지 정맥 폐쇄에 대한 레이저 치료의 효과

손정현(Jeong Hyeon Sohn),오세오(Se Oh Oh),이재흥(Jae Heung Lee) 대한안과학회 1993 대한안과학회지 Vol.34 No.6

THE BONDAGE NUMBER OF C₃×C_n

Sohn, Moo-Young,Xudong, Yuan,Jeong, Hyeon-Seok Korean Mathematical Society 2007 대한수학회지 Vol.44 No.6

The domination number ${\gamma}(G)$ of a graph G=(V,E) is the minimum cardinality of a subset of V such that every vertex is either in the set or is adjacent to some vertex in the set. The bondage number of b(G) of a graph G is the cardinality of a smallest set of edges whose removal from G results in a graph with domination number greater than ${\gamma}(G)$. In this paper, we calculate the bondage number of the Cartesian product of cycles $C_3\;and\;C_n$ for all n.

초등학교 수학과 수준별 수업을 위한 차시 내 단계형 개별화 프로그램과 피드백의 효과에 관한 연구

정서현, 손교용 대구교육대학교 초등교육연구소 2022 초등교육연구논총 Vol.38 No.1

This study was conducted to find out the effect of in-class step-by-step individualization programs and feedback for elementary school mathematics classes by level, and to find out the effect of in-class step-by-step individualization programs on students' math academic achievement and mathematical attitude. In order to find out the effect of the application of in-class step-by-step individualization program for classes by level and feedback, Classes were conducted in which a step-by-step individualization program was applied to the experimental group (24 students), and general classes were conducted to the comparative group (23 students). The conclusions obtained through this study are as follows. First, the in-time step-by-step individualization program and feedback improved the average score of students' math academic achievement evaluation, and in particular, the lower-ranked students had statistically significant effects compared to the comparative group. Second, the step-by-step individualization program positively changed some areas of students' mathematical attitudes. In particular, there were statistically significant changes in the areas of 'attention concentration' and 'achievement motivation' compared to the comparative group. Third, in a survey of in-class step-by-step individualization program for classes by level, students answered that the teaching method helps improve their math skills and confidence and promotes mathematical communication. Through this study, it was revealed that the application of in-time step-by-step individualization programs for level-by-level classes and feedback improved the mathematical achievement of lower-ranked students statistically significantly compared to the comparative group during the experiment period. In addition, through the survey, students' positive thoughts on the in-class step-by-step individualization program for classes by level and feedback and the advantages of the program were discovered. 본 연구는 수학과 수준별 수업을 위한 차시 내 단계형 개별화 프로그램과 피드백의 활용한 수업이 초등학교 4학년 학생들의 수학 학업성취도와 수학적 태도에 미치는 효과를 알아보았다. 연구대상은 초등학교 4학년 24명을 선정하여 실험집단에 차시 내 단계형 개별화 프로그램을 적용한 수업을 3단원 30차시를 실시하였으며, 비교집단의 23명은 일반적인 수업을 실시하였다. 연구 결과는 다음과 같다. 첫째, 차시 내 단계형 개별화 프로그램과 피드백을 실시한 결과 학생들의 수학 학업성취도에 긍정적인 영향을 주었다. 특히, 점수별 세 개의 소집단으로 분류 된 하위권집단 학생들의 학업성취도에 유의미한 효과가 있었다. 둘째, 차시 내 단계형 개별화 프로그램은 학생들이 수학적 태도의 하위요소인 주의집중과 성취동기 영역에서 유의미한 효과 가 있었다. 셋째, 차시 내 단계형 개별화 프로그램은 수업 방식이 학생들의 수학실력과 자신감 향상에 도움을 주며 수학적 의사소통을 활발하게 해 주었다.

Contribution to deciphering emplacement processes of ancient ignimbrites via analyses of magnetic susceptibility and isothermal remanent magnetization: a case study from the Southern Kusandong Tuff

Hyeon-Seon Ahn,Jong Ok Jeong,Young Kwan Sohn,Moon Son,Hyeongseong Cho 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10

Ignimbrites are commonly structureless and thus often need diverse analytical tools to reveal their associated geological processes. Analyses utilizing magnetic property measurements that allow identification of the type, amount, grain size distribution and other additional informative features of the constituent magnetic minerals of ignimbrites can aid in deciphering such ignimbrite-related processes. In this work, magnetic property analyses of magnetic susceptibility (MS) and isothermal remanent magnetization (IRM), together with optical and electron microscopic observations, have been conducted on massive parts of the Cretaceous Southern Kusandong Tuff (12 localities) to better understand its related emplacement processes. The massive parts show systematic vertical variation in MS within each locality, and the vertical variation patterns vary from locality to locality, being classified broadly into three types. A linear relationship between MS and IRM indicates predominant contribution of ferri- and antiferro-magnetic minerals to MS in the majority of this tuff. Integrated results of microscope images, temperature variations of MS, and IRM component analyses indicate that the major magnetic minerals are coarse magnetite (with occasionally partial maghemitization) of both primary and secondary origins, very fine secondary magnetite, and secondary hematite and goethite. Quantitative comparison of the unmixed magnetic mineral components reveals that those vertical MS variations are related to some combination of magnetite destruction and subsequent precipitation of antiferromagnetic minerals by post-depositional alterations at different stages and magnetite supply by deposition of additional cooling unit. Despite the recognition of the adverse post-depositional modifications of MS, it is found that the massive part of this tuff is a composite unit formed by accumulation of multiple cooling units from multiple pyroclastic current pulses probably associated with fluctuations in eruption rate at one or multiple source vent(s). This work exemplifies how the methodological approach using MS and IRM can provide additional contribution to characterize the nature of ignimbrite.

Development of self-microemulsifying bilayer tablets for pH-independent fast release of candesartan cilexetil.

Sohn, Yesung,Lee, Su Yeon,Lee, Ga Hyeon,Na, Yeon-Joo,Kim, Seong Yeon,Seong, Ilkyeong,Lee, Beom-Jin,Kuh, Hyo-Jeong,Lee, Jaehwi Govi-Verlag Pharmazeutischer Verlag [etc.] ; Verla 2012 PHARMAZIE Vol.67 No.11

<P>The aim of this study was to design self-microemulsifying tablets for pH-independent fast release of poorly soluble candesartan cilexetil (CDC). To improve the solubility of CDC, a self-microemulsifying drug delivery system (SMEDDS) was prepared composed of Capryol 90, Tween 80 and tetraglycol at a ratio of 5:35:60. Drug containing SMEDDS was adsorbed onto Fujicalin and Neusilin UFL2, respectively, used as solidification carriers and subsequently compressed into tablets (self-microemulsifying tablet, SMET). SMET using Fujicalin exhibited immediate CDC release in pH 1.2 medium while Neusilin UFL2-based SMET showed fast release, especially at pH 6.5. Thus, optimized SMET could be produced with one layer of Fujicalin and the other layer with Neusilin UFL2, demonstrating CDC release of 75% of the initial dose within 15 min in all pH conditions (1.2, 4.5, and 6.5). The average diameter of emulsion droplets formed from SMET was less than 200 nm. It was thus expected that Fujicalin and Neusilin UFL2-based bi-layer SMET would overcome low oral bioavailability of CDC due to its limited solubility at physiological pH conditions in the gastrointestinal tract.</P>

Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways

SOHN, EUN JEONG,SHIN, MIN JEA,EUM, WON SIK,KIM, DAE WON,YONG, JI IN,RYU, EUN JI,PARK, JUNG HWAN,CHO, SU BIN,CHA, HYUN JU,KIM, SANG JIN,YEO, HYEON JI,YEO, EUN JI,CHOI, YEON JOO,IM, SEUNG KWON,KWEON, HA Spandidos Publications 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.38 No.1

<P>Oxidative stress-induced apoptosis is associated with neuronal cell death and ischemia. The NOL3 [nucleolar protein 3 (apoptosis repressor with CARD domain)] protein protects against oxidative stress-induced cell death. However, the protective mechanism responsible for this effect as well as the effects of NOL3 against oxidative stress in ischemia remain unclear. Thus, we examined the protective effects of NOL3 protein on hydrogen peroxide (H2O2)-induced oxidative stress and the mechanism responsible for these effects in hippocampal neuronal HT22 cells and in an animal model of forebrain ischemia using Tat-fused NOL3 protein (Tat-NOL3). Purified Tat-NOL3 protein transduced into the H2O2-exposed HT22 cells and inhibited the production of reactive oxygen species (ROS), DNA fragmentation and reduced mitochondrial membrane potential (Delta(Psi m)). In addition, Tat-NOL3 prevented neuronal cell death through the regulation of apoptotic signaling pathways including Bax, Bcl-2, caspase-2, -3 and -8, PARP and p53. In addition, Tat-NOL3 protein transduced into the animal brains and significantly protected against neuronal cell death in the CA1 region of the hippocampus by regulating the activation of microglia and astrocytes. Taken together, these findings demonstrate that Tat-NOL3 protein protects against oxidative stress-induced neuronal cell death by regulating oxidative stress and by acting as an anti-apoptotic protein. Thus, we suggest that Tat-NOL3 represents a potential therapeutic agent for protection against ischemic brain injury.</P>